Pharmacology/Pharmaceutical Industry | Page 162 of 166 | Links Medicus Content Curation & Alerts in Medicine

New Long-Acting Injectable HIV Therapies

25 Jul, 2017 | 00:15h | UTC

Long-acting intramuscular cabotegravir and rilpivirine in adults with HIV-1 infection (LATTE-2): 96-week results of a randomised, open-label, phase 2b, non-inferiority trial – The Lancet (free)

Commentary: Long-Acting Injectable HIV Regimens Show Promise – Physician’s First Watch (free) AND Injections ‘next revolution’ in HIV: study – BBC (free)

NHS to end prescription of homeopathic remedies

24 Jul, 2017 | 01:00h | UTC

“A misuse of scarce funds”: NHS to end prescription of homeopathic remedies – The Guardian (free)

The Myth of Drug Expiration Dates

23 Jul, 2017 | 21:11h | UTC

The Myth of Drug Expiration Dates – ProPublica (free)

“Hospitals and pharmacies are required to toss expired drugs, no matter how expensive or vital. Meanwhile the FDA has long known that many remain safe and potent for years longer”.

Prophylactic Early Erythropoietin for Neuroprotection in Preterm Infants

23 Jul, 2017 | 19:06h | UTC

Prophylactic Early Erythropoietin for Neuroprotection in Preterm Infants: A Meta-analysis – Pediatrics (link to abstract – $ for full-text)

Commentary: Early EPO Offers Neuroprotection for Preemies: Meta-analysis – Medscape (free registration required)

Report: Pain Management and the Opioid Epidemic: Balancing Societal and Individual Benefits and Risks of Prescription Opioid Use

23 Jul, 2017 | 16:32h | UTC

Report: Pain Management and the Opioid Epidemic: Balancing Societal and Individual Benefits and Risks of Prescription Opioid Use – National Academies Press (US) (free)

News Release: National Strategy to Reduce Opioid Epidemic, an Urgent Public Health Priority, Presented in New Report (free)

Commentary: National Academies Recommend Steps to Address Opioid Crisis – Physician’s First Watch (free)

Surrogate endpoints in oncology: when are they acceptable for regulatory and clinical decisions, and are they currently overused?

23 Jul, 2017 | 19:41h | UTC

Surrogate endpoints in oncology: when are they acceptable for regulatory and clinical decisions, and are they currently overused? – BMC Medicine (free)

Reviews on thrombosis and hemostasis

23 Jul, 2017 | 13:53h | UTC

Selection of state-of-the-art open access reviews on thrombosis and hemostasis, celebrating the 60th anniversary of the Journal – Thrombosis and Haemostasis (free PDF Articles)

– Homepage

– Editorial: Thrombosis and Haemostasis: Past, present and future

– Venous thromboembolism: Past, present and future

– Stroke prevention in atrial fibrillation: Past, present and future

– Antithrombotic therapy for acute coronary syndrome: Past, present and future

– Therapeutic strategies for atherosclerosis and atherothrombosis: Past, present and future

– NOACs for treatment of venous thromboembolism in clinical practice

– The management of acute venous thromboembolism in clinical practice

Source: Critical Care Reviews Topic of The Week

Emicizumab Prophylaxis in Hemophilia A with Inhibitors

23 Jul, 2017 | 14:55h | UTC

Emicizumab Prophylaxis in Hemophilia A with Inhibitors – New England Journal of Medicine (free)

Editorial: Bispecific Antibody Therapy in Hemophilia (free)

Commentaries: Disruptive technology for the treatment of hemophilia – Children’s Hospital Los Angeles, via EurekAlert (free) AND Novel Hemophilia A Treatments Advance – MedPage Today (free registration required) AND Emicizumab Replaces Factor VIII Function in Hemophilia A – Medscape (free registration required)

Effectiveness of Pharmacist Intervention to Reduce Medication Errors and Health-Care Resources Utilization After Transitions of Care

22 Jul, 2017 | 20:16h | UTC

Effectiveness of Pharmacist Intervention to Reduce Medication Errors and Health-Care Resources Utilization After Transitions of Care: A Meta-analysis of Randomized Controlled Trials – Journal of Patient Safety (link to abstract – $ for full-text)

Source: Hospital Medicine Virtual Journal Club (free resource to find articles of interest)

Pharmacist transition of care intervention seems to be an effective strategy to reduce medication errors after hospital discharge and to reduce subsequent emergency room visits.

