Pharmacology/Pharmaceutical Industry | Page 86 of 172 | Links Medicus Content Curation & Alerts in Medicine

Study: One Pfizer/BioNTech shot gives 85% Covid protection

21 Feb, 2021 | 22:41h | UTC

One Pfizer/BioNTech shot gives 85% Covid protection – study – The Guardian

Original study: Early rate reductions of SARS-CoV-2 infection and COVID-19 in BNT162b2 vaccine recipients – The Lancet

Commentary on Twitter

NEW Correspondence reports early findings from study of #Pfizer #vaccine in health-care workers in Israel, suggesting early reductions in #COVID19 infection and symptomatic rates following first dose. Read https://t.co/ONU8bS3Iwo pic.twitter.com/BDDvA7Juyb

— The Lancet (@TheLancet) February 19, 2021

Pfizer vaccine doesn’t need ultra-cold storage after all, company says

21 Feb, 2021 | 22:37h | UTC

Pfizer vaccine doesn’t need ultra-cold storage after all, company says – ARS Technica

News release: PFIZER AND BIONTECH SUBMIT COVID-19 VACCINE STABILITY DATA AT STANDARD FREEZER TEMPERATURE TO THE U.S. FDA

Commentary on Twitter

🔥Pfizer BioNTech announced submission of new data to the U.S. FDA demonstrating the stability of their COVID-19 vaccine when stored at -25°C to -15°C (-13°F to 5°F), temperatures more commonly found in pharmaceutical freezers and refrigerators🔥https://t.co/egFsSe4oBB

— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) February 19, 2021

A single dose of the Pfizer–BioNTech vaccine is 92.6% effective in preventing Covid-19. Is delaying the second dose to get more people vaccinated an alternative?

19 Feb, 2021 | 02:59h | UTC

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine – New England Journal of Medicine

Commentary: Researchers urge delaying Pfizer vaccine’s second dose as first highly effective – Reuters

Covid-19: In vitro studies show Pfizer-BioNTech and Moderna vaccines produce fewer antibodies against South African variant

19 Feb, 2021 | 03:01h | UTC

Study 1: Neutralizing Activity of BNT162b2-Elicited Serum — Preliminary Report – New England Journal of Medicine

Study 2: Serum Neutralizing Activity Elicited by mRNA-1273 Vaccine — Preliminary Report – New England Journal of Medicine

Commentaries: Expert reaction to two NEJM Correspondence articles on in vitro studies of the Pfizer-BioNTech and Moderna vaccines and different variants/mutations including mutations on the South Africa variant – Science Media Centre AND Lab studies suggest Pfizer, Moderna vaccines can protect against coronavirus variant – CNN AND Pfizer and Moderna vaccines have reduced effectiveness against South African variant, newly published studies show – The Washington Post AND Pfizer, Moderna vaccines less effective against South African COVID variant – MedicalXpress

Commentary on Twitter

New reports @NEJM today confirming some immune evasion of the B.1.351 variant (identified in South Africa) to both the mRNA vaccines, in vitro data @BioNTech_Group/@Pfizer and @moderna_tx. Less vaccine efficacy vs B.1.351 has been confirmed in clinical trials for 3 vaccines pic.twitter.com/2N7eKDllso

— Eric Topol (@EricTopol) February 17, 2021

What does 95% COVID-19 vaccine efficacy really mean?

19 Feb, 2021 | 02:58h | UTC

What does 95% COVID-19 vaccine efficacy really mean? – The Lancet Infectious Diseases

Fauci: There’s evidence COVID-19 vaccines don’t just protect you — they may stop you from spreading the virus to others, too

19 Feb, 2021 | 02:46h | UTC

Fauci: There’s evidence COVID-19 vaccines don’t just protect you — they may stop you from spreading the virus to others, too – Insider

The price of success—how to evaluate Covid-19 vaccines when they’re available outside of clinical trials

19 Feb, 2021 | 02:43h | UTC

The Price of Success—How to Evaluate COVID-19 Vaccines When They’re Available Outside of Clinical Trials – JAMA

M-A: Not enough evidence there are individual differences in response to antidepressants

19 Feb, 2021 | 02:15h | UTC

Individual Differences in Response to Antidepressants: A Meta-analysis of Placebo-Controlled Randomized Clinical Trials – JAMA Psychiatry (free for a limited period)

Editorial: New Directions in Research on Heterogeneity of Treatment Effects for Major Depression (free for a limited period)

Commentary: Antidepressants for MDD: Time to Rethink Personalized Therapy? – Physician’s Weekly

Commentary on Twitter (thread – click for more)

https://twitter.com/PloederlM/status/1362294365255852032

RCT: Treatment of uterine fibroid symptoms with Relugolix combination therapy

19 Feb, 2021 | 02:08h | UTC

Treatment of Uterine Fibroid Symptoms with Relugolix Combination Therapy – New England Journal of Medicine

RCT: Vitamin D3 does not improve outcomes in hospitalized patients with moderate to severe COVID-19

