Pediatrics – Neonatal/Perinatal

SR | BNP and NT-proBNP for the diagnosis of hemodynamically significant patent ductus arteriosus in preterm neonates.

14 Dec, 2022 | 14:49h | UTC

Brain natriuretic peptide and N‐terminal brain natriuretic peptide for the diagnosis of haemodynamically significant patent ductus arteriosus in preterm neonates – Cochrane Library

Summary: In preterm infants, how accurate are the blood tests BNP and NT-proBNP in identifying PDAs (patent ductus arteriosus) that require further treatment? – Cochrane Library

 

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Respiratory distress syndrome management in resource limited settings — Current evidence and opportunities.

12 Dec, 2022 | 12:18h | UTC

Respiratory distress syndrome management in resource limited settings—Current evidence and opportunities in 2022 – Frontiers in Pediatrics

 

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Cohort Study | Comparative safety of antiseizure medication monotherapy in pregnancy for major malformations.

9 Dec, 2022 | 13:10h | UTC

Comparative safety of antiseizure medication monotherapy for major malformations – Annals of Neurology (link to abstract – $ for full-text)

Commentary: Children Exposed to Valproate and Topiramate Before Birth at Higher Risk of Major Congenital Malformations – Neurology Today

Related:

Risks of 23 Specific Malformations Associated with Prenatal Exposure to 10 Antiepileptic Drugs

Research: Topiramate Use Early in Pregnancy and the Risk of Oral Clefts

Cohort Study: Association of prenatal exposure to antiseizure medication with risk of autism and intellectual disability.

Diagnosis and management of individuals with Fetal Valproate Spectrum Disorder; a consensus statement from the European Reference Network for Congenital Malformations and Intellectual Disability – Orphanet Journal of Rare Diseases

Thirteen UK healthcare bodies launch ‘pragmatic’ guidance on valproate use – Royal College of General Practitioners

Association of Prenatal Exposure to Valproate and Other Antiepileptic Drugs With Risk for Attention-Deficit/Hyperactivity Disorder in Offspring – JAMA Network Open

Educational attainment of children born to mothers with epilepsy – Journal of Neurology, Neurosurgery, and Psychiatry (link to abstract – $ for full-text)

 

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Cohort Study | Association of in utero antipsychotic medication exposure with risk of congenital malformations.

8 Dec, 2022 | 13:00h | UTC

Association of In Utero Antipsychotic Medication Exposure With Risk of Congenital Malformations in Nordic Countries and the US – JAMA Psychiatry (free for a limited period)

Related:

Association of antipsychotic drug exposure in pregnancy with risk of neurodevelopmental disorders: a national birth cohort study.

 

Commentary on Twitter

New findings from a large cohort study including 26,000 antipsychotic-exposed pregnancies from 6 countries suggest that prenatal exposure to individual antipsychotics is generally not associated with an increase in risk of major congenital malformations https://t.co/4cUm8sXgsi

— JAMA Psychiatry (@JAMAPsych) December 7, 2022

 

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Cohort Study | Obstetric and perinatal outcomes of singleton births following single- vs. double-embryo transfer.

6 Dec, 2022 | 13:45h | UTC

Obstetric and Perinatal Outcomes of Singleton Births Following Single- vs Double-Embryo Transfer in Sweden – JAMA Pediatrics

 

Commentary on Twitter

Swedish study comparing outcomes in singleton births following either single or double embryo transfer found higher risks of very preterm birth and low birth weight after double embryo transfer, especially when using frozen embryos and blastocysts. https://t.co/CXRXrchbw1

— JAMA Pediatrics (@JAMAPediatrics) December 5, 2022

 

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2022 International Consensus on CPR and emergency cardiovascular care science with treatment recommendations.

5 Dec, 2022 | 00:25h | UTC

2022 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations: Summary From the Basic Life Support; Advanced Life Support; Pediatric Life Support; Neonatal Life Support; Education, Implementation, and Teams; and First Aid Task Forces – Resuscitation

 

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Review | The complex challenge of antenatal steroid therapy nonresponsiveness.

