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RCT: In patients with atrial fibrillation or mechanical heart valves treated with warfarin undergoing surgery, postoperative bridging treatment with low molecular weight heparin did not prevent major thromboembolism.

11 Jun, 2021 | 08:19h | UTC

Postoperative low molecular weight heparin bridging treatment for patients at high risk of arterial thromboembolism (PERIOP2): double blind randomised controlled trial – The BMJ

 

Commentary on Twitter

 

WHO Report: Global antimicrobial resistance and use surveillance system.

11 Jun, 2021 | 08:22h | UTC

Global Antimicrobial Resistance and Use Surveillance System (GLASS) Report: 2021 – World Health Organization

News Release: Record response to WHO’s call for antimicrobial resistance surveillance reports in 2020 – World Health Organization

Commentary: WHO reveals new global antibiotic resistance data, more concerns – CIDRAP

 

Commentary on Twitter (thread – click for more)

 

Case series: Adjunct immune globulin for vaccine-induced thrombotic thrombocytopenia.

10 Jun, 2021 | 09:46h | UTC

Adjunct Immune Globulin for Vaccine-Induced Thrombotic Thrombocytopenia – New England Journal of Medicine

 

Cohort study: the use of potentially inappropriate medications in adults with chronic kidney disease is common and linked to increased risk of hospitalization, mortality, and falls.

11 Jun, 2021 | 08:11h | UTC

Risk of Potentially Inappropriate Medications in Adults With CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study – American Journal of Kidney Diseases (link to abstract – $ for full-text)

 

Commentary on Twitter

 

2021 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis.

10 Jun, 2021 | 09:37h | UTC

2021 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis – Arthritis Care & Research

Commentary: The 2021 Treatment Guidelines for Rheumatoid Arthritis – Rheumatology Network

 

[Preprint] RECOVERY trial finds aspirin does not improve survival for patients hospitalized with COVID-19.

9 Jun, 2021 | 08:28h | UTC

News Release: RECOVERY trial finds aspirin does not improve survival for patients hospitalised with COVID-19 – University of Oxford

Original Study: Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial – medRxiv

 

Commentary on Twitter (thread – click for more)

 

China to offer COVID-19 vaccine to children as young as three.

9 Jun, 2021 | 08:26h | UTC

China to offer COVID-19 vaccine to children as young as three – MedicalXpress

See also: Sinovac says its vaccine is safe for children as young as 3 – Associated Press

 

Summary | WHO recommendations on the treatment of drug-resistant tuberculosis, 2020 update.

9 Jun, 2021 | 08:12h | UTC

World Health Organization recommendations on the treatment of drug-resistant tuberculosis, 2020 update – European Respiratory Review

Original Guideline: WHO Consolidated Guidelines on Tuberculosis, Module 4: Treatment – Drug-Resistant Tuberculosis Treatment

 

Commentary on Twitter

 

No health issues in babies whose moms got flu vaccine while pregnant.

9 Jun, 2021 | 08:17h | UTC

No health issues in babies whose moms got flu vaccine while pregnant – CIDRAP

Original study: Association of Maternal Influenza Vaccination During Pregnancy With Early Childhood Health Outcomes – JAMA (free for a limited period)

Editorial: Realizing the Potential of Maternal Influenza Vaccination (free for a limited period)

 

Commentary on Twitter

https://twitter.com/ericbenchimol/status/1402307635240706048

 

FDA approvement of Alzheimer’s drug sparks controversy among doctors.

