Pharmacology/Pharmaceutical Industry
Systematic Review: Video-observed therapy vs. directly observed therapy in patients with tuberculosis.
9 Feb, 2022 | 08:35h | UTCVideo-Observed Therapy Versus Directly Observed Therapy in Patients With Tuberculosis – American Journal of Preventive Medicine (link to abstract – $ for full-text)
Commentary on Twitter
Our latest publication on @AmJPrevMed : Video-Observed Therapy Versus Directly Observed Therapy in Patients With Tuberculosis. Implementation of VOT improved medication adherence and bacteriological resolution compared with that of DOT in TB patients.https://t.co/xcWzrxLbHB? pic.twitter.com/4ldYJ2umd7
— Bang Truong (@bangphd_epi) December 13, 2021
M-A: Direct oral anticoagulants vs. warfarin in patients with atrial fibrillation.
9 Feb, 2022 | 08:29h | UTCDirect Oral Anticoagulants versus Warfarin in Patients with Atrial Fibrillation: Patient-Level Network Meta-Analyses of Randomized Clinical Trials with Interaction Testing by Age and Sex – Circulation (link to abstract – $ for full-text)
Randomized crossover study shows regular use of Paracetamol increases systolic blood pressure by approximately 5 mm Hg when compared with placebo in hypertensive individuals.
8 Feb, 2022 | 10:11h | UTCRegular Acetaminophen Use and Blood Pressure in People With Hypertension: The PATH-BP Trial – Circulation (link to abstract – $ for full-text)
Commentaries:
Regular paracetamol use linked to higher blood pressure, study finds – University of Edinburg
Blood pressure warning over long-term paracetamol use – BBC
Perspective | Three, four or more: what’s the magic number for booster shots?
8 Feb, 2022 | 10:03h | UTCThree, four or more: what’s the magic number for booster shots? – Nature
In patients taking anticoagulants (DOAC or Warfarin), a respiratory tract infection not treated with antibiotics is associated with a greater than twofold increase in the risk of bleeding during the next 0-14 days.
8 Feb, 2022 | 08:46h | UTC
Commentary on Twitter
In new research of 1208 oral anticoagulant users, a greater than twofold increase was seen in the risk of major bleeding & clinically relevant non-major bleeding in the 0-14 days after a respiratory tract infection for which no antibiotics were prescribed https://t.co/wMIb2eDBKk
— The BMJ (@bmj_latest) December 21, 2021
Summary: 2021 CDC guidelines on sexually transmitted infections.
7 Feb, 2022 | 08:33h | UTC2021 CDC guidelines on sexually transmitted infections – Family Medicine
Original Guideline: CDC releases new guidelines for the treatment of sexually transmitted infections.
Related: WHO Guidelines for the management of symptomatic sexually transmitted infections.
RCT: Ketamine is a short-term effective treatment for some suicidal patients in hospital.
4 Feb, 2022 | 10:05h | UTCNews Release: Ketamine is a short-term effective treatment for some suicidal patients in hospital – BMJ
Original Article: Ketamine for the acute treatment of severe suicidal ideation: double blind, randomised placebo controlled trial – The BMJ
Editorial: Ketamine for suicidal ideation – The BMJ
Related:
Systematic Review: Ketamine for the treatment of mental health and substance use disorders.
Randomized trial: Repeated Ketamine administration for chronic posttraumatic stress disorder
Ketamine and Depression: A Narrative Review
Implementation of a pharmacist-to-dose direct oral anticoagulant (DOAC) protocol was associated with a 44% reduction in DOAC-related medication errors at an academic medical center.
7 Feb, 2022 | 08:10h | UTCA pharmacist-to-dose direct oral anticoagulant protocol on medication errors at an academic medical center – Journal of the American College of Clinical Pharmacy (link to abstract – $ for full-text)
Commentary: Pharmacist-to-Dose DOAC Protocol Reduces Medication Errors – American College of Cardiology
Consensus Statement: Preoperative Management of Medications for Neurologic Diseases.
4 Feb, 2022 | 10:00h | UTCPreoperative Management of Medications for Neurologic Diseases – Mayo Clinic Proceedings
Related: Consensus Statement: Preoperative management of medications for psychiatric diseases.
Experts question unusual authorization plan for Covid vaccine for kids under 5.
4 Feb, 2022 | 09:57h | UTCExperts question unusual authorization plan for Covid vaccine for kids under 5 – STAT
Related:
Pfizer asks FDA to allow COVID-19 vaccine for kids under 5 – Associated Press
Pfizer Asks FDA to Approve Its Vaccine for the Youngest Children – HealthDay
Five-Year Survival Outcomes From the PACIFIC Trial: Durvalumab After Chemoradiotherapy in Stage III Non–Small-Cell Lung Cancer.
4 Feb, 2022 | 08:38h | UTCOriginal Study: Randomized Trial: Overall Survival with Durvalumab after Chemoradiotherapy in Stage III NSCLC
Hyaluronic acid injections have increased for knee arthritis in the US, despite guideline recommendations against their use.
