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Pharmacology/Pharmaceutical Industry

Another study shows a high frequency of antibiotic use among patients hospitalized with Covid-19 (85.2%), despite low rates of confirmed secondary bacterial infections.

4 Jun, 2021 | 10:43h | UTC

Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective cohort study – The Lancet Microbe

Commentaries: Very high use of antibiotics in COVID-19 treatment could be reduced – University of Glasgow AND More evidence of frequent antibiotic use noted in COVID patients – CIDRAP AND Covid-19: Antimicrobial use was high during first wave despite bacterial co-infections being rare, study finds – The BMJ

Related: Many hospitalized Covid-19 patients are given antibiotics. That’s a problem – STAT

 

Commentary on Twitter (thread – click for more)

 


M-A: Prehospital Tranexamic Acid reduces mortality among bleeding trauma patients without increasing the risk of venous thromboembolism.

6 Jun, 2021 | 23:34h | UTC

The impact of prehospital TXA on mortality among bleeding trauma patients: A systematic review and meta-analysis – Journal of Trauma and Acute Care Surgery (link to abstract – $ for full-text)

Commentary: Prehospital TXA for Trauma – Meta-analysis – JournalFeed

 


In a Mendelian randomization study, researchers found no genetic evidence to support an association between Vitamin D levels and COVID-19 susceptibility, severity, or hospitalization.

4 Jun, 2021 | 10:35h | UTC

Vitamin D and COVID-19 susceptibility and severity in the COVID-19 Host Genetics Initiative: A Mendelian randomization study – PLOS Medicine

Commentary: Vitamin D may not provide protection from COVID-19 susceptibility or disease severity, study suggests – PLOS

Related: Living systematic review: The evidence is insufficient to determine the benefits and harms of vitamin D supplementation as a treatment of COVID‐19. AND RCT: Vitamin D3 does not improve outcomes in hospitalized patients with moderate to severe COVID-19

 


RCT: Prophylactic post-exposure prophylaxis with Bamlanivimab reduced the incidence of Covid-19 among residents and staff of skilled nursing and assisted living facilities.

4 Jun, 2021 | 10:40h | UTC

Effect of Bamlanivimab vs Placebo on Incidence of COVID-19 Among Residents and Staff of Skilled Nursing and Assisted Living Facilities: A Randomized Clinical Trial – JAMA

Editorial: Bamlanivimab for Prevention of COVID-19

 


United States Unveils Global Vaccine Sharing Scheme for 80 Million Doses by End June

4 Jun, 2021 | 10:32h | UTC

BREAKING – United States Unveils Global Vaccine Sharing Scheme for 80 Million Doses by End June – Health Policy Watch

See also: Statement by President Joe Biden on Global Vaccine Distribution – The White House

 


RCT: Adjuvant Nivolumab vs. Placebo in Muscle-Invasive Urothelial Carcinoma.

3 Jun, 2021 | 10:36h | UTC

Adjuvant Nivolumab versus Placebo in Muscle-Invasive Urothelial Carcinoma – New England Journal of Medicine

 


Israel reports link between rare cases of heart inflammation and COVID-19 vaccination in young men.

2 Jun, 2021 | 08:37h | UTC

Israel reports link between rare cases of heart inflammation and COVID-19 vaccination in young men – Science (a few articles per month are free)

Related: CDC is investigating several reports that teenagers and young adults may have developed myocarditis after receiving mRNA vaccines. Most cases were mild, more often in males than females, more often following dose 2 than dose 1, and typically, within 4 days after vaccination.

 

Commentary on Twitter

 


WHO validates Sinovac-CoronaVac COVID-19 vaccine for emergency use and issues interim policy recommendations.

2 Jun, 2021 | 08:42h | UTC

WHO validates Sinovac COVID-19 vaccine for emergency use and issues interim policy recommendations – World Health Organization

Commentary: WHO grants emergency approval to 2nd Chinese COVID vaccine – MedicalXpress

 

Commentary on Twitter (thread – click for more)


After COVID-19 successes, researchers push to develop mRNA vaccines for other infectious diseases and cancer.

2 Jun, 2021 | 08:34h | UTC

After COVID-19 successes, researchers push to develop mRNA vaccines for other diseases – Nature Medicine

 


[Press release – not published yet] The city of Serrana in Brazil has seen a 95% drop in Covid-19 deaths after almost all adults were vaccinated with Chinese CoronaVac – The findings suggest the pandemic can be controlled after 75% of people are fully vaccinated.

2 Jun, 2021 | 08:39h | UTC

Immunization of Serrana´s population with Butantan´s vaccine has a high decrease of 80% cases and 95% in deaths by COVID – Instituto Butantan

Commentaries: Study in Brazilian town shows 95% efficacy of Sinovac’s vaccine in reducing death by COVID-19 – Global Times AND Brazil Covid: Deaths plunge after town’s adults vaccinated – BBC AND Sinovac vaccine restores a Brazilian city to near normal – Associated Press

 


Systematic review: Driving performance under treatment of most frequently prescribed drugs for mental disorders – 31% of schizophrenic or schizoaffective patients under antipsychotics, and 18% of unipolar and bipolar patients under antidepressants showed severe impairment in skills relevant for driving.

2 Jun, 2021 | 08:24h | UTC

Driving performance under treatment of most frequently prescribed drugs for mental disorders: a systematic review of patient studies – International Journal of Neuropsychopharmacology

 


Perspective | Can I get AstraZeneca now and Pfizer later? Why mixing and matching COVID vaccines could help solve many rollout problems.

1 Jun, 2021 | 08:20h | UTC

Can I get AstraZeneca now and Pfizer later? Why mixing and matching COVID vaccines could help solve many rollout problems – The Conversation

 


Vaccines that can protect against many coronaviruses could prevent another pandemic.

