Pharmacology/Pharmaceutical Industry
Why Do People Stop Taking Their Meds?
24 Sep, 2017 | 00:24h | UTCWhy Do People Stop Taking Their Meds? Cost Is Just One Reason – NPR (free)
WHO Report: The world is running out of antibiotics
20 Sep, 2017 | 22:29h | UTCThe world is running out of antibiotics, WHO report confirms – World Health Organization (free)
See WHO Reports: Antibacterial Agents in Clinical Development (free) AND Global priority list of antibiotic-resistant bacteria to guide research, discovery, and development of new antibiotics (free)
See also WHO Resources on Antibiotic Resistance
Commentaries: WHO report paints dire picture of antibiotic development – CIDRAP (free) AND Too few antibiotics in pipeline to tackle global drug-resistance crisis, WHO warns – The Guardian (free) AND The world is running out of antibiotics, WHO says – CNN (free text and video)
Guideline: Corticosteroids for sore throat
20 Sep, 2017 | 22:28h | UTCRapid Recommendations: Corticosteroids for sore throat: a clinical practice guideline – The BMJ (free text and infographic)
See also other Rapid Recommendations from The BMJ (all free)
Effects of Intensive Systolic Blood Pressure Control on Kidney and Cardiovascular Outcomes in Persons Without Kidney Disease
20 Sep, 2017 | 21:12h | UTCCommentary: Cardiovascular benefits of intensive systolic blood pressure control may outweigh risks of chronic kidney disease events – 2 Minute Medicine (free)
Blood pressure measures in the SPRINT trial were done in a different way than most trials. If these results are to be incorporated in clinical practice, blood pressure measurement must be done in the same way. More details in Cardiobrief: Can SPRINT Be Used To Inform Hypertension Treatment? (free)
Review: Evaluation of bleeding in patients receiving direct oral anticoagulants
20 Sep, 2017 | 21:11h | UTC
Randomized Controled Trial: Efficacy of Thalidomide in Preventing Delayed Nausea and Vomiting Induced by Chemotherapy
20 Sep, 2017 | 20:55h | UTCEfficacy of Thalidomide in Preventing Delayed Nausea and Vomiting Induced by Highly Emetogenic Chemotherapy: A Randomized, Multicenter, Double-Blind, Placebo-Controlled Phase III Trial (CLOG1302 study) – Journal of Clinical Oncology (link to abstract – $ for full-text)
Commentaries: Thalidomide Improves Prevention of Delayed Nausea and Vomiting Induced by Highly Emetogenic Chemotherapy – PracticeUpdate (free registration required) AND Adding Thalidomide to Palonosetron, Dexamethasone Reduces CINV – Oncology Nurse Advisor (free)
FDA recommends separating dosing of potassium-lowering drug sodium polystyrene sulfonate (Kayexalate) from all other oral drugs
20 Sep, 2017 | 20:50h | UTCFDA Drug Safety Communication: FDA recommends separating dosing of potassium-lowering drug sodium polystyrene sulfonate (Kayexalate) from all other oral drugs (free)
Commentary: Don’t Give Kayexalate With Other Oral Drugs, FDA Warns – Medscape (free registration required)
“Patients should take orally administered prescription and over-the-counter (OTC) medicines at least 3 hours before or 3 hours after sodium polystyrene sulfonate”
Review: Common Drug Side Effects and Drug-Drug Interactions in Elderly Adults in Primary Care
20 Sep, 2017 | 20:44h | UTCCommon Drug Side Effects and Drug-Drug Interactions in Elderly Adults in Primary Care – Journal of The American Geriatrics Society, via Medscape (free registration required)
Meta-Analysis: Corticosteroids in patients hospitalized with community-acquired pneumonia
19 Sep, 2017 | 22:34h | UTCCorticosteroids in patients hospitalized with community-acquired pneumonia: systematic review and individual patient data meta-analysis – Clinical Infectious Diseases (link to abstract – $ for full-text)
Related Meta-analysis: Efficacy and Safety of Adjunctive Corticosteroids Therapy for Severe Community-Acquired Pneumonia in Adults: An Updated Systematic Review and Meta-Analysis – PLOS One (free) AND Efficacy and Safety of Corticosteroids for Community-Acquired Pneumonia – Chest (free) AND Adjunctive Systemic Corticosteroids for Hospitalized Community-Acquired Pneumonia: Systematic Review and Meta-Analysis 2015 Update – Scientific Reports (free)
Systematic Review: Strategies to reduce antibiotic prescribing for acute respiratory infections in primary care
19 Sep, 2017 | 22:18h | UTCOriginal article: Clinician-targeted interventions to influence antibiotic prescribing behaviour for acute respiratory infections in primary care: an overview of systematic reviews – Cochrane Library (link to abstract – $ for full-text)
Study: Safety of Medical Abortion Provided Through Telemedicine
18 Sep, 2017 | 16:33h | UTCCommentaries: Abortion via telemedicine as safe as seeing doctor in person – Reuters (free) AND Abortion Via Telemedicine Is Totally Safe, Study Says – HuffPost (free) AND Medical Abortion Via Telemedicine Found Safe – MedPage Today (free registration required)
Community pharmacy: public health interventions
18 Sep, 2017 | 14:34h | UTCCommunity pharmacy: public health interventions – Public Health England (free PDF)
“This document sets out a range of opportunities for pharmacy teams working in communities, and through their daily interactions with patients and the public, to play an important role in protecting and improving the health of the nation”.