9 Jun, 2021 | 08:18h | UTC

News release: FDA Grants Accelerated Approval for Alzheimer’s Drug – U.S. Food & Drug Administration

Commentaries: ICER Issues Statement on the FDA’s Approval of Aducanumab for Alzheimer’s Disease – Institute for Clinical and Economic Review AND Landmark Alzheimer’s Drug Approval Confounds Research Community – Nature AND FDA approves Alzheimer’s drug from Biogen, against experts’ advice – NBC News AND F.D.A. Approves Alzheimer’s Drug Despite Fierce Debate Over Whether It Works – The New York Times (a few articles per month are free) AND Alzheimer’s drug approved despite doubts about effectiveness – Science (a few articles per month are free) AND The FDA Has Approved A New Alzheimer’s Drug — Here’s Why That’s Controversial – NPR AND Opinion: Bad medicine: aducanumab is a lackluster drug with a high price tag – STAT

 

Are SARS-CoV-2 Human Challenge Trials Ethical? – “A clinical trial is underway in the UK in which young, healthy participants are exposed deliberately to SARS-CoV-2 to assess the viral inoculum needed to produce an infection and to test vaccine efficacy”.

8 Jun, 2021 | 09:29h | UTC

Are SARS-CoV-2 Human Challenge Trials Ethical? – JAMA Internal Medicine

Related: World’s first coronavirus “Human Challenge” study receives ethics approval in the UK (several texts on the subject)

 

Commentary on Twitter

 

RCT: In patients hospitalized with Covid-19 with elevated D-Dimer, a full-dose anticoagulation strategy based on rivaroxaban (full-dose heparins in unstable patients) + rivaroxaban to day 30 was not better than prophylactic anticoagulation and increased bleeding risk.

7 Jun, 2021 | 00:01h | UTC

Therapeutic versus prophylactic anticoagulation for patients admitted to hospital with COVID-19 and elevated D-dimer concentration (ACTION): an open-label, multicentre, randomised, controlled trial – The Lancet

Related: #ACC21 – [Not published yet] RCT: Among hospitalized patients with Covid-19 and elevated D-Dimer, therapeutic anticoagulation with Rivaroxaban 20 mg was not associated with improved outcomes and resulted in increased major bleeding.

 

Commentary on Twitter

https://twitter.com/RenatoDLopes1/status/1400962037610582026

 

Six months of COVID vaccines: what 1.7 billion doses have taught scientists.

6 Jun, 2021 | 23:57h | UTC

Six months of COVID vaccines: what 1.7 billion doses have taught scientists – Nature

See also: Coronavirus (COVID-19) Vaccinations – Our World in Data

 

Related commentary on Twitter

 

WHO approval of Chinese CoronaVac COVID vaccine will be crucial to curbing pandemic.

6 Jun, 2021 | 23:56h | UTC

WHO approval of Chinese CoronaVac COVID vaccine will be crucial to curbing pandemic – Nature

Related: WHO validates Sinovac-CoronaVac COVID-19 vaccine for emergency use and issues interim policy recommendations. AND Brazilian town experiment shows mass vaccination can wipe out COVID-19.

 

Study shows reduced neutralizing antibody activity induced by Pfizer–BioNTech vaccine against SARS-CoV-2 variants of concern B.1.617.2 (Delta) and B.1.351 (Beta).

6 Jun, 2021 | 23:59h | UTC

Neutralising antibody activity against SARS-CoV-2 VOCs B.1.617.2  and B.1.351 (Beta) by BNT162b2 vaccination – The Lancet

Commentary: Pfizer-BioNTech vaccine recipients have lower antibody levels targeting the Delta variant – The Francis Crick Institute

 

Commentary on Twitter (thread – click for more)

 

Case report: Successful treatment of vaccine-induced prothrombotic immune thrombocytopenia (VIPIT).

6 Jun, 2021 | 23:55h | UTC

Successful treatment of vaccine-induced prothrombotic immune thrombocytopenia (VIPIT) – Journal of Thrombosis and Haemostasis

Commentary: COVID-19 vaccination: Thrombosis can be prevented by prompt treatment, researchers report – Medical University of Vienna

 

Perspective | Could statins do more than lower cholesterol in patients with COVID-19? – “Don’t Start, Don’t Stop”.

6 Jun, 2021 | 23:49h | UTC

Could Statins Do More Than Lower Cholesterol in Patients With COVID-19? – JAMA

 

Another study shows a high frequency of antibiotic use among patients hospitalized with Covid-19 (85.2%), despite low rates of confirmed secondary bacterial infections.

