Pharmacology/Pharmaceutical Industry
#ESCCongress – RCT: In patients with A. Fibrillation who underwent TAVR, Edoxaban was noninferior to Vit. K Antagonist regarding the composite primary outcome of adverse clinical events, but resulted in a higher incidence of major bleeding.
29 Aug, 2021 | 18:17h | UTCCommentaries:
ENVISAGE-TAVI AF: Edoxaban Disappoints in TAVI Setting – TCTMD
#ESCCongress – RCT: In patients who underwent PCI at high bleeding risk, 1 month of dual antiplatelet therapy was noninferior to the continuation of dual therapy for at least 2 additional months and resulted in a lower incidence of bleeding events.
29 Aug, 2021 | 18:16h | UTCCommentaries:
#ESCCongress – RCT: Finerenone reduced CV events in patients with kidney disease and type 2 diabetes (12.4% vs. 14.2% during a median follow-up of 3.4 years), but the risk of hyperkalemia was increased (10.8% vs. 5.3%).
29 Aug, 2021 | 18:14h | UTCNews release: Finerenone benefits patients with diabetes across spectrum of kidney disease – European Society of Cardiology
Commentaries:
Related:
Commentary on Twitter
FIGARO-DKD: Among patients with stage 1 to 4 CKD and T2 diabetes, finerenone improved CV outcomes as compared with placebo. #ESCCongress https://t.co/mcfmvftBvy pic.twitter.com/qizit80NBa
— NEJM (@NEJM) August 28, 2021
#ESCCongress – RCT: Initial hypertension treatment with a single pill with 4 drugs at quarter doses (irbesartan 37.5 mg, amlodipine 1.25 mg, indapamide 0.625 mg, and bisoprolol 2.5 mg) achieved better BP lowering vs. standard monotherapy (irbesartan 150 mg).
29 Aug, 2021 | 18:11h | UTCInitial treatment with a single pill containing quadruple combination of quarter doses of blood pressure medicines versus standard dose monotherapy in patients with hypertension (QUARTET): a phase 3, randomised, double-blind, active-controlled trial – The Lancet (link to abstract – $ for full-text)
Commentary: Quadruple UltrA-low-dose tReaTment for hypErTension – QUARTET – American College of Cardiology
[Press release – not published yet] Study shows vaccine protection wanes over time, but vaccines still offer good protection against severe disease.
27 Aug, 2021 | 10:11h | UTCPress release: Is COVID vaccine protection fading? – ZOE Covid Study
Commentaries:
Covid infection protection waning in double jabbed – BBC
[Preprint] Observational data suggests natural immunity after a SARS-CoV-2 infection confers longer lasting and stronger protection compared to vaccine-induced immunity.
27 Aug, 2021 | 10:16h | UTC
Commentary on Twitter (thread – click for more)
https://twitter.com/andrew_croxford/status/1430799815693250562
Editorial: The Guardian view on global vaccine inequality: unwise as well as unethical.
27 Aug, 2021 | 10:09h | UTCThe Guardian view on global vaccine inequality: unwise as well as unethical
Covid-19 vaccines flirted with perfection at first. Reality is more complicated.
27 Aug, 2021 | 10:05h | UTCCovid-19 vaccines flirted with perfection at first. Reality is more complicated – STAT
Commentary on Twitter
The mixed blessing of the 95% VE: When Pfizer & Moderna reported late last year that their Covid vaccines were highly effective, our expectations for these vaccines soared. It's time for us to get more realistic about what the vaccines can do. https://t.co/BFpje2qRmS
— Helen Branswell 🇨🇦 (@HelenBranswell) August 25, 2021
mRNA vaccines for infectious diseases: principles, delivery and clinical translation.
27 Aug, 2021 | 10:03h | UTC
Commentary on Twitter
It took over 3 decades for mRNA vaccines to be developed. Now their potential against Covid variants and other pathogens is limitless. An outstanding new review @NatRevDrugDisc https://t.co/HETmUVru0Q @WeissmanLab @KWhiteheadLab pic.twitter.com/dN0jgsrEh3
— Eric Topol (@EricTopol) August 27, 2021
Exposure to antipsychotics in womb not found to increase risk of ADHD, autism in offspring.
27 Aug, 2021 | 09:03h | UTC
A review of the epidemiology, pathophysiology, and efficacy of anti-diabetic drugs used in the treatment of nonalcoholic fatty liver disease.
27 Aug, 2021 | 08:59h | UTC
Large Observational study shows Pfizer Covid vaccine is mostly safe but is associated with increased risk of myocarditis, adenopathy, appendicitis, and herpes zoster.
26 Aug, 2021 | 09:16h | UTCCommentaries on Twitter
For those who still believe getting Covid-19 is less risky than taking the vaccine, take a look at this chart from an observational study of nearly 1 million people in Israel. The risk of these conditions is much higher in those infected than vaccinated.https://t.co/Io08oFYRqW pic.twitter.com/57hOaoT5wQ
— Benjy Renton (@bhrenton) August 25, 2021
(thread from the author – click for more)
1/
Vaccine safety: We compared excess adverse events after #COVID19 vaccination (Pfizer-BioNTech) and after documented #SARSCoV2 infection.https://t.co/PNyCTqkq0tTake-home message: Low excess risk of adverse events after vaccination, higher after infection.
Some thoughts👇 pic.twitter.com/pbpJwCRd3D
— Miguel Hernán (@_MiguelHernan) August 25, 2021
COVID vaccines show no signs of harming fertility or sexual function.
26 Aug, 2021 | 09:12h | UTCCOVID Vaccines Show No Signs of Harming Fertility or Sexual Function – Scientific American
Related: Study: Sperm parameters not changed before and after COVID-19 mRNA vaccination.