Guidelines on perioperative venous thromboembolism prophylaxis: Surgery in the elderly
18 Sep, 2017 | 14:05h | UTC
Study: pioglitazone versus sulfonylureas in patients with type 2 diabetes
18 Sep, 2017 | 14:04h | UTCEffects on the incidence of cardiovascular events of the addition of pioglitazone versus sulfonylureas in patients with type 2 diabetes inadequately controlled with metformin (TOSCA.IT): a randomised, multicentre trial – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)
Commentary: Sulfonylureas, Pioglitazone Similarly Safe for Add-On Therapy in Type 2 Diabetes – Physician’s First Watch (free)
Study: Effects of acarbose on cardiovascular and diabetes outcomes in patients with coronary heart disease and impaired glucose tolerance
18 Sep, 2017 | 13:56h | UTCEffects of acarbose on cardiovascular and diabetes outcomes in patients with coronary heart disease and impaired glucose tolerance (ACE): a randomised, double-blind, placebo-controlled trial – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)
Commentary: Acarbose Offers No CVD Protection in ACE, but May Cut Diabetes Risk – Medscape (free registration required)
Systematic Review: Risk of relapse after antidepressant discontinuation in anxiety disorders, obsessive-compulsive disorder, and post-traumatic stress disorder
16 Sep, 2017 | 18:33h | UTCCommentary: Researchers: Antidepressants for Anxiety Should Be Continued for at Least a Year After Treatment Response – Physician’s First Watch (free)
Study: Spending to Bring a Single Cancer Drug to Market and Revenues After Approval
16 Sep, 2017 | 18:25h | UTCAuthor interview: Cost of Developing a Single Cancer Drug (free audio)
Invited commentary: A Much-Needed Corrective on Drug Development Costs (free)
Commentaries: R&D Costs For Cancer Drugs Are Likely Much Less Than Industry Claims, Study Finds – NPR (free) AND A new study undermines Big Pharma’s justification for charging high drug prices – Business Insider (free) AND What Does It Cost to Create a Cancer Drug? Less Than You’d Think – The New York Times (10 articles per month are free)
Guideline: Antiretroviral therapy in pregnant women living with HIV
16 Sep, 2017 | 18:24h | UTCAntiretroviral therapy in pregnant women living with HIV: a clinical practice guideline – The BMJ (free guideline and infographic)
Study: Menopausal Hormone Therapy and Long-term All-Cause and Cause-Specific Mortality
16 Sep, 2017 | 18:23h | UTCMenopausal Hormone Therapy and Long-term All-Cause and Cause-Specific Mortality: The Women’s Health Initiative Randomized Trials – JAMA (link to abstract – $ for full-text)
Commentaries: Taking Hormones for Menopause Doesn’t Raise Early Death Risk – The New York Times (free) AND Menopause hormone therapy not linked to premature death – Reuters (free) AND Menopause hormones don’t shorten lives, long follow-up says – STAT (free)
Guideline for the Management of Chronic Pain in Patients Living With HIV
16 Sep, 2017 | 18:18h | UTC
Study: LDL-Cholesterol Lowering for the Primary Prevention of Cardiovascular Disease Among Men
16 Sep, 2017 | 18:20h | UTCCommentary: Statins cut heart deaths in men by 28% finds study – NHS Choices (free)
Metformin: a review of its potential indications
16 Sep, 2017 | 18:05h | UTCMetformin: a review of its potential indications – Drug Design, Development and Therapy (free)
Review: Targeted therapy of ovarian cancer including immune check point inhibitor
16 Sep, 2017 | 18:02h | UTC
Review: Stent thrombosis and optimal duration of dual antiplatelet therapy after coronary stenting
16 Sep, 2017 | 18:01h | UTC
Meta-analysis: More Intensive vs Less Intensive Blood Pressure Lowering in Chronic Kidney Disease
15 Sep, 2017 | 19:16h | UTCAssociation Between More Intensive vs Less Intensive Blood Pressure Lowering and Risk of Mortality in Chronic Kidney Disease Stages 3 to 5: A Systematic Review and Meta-analysis – JAMA Internal Medicine (link to abstract – $ for full-text)
Commentaries: Intensive blood pressure lowering linked to decreased mortality in patients with chronic kidney disease – 2 Minute Medicine (free) AND Intensive BP Lowering in Chronic Kidney Disease Associated with Lower Mortality – Physician’s First Watch (free) AND Is Strict BP Control a Good Bet for CKD Patients? – MedPage Today (free registration required)