Respiratory Rehabilitation | Page 4 of 11 | Links Medicus Content Curation & Alerts in Medicine

[Preprint] Long Covid: A systematic review and meta-analysis of 120,970 patients.

13 May, 2022 | 11:30h | UTC

Long Covid: A Systematic Review and Meta-Analysis of 120,970 Patients – Preprints with The Lancet

Commentary on Twitter

A systematic #LongCovid review of nearly 200 studies and over 120,000 participants, reinforces the high frequency of symptoms > 6 months, not linked to severity of acute illness, and potential for marked disabilityhttps://t.co/9NYQT1P79G pic.twitter.com/WFzBqghbGI

— Eric Topol (@EricTopol) May 6, 2022

Review: Comfort during non-invasive ventilation.

12 May, 2022 | 08:07h | UTC

Comfort During Non-invasive Ventilation – Frontiers in Medicine

Review: Mucus clearance strategies in mechanically ventilated patients.

12 May, 2022 | 08:06h | UTC

Mucus Clearance Strategies in Mechanically Ventilated Patients – Frontiers in Physiology

Brief Review | In search of the Holy Grail: identifying the best PEEP in ventilated patients.

9 May, 2022 | 01:50h | UTC

In search of the Holy Grail: identifying the best PEEP in ventilated patients – Intensive Care Medicine

Commentary on Twitter

Best PEEP on MV?? Individual-specific providing oxygenation (SpO2 >90%/no excessive FiO2 + acceptable PaCO2 (<50/55 mmHg) & minimal need for fluids/cardioactives. Start at 10-12 but stay alert to hemodynamic impact & as set, serially asses need/adequacy.
🖇https://t.co/wdK92bs8B9 pic.twitter.com/NlTzoxfwa5

— Intensive Care Medicine (@yourICM) May 5, 2022

Brief Review | Oxygen targets.

9 May, 2022 | 01:48h | UTC

Oxygen targets – Intensive Care Medicine (if the link is paywalled, try this one)

Thoracic Society of Australia and New Zealand Position Statement on Acute Oxygen Use in Adults: ‘Swimming between the flags’ – Respirology

Long-term mortality and health-related quality of life of lower versus higher oxygenation targets in ICU patients with severe hypoxaemia – Intensive Care Medicine

Oxygen Targets During Mechanical Ventilation in the ICU: A Systematic Review and Meta-Analysis – Critical Care Explorations

Effect of Low-Normal vs High-Normal Oxygenation Targets on Organ Dysfunction in Critically Ill Patients: A Randomized Clinical Trial – JAMA

Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure – New England Journal of Medicine

Commentary on Twitter

Oxygen targets in #ICU?? Supplemental O2 often required in critically ill, but balancing opposing risks hypo/hyperxaemia required to choose right amount to give. Hyperoxaemia associated with negative cellular/physiological effects: O2 can harm!#FOAMcc
🫧 https://t.co/F4r3Qg7hXg pic.twitter.com/EizwMNjjnc

— Intensive Care Medicine (@yourICM) May 7, 2022

RCT: Effect of early vs. standard approach to tracheostomy on functional outcome at 6 months among patients with severe stroke receiving mechanical ventilation.

6 May, 2022 | 11:13h | UTC

Effect of Early vs Standard Approach to Tracheostomy on Functional Outcome at 6 Months Among Patients With Severe Stroke Receiving Mechanical Ventilation: The SETPOINT2 Randomized Clinical Trial – JAMA (free for a limited period)

Commentary on Twitter

In this study, among patients with severe stroke receiving mechanical ventilation, a strategy of early tracheostomy, compared with a standard approach to tracheostomy, did not significantly improve functional outcome at 6 months. https://t.co/bLZ4b6hBxr

— JAMA (@JAMA_current) May 4, 2022

Long COVID: aiming for a consensus.

6 May, 2022 | 11:03h | UTC

Long COVID: aiming for a consensus – The Lancet Respiratory Medicine

Commentary on Twitter

There is an urgent need for unification of terminology for the sequelae of #SARSCoV2 infection to ensure that research is directed towards and translated into interventional trials to improve outcomes

NEW Comment—#LongCOVID: aiming for a consensushttps://t.co/dZO4rBVCSY pic.twitter.com/H5ezqL0RLb

— The Lancet Respiratory Medicine (@LancetRespirMed) May 5, 2022

RCT: Effects of an online breathing and wellbeing program for people with persistent symptoms following COVID-19.

3 May, 2022 | 11:16h | UTC

An online breathing and wellbeing programme (ENO Breathe) for people with persistent symptoms following COVID-19: a parallel-group, single-blind, randomised controlled trial – The Lancet Respiratory Medicine

Invited Commentary: Treating COVID-19-related breathlessness with novel interventions – The Lancet Respiratory Medicine

News Release: Singing techniques can improve quality of life and breathlessness after COVID-19 – Imperial College London

Commentary on Twitter

https://twitter.com/LancetRespirMed/status/1519572126772064256

Systematic Review: Telerehabilitation improves physical function and reduces dyspnea in people with COVID-19 and post-COVID-19 conditions.

