Oncology (all articles) | Page 79 of 124 | Links Medicus Content Curation & Alerts in Medicine

6 words not often seen in top tier journals: "These findings have profound therapeutic implications …and highlight the potential advantages of cfDNA [liquid biopsy] over tissue biopsy in the setting of acquired [#cancer] resistance.https://t.co/92gF4OX10H @NatureMedicine pic.twitter.com/mj0NQC17SP

— Eric Topol (@EricTopol) September 10, 2019

Study: Progress in Cancer Survival, Mortality, and Incidence in Seven High-income Countries 1995–2014

15 Sep, 2019 | 23:35h | UTC

Progress in cancer survival, mortality, and incidence in seven high-income countries 1995–2014 (ICBP SURVMARK-2): a population-based study – The Lancet Oncology (free)

Commentaries: Cancer Patients in Rich Countries Are Gaining Years, Study Shows – Bloomberg (free) AND Cancer survival in high income countries is improving but international disparities persist – eCancer News (free)

Related Commentary on Twitter

1-yr & 5-yr survival of seven #cancers (oesophagus, stomach, colon, rectum, pancreas, lung & ovary) improved in Australia, Canada, Denmark, Ireland, New Zealand, Norway & UK: SURVMARK-2 study of 3.9m cancer cases 1995-2014 @IARCWHO https://t.co/NqWmKl5T6R pic.twitter.com/xhmIpCwflq

— The Lancet Oncology (@TheLancetOncol) September 11, 2019

Study: Off-target Toxicity is a Common Mechanism of Action of Cancer Drugs Undergoing Clinical Trials

13 Sep, 2019 | 08:19h | UTC

Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials – Science Translational Medicine (free for a limited period)

Commentaries: Cancer drugs don’t always work as intended, researchers warn – Cold Spring Harbor Laboratory (free) AND Why Aren’t Cancer Drugs Better? The Targets Might Be Wrong – The New York Times (10 articles per month are free)

[Abstract Only] Study: Older Women with comorbidities Have Little Benefit from Mammography Screening

12 Sep, 2019 | 08:42h | UTC

Screening mammography outcomes: risk of breast cancer and mortality by comorbidity score and age – JNCI: Journal of the National Cancer Institute (link to abstract – $ for full-text)

Commentaries: More evidence screening mammograms not needed for many older women – Reuters (free) AND Mammography unlikely to benefit older women with chronic illnesses – Georgetown University Medical Center (free)

Randomized Trial: Effects of Helicobacter pylori Treatment and Vitamin and Garlic Supplementation on Gastric Cancer Incidence and Mortality

12 Sep, 2019 | 08:09h | UTC

Effects of Helicobacter pylori treatment and vitamin and garlic supplementation on gastric cancer incidence and mortality: follow-up of a randomized intervention trial – The BMJ (free)

Related Commentary on Twitter

Treating Helicobacter pylori with antibiotics for two weeks and taking vitamin or garlic supplements for just over seven years may be linked to a lower risk of developing stomach cancer in those at high risk, finds new research https://t.co/Jq7SBTdDAO

— The BMJ (@bmj_latest) September 12, 2019

ASTRO Guideline: Radiation Therapy for Pancreatic Cancer

12 Sep, 2019 | 08:01h | UTC

Radiation Therapy for Pancreatic Cancer: Executive Summary of an ASTRO Clinical Practice Guideline – Practical Radiation Oncology (free)

Commentaries: ASTRO Guideline on Use of Radiation Therapy for Patients With Pancreatic Cancer – The ASCO Post (free) AND New guideline clarifies role of radiation therapy in pancreatic cancer treatment – American Society for Radiation Oncology (free)

[Abstract Only] Observational Study: Men with Prostate Cancer and Pre-existing CV Comorbidities Have Increased Mortality Risk Following Oral Antiandrogen Therapy

12 Sep, 2019 | 07:53h | UTC

Mortality and Hospitalization Risk Following Oral Androgen Signaling Inhibitors Among Men with Advanced Prostate Cancer by Pre-existing Cardiovascular Comorbidities – European Urology (link to abstract – $ for full-text)

