Pharmacology/Pharmaceutical Industry
Randomized trial: Remdesivir vs. standard care in patients with moderate COVID-19
24 Aug, 2020 | 00:53h | UTCEditorial: Efficacy of Remdesivir in COVID-19
Commentaries: Study: Remdesivir doesn’t boost outcomes in moderate pneumonia from COVID-19 – UPI AND New Remdesivir Study Shows the Trouble With Bad Science – The Wire
Commentary on Twitter
Remdesivir….good editorial, concludes we don't know who to give it to, nor for how long, nor if it improves outcomes, nor whether, if it does, it does that beyond what dexamethasone or other corticosteroids do. https://t.co/Qi1dTSPcYi
— Dr. Tom Frieden (@DrTomFrieden) August 21, 2020
CDC Guideline: Prevention and control of seasonal influenza with vaccines
24 Aug, 2020 | 00:29h | UTC
Dexamethasone and hydroxychloroquine: Why randomized controlled trials matter
21 Aug, 2020 | 02:37h | UTC
Meta-analysis: Effectiveness of honey for symptomatic relief in upper respiratory tract infections
20 Aug, 2020 | 09:15h | UTCCommentaries: Honey may be better at treating coughs and colds than over-the-counter medicines – CNN AND Honey found to be a better treatment for upper respiratory tract infections than traditional remedies – MedicalXpress AND Honey better treatment for coughs and colds than antibiotics, study claims – The Guardian
[Abstract Only] Observational study: Atypical femur fracture risk vs. fragility fracture prevention with bisphosphonates
20 Aug, 2020 | 09:12h | UTC
Perspective: What the immune response to the coronavirus says about the prospects for a vaccine
19 Aug, 2020 | 09:39h | UTCWhat the immune response to the coronavirus says about the prospects for a vaccine – Nature
Meta-analysis: Use of inhibitors of the renin‐angiotensin system in hypertensive patients and COVID‐19 severity
19 Aug, 2020 | 09:35h | UTC
Study: 75% of Patients with dementia using psychotropic and opioid medications not made for the disease
19 Aug, 2020 | 09:27h | UTCPrevalence of Psychotropic and Opioid Prescription Fills Among Community-Dwelling Older Adults With Dementia in the US – JAMA (free for a limited period)
Commentaries: These Drugs Carry Risks and May Not Help, But Many Dementia Patients Get Them Anyway – Michigan Medicine AND 3 in 4 Elders with Dementia Fill Prescriptions for Psychotropics or Opioids – NEJM Journal Watch
Commentary from the author (Thread – click for more)
https://twitter.com/dtmaust/status/1295759727754977281
Prior routine use of NSAIDs and outcomes in hospitalized patients with COVID-19
18 Aug, 2020 | 07:36h | UTCCommentary: Study finds ibuprofen does not increase risk of death from COVID-19 – University of Aberdeen
[Abstract Only] Randomized trial: Effect of sustained-release morphine for refractory breathlessness in COPD
18 Aug, 2020 | 07:25h | UTC
Commentary on Twitter
https://twitter.com/DJAJanssen/status/1295381522996957184
ACP/AAFP Guideline: Nonpharmacologic and pharmacologic management of acute pain from non–low back, musculoskeletal injuries in adults
18 Aug, 2020 | 07:30h | UTCNews Release: ACP, AAFP release new guideline for treatment of non-low back pain – American College of Physicians
Commentary: ACP, AAFP issue joint guideline on non-low back pain from musculoskeletal injuries in adults – ACP Internist
Randomized trial: Imipenem/Cilastatin/Relebactam vs. Piperacillin/Tazobactam in adults with hospital-acquired or ventilator-associated bacterial pneumonia
16 Aug, 2020 | 22:12h | UTC
Randomized trial: Methylprednisolone as adjunctive therapy for patients hospitalized with COVID-19
14 Aug, 2020 | 01:53h | UTCRelated Study: Dexamethasone in Hospitalized Patients with Covid-19 — Preliminary Report – New England Journal of Medicine