3 May, 2022 | 11:05h | UTC

Telerehabilitation improves physical function and reduces dyspnoea in people with COVID-19 and post-COVID-19 conditions: a systematic review – Journal of Physiotherapy

Brief Review: Lung recruitment.

3 May, 2022 | 10:49h | UTC

Lung recruitment – Intensive Care Medicine

Commentary on Twitter

Lung recruitment
💨 what's it?
💨 how to explain variability in recruitability among pts?
💨 how can recruitment be measured? Directly &/or indirectly?
Knowing potential recruitability crucial to optimize MV: lot of questions, answers #FOAMcc on @yourICM
📎https://t.co/y3LizTsWWZ pic.twitter.com/9CNS382O9H

— Intensive Care Medicine (@yourICM) May 2, 2022

Development and validation of the symptom burden questionnaire for long covid (SBQ-LC): Rasch analysis.

28 Apr, 2022 | 10:56h | UTC

Development and validation of the symptom burden questionnaire for long covid (SBQ-LC): Rasch analysis – The BMJ

Commentary on Twitter

https://twitter.com/bmj_latest/status/1519430941759918080

Covid-19: Only a quarter of patients admitted to hospital feel fully recovered after a year, study finds.

26 Apr, 2022 | 08:45h | UTC

Covid-19: Only a quarter of patients admitted to hospital feel fully recovered after a year, study finds – The BMJ

Original Study: Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study – The Lancet Respiratory Medicine

Invited Commentary: Long COVID: systemic inflammation and obesity as therapeutic targets – The Lancet Respiratory Medicine

Commentary on Twitter (thread – click for more)

PHOSP-COVID study:
– 232 (29%) of 804 pts fully recovered at 1y
– Female sex, obesity, & IMV = less likely to feel fully recovered
– inflamm mediators📈in those w/ most severe physical, mental health, & cognitive impairments

Read it here: https://t.co/rVZuVDo4xl

— The Lancet Respiratory Medicine (@LancetRespirMed) April 25, 2022

Persistent COVID-19 symptoms in a community study of 606,434 people in England.

26 Apr, 2022 | 08:48h | UTC

Persistent COVID-19 symptoms in a community study of 606,434 people in England – Nature Communications

Commentary on Twitter

Thirty-eight percent of participants from a community-based study of symptoms following COVID-19 reported persistent symptoms that lasted 12 weeks or more, according to an article published in @NatureComms. https://t.co/sAEutdOkSS pic.twitter.com/oCyyXGIRbk

— Nature Portfolio (@NaturePortfolio) April 20, 2022

One-year follow-up of a RCT: In ICU patients with severe hypoxemia, there was no difference in long-term mortality and health-related quality of life with lower vs. higher oxygenation targets.

22 Apr, 2022 | 09:32h | UTC

Long-term mortality and health-related quality of life of lower versus higher oxygenation targets in ICU patients with severe hypoxaemia – Intensive Care Medicine

Original Study: Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure – New England Journal of Medicine

Commentary on Twitter

Lower (8 kPa) vs higher oxygenation (12 kPa) targets: no longterm survival benefit nor HRQoL improvement at 1y in #ICU pts with severe hypoxaemia (HOT-ICU trial cohort). Substantial impairments in several EQ-5D-5L dimensions in survivors in both groups.
🖇️ https://t.co/P48Cd5sIWK pic.twitter.com/JBFEIqDdcB

— Intensive Care Medicine (@yourICM) April 20, 2022

A nonrandomized controlled study found awake prone position (median of 4.2 hours per day) may not benefit hospitalized adults with Covid-19.

20 Apr, 2022 | 09:56h | UTC

Assessment of Awake Prone Positioning in Hospitalized Adults With COVID-19: A Nonrandomized Controlled Trial – JAMA Internal Medicine

Commentaries:

Prone Positioning for Nonintubated Patients With COVID-19—Potential Dangers of Extrapolation and Intermediate Outcome Variables – JAMA Internal Medicine

Study suggests worse outcomes for awake COVID patients in prone position – CIDRAP

Putting Hospitalized COVID Patients on Their Belly May Not Be a Good Idea After All – HealthDay

Awake prone positioning for non-intubated patients with COVID-19-related acute hypoxaemic respiratory failure: a systematic review and meta-analysis – The Lancet Respiratory Medicine

Prone positioning of patients with moderate hypoxaemia due to covid-19: multicentre pragmatic randomised trial (COVID-PRONE) – The BMJ

RCT: Prone positioning of patients with moderate hypoxia due to COVID-19 – medRxiv

Awake prone positioning for COVID-19 acute hypoxaemic respiratory failure: a randomised, controlled, multinational, open-label meta-trial – The Lancet Respiratory Medicine

Awake prone positioning in patients with hypoxemic respiratory failure due to COVID-19: the PROFLO multicenter randomized clinical trial – Critical Care

Prone Positioning of Nonintubated Patients With Coronavirus Disease 2019—A Systematic Review and Meta-Analysis – Critical Care Medicine

Commentary on Twitter (thread – click for more)

Important negative study: non randomized trial finds no clinical benefit to awake proning vs usual care in COVID

No difference in rates of intubation, length of stay, or 28 day mortality

Medicine is humbling. This emphasizes the importance of trials
📄https://t.co/ksh9Ic9XBL
1/ pic.twitter.com/sjHHv4WQs8

— Nick Mark MD (@nickmmark) April 18, 2022

M-A: Global prevalence of post COVID-19 condition or long COVID.