1 Jun, 2021 | 08:15h | UTC

Vaccines that can protect against many coronaviruses could prevent another pandemic – Science (a few articles per month are free)

 


M-A: Triple vs. dual inhaler therapy in patients with moderate to severe asthma – fewer severe asthma exacerbations, but without significant differences in quality of life or mortality.

1 Jun, 2021 | 08:12h | UTC

Triple vs Dual Inhaler Therapy and Asthma Outcomes in Moderate to Severe Asthma: A Systematic Review and Meta-analysis – JAMA (free for a limited period)

 

Commentary on Twitter

 


AGA Clinical Practice Guidelines on the Medical Management of Moderate to Severe Luminal and Perianal Fistulizing Crohn’s Disease.

1 Jun, 2021 | 08:07h | UTC

AGA Clinical Practice Guidelines on the Medical Management of Moderate to Severe Luminal and Perianal Fistulizing Crohn’s Disease – Gastroenterology

News Release: AGA recommends early use of biologics in patients with moderate-to-severe Crohn’s disease – American Gastroenterology Association

Technical Review: AGA Technical Review on the Medical Management of Moderate to Severe Luminal and Perianal Fistulizing Crohn’s Disease

Clinical Decision Support Tool / Algorithm: Medical Management of Adult Outpatients With Moderate to Severe Lunminal Crohn’s Disease

 

Commentary on Twitter

 


Opinion | 7 reasons why we should not need boosters for COVID-19.

31 May, 2021 | 08:21h | UTC

7 Reasons Why We Should Not Need Boosters for COVID-19 – by Monica Ghandi, MD

 


Covid-19 vaccination prevents transmission from vaccinated to unvaccinated household members.

31 May, 2021 | 08:18h | UTC

The indirect effect of mRNA-based Covid-19 vaccination on unvaccinated household members – medRxiv

Related: Can people vaccinated against COVID-19 still spread the coronavirus? – “Preliminary evidence seems to suggest the COVID-19 vaccines make it less likely someone who’s vaccinated will transmit the coronavirus”.

 

Commentary on Twitter

 


[Not published yet] Observational study in Uruguay found CoronaVac reduced mortality by 97 percent – “In people who had received two doses, it reduced infection with the coronavirus by 57 percent and intensive care admissions by 95 percent”.

31 May, 2021 | 08:14h | UTC

CoronaVac reduces mortality by 97 percent: Uruguay study – Associated Press

 


Observational study suggests ceftriaxone is similarly effective to benzylpenicillin for the treatment of neurosyphilis, potentially decreasing the length of hospital stay (mean 13.8 days vs. 8.9 days).

31 May, 2021 | 08:06h | UTC

Ceftriaxone compared with benzylpenicillin in the treatment of neurosyphilis in France: a retrospective multicentre study – The Lancet Infectious Diseases (link to abstract – $ for full-text)

 


Lab study found CoronaVac serum neutralization efficiency was significantly decreased against B.1.526, P.1, and B1.351 SARS-CoV-2 variants.

28 May, 2021 | 08:26h | UTC

Serum neutralising activity against SARS-CoV-2 variants elicited by CoronaVac – The Lancet Infectious Diseases

 


COLCORONA RCT: Colchicine for community-treated patients with COVID-19 – findings suggest it may lower death and hospital admission rates, but further studies are required.

28 May, 2021 | 08:27h | UTC

Colchicine for community-treated patients with COVID-19 (COLCORONA): a phase 3, randomised, double-blinded, adaptive, placebo-controlled, multicentre trial – The Lancet Respiratory Medicine

Invited Commentary: Exploiting an early immunological window of opportunity in COVID-19 – The Lancet Respiratory Medicine

 


RCT: Pfizer-BioNTech Covid-19 vaccine shows 100% efficacy in adolescents – mainly transient mild-to-moderate reactogenicity was frequently observed, such as injection-site pain (in 79 to 86% of participants), fatigue (in 60 to 66%), and headache (in 55 to 65%).

28 May, 2021 | 08:24h | UTC

Safety, Immunogenicity, and Efficacy of the BNT162b2 Covid-19 Vaccine in Adolescents – New England Journal of Medicine

Related: [Press release – not published yet] Pfizer-BioNTech vaccine 100% effective against Covid-19 in adolescents

 

Commentary on Twitter

 


Covid-19: Pfizer-BioNTech vaccine is “likely” responsible for deaths of some elderly patients, Norwegian review finds.

28 May, 2021 | 08:22h | UTC

Covid-19: Pfizer-BioNTech vaccine is “likely” responsible for deaths of some elderly patients, Norwegian review finds – The BMJ

 

Commentary on Twitter

 


RCT: 2 inactivated SARS-CoV-2 vaccines show efficacy of 72.8% and 78.1% on symptomatic COVID-19 infection in adults.

27 May, 2021 | 08:38h | UTC

Effect of 2 Inactivated SARS-CoV-2 Vaccines on Symptomatic COVID-19 Infection in Adults: A Randomized Clinical Trial – JAMA

Commentary: China’s Sinopharm Publishes Awaited Covid Vaccine Study Details – Bloomberg

 

Commentary on Twitter (thread – click for more)

 


Can people vaccinated against COVID-19 still spread the coronavirus? – “Preliminary evidence seems to suggest the COVID-19 vaccines make it less likely someone who’s vaccinated will transmit the coronavirus”.

27 May, 2021 | 08:27h | UTC

Can people vaccinated against COVID-19 still spread the coronavirus? – The Conversation

Related: Indirect Protection by Reducing Transmission: Ending the Pandemic with SARS-CoV-2 Vaccination – “Tell the hesitant: the vaccines protect both you and protect others — a lot!”

 


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