Oncology (all articles)
Allergan Recalls Textured Breast Implant Tied to Rare Cancer
25 Jul, 2019 | 01:54h | UTCAllergan Recalls Textured Breast Implant Tied to Rare Cancer – Associated Press (free)
See also: FDA Requests Manufacturer Recall of Some Textured Breast Implants – The ASCO Post (free) AND FDA asks Allergan to recall textured breast implants worldwide – Reuters (free) AND Worldwide recall issued for textured breast implants tied to rare cancer – CNN (free)
Related: FDA Report: 660 Cases of Breast Implant-Associated Anaplastic Large Cell Lymphoma (link to statement and other studies)
Consensus Guidelines on Genetic Testing for Hereditary Breast Cancer
25 Jul, 2019 | 01:20h | UTC
Guideline: Medication-Related Osteonecrosis of the Jaw
24 Jul, 2019 | 09:22h | UTC
[Abstract Only] Randomized Trial: 2-cm vs. 4-cm Surgical Excision Margins for Cutaneous Melanoma Thicker than 2 mm
24 Jul, 2019 | 02:10h | UTC2-cm versus 4-cm surgical excision margins for primary cutaneous melanoma thicker than 2 mm: long-term follow-up of a multicentre, randomised trial – The Lancet (link to abstract – $ for full-text)
Commentaries: Does Size of Surgical Excision Margins for Thick Localized Cutaneous Melanoma Affect Survival Outcomes? – The ASCO Post (free) AND Quick Take: 2-cm versus 4-cm surgical excision margins for primary cutaneous melanoma thicker than 2 mm – 2 Minute Medicine (free)
Related Commentary on Twitter
In randomized study of 2 cm vs 4 cm margins for patients with thick (>2 mm) localised cutaneous melanoma, at 19.6 years of follow up, the narrow excision margin was as oncologically effective as the wider margin.: https://t.co/orX2wnLbnb #melsm #surgonc
— NatureRevClinOncol (@NatRevClinOncol) July 12, 2019
Study: More Colon Cancer Cases are Being Diagnosed in People Under 50
23 Jul, 2019 | 01:51h | UTCRecent trends in the age at diagnosis of colorectal cancer in the US National Cancer Data Base, 2004‐2015 – Cancer (link to abstract – $ for full-text)
Commentaries: Colon cancer cases rising among adults under 50 – UPI (free) AND More colorectal cancer cases are being diagnosed in younger patients – Wiley (free)
Related Studies: Another Study Shows Increased Incidence of Colorectal Cancer in Adults Aged 40 Through 49 Years (link to abstract and commentaries) AND Two Studies Point to Increase in Colorectal Cancer Incidence in Young Adults (link to abstract and commentaries)
Cohort Study: Association of Immune Marker Changes With Progression of MGUS to Multiple Myeloma
23 Jul, 2019 | 01:27h | UTCAssociation of Immune Marker Changes With Progression of Monoclonal Gammopathy of Undetermined Significance to Multiple Myeloma – JAMA Oncology (free for a limited period)
Commentaries: Monoclonal Gammopathy May Be of Unpredictable Significance – JAMA Oncology (free for a limited period) AND Study Supports Annual Monitoring for Patients with Monoclonal Gammopathy of Undetermined Significance – NEJM Journal Watch (free)
Management of Gastrointestinal Toxicity from Immune Checkpoint Inhibitor
23 Jul, 2019 | 01:23h | UTC
Cancer and Heart Disease: Associations and Relations
21 Jul, 2019 | 21:55h | UTCCancer and heart disease: associations and relations – European Journal of Heart Failure (free)
Antimicrobial Stewardship in Cancer Patients: The Time is Now
21 Jul, 2019 | 21:53h | UTC
Perspective: The Promise and Price of Cellular Therapies
19 Jul, 2019 | 09:43h | UTCThe Promise and Price of Cellular Therapies – The New Yorker (a few articles per month are free)
“New “living drugs”—made from a patient’s own cells—can cure once incurable cancers. But can we afford them?”