29 Nov, 2022 | 13:52h | UTC

The complex challenge of antenatal steroid therapy nonresponsiveness – American Journal of Obstetrics & Gynecology

 

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WHO recommendations for care of the preterm or low-birth-weight infant.

27 Nov, 2022 | 22:31h | UTC

WHO recommendations for care of the preterm or low-birth-weight infant – World Health Organization

News Release: Launch of the WHO recommendations for care of the preterm or low birth weight infant – World Health Organization

Commentary: Skin to Skin Contact between Mothers and Preterm, Underweight Babies Improve Chances of Survival, says WHO – Health Policy Watch

 

Commentary on Twitter (thread – click for more)

? Ahead of #WorldPrematurityDay (17 Nov.), WHO published new guidelines to improve survival and health outcomes for babies born early (before 37 weeks of pregnancy) or small (under 2.5kg at birth) https://t.co/Jl0dg5TMAs pic.twitter.com/ZBn35RwE9G

— World Health Organization (WHO) (@WHO) November 15, 2022

 

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SR | Masks vs. prongs as interfaces for nasal continuous positive airway pressure in preterm infants.

16 Nov, 2022 | 13:31h | UTC

Masks versus prongs as interfaces for nasal continuous positive airway pressure in preterm infants – Cochrane Library

Summary: Nasal masks versus nasal prongs for continuous positive airway pressure in preterm infants – Cochrane Library

 

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Editorial | The urgent need to recognize and properly address prenatal-onset group B Streptococcus disease.

10 Nov, 2022 | 13:59h | UTC

The urgent need to recognize and properly address prenatal-onset group B Streptococcus disease – International Journal of Infectious Diseases

 

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RCT | Early amino acids in extremely preterm infants did improve neurodisability at 2 Years.

7 Nov, 2022 | 12:52h | UTC

Early Amino Acids in Extremely Preterm Infants and Neurodisability at 2 Years – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Extra Parenteral Amino Acids No Benefit for Extremely Preterm Infants – HealthDay

 

Commentary on Twitter

ProVIDE trial @NEJM: In ELBW infants, extra parenteral amino acids at a dose of 1 g/day for 5 days after birth did not improve survival free from neurodisability at 2 yrs.
Higher rates of mod-sev disability noted in intervention group.https://t.co/8hT3Ol3qOi#EBNEOalerts #neoEBM pic.twitter.com/2Z9qgkQF54

— Evidence-Based Neo (@EBNEO) November 5, 2022

 

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Cohort Study | Low Apgar score and asphyxia complications at birth and risk of longer-term cardiovascular disease.

4 Nov, 2022 | 13:31h | UTC

Low Apgar score and asphyxia complications at birth and risk of longer-term cardiovascular disease: A nationwide population-based study of term infants – The Lancet Regional Health – Europe

News Release: Oxygen deprivation at birth could increase risk of cardiovascular disease – Karolinska Institutet

 

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Cohort Study | Association of maternal caffeine consumption during pregnancy with child growth.

3 Nov, 2022 | 13:51h | UTC

Association of Maternal Caffeine Consumption During Pregnancy With Child Growth – JAMA Network Open

Commentaries:

Expert reaction to study looking at caffeine in pregnancy and child height – Science Media Centre

Even a Little Coffee in Pregnancy Might Stunt a Child’s Growth – HealthDay

Is maternal caffeine consumption associated with child growth, and are such associations present in low-consumption groups? – News Medical

Related:

Relationship between maternal caffeine and coffee intake and pregnancy loss: A grading of recommendations assessment, development, and evaluation-assessed, dose-response meta-analysis of observational studies – Frontiers in Nutrition

Cohort study: Even small amounts of Caffeine consumption in pregnancy were linked to smaller neonatal birth size

Maternal caffeine consumption and pregnancy outcomes: A narrative review with implications for advice to mothers and mothers-to-be

Cohort Study: Associations of Maternal Caffeine Intake with Birth Outcomes

 

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Opinion | Time to stop placebo injections in neonatal research projects.

