Pediatrics – Neurology
Brain volume abnormalities and clinical outcomes following pediatric traumatic brain injury.
15 Jul, 2022 | 12:41h | UTCBrain volume abnormalities and clinical outcomes following paediatric traumatic brain injury – Brain
News Release: Head injuries in children linked to reduced brain size and learning difficulties – Imperial College London
Commentary: Experts use MRI to pinpoint link between pediatric TBI and cognitive impairment – Health Imaging
Commentary on Twitter
Bourke et al. identify paediatric brain injury patients with low brain volume for their age and associated cognitive difficulties by generating age norms from over 1,200 healthy paediatric controls. https://t.co/N06ELchNPd pic.twitter.com/ouDU1kTYPT
— Brain (@Brain1878) July 8, 2022
M-A | Risk factors of delirium in pediatric intensive care units.
13 Jul, 2022 | 11:35h | UTCRisk factors of delirium in paediatric intensive care units: A meta-analysis – PLOS One
Development and validation of a prediction model for perinatal arterial ischemic stroke in term neonates.
6 Jul, 2022 | 11:21h | UTCConsensus | Pediatric headache in primary care and emergency departments.
5 Jul, 2022 | 12:00h | UTCPediatric Headache in Primary Care and Emergency Departments: Consensus with RAND/UCLA Method – Life
M-A: Incidence and etiology of infant Gram-negative bacteremia and meningitis in children.
23 Jun, 2022 | 10:27h | UTC
Single-arm phase 3 Trial: Onasemnogene abeparvovec for presymptomatic infants with three copies of SMN2 at risk for spinal muscular atrophy.
20 Jun, 2022 | 01:04h | UTC
Commentary on Twitter
For infants with three copies of #SMN1 at risk for #SMA type 1, onasemnogene abeparvovec improves ventilator-free survival and nutritional/respiratory independence and allows motor development similar to healthy children without SMA. #2022SMAConferencehttps://t.co/tIsR1fByNK
— Nature Medicine (@NatureMedicine) June 17, 2022
Artificial intelligence may detect autism speech patterns across different languages, study finds.
20 Jun, 2022 | 01:05h | UTCNews Release: AI detects autism speech patterns across different languages – Northwestern University
Original Study: Cross-linguistic patterns of speech prosodic differences in autism: A machine learning study – PLOS One
Cohort Study: Neurodevelopmental outcomes at 1 year in infants of mothers who tested positive for SARS-CoV-2 during pregnancy.
10 Jun, 2022 | 12:14h | UTCCommentaries:
Commentary on Twitter
This cohort study of #SARSCoV2 exposure in utero found preliminary evidence that maternal SARS-CoV-2 may be associated with neurodevelopmental sequelae in some offspring. https://t.co/dYdoJbNOdl
— JAMA Network Open (@JAMANetworkOpen) June 9, 2022
CDC Report: Pediatric melatonin ingestions in the US.
9 Jun, 2022 | 11:32h | UTCPediatric Melatonin Ingestions — United States, 2012–2021 – Morbidity and Mortality Weekly Report
Commentaries:
Thousands of kids are getting sick from downing melatonin pills – NPR
Melatonin poisoning reports are up in kids, study says – Associated Press
Melatonin Overdoses Among Kids Are Up 530%, New Research Finds – TIME
Reports of melatonin poisoning in kids have increased 530% since 2012 – Yahoo News
Commentary on Twitter
New MMWR describes a 530% increase in pediatric melatonin ingestions reported to US poison control over the last decade; the largest increase occurred during the pandemic. https://t.co/SwJqTRG4s9 pic.twitter.com/AUxBrGX0Hj
— MMWR (@CDCMMWR) June 3, 2022
Management of sleep disorders among children and adolescents with neurodevelopmental disorders: A practical guide for clinicians.
9 Jun, 2022 | 11:21h | UTC
Consensus Statement: Assessment of foot alignment and function for ambulatory children with cerebral palsy.
9 Jun, 2022 | 10:59h | UTC
M-A: Intelligence outcome of pediatric intensive care unit survivors.
8 Jun, 2022 | 10:36h | UTC
Cohort Study: Association of prenatal exposure to antiseizure medication with risk of autism and intellectual disability.
1 Jun, 2022 | 11:44h | UTCAuthor Interview: Prenatal Exposure to Antiseizure Medication With Risk of Autism and Intellectual Disability – JAMA
Commentaries:
Prenatal Exposure to Certain Antiseizure Meds Linked to Autism – HealthDay
Related:
Risks of 23 specific malformations associated with prenatal exposure to 10 antiepileptic drugs – Neurology (link to abstract – $ for full-text)
Educational attainment of children born to mothers with epilepsy – Journal of Neurology, Neurosurgery, and Psychiatry (link to abstract – $ for full-text)
Commentary on Twitter
Nordic study of 4.5 million children found an association between prenatal exposure to topiramate and valproate and child intellectual disability and #autism. https://t.co/UH2THznPiV
— JAMA Neurology (@JAMANeuro) May 31, 2022
RCT: Efficacy and safety of fenfluramine for the treatment of seizures associated With Lennox-Gastaut Syndrome.