Studies Compare Types of Insulin for Reducing Episodes of Low Blood Sugar for Patients with Type 1 or 2 Diabetes

22 Jul, 2017 | 21:21h | UTC

Studies Compare Types of Insulin for Reducing Episodes of Low Blood Sugar for Patients with Type 1 or 2 Diabetes – The JAMA Network (free commentary)

Original article 1: Effect of Insulin Degludec vs Insulin Glargine U100 on Hypoglycemia in Patients With Type 1 Diabetes: The SWITCH 1 Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Original article 2: Effect of Insulin Degludec vs Insulin Glargine U100 on Hypoglycemia in Patients With Type 2 Diabetes: The SWITCH 2 Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentaries: Lower rates of hypoglycemia in patients treated with insulin degludec – 2 Minute Medicine (free) AND Insulin Degludec Tied to Fewer Hypoglycemic Episodes Than Insulin Glargine – Physician’s First Watch (free)

Poor-Quality Medicine: A Global Pandemic

22 Jul, 2017 | 17:24h | UTC

Poor-Quality Medicine: A Global Pandemic – Devex (free)

“Each year, the proliferation of substandard and falsified medicines puts the lives of millions of people – particularly those living in developing countries – at risk”

Antiplatelet Regimen for Patients With Breakthrough Strokes While on Aspirin

21 Jul, 2017 | 17:51h | UTC

Antiplatelet Regimen for Patients With Breakthrough Strokes While on Aspirin: A Systematic Review and Meta-Analysis – Stroke (link to abstract – $ for full-text)

Commentary: Adjusting Antiplatelet Regimen Could Decrease Risk For Stroke Patients on Aspirin Monotherapy – American College of Cardiology, Latest in Cardiology (free)

Meta-analysis of cohort studies: in patients who experienced an ischemic stroke or transient ischemic attack while on aspirin monotherapy, the addition of or a switch to another antiplatelet agent, versus aspirin monotherapy, was associated with a 32 percent reduction in the risk of major adverse cardiovascular events (HR 0.68; 0.54–0.85) and 30 percent reduction in recurrent strokes (HR, 0.70; 0.54–0.92). Additional randomized trials would better clarify the best antiplatet regimen for these patients.

Antidepressants during pregnancy and autism in offspring

21 Jul, 2017 | 17:49h | UTC

Antidepressants during pregnancy and autism in offspring: population based cohort study – The BMJ (free)

Editorial: Prenatal antidepressant use and risk of autism (free)

Commentaries: Antidepressants and pregnancy: study didn’t find they actually cause autism – The Conversation (free) AND Antidepressant use in pregnancy linked to autism in children – OnMedica (free) AND Study finds slight autism risk link to antidepressants in pregnancy – Reuters (free)

Use of antibiotics during pregnancy and the risk of major congenital malformations

21 Jul, 2017 | 00:22h | UTC

Use of antibiotics during pregnancy and the risk of major congenital malformations: A population based cohort study – British Journal of Pharmacology (link to abstract – $ for full-text)

Commentary: New study finds link between certain antibiotics during pregnancy and risk for birth defects – News Medical (free)

In this large cohort clindamycin, doxycycline, quinolones, macrolides, and phenoxymethylpenicillin were associated with congenital malformations. Amoxicillin, cephalosporins, and nitrofurantoin were not associated with birth defects.