4 Feb, 2022 | 08:32h | UTCHyaluronic Acid Injections for Knee Osteoarthritis: Has Utilization Among Medicare Beneficiaries Changed Between 2012 and 2018? – The Journal of Bone & Joint Surgery (link to abstract – $ for full-text)
News Release: Hyaluronic acid injections have increased for knee arthritis – despite recommendations against their use
Related Guideline: Treatment of Osteoarthritis of the Knee: Evidence-Based Guideline, 2nd Edition – Journal of the American Academy of Orthopaedic Surgeons
An observational study including 15.670 people using methotrexate and 2.689 using leflunomide showed the incidences of discontinuation related to cytopenia, liver enzyme elevation, or kidney function decline.
4 Feb, 2022 | 08:21h | UTC
Consensus Statement: Preoperative management of medications for psychiatric diseases.
3 Feb, 2022 | 09:59h | UTC
RCT: In patients with advanced esophageal squamous-cell carcinoma, both nivolumab plus chemotherapy and nivolumab plus ipilimumab resulted in longer overall survival than chemotherapy alone.
3 Feb, 2022 | 09:46h | UTCNivolumab Combination Therapy in Advanced Esophageal Squamous-Cell Carcinoma – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary (2021 ASCO Annual Meeting): Nivolumab Plus Chemotherapy and Nivolumab Plus Ipilimumab as First-Line Treatment for Patients With Advanced Esophageal Cancer – The ASCO Post
Commentary on Twitter
First-line treatment of advanced esophageal squamous-cell carcinoma with either nivolumab plus chemo or nivolumab plus ipilimumab resulted in a significant overall survival benefit and durable responses as compared with chemo alone. https://t.co/a000bDsh1N pic.twitter.com/NuY2eX58gp
— NEJM (@NEJM) February 2, 2022
Cluster randomized controlled trial: An innovative telemedical network to improve infectious disease management in critically ill patients and outpatients.
3 Feb, 2022 | 08:53h | UTCRelated:
The “Choosing Wisely” initiative in infectious diseases – German Society of Infectious Diseases (link to abstract – $ for full-text)
Infectious Diseases Society of America: Five Things Physicians and Patients Should Question
Outpatient Therapies for COVID-19: How do we choose?
2 Feb, 2022 | 08:53h | UTCOutpatient Therapies for COVID-19: How do we choose? – Open Forum Infectious Diseases
Updated NIH COVID-19 Treatment Guidelines: Therapeutic management of nonhospitalized adults with COVID-19.
2 Feb, 2022 | 08:50h | UTCTherapeutic Management of Nonhospitalized Adults With COVID-19 – NIH COVID-19 Treatment Guidelines
Commentary on Twitter
NIH update??
Therapeutic Management of Nonhospitalized Adults With #COVID19 #TwitteRx #medtwitter #TwitteRx #MedEd https://t.co/QpKsVJArUj pic.twitter.com/HKb81dB5b8— Antibiotic Stewa®️x? Bassam Ghanem (@ABsteward) February 1, 2022
Ten billion COVID vaccinations: world hits new milestone.
2 Feb, 2022 | 08:48h | UTCTen billion COVID vaccinations: world hits new milestone – Nature
Commentary on Twitter
10 billion doses given, <1 billion were boosters
1 continent nearly left outhttps://t.co/DrCqQ4b7tJ
and @OurWorldInData“It is a huge scientific achievement that ten billion doses of vaccines to a new pathogen were developed in two years from its identification”—@doctorsoumya pic.twitter.com/pyLXlvI22Q
— Eric Topol (@EricTopol) February 1, 2022
M-A: Impact of Ketamine on analgosedative consumption in critically ill patients.
2 Feb, 2022 | 08:44h | UTCRelated:
Perspective: Avoidance of β-blockers in patients who use stimulants is not supported by good evidence.
2 Feb, 2022 | 08:39h | UTC
Using melatonin for sleep is on the rise, study says, despite potential health harms.
2 Feb, 2022 | 08:41h | UTCUsing melatonin for sleep is on the rise, study says, despite potential health harms – CNN
Original Study: Trends in Use of Melatonin Supplements Among US Adults, 1999-2018 – JAMA (free for a limited period)
RCT: Safety and efficacy of agomelatine in children and adolescents with major depressive disorder receiving psychosocial counselling.
2 Feb, 2022 | 08:34h | UTCSafety and efficacy of agomelatine in children and adolescents with major depressive disorder receiving psychosocial counselling: a double-blind, randomised, controlled, phase 3 trial in nine countries – The Lancet Psychiatry (link to abstract – $ for full-text)
Commentary on Twitter
RCT: 10 to 25 mg/day agomelatine resulted in an improvement versus placebo in CDRS-R raw score of 4·22 (0·63–7·82) at 12 weeks in C&A with MDD, with a similar effect for fluoxetine. The overall effect was confirmed in adolescents, but not in children https://t.co/keecz57fQw
— PfOL (@psychopharmacol) December 23, 2021
RCT: Efficacy and safety of Risankizumab for active psoriatic arthritis.
2 Feb, 2022 | 08:23h | UTC
Short Review | Hypersensitivity reactions to vaccines in children: from measles to SARS-CoV-2.
2 Feb, 2022 | 08:13h | UTCCommentary: Vaccine hypersensitivity in children – News Medical