4 Jun, 2021 | 10:43h | UTC

Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective cohort study – The Lancet Microbe

Commentaries: Very high use of antibiotics in COVID-19 treatment could be reduced – University of Glasgow AND More evidence of frequent antibiotic use noted in COVID patients – CIDRAP AND Covid-19: Antimicrobial use was high during first wave despite bacterial co-infections being rare, study finds – The BMJ

Related: Many hospitalized Covid-19 patients are given antibiotics. That’s a problem – STAT

 

Commentary on Twitter (thread – click for more)

 

M-A: Prehospital Tranexamic Acid reduces mortality among bleeding trauma patients without increasing the risk of venous thromboembolism.

6 Jun, 2021 | 23:34h | UTC

The impact of prehospital TXA on mortality among bleeding trauma patients: A systematic review and meta-analysis – Journal of Trauma and Acute Care Surgery (link to abstract – $ for full-text)

Commentary: Prehospital TXA for Trauma – Meta-analysis – JournalFeed

 

In a Mendelian randomization study, researchers found no genetic evidence to support an association between Vitamin D levels and COVID-19 susceptibility, severity, or hospitalization.

4 Jun, 2021 | 10:35h | UTC

Vitamin D and COVID-19 susceptibility and severity in the COVID-19 Host Genetics Initiative: A Mendelian randomization study – PLOS Medicine

Commentary: Vitamin D may not provide protection from COVID-19 susceptibility or disease severity, study suggests – PLOS

Related: Living systematic review: The evidence is insufficient to determine the benefits and harms of vitamin D supplementation as a treatment of COVID‐19. AND RCT: Vitamin D3 does not improve outcomes in hospitalized patients with moderate to severe COVID-19

 

RCT: Prophylactic post-exposure prophylaxis with Bamlanivimab reduced the incidence of Covid-19 among residents and staff of skilled nursing and assisted living facilities.

4 Jun, 2021 | 10:40h | UTC

Effect of Bamlanivimab vs Placebo on Incidence of COVID-19 Among Residents and Staff of Skilled Nursing and Assisted Living Facilities: A Randomized Clinical Trial – JAMA

Editorial: Bamlanivimab for Prevention of COVID-19

 

United States Unveils Global Vaccine Sharing Scheme for 80 Million Doses by End June

4 Jun, 2021 | 10:32h | UTC

BREAKING – United States Unveils Global Vaccine Sharing Scheme for 80 Million Doses by End June – Health Policy Watch

See also: Statement by President Joe Biden on Global Vaccine Distribution – The White House

 

RCT: Adjuvant Nivolumab vs. Placebo in Muscle-Invasive Urothelial Carcinoma.

3 Jun, 2021 | 10:36h | UTC

Adjuvant Nivolumab versus Placebo in Muscle-Invasive Urothelial Carcinoma – New England Journal of Medicine

 

Israel reports link between rare cases of heart inflammation and COVID-19 vaccination in young men.

2 Jun, 2021 | 08:37h | UTC

Israel reports link between rare cases of heart inflammation and COVID-19 vaccination in young men – Science (a few articles per month are free)

Related: CDC is investigating several reports that teenagers and young adults may have developed myocarditis after receiving mRNA vaccines. Most cases were mild, more often in males than females, more often following dose 2 than dose 1, and typically, within 4 days after vaccination.

 

Commentary on Twitter

https://twitter.com/rfsquared/status/1399803644288061442

 

WHO validates Sinovac-CoronaVac COVID-19 vaccine for emergency use and issues interim policy recommendations.

2 Jun, 2021 | 08:42h | UTC

WHO validates Sinovac COVID-19 vaccine for emergency use and issues interim policy recommendations – World Health Organization

Commentary: WHO grants emergency approval to 2nd Chinese COVID vaccine – MedicalXpress

 

Commentary on Twitter (thread – click for more)

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