American Society of Clinical Oncology Position Statement On Addressing the Affordability of Cancer Drugs

21 Jul, 2017 | 00:23h | UTC

Position statement: American Society of Clinical Oncology Position Statement On Addressing the Affordability of Cancer Drugs (free PDF)

Commentaries: ASCO Offers Path to Addressing Affordability of Cancer Drugs in New Position Statement – ASCO Post (free) AND ASCO Tackles Affordability of Cancer Drugs – Physician’s First Watch (free) AND ASCO Advocates Value in Drug Pricing – MedPage Today (free registration required) AND ASCO Addresses High Cost of Cancer Drugs – Medscape (free registration required)

New European Society of Medical Oncology (ESMO) Updated Clinical Practice Guidelines

20 Jul, 2017 | 00:07h | UTC

Homepage – New European Society of Medical Oncology (ESMO) Updated Clinical Practice Guidelines

New available guidelines are:

– Early and locally advanced non-small-cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up (free)

– Rectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up (free)

– Chronic myeloid leukaemia: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up (free)

– Multiple myeloma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up (free)

– Newly diagnosed and relapsed mantle cell lymphoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up (free)

– Cervical cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up (free)

– EANO–ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up of patients with leptomeningeal metastasis from solid tumours (free)

– Management of infusion reactions to systemic anticancer therapy: ESMO Clinical Practice Guidelines (free)

– Management of toxicities from immunotherapy: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up (free)

Oral antifungal medication for toenail onychomycosis

20 Jul, 2017 | 00:08h | UTC

Cochrane What is the best medication for a fungal infection of the toenail? – Cochrane Library (free)

Full review: Oral antifungal medication for toenail onychomycosis – Cochrane Library (link to abstract – $ for full-text)

Terbinafine probably leads to better cure rates than azoles, with the same risk of adverse events. Griseofulvin is no better and has more adverse effects than azoles.

Patient Outcomes in Dose Reduction or Discontinuation of Long-Term Opioid Therapy

20 Jul, 2017 | 00:04h | UTC

Patient Outcomes in Dose Reduction or Discontinuation of Long-Term Opioid Therapy: A Systematic Review – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Tapering long-term opioid therapy may improve outcomes in chronic pain, review finds – ACP Internist (free) AND Opioid Reduction Therapy Offers Some Benefits to Patients with Chronic Pain – Physician’s First Watch (free) AND How tapering off opioids can help people with chronic pain – CNN (free)

“Opioid tapering:

– less pain: 8 of 8 studies

– Improved function: 5 of 5 studies

– Improved QOL: 3 of 3 studies” (RT @DavidJuurlink see Tweet)

ECCO Position Statement on the Use of Biosimilars for Inflammatory Bowel Disease

18 Jul, 2017 | 23:14h | UTC

Guideline: ECCO Position Statement on the Use of Biosimilars for Inflammatory Bowel Disease: An Update – Journal of Crohn’s and Colitis (free)

Enabling Precision Medicine: The Role of Genetics in Clinical Drug Development

18 Jul, 2017 | 22:56h | UTC

Report: Enabling Precision Medicine: The Role of Genetics in Clinical Drug Development: Proceedings of a Workshop – National Academies Press (US) (free)

Systematic review: Antiepileptic drug monotherapy

17 Jul, 2017 | 01:35h | UTC

Systematic review: Antiepileptic drug monotherapy (single drug treatment) for epilepsy – Cochrane Library (free)

Original review: Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data (link to summary – $ for full-text)

The hidden truth about our prescription medications

16 Jul, 2017 | 23:44h | UTC

The hidden truth about our prescription medications – Ideas.Ted.Com (free)

“Uncovering the tale of hidden clinical trial data on prescription drugs” (RT @CebmOxford see Tweet) AND “Around half of the clinical trials that were done on the medicines we use today have never published their results…” (RT @Students4BE see Tweet)