3 Nov, 2022 | 13:48h | UTC

Time to stop placebo injections in neonatal research projects – Neonatal Research

 

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RCT | A multicomponent intervention at preconception, pregnancy, and early childhood can improve child health at 24 months.

1 Nov, 2022 | 11:51h | UTC

Impact of a package of health, nutrition, psychosocial support, and WaSH interventions delivered during preconception, pregnancy, and early childhood periods on birth outcomes and on linear growth at 24 months of age: factorial, individually randomised controlled trial – The BMJ

 

Commentary on Twitter

Study shows a package of health, nutrition, psychosocial care, and water, sanitation and hygiene interventions delivered during preconception, pregnancy, and early childhood reduces the risk of low birth weight and stunting at 24 months of agehttps://t.co/VyzGprkAFH @CHRDSAS

— The BMJ (@bmj_latest) October 28, 2022

 

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Systematic Review | Support for healthy breastfeeding mothers with healthy term babies.

28 Oct, 2022 | 13:23h | UTC

Support for healthy breastfeeding mothers with healthy term babies – Cochrane Library

Summary: Support for breastfeeding mothers – Cochrane Library

 

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Cohort Study | Maternal hypertensive disorder of pregnancy and mortality in offspring from birth to young adulthood.

27 Oct, 2022 | 12:31h | UTC

Maternal hypertensive disorder of pregnancy and mortality in offspring from birth to young adulthood: national population based cohort study – The BMJ

News Release: Blood pressure disorder in pregnancy linked to heightened risk of death in offspring – BMJ Newsroom

 

Commentary on Twitter

NEW research: Maternal HDP, particularly eclampsia and severe pre-eclampsia, is associated with increased risks of overall mortality and various cause specific mortalities in offspring from birth to young adulthood https://t.co/kfczWFwzG5

— The BMJ (@bmj_latest) October 23, 2022

 

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Caffeine to prevent intermittent hypoxemia in late preterm infants: randomized controlled dosage trial.

21 Oct, 2022 | 12:49h | UTC

Caffeine to prevent intermittent hypoxaemia in late preterm infants: randomised controlled dosage trial – ADC Fetal & Neonatal

Summary: What dose of caffeine to use? – Neonatal Research

 

Commentary on Twitter

Caffiene for late prems and reduction of intermittent hypoxaemia events by Oliphant et al in @ADC_FN #EBNEOalerts #neoEBM #neotwitter https://t.co/bkKqRabe0h pic.twitter.com/VRV8GHrywN

— Evidence-Based Neo (@EBNEO) September 2, 2022

 

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RCT | Moderate vs. intensive pushing during the active phase of the 2nd stage of labor among nulliparous women with an epidural.

18 Oct, 2022 | 12:56h | UTC

Alternative to intensive management of the active phase of the second stage of labor: a multicenter randomized trial (Phase Active du Second STade trial) among nulliparous women with an epidural – American Journal of Obstetrics & Gynecology (link to abstract – $ for full-text)

 

Commentary on Twitter

Alternative to intensive management of the active phase of the second stage of labor: a multicenter randomized trial (PASST trial) among nulliparous women with an epidural – A, Intervention (moderate pushing) group. B, Control (intensive pushing) group. https://t.co/IfdNfWHo57 pic.twitter.com/KmZTYV8eIP

— AJOG (@AJOG_thegray) October 14, 2022

 

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Special Statement | Postpartum visit checklists for normal pregnancy and complicated pregnancy.

14 Oct, 2022 | 14:18h | UTC

Society for Maternal-Fetal Medicine Special Statement: Postpartum visit checklists for normal pregnancy and complicated pregnancy – American Journal of Obstetrics & Gynecology

Original Guideline: ACOG Postpartum Toolkit (PDF)

 

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M-A | Perinatal outcomes in pregnancies complicated by maternal cardiomyopathy.