Pregnant women do well with COVID vaccine, survey finds.
26 Aug, 2021 | 09:03h | UTCOriginal study: Short-term Reactions Among Pregnant and Lactating Individuals in the First Wave of the COVID-19 Vaccine Rollout – JAMA Network Open
Related: CDC Guidance: Pregnant people should be vaccinated against COVID-19.
Commentary on Twitter
Another study showing that #COVID19 mRNA vaccines are safe in pregnant women, who are at an increased risk from the disease. #COVID #Covid_19 #coronavirus #Corona #CoronavirusPandemic #CovidVaccine #COVIDVaccination https://t.co/EtJUxrUVeQ
— Martin Michaelis (@MartMichaelis) August 19, 2021
Johnson & Johnson booster shot prompts large increase in immune response, company says.
26 Aug, 2021 | 09:14h | UTCJohnson & Johnson booster shot prompts large increase in immune response, company says – CNN
News release: Johnson & Johnson Announces Data to Support Boosting its Single-Shot COVID-19 Vaccine
5 Crucial Things to Know About COVID-19 Vaccines and Pregnancy.
26 Aug, 2021 | 09:05h | UTC5 Crucial Things to Know About COVID-19 Vaccines and Pregnancy – Self
Related: CDC Guidance: Pregnant people should be vaccinated against COVID-19.
Commentary on Twitter
My latest @SELFmagazine: examining what we know about pregnancy and COVID-19 infections and vaccines. https://t.co/tnDAyQmoeu
— Dr. Tara C. Smith (@aetiology) August 25, 2021
New WHO Guideline for the pharmacological treatment of hypertension in adults.
26 Aug, 2021 | 08:57h | UTCGuideline for the pharmacological treatment of hypertension in adults – World Health Organization
Commentary on Twitter (thread – click for more)
The number of adults aged 30-79 living with #hypertension has doubled from 650 million to 1.28 billion since 1990, according to a 🆕 comprehensive global 🌎🌍🌏 analysis of trends in hypertension prevalence, detection, treatment and control.
👉 https://t.co/MI48CX2kEO pic.twitter.com/ARpS8uipeY
— World Health Organization (WHO) (@WHO) August 25, 2021
Supplement: The future of JAK1 selective inhibitors in rheumatology.
26 Aug, 2021 | 08:30h | UTCHomepage: The future of JAK1 selective inhibitors – Rheumatology
How important is JAK1 selectivity?
JAK1: Number one in the family; number one in inflammation?
Early phase studies of JAK1 selective inhibitors in rheumatoid arthritis
Phase III trials of JAK1 selective inhibitors in rheumatoid arthritis
The safety of JAK-1 inhibitors
Clinical use of Jak 1 inhibitors for rheumatoid arthritis
JAK1 selective inhibitors for the treatment of spondyloarthropathies
JAK1 inhibition and inflammatory bowel disease
CDC Report: Unvaccinated 5 times more likely to get COVID-19 and 29 times more likely to be hospitalized than vaccinated individuals.
25 Aug, 2021 | 09:56h | UTCCommentary: CDC: Unvaccinated 5 times more likely to get COVID-19 – CIDRAP
Commentary on Twitter
A new CDC study finds that while the #DeltaVariant surged in Los Angeles, CA the COVID-19 vaccines continued to prevent #COVID19 related infections, hospitalizations, ICU stays, or deaths. Get a COVID-19 vaccine to help protect yourself and others. More: https://t.co/zMQN3NOytB. pic.twitter.com/j8GTOd13vm
— CDC (@CDCgov) August 24, 2021
CDC Report: Vaccine effectiveness dropped from 91% to 66% since the SARS-CoV-2 Delta variant became predominant.
25 Aug, 2021 | 09:11h | UTCCommentaries:
Messenger RNA COVID vaccines 66% effective against Delta: US study – Associated Press
Third Pfizer dose 86% effective in over 60s, Israeli HMO says.
25 Aug, 2021 | 09:01h | UTCThird Pfizer dose 86% effective in over 60s, Israeli HMO says – Reuters
Commentary on Twitter
A third dose of Pfizer (PFE.N)/BioNTech's (https://t.co/eeCVHZYuCn) COVID-19 vaccine was found to be 86% effective in people aged over 60, an Israeli healthcare provider said on Wednesday, citing initial results from a study of thousands of members. https://t.co/BQMzYmMHUt
— Reuters Health (@Reuters_Health) August 18, 2021
RCT: No effect of Vitamin D supplementation on kidney function in adults with prediabetes.
25 Aug, 2021 | 08:41h | UTCEffect of Vitamin D Supplementation on Kidney Function in Adults with Prediabetes: A Secondary Analysis of a Randomized Trial – Clinical Journal of the American Society of Nephrology (link to abstract – $ for full-text)
Commentary on Twitter
Low circulating 25-hydroxyvitamin D concentration has been suggested as a risk factor for both type 2 diabetes and kidney disease. This study found that in persons with prediabetes, vitamin D supplementation did not affect progression of KDIGO risk scores https://t.co/e1EmP403TD pic.twitter.com/yEQjrvZr7A
— CJASN (@CJASN) August 24, 2021
Things we do for no reason: routinely holding metformin in the hospital.
25 Aug, 2021 | 08:43h | UTC
Covid-19 booster vaccines: What we know and who’s doing what.
24 Aug, 2021 | 10:04h | UTCCovid-19 booster vaccines: What we know and who’s doing what – The BMJ
WHO head calls for two-month vaccine booster moratorium.
24 Aug, 2021 | 10:02h | UTCWHO head calls for two-month vaccine booster moratorium – Associated Press