16 May, 2022 | 01:29h | UTCCommentaries:
Fenfluramine Found Effective for Treatment of Lennox-Gastaut Syndrome Seizures – NeurologyToday
Fenfluramine Seems Effective for Lennox-Gastaut Syndrome – HealthDay
Commentary on Twitter
In this randomized clinical trial, fenfluramine was a safe and effective treatment option for patients with Lennox-Gastaut syndrome. https://t.co/Ukopx9cV9r @Zogenix pic.twitter.com/dRetoOZSiB
— JAMA Neurology (@JAMANeuro) May 2, 2022
Review: Current status and future directions of neuromonitoring with emerging technologies in neonatal care.
5 May, 2022 | 09:47h | UTC
M-A: Efficacy and safety of Selumetinib in pediatric patients with Neurofibromatosis Type 1.
5 May, 2022 | 09:41h | UTCEfficacy and Safety of Selumetinib in Pediatric Patients With Neurofibromatosis Type 1: A Systematic Review and Meta-analysis – Neurology (link to abstract – $ for full-text)
Commentary on Twitter
A study via @GreenJournal reported that #selumetinib is a safe and effective treatment for pediatric patients with symptomatic, inoperable plexiform neurofibromas, but further studies are needed to confirm long-term outcomes. https://t.co/sRVaNFPKwV#NeuroTwitter pic.twitter.com/hYJNpN1EoU
— Neurology Today (@NeurologyToday) March 11, 2022
Review: The brain in pediatric critical care: unique aspects of assessment, monitoring, investigations, and follow-up.
25 Apr, 2022 | 00:26h | UTC
Commentary on Twitter
The brain in #PICU
?vulnerable brains
?(age-appropriate) tools to assess neuro-function
?latest evidence related to neurocritical care monitoring in #PedsICU
?post discharge: PICS‑p & approaches for neurodevelopmental follow‑up #FOAMcc #FOAMped
? https://t.co/F8c1L7ysPy pic.twitter.com/zsXe3Tv5ns— Intensive Care Medicine (@yourICM) April 22, 2022
Cohort Study: Rates and causes of mortality among children and young people with and without intellectual disabilities in Scotland.
20 Apr, 2022 | 09:22h | UTC
Commentary on Twitter
Very sobering study based on Scottish data. Children and young people with intellectual disability are at far higher risk of death and are more likely to have an avoidable death – one amenable to timely, effective care. https://t.co/xuxYjVrRd8
— Mary Dixon-Woods (@MaryDixonWoods) April 16, 2022
Cohort Study: Association of treatment with antipsychotics, antidepressants, or both with movement disorders and seizures among children and adolescents with depression.
19 Apr, 2022 | 01:50h | UTC
Commentary on Twitter
In this cohort study, adjunctive antipsychotics with antidepressants were associated with movement disorders and seizures compared with antidepressant monotherapy in children and adolescents with depression. https://t.co/3SVKEThwkR
— JAMA Network Open (@JAMANetworkOpen) April 15, 2022
RCT: Safety and efficacy of ganaxolone in patients with CDKL5 deficiency disorder.
19 Apr, 2022 | 01:20h | UTCSafety and efficacy of ganaxolone in patients with CDKL5 deficiency disorder: results from the double-blind phase of a randomised, placebo-controlled, phase 3 trial – The Lancet Neurology (link to abstract – $ for full-text)
RCT: Effect of different corticosteroid dosing regimens on clinical outcomes in boys with Duchenne Muscular Dystrophy.
7 Apr, 2022 | 08:53h | UTCEffect of Different Corticosteroid Dosing Regimens on Clinical Outcomes in Boys With Duchenne Muscular Dystrophy: A Randomized Clinical Trial – JAMA (free for a limited period)
Related:
RCT: Routine lung volume recruitment is not beneficial for boys with Duchenne muscular dystrophy.
Research: Long-term effects of glucocorticoids in patients with Duchenne muscular dystrophy
Commentary on Twitter
In this randomized clinical trial of boys with Duchenne muscular dystrophy, treatment with daily #prednisone or daily #deflazacort resulted in significantly better outcomes compared with intermittent prednisone. https://t.co/rKjSrjVemR #AAN2022 pic.twitter.com/qPNV9KBOXv
— JAMA (@JAMA_current) April 5, 2022
Association of antipsychotic drug exposure in pregnancy with risk of neurodevelopmental disorders: a national birth cohort study.
29 Mar, 2022 | 08:46h | UTCAssociation of Antipsychotic Drug Exposure in Pregnancy With Risk of Neurodevelopmental Disorders: A National Birth Cohort Study – JAMA Internal Medicine (free for a limited period)
European clinical guidelines for Tourette syndrome and other tic disorders.
29 Mar, 2022 | 08:26h | UTCPart I: assessment
Part II: psychological interventions
Part III: pharmacological treatment
Part IV: deep brain stimulation
Related: Guideline: Treatment of Tics in People with Tourette Syndrome and Chronic Tic Disorders
Cohort Study: Risk of mental health problems in children and youths following concussion.
25 Mar, 2022 | 08:29h | UTCRisk of Mental Health Problems in Children and Youths Following Concussion – JAMA Network Open
Commentaries:
Concussion Linked to Mental Health Issues Among Children Aged 5 to 18 Years – HealthDay
Guidelines on sickle cell disease: secondary stroke prevention in children and adolescents.
22 Mar, 2022 | 08:34h | UTC