11 Oct, 2022 | 13:24h | UTC

Perinatal outcomes in pregnancies complicated by maternal cardiomyopathy: A systematic review and meta-analysis – American Journal of Obstetrics & Gynecology

 

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Review | Aerosol delivery of lung surfactant and nasal CPAP in the treatment of neonatal respiratory distress syndrome.

19 Sep, 2022 | 12:29h | UTC

Aerosol Delivery of Lung Surfactant and Nasal CPAP in the Treatment of Neonatal Respiratory Distress Syndrome – Frontiers in Medicine

 

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RCT | Among neonates with probable bacterial infection, switching from intravenous to oral antibiotics (amoxicillin–clavulanic acid) was noninferior to a full course of intravenous antibiotics and resulted in shorter hospitalization (median duration of 3.4 vs. 6.8 days).

16 Sep, 2022 | 12:59h | UTC

Efficacy and safety of switching from intravenous to oral antibiotics (amoxicillin–clavulanic acid) versus a full course of intravenous antibiotics in neonates with probable bacterial infection (RAIN): a multicentre, randomised, open-label, non-inferiority trial – The Lancet Child & Adolescent Health (link to abstract – $ for full-text)

Commentary: Dutch team devise less painful ‘drip and drink’ antibiotics treatment for babies – Dutch News

 

Commentaries on Twitter

*New trial*—early switch to #OralAntibiotics is not inferior to full-course IV antibiotics in #neonates with probable bacterial infection; & adverse events were not increased with use of oral antibiotics

By @IKMReiss @karelallegaert & colleagues

https://t.co/2yzeh3ptuc pic.twitter.com/BgBosxfECC

— The Lancet Child & Adolescent Health (@LancetChildAdol) September 12, 2022

In term and near-term infants <28 days with probable bacterial infection, how safe is it to switch to oral Amox-Clav as opposed to completing a course of intravenous antibiotics? A new RCT in @Lancet tries to answer this question.https://t.co/M2Za54cfxF#EBNeoAlerts#NeoEBM pic.twitter.com/zKpIiW1Whx

— Evidence-Based Neo (@EBNEO) September 12, 2022

(Thread – click for more)

Efficacy & safety of switching from intravenous to oral antibiotics (amoxicillin–clavulanic acid) vs full course of IV antibiotics in neonates with probable bacterial infection (RAIN):multicentre, randomised,open-label,non-inferiority trial -The Lancet https://t.co/mcyr9bILRq

— Prof. Dr. Sanjeev Bagai (@BagaiDr) September 13, 2022

 

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Cluster RCT | Tighter vs. less tight glycemic targets for women with gestational diabetes mellitus for reducing maternal and perinatal morbidity.

13 Sep, 2022 | 13:21h | UTC

Tighter or less tight glycaemic targets for women with gestational diabetes mellitus for reducing maternal and perinatal morbidity: A stepped-wedge, cluster-randomised trial – PLOS Medicine

 

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Cluster RCT | Umbilical cord milking may improve health in non-vigorous term and near-term infants.

8 Sep, 2022 | 14:47h | UTC

News Release: Umbilical cord milking may improve health in non-vigorous term and near-term infants – NIH News Releases

Original Study: Umbilical cord milking in non-vigorous infants: A cluster-randomized crossover trial – American Journal of Obstetrics & Gynecology (link to abstract – $ for full-text)

 

Commentary on Twitter

Does milking the umbilical cord benefit infants non-vigorous at birth?

A new RCT by @NeoAnup published in @AJOG_thegray evaluates this https://t.co/M5RRAzdEHz#neoEBM #neoTwitter #EBNEOAlerts pic.twitter.com/mZnSKjcGNt

— Evidence-Based Neo (@EBNEO) August 20, 2022

 

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