Pharmacology/Pharmaceutical Industry
Research: Drivers not always told about their prescriptions’ potentially impairing effects
11 Nov, 2017 | 18:56h | UTCCommentaries: Drivers not always told about their prescriptions’ potentially impairing effects – ACP Internist (free)
Research: Effectiveness of β-Lactam Monotherapy vs Macrolide Combination Therapy for Children Hospitalized With Pneumonia
11 Nov, 2017 | 17:03h | UTCEffectiveness of β-Lactam Monotherapy vs Macrolide Combination Therapy for Children Hospitalized With Pneumonia – JAMA Pediatrics (link to abstract – $ for full-text)
Commentaries: Study: Azithromycin overprescribed for kids’ pneumonia – CIDRAP (free) AND Vanderbilt study shows azithromycin overprescribed for childhood pneumonia – Vanderbilt University Medical Center, via EurekAlert (free)
Research: Association of Warfarin Use With Lower Overall Cancer Incidence
11 Nov, 2017 | 16:56h | UTC“In this population-based cohort study of 1.256.725 persons, there was a significantly lower age- and sex-adjusted incidence rate ratio of cancer among warfarin users vs nonusers”.
Guidelines for treatment of HIV-positive adults
6 Nov, 2017 | 14:43h | UTCEuropean Guidelines for treatment of HIV-positive adults – European AIDS Clinical Society (EACS)
Commentary: New EACS treatment guidelines – Aidsmap (free) AND EACS updates HIV guidelines for adults – Healio (free registration required)
Research: Effect of Sertraline on Depressive Symptoms in Patients With Chronic Kidney Disease
6 Nov, 2017 | 14:43h | UTCEditorial: Treating Depression in Patients With Advanced CKD: Beyond the Generalizability Frontier (free)
Commentary: Standard Antidepressant May Not Help Patients with Chronic Kidney Disease – UT Southwestern Medical Center, via NewsWise (free)
“Not only doesn’t help treat moderate depression, sertraline causes worse nausea (NNH=8) & diarrhea (NNH=10)” (RT @AnilMakam see Tweet 1 and Tweet 2)
Systematic Review: Glucocorticosteroids for people with alcoholic hepatitis
6 Nov, 2017 | 14:30h | UTCGlucocorticosteroids for people with alcoholic hepatitis – Cochrane Library (free)
Original article: Glucocorticosteroids for people with alcoholic hepatitis – Cochrane Library (link to abstract – $ for full-text)
“We found no evidence of a difference between glucocorticosteroids and placebo or no intervention on all-cause mortality, health-related quality of life, and serious adverse events during treatment”.
Guideline: Familial hypercholesterolaemia
5 Nov, 2017 | 20:37h | UTCFamilial hypercholesterolaemia: identification and management – NICE Guideline (free)
News release: Inherited risk of high cholesterol should be identified and treated as early as possible, NICE says in updated guidance (free)
Research: Balanced Crystalloids vs Saline for Critically Ill Adults
5 Nov, 2017 | 20:38h | UTCBalanced Crystalloids vs Saline for Critically Ill Adults – American College of Chest Physicians Annual Meeting (free abstract)
Related Study: Balanced Crystalloids vs Saline for Noncritically Ill Adults in the Emergency Department – American College of Chest Physicians Annual Meeting (free abstract)
Commentaries: Landmark Trials Deliver Evidence to Rethink Saline Use – Medscape (free registration required) AND Saline on the Ropes? Studies find balanced crystalloid fluids safer – MedPage Today (free registration required)
Guideline: Treatment and Outcome of Hemorrhagic Transformation After Intravenous Alteplase in Acute Ischemic Stroke
5 Nov, 2017 | 20:36h | UTCCommentary: Intracranial Hemorrhage After Stroke Thrombolysis: More Questions Than Answers (free)
Top Ten Things to Know: Treatment and Outcome of Hemorrhagic Transformation After Intravenous Alteplase in Acute Ischemic Stroke (free PDF)
Slide Set: Treatment and Outcome of Hemorrhagic Transformation After Intravenous Alteplase in AIS (free PDF)
Related AHA/ASA Guidelines: Guidelines for the Early Management of Patients With Acute Ischemic Stroke (free) AND Guidelines for the Management of Spontaneous Intracerebral Hemorrhage (free)
A ‘smart’ approach to performance drugs
5 Nov, 2017 | 20:35h | UTCA ‘smart’ approach to performance drugs – ACP Internist (free)
Related: Growing use of smart drugs by students could be a recipe for disaster – The Conversation (free) AND Brain Hackers Seeking Peak Performance Use Risky Chemical Cocktails: “Smart drugs” are not clinically proven and could be dangerous – Scientific American (free) AND Universities must do more to tackle use of smart drugs, say experts – The Guardian (free) AND Tweaking brains with ‘smart drugs’ to get ahead in Silicon Valley – The Washington Post (free) AND Professors take same ‘smart drugs’ as students to keep up with workloads, claims academic – Independent (free)
Opinion: Drug company sales reps should be banned from hospitals
5 Nov, 2017 | 20:33h | UTCDrug company sales reps should be banned from hospitals – STAT (free)
Research: Mortality lower with prolonged vs. short-term IV infusion of antipseudomonal beta-lactams
5 Nov, 2017 | 20:08h | UTCOriginal article: Prolonged versus short-term intravenous infusion of antipseudomonal β-lactams for patients with sepsis: a systematic review and meta-analysis of randomised trials – The Lancet Infectious Diseases (link to abstract – $ for full-text)
Research: Long-term proton pump inhibitors and risk of gastric cancer development after treatment for Helicobacter pylori
5 Nov, 2017 | 19:59h | UTCLong-term proton pump inhibitors and risk of gastric cancer development after treatment for Helicobacter pylori: a population-based study – Gut (link to abstract – $ for full-text)
Commentaries: Acid reflux drug linked to more than doubled risk of stomach cancer – study – The Guardian (free) AND Gastric Cancer Risk Doubled With Long-term PPI Use – Medscape (free registration required) AND PPI Use After H. pylori Eradication Therapy Tied to Increased Risk for Gastric Cancer – Physician’s First Watch (free)
Research: Maintenance therapy with proton pump inhibitors and risk of gastric cancer
5 Nov, 2017 | 19:58h | UTC“Among 797 067 individuals on maintenance PPI therapy, the SIR of gastric cancer was over threefold increased (SIR=3.38, 95% CI 3.23 to 3.53)”.