International Registry: 16.6% of Patients with Takotsubo Syndrome Have Underlying Malignancy
18 Jul, 2019 | 10:15h | UTCEditorial: Is Transient Takotsubo Syndrome Associated With Cancer? Why, and With What Implications for Oncocardiology? (free)
Commentary: Cancer Rates High in Patients with Takotsubo Syndrome – NEJM Journal Watch (free)
Critical Care Management of Chimeric Antigen Receptor T Cell–related Toxicity. Be Aware and Prepared
14 Jul, 2019 | 19:41h | UTCRelated reviews: Toxicities of chimeric antigen receptor T cells: recognition and management – Blood (free) AND Toxicity and management in CAR T-cell therapy – Molecular Therapy Oncolytics (free) AND New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management – Critical Care (free) AND CAR T-Cell Therapy – What do you need to know for the ED? – emDocs (free) AND Managing the toxicities of CAR T‐cell therapy – Hematological Oncology (free)
Source: Critical Care Reviews Newsletter
Cohort Study: Possible Link Between Sugary Drinks and Cancer
12 Jul, 2019 | 06:32h | UTCCommentaries: Possible link between sugary drinks and cancer – The BMJ (free) Sugary drinks linked to cancer – NHS Choices (free) AND A small glass of juice or soda a day is linked to increased risk of cancer, study finds – CNN (free) AND Are sugary drinks causing cancer? – BBC (free)
Androgen Deprivation Therapy Linked to Increased Risk of Dementia in Men with Prostate Cancer
10 Jul, 2019 | 09:30h | UTCCommentaries: Hormone therapy for prostate cancer may raise risk of Alzheimer’s, Dementia – Penn Medicine (free) AND Prostate cancer treatment linked to heightened Alzheimer’s risk – UPI (free) AND Men’s dementia risk higher after androgen deprivation therapy – OnMedica (free) AND Risk of dementia rises with prostate cancer hormone-blocking therapy – Reuters (free)
Guidelines on the Diagnosis and Management of Patients at Risk of Gastric Adenocarcinoma
9 Jul, 2019 | 10:30h | UTC
[Abstract Only] Randomized Trial: MRI vs. Mammography for Breast Cancer Screening in Women with Familial Risk
5 Jul, 2019 | 02:36h | UTCMRI versus mammography for breast cancer screening in women with familial risk (FaMRIsc): a multicentre, randomised, controlled trial – The Lancet Oncology (link to abstract – $ for full-text)
Commentary: MRI Breast Screening Better for Women With Familial Cancer Risk – MedPage Today (free registration required)
Related Commentary on Twitter
#OncoAlert #bcsm This government-funded Dutch study show that #BreastCancer screening using MRI (vs mammography) identified less later stage cancers potentially impacting treatment morbidity and cancer survival but at the cost of more false positives https://t.co/uZJqST8Vt4
— Philippe Aftimos, MD (@aftimosp) June 18, 2019
Myocarditis in the Setting of Cancer Therapeutics: Proposed Case Definitions for Emerging Clinical Syndromes in Cardio-Oncology
5 Jul, 2019 | 02:26h | UTCMyocarditis in the Setting of Cancer Therapeutics: Proposed Case Definitions for Emerging Clinical Syndromes in Cardio-Oncology – Circulation (free) (via @Abraham_RMI)
Related: AHA Scientific Statement on Cardio-Oncology: Vascular and Metabolic Perspectives (several guidelines on the subject)
Review: Immune Checkpoint Inhibitor Toxicities
3 Jul, 2019 | 06:14h | UTCImmune Checkpoint Inhibitor Toxicities – Mayo Clinic Proceedings (free)
Related Guidelines: Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline (free) AND Management of Immunotherapy-Related Toxicities, Version 1.2019, NCCN Clinical Practice Guidelines in Oncology (free) AND Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group (free)
Related Reviews: New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management – Critical Care (free) AND Severe toxicity from checkpoint protein inhibitors: What intensive care physicians need to know? – Annals of Intensive Care (free) AND Checkpoint Inhibitors: The diagnosis and treatment of side effects – Deutsches Ärzteblatt international (free)
Study: Association of Radioactive Iodine Treatment With Cancer Mortality in Patients With Hyperthyroidism
2 Jul, 2019 | 06:20h | UTCCommentaries: NIH study finds long-term increased risk of cancer death following common treatment for hyperthyroidism – NIH News Releases (free) AND Treatment for overactive thyroid linked to increased risk of dying from cancer – CNN (free) AND Expert reaction to study looking at radioactive iodine treatment for overactive thyroid and risk of cancer – Science Media Centre (free)
NCCN Guideline: Acute Myeloid Leukemia
2 Jul, 2019 | 01:16h | UTC
Systematic Review: Immune Checkpoint Inhibitor Therapy and Myocarditis
2 Jul, 2019 | 01:10h | UTC
Estimation of Kidney Function in Oncology
30 Jun, 2019 | 17:47h | UTC“In one retrospective study, approximately one half of kidney function–impaired patients with solid tumors who were receiving a drug that necessitated dose adjustments for kidney function received almost 50% of their prescriptions at standard doses”.
Update: Management of Metastatic Cutaneous Melanoma
30 Jun, 2019 | 17:21h | UTC
[Abstract Only] Randomized Trial: Treatments for Patients with Multiple Myeloma Eligible for Transplantation Compared
30 Jun, 2019 | 17:20h | UTCBortezomib, thalidomide, and dexamethasone with or without daratumumab before and after autologous stem-cell transplantation for newly diagnosed multiple myeloma (CASSIOPEIA): a randomised, open-label, phase 3 study – The Lancet (link to abstract – $ for full-text)
Commentary: EHA 2019: CASSIOPEIA Trial Examines Addition of Daratumumab to Standard Treatment Before and After ASCT in Multiple Myeloma – The ASCO Post (free)
[Abstract Only] Randomized Trial: First-Line Therapies for Metastatic Prostate Cancer Compared
30 Jun, 2019 | 17:16h | UTCEnzalutamide with Standard First-Line Therapy in Metastatic Prostate Cancer – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: ENZAMET Trial Shows Enzalutamide Improves Overall Survival in Hormone-Sensitive Metastatic Prostate Cancer – The ASCO Post (free)