19 Apr, 2022 | 02:18h | UTC

Global Prevalence of Post COVID-19 Condition or Long COVID: A Meta-Analysis and Systematic Review – The Journal of Infectious Diseases

Commentary: Global data reveal half may have long COVID 4 months on – CIDRAP

Commentary on Twitter (thread – click for more)

🚨The so far largest meta-analysis of more than 1.5 million infected individuals puts the global prevalence of #LongCovid at 43%. Some additional key findings. 🧵https://t.co/XGu23MV3Ra
1/

— Jonas R. Kunst (@kunstjonas.bsky.social) (@KunstJonas) April 17, 2022

M-A: Oxygen targets during mechanical ventilation in the ICU.

11 Apr, 2022 | 01:26h | UTC

Oxygen Targets During Mechanical Ventilation in the ICU: A Systematic Review and Meta-Analysis – Critical Care Explorations

Long COVID in children: a modified Delphi process.

8 Apr, 2022 | 10:40h | UTC

Long COVID (post-COVID-19 condition) in children: a modified Delphi process – Archives of Disease in Childhood

First research definition for ‘Long COVID’ in kids and young people formally agreed.

Cohort Study: Physical and mental health 3 months after SARS-CoV-2 infection (long COVID) among adolescents in England.

A nationwide cohort study in Denmark showed Long Covid in children is rare and mainly of short duration.

E ditorial | Long covid in children and adolescents – “Risk appears low, but many questions remain”.

M-A: Persistent symptoms following SARS-CoV-2 infection among children and young people – “Higher study quality was associated with lower prevalence of all symptoms, except loss of smell and cognitive symptoms”.

Review: Long COVID symptoms in children rarely persist beyond three months.

Cohort study: long term follow-up showed most patients with post–COVID-19 Multisystem Inflammatory Syndrome in Children had good outcomes with no significant medium- or long-term sequelae.

Do kids get long COVID? And how often? A pediatrician looks at the data – Children also get Long Covid, but much less often than adults.

Illness duration and symptom profile in symptomatic school-aged children tested for SARS-CoV-2 – “Only 25 (1.8%) of 1379 children experienced symptoms for at least 56 days.”

Long-term Symptoms After SARS-CoV-2 Infection in Children and Adolescents – “This study found a low prevalence of symptoms compatible with long COVID in a randomly selected cohort of children assessed 6 months after serologic testing”.

Study shows low incidence of post-acute COVID-19 symptoms (“Long Covid”) in children after mild disease

Perspective | Studying severe long COVID to understand post-infectious disorders beyond COVID-19.

7 Apr, 2022 | 08:45h | UTC

Studying severe long COVID to understand post-infectious disorders beyond COVID-19 – Nature Medicine

Review: Post-acute COVID-19 syndrome.

ESCMID rapid guidelines for assessment and management of long COVID.

ERS statement on Long COVID-19 follow-up.

Proposed subtypes of long-Covid and their respective potential therapies.

EuGMS Guidance: Management of post-acute COVID-19 patients in geriatric rehabilitation.

Addressing Post-COVID Symptoms: A Guide for Primary Care Physicians.

Global surveillance, research, and collaboration needed to improve understanding and management of long COVID.

Provocative study suggests that persistent physical symptoms after COVID-19 infection may be associated more with the belief in having been infected with SARS-CoV-2 than with having laboratory-confirmed COVID-19 infection.

Update to post-acute sequelae of SARS-CoV-2 infection: Caring for the ‘long-haulers’.

Systematic Review: Short-term and long-term rates of postacute sequelae of SARS-CoV-2 infection.

WHO Consensus: A clinical case definition of post COVID-19 condition (Long Covid).

Characterizing long COVID: a living systematic review.

Long Covid – The illness narratives.

New guidelines to help doctors manage long COVID patients published.

M-A: More than 50 long-term effects of COVID-19. (several articles on the subject)

2022 ACC expert consensus decision pathway on cardiovascular sequelae of COVID-19 in adults: myocarditis and other myocardial involvement, post-acute sequelae of SARS-CoV-2 infection, and return to play.

Review | Long COVID: post-acute sequelae of COVID-19 with a cardiovascular focus.

The pathogenesis and long-term consequences of Covid-19 cardiac injury: state-of-the-art review.

COVID-19 infections increase risk of heart conditions up to a year later, study finds.

Commentary from the author on Twitter (thread – click for more)

1/ HGE (https://t.co/VMUVMAo1bJ) position paper on #LongCOVID #PACS . By focusing on the most severe patients, w severe organ damage/dysfunction following mild/moderate #COVID19 – we will search for genetic and immunological mechanisms of disease https://t.co/dZQPEoNkhl pic.twitter.com/tgblk7oFQG

— Petter Brodin (@BrodinPetter) April 5, 2022