Commentary on Twitter
Metcovid Double Blind PH. 2
RCT 🇧🇷~ 400 pts #CID
Methylprednisolon 0.5mg/kg twice daily x5d #COVID19 Hospitalized pts #COVID19 did not reduce 28d mortality V placebo
Is it Right Drug, Dose, Duration
High dose vs RECOVERY
DEX less mineralocorticoid
5 v 10 https://t.co/EBIRWYouSQ pic.twitter.com/OzGJkqjkrJ— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) August 13, 2020
These Covid-19 vaccine candidates could change the way we make vaccines — if they work
14 Aug, 2020 | 01:43h | UTCThese Covid-19 vaccine candidates could change the way we make vaccines — if they work – Vox
Effect of an inactivated vaccine against SARS-CoV-2 on safety and immunogenicity outcomes
14 Aug, 2020 | 01:44h | UTC
Commentary on Twitter
Inactivated #COVID19 #vaccine had a low rate of adverse reactions and demonstrated immunogenicity, but longer-term assessment of safety and efficacy will require phase 3 trials https://t.co/atmhXFFHSw
— JAMA (@JAMA_current) August 13, 2020
Systematic review: The use of erythropoietin plus iron to correct anemia before surgery to reduce the risk of blood transfusion
14 Aug, 2020 | 01:04h | UTC
Randomized trial: AVIFAVIR for Treatment of Patients with Moderate COVID-19
13 Aug, 2020 | 00:28h | UTC
Commentary on Twitter
NEW 🔥🔥 #CID @IDSAInfo
AVIFAVIR(favipiravir) for Treatment of Patients with Moderate #COVID19 : Interim Results of a Phase II/III Multicenter Randomized Clinical Trial #IDTwitter https://t.co/PwUcCWu5KQ pic.twitter.com/6N6lxHUu9K— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) August 8, 2020
Russia’s rapid COVID-19 vaccine approval draws intense criticism from some – and offers to collaborate from others
13 Aug, 2020 | 00:25h | UTC
[Abstract Only] Randomized trial: Effect of aspirin on cancer incidence and mortality in older adults
12 Aug, 2020 | 23:59h | UTCCommentary: Aspirin may accelerate progression of advanced cancers in older adults – Massachusetts General Hospital
Randomized trial: No benefit from combination therapy of vitamin C and thiamine for septic shock
13 Aug, 2020 | 00:01h | UTC
Antibody therapies could be a bridge to a coronavirus vaccine — but will the world benefit?
12 Aug, 2020 | 02:38h | UTCAntibody therapies could be a bridge to a coronavirus vaccine — but will the world benefit? – Nature
Related: Antibody drugs could be one of the best weapons against Covid-19. But will they matter? – STAT AND Designer antibodies could battle COVID-19 before vaccines arrive – Science
Russia has approved ‘world first’ Covid-19 vaccine. But questions over its safety remain
12 Aug, 2020 | 02:28h | UTCSee also: Russia has launched the world’s first COVID-19 vaccine: Here’s all you need to know – Firstpost AND Coronavirus: Putin says vaccine has been approved for use – BBC AND Russia Approves Coronavirus Vaccine Before Completing Tests – The New York Times AND The Russian Vaccine – Science Translational Medicine AND Russia claims first coronavirus vaccine as global cases top 20 million – MedicalXpress
Opinion – “Covid-19 drug research is a big huge mess”
11 Aug, 2020 | 10:25h | UTCCovid-19 Drug Research Is a Big Huge Mess – Wired
[Preprint] Immunogenicity and safety of a SARS-CoV-2 inactivated vaccine in healthy adults aged 18-59 years: Report of the randomized, double-blind, and placebo-controlled phase 2 clinical trial
11 Aug, 2020 | 10:19h | UTC
Commentary on Twitter
https://twitter.com/hildabast/status/1293062320319426560
[Abstract Only] Randomized trial: Prevention of benign paroxysmal positional vertigo with Vit D supplementation
10 Aug, 2020 | 01:49h | UTCCommentary: Fewer Vertigo Recurrences with Vitamin D, Calcium – Physician’s Weekly