Research: Long-term aspirin use reduces the incidence of digestive cancers by up to 47%
5 Nov, 2017 | 19:56h | UTC25th UEG (United European Gastroenterology) Week: Long-term aspirin use reduces the incidence of digestive cancers by up to 47% (free)
Commentaries: Long-Term Aspirin Use May Reduce Cancer Risk, Study Finds – Forbes (free) AND Aspirin slashes risk of gastrointestinal cancer – Medical News Today (free)
Guideline: Acute Sinusitis
5 Nov, 2017 | 19:24h | UTCNICE Guideline: Sinusitis (acute): antimicrobial prescribing (free)
News release: Antibiotics should not be used to treat the majority of sinus infections, NICE says (free)
Research: Influence of pharmaceutical marketing on prescriptions
5 Nov, 2017 | 19:20h | UTCCommentaries: The More Lavish the Gifts to Doctors, the Costlier the Drugs They Prescribe – The New York Times (10 articles per month are free) AND Study finds even small gifts from pharma companies change prescribing habits – FierceHealthcare (free) AND Pharma gifts to providers result in more branded, expensive prescriptions – Georgetown University Medical Center, via EurekAlert (free)
Terbinafine is probably first choice oral drug for fungal toenail infection
29 Oct, 2017 | 01:31h | UTCTerbinafine is probably first choice oral drug for fungal toenail infection – NIHR Signal (free)
Original article: Oral antifungal medication for toenail onychomycosis – Cochrane Library (free)
Research: Payments by US pharmaceutical and medical device manufacturers to US medical journal editors
29 Oct, 2017 | 01:33h | UTC“Industry payments to journal editors are common and often large, particularly for certain subspecialties. Journals should consider the potential impact of such payments on public trust in published research”.
Guidelines for the prevention and treatment of osteoporosis
29 Oct, 2017 | 01:29h | UTC
Research: Less dementia with oral anticoagulation in atrial fibrillation
29 Oct, 2017 | 01:25h | UTCLess dementia with oral anticoagulation in atrial fibrillation – European Heart Journal (free)
Commentaries: Blood-thinning drugs appear to protect against dementia in AF patients – OnMedica (free) AND Blood-thinning drugs ‘can reduce risk of dementia by up to 48%’ – The Guardian (free) AND Oral Anticoagulants Tied to Less Dementia in Patients with Atrial Fibrillation – Physician’s First Watch (free)
Eeffect of maternal multiple micronutrient supplementation on stillbirth, birth outcomes, and infant mortality
29 Oct, 2017 | 01:26h | UTCCommentaries: Antenatal multiple micronutrient supplementation: benefits beyond iron-folic acid alone – The Lancet Global Health (free) AND Multiple micronutrient supplements to mothers improve survival for newborn girls – Harvard School of Public health (free)
Related systematic review: Multiple-micronutrient supplementation for women during pregnancy – Cochrane Library (free summary)
Guideline: Long-Acting Reversible Contraception
29 Oct, 2017 | 01:22h | UTCGuideline: Long-Acting Reversible Contraception: Implants and Intrauterine Devices – American College of Obstetricians and Gynecologists (free)
News release: LARC and Reproductive Choice (free)
Commentary: New Guidelines on LARC Released by ACOG – Medscape (free registration required)
Systematic review: Aerosol delivery during invasive mechanical ventilation
29 Oct, 2017 | 01:05h | UTCAerosol delivery during invasive mechanical ventilation: a systematic review – Critical Care (free)
Research: Statin use and risk of developing diabetes
29 Oct, 2017 | 01:03h | UTCCommentaries: Statins increase the risk of developing diabetes in at-risk people – Medical News Today (free) AND Statin use link to heightened type 2 diabetes risk in some people – OnMedica (free)