18 Feb, 2021 | 03:20h | UTC

Effect of a Single High Dose of Vitamin D₃ on Hospital Length of Stay in Patients With Moderate to Severe COVID-19: A Randomized Clinical Trial – JAMA

Editorial: Vitamin D₃ to Treat COVID-19: Different Disease, Same Answer

In this RCT a single high dose of #vitaminD3 (100K IU) raised mean serum 25OH D levels but had no effect on hospital LOS (primary outcome), in-hospital mortality, ICU admission, or need for mechanical ventilation (secondary outcomes) https://t.co/eozVaYnb25

— JAMA (@JAMA_current) February 17, 2021

Clinical decisions: Delayed second dose vs. standard regimen for Covid-19 vaccination

18 Feb, 2021 | 03:17h | UTC

Delayed Second Dose versus Standard Regimen for Covid-19 Vaccination – New England Journal of Medicine

SR: Concomitant use of levothyroxine and proton pump inhibitors causes a significant increase in TSH concentration

18 Feb, 2021 | 02:48h | UTC

Concomitant Use of Levothyroxine and Proton Pump Inhibitors in Patients with Primary Hypothyroidism: a Systematic Review – Journal of General Internal Medicine

A small, randomized cross-over trial showed Ivabradine may be a useful medication for hyperadrenergic POTS (Postural orthostatic tachycardia syndrome)

18 Feb, 2021 | 02:56h | UTC

Randomized Trial of Ivabradine in Patients With Hyperadrenergic Postural Orthostatic Tachycardia Syndrome – Journal of the American Academy of Cardiology (link to abstract – $ for full-text)

Commentaries: Existing heart failure drug may treat potential COVID-19 long-hauler symptom, study suggests – University of California – San Diego AND Randomized Trial of Ivabradine in Patients With Hyperadrenergic Postural Orthostatic Tachycardia Syndrome – Ivabradine in POTS – American College of Cardiology

Commentary on Twitter

Our study showing ivabradine's benefit for POTS patients is out @JACCJournals. Also has implications for post-COVID 19 POTS (part of long haulers syndrome). Congrats to my co-first author/mentee @AdenaZadourian and the rest of my research team. @Dysautonomia @NIH @UCSDHealth pic.twitter.com/KGtzFh9CnT

— Pam R. Taub, MD❤️💃🏻 (@PamTaubMD) February 15, 2021

M-A: Preventable medication harm across health care settings

18 Feb, 2021 | 02:43h | UTC

Preventable medication harm across health care settings: a systematic review and meta-analysis – BMC Medicine

Commentary: Preventable medication harm across health care settings: a systematic review and meta-analysis – PSNet

RCT: Avacopan for the treatment of ANCA-associated vasculitis

18 Feb, 2021 | 02:50h | UTC

Avacopan for the Treatment of ANCA-Associated Vasculitis – New England Journal of Medicine (link to abstract – $ for full-text)

RCT: Cemiplimab monotherapy for first-line treatment of advanced non-small-cell lung cancer with PD-L1 of at least 50%

18 Feb, 2021 | 02:34h | UTC

Cemiplimab monotherapy for first-line treatment of advanced non-small-cell lung cancer with PD-L1 of at least 50%: a multicentre, open-label, global, phase 3, randomised, controlled trial – The Lancet

Commentary on Twitter

Phase 3 trial suggests #cemiplimab could be used as new first-line monotherapy option for patients with advanced non-small-cell #lungcancer with PD-L1 of at least 50%—it improved overall & progression-free survival compared with chemotherapy. Read https://t.co/O06Of6wx07 pic.twitter.com/KtQ24lEoR5

— The Lancet (@TheLancet) February 17, 2021

How effective is magnesium in for the treatment of migraine?

16 Feb, 2021 | 01:48h | UTC

How Effective is Magnesium in your MAGraine Cocktail? – Journal Feed

Original study: MAGraine: Magnesium compared to conventional therapy for treatment of migraines – American Journal of Emergency Medicine

Should you mix and match COVID-19 vaccines? Scientists are seeking answers

16 Feb, 2021 | 02:18h | UTC

Should you mix and match COVID-19 vaccines? Scientists are seeking answers – Science (a few articles per month are free)

Escaping Catch-22 — Overcoming Covid Vaccine Hesitancy

16 Feb, 2021 | 02:12h | UTC

Escaping Catch-22 — Overcoming Covid Vaccine Hesitancy – New England Journal of Medicine

Potential health and economic impacts of dexamethasone treatment for patients with COVID-19

16 Feb, 2021 | 02:10h | UTC

Potential health and economic impacts of dexamethasone treatment for patients with COVID-19 – Nature Communications

Commentary on Twitter

RCTs Save Live$
DEXA saves live$
Potential health&economic impacts of dexamethasone treatment for #COVID19 patients
The study estimate that between July & Dec 2020, for 🇬🇧, ~12,000 lives could be saved & ~650,000 lives saved globally over the same time https://t.co/B7jVa5Xc0s pic.twitter.com/mI0wPVUj4C

— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) February 10, 2021