Commentaries: CVD Prior to Oral Antiandrogen Therapy for Prostate Cancer Increases Mortality Risk – Cancer Therapy Advisor (free) AND Risks of Novel Oral Prostate Cancer Therapies and Pre-existing Conditions – Thomas Jefferson University (free)

Systematic Review: Follow‐up Strategies for Patients Treated for Non‐metastatic Colorectal Cancer

11 Sep, 2019 | 00:03h | UTC

Follow‐up strategies for patients treated for non‐metastatic colorectal cancer – Cochrane Library (free)

Summary: Follow-up strategies for participants treated for non-metastatic colorectal cancer – Cochrane Library (free)

NCCN Guideline: Small Bowel Adenocarcinoma

10 Sep, 2019 | 01:18h | UTC

Small Bowel Adenocarcinoma, Version 1.2020, NCCN Clinical Practice Guidelines in Oncology – Journal of the National Comprehensive Cancer Network (free)

NCCN Guidelines Insights: Genetic/Familial High-Risk Assessment of Colorectal Cancer

10 Sep, 2019 | 01:19h | UTC

NCCN Guidelines Insights: Genetic/Familial High-Risk Assessment: Colorectal, Version 2.2019 – Journal of the National Comprehensive Cancer Network (free)

[Abstract Only] Randomized Trial: Adjuvant Radiotherapy Following Radical Prostatectomy vs. Radical Prostatectomy Alone in Prostate Cancer Patients with Positive Margins or Extracapsular Extension

10 Sep, 2019 | 00:56h | UTC

Randomised Trial of Adjuvant Radiotherapy Following Radical Prostatectomy Versus Radical Prostatectomy Alone in Prostate Cancer Patients with Positive Margins or Extracapsular Extension – European Urology (link to abstract – $ for full-text)

Commentaries: Adjuvant Radiotherapy After Radical Prostatectomy vs Radical Prostatectomy Alone in Patients With Positive Margins or Extracapsular Extension – The ASCO Post (free) AND Adjuvant radiotherapy may be beneficial in treating locally advanced prostate cancer – University of Helsinki (free)

Source: EvidenceAlerts

[Abstract Only] Another Study Points to Increased Colorectal Cancer Incidence in Young Adults

8 Sep, 2019 | 23:05h | UTC

Global patterns and trends in colorectal cancer incidence in young adults – Gut (link to abstract – $ for full-text)

Commentaries: Global analysis finds early onset colorectal cancer rising in many high-income countries – American Cancer Society (free) AND Increase in CRC in Young Adults in Many High-Income Countries – Medscape (free registration required)

Related: More Colon Cancer Cases are Being Diagnosed in People Under 50 (link to abstract and commentaries)

Systematic Review: Hypofractionation (Fewer, Larger Doses of Daily Radiation) for Clinically Localized Prostate Cancer Results in Similar Oncologic Outcomes

8 Sep, 2019 | 23:00h | UTC

Hypofractionation for clinically localized prostate cancer – Cochrane Library (free)

Systematic Review: Taxanes for Adjuvant Treatment of Early Breast Cancer

8 Sep, 2019 | 22:59h | UTC

Taxanes for adjuvant treatment of early breast cancer – Cochrane Library (free)

Summary: Taxane-containing chemotherapy for women after surgery for early breast cancer – Cochrane Library (free)

Population-based Cohort Study: Exposure to Diagnostic Low-Dose Ionizing Radiation Associated with Increased Risk for Many Types of Cancers

5 Sep, 2019 | 08:27h | UTC

Association of Exposure to Diagnostic Low-Dose Ionizing Radiation With Risk of Cancer Among Youths in South Korea – JAMA Network Open (free)

ASCO Guideline: Use of Endocrine Therapy for Breast Cancer Risk Reduction

5 Sep, 2019 | 08:15h | UTC

Use of Endocrine Therapy for Breast Cancer Risk Reduction: ASCO Clinical Practice Guideline Update – Journal of Clinical Oncology (free)

USPSTF Recommendation Statement: Medication Use to Reduce Risk of Breast Cancer

4 Sep, 2019 | 09:11h | UTC

Medication Use to Reduce Risk of Breast Cancer: US Preventive Services Task Force Recommendation Statement – JAMA (free)

Recommendation Summary: Medication Use to Reduce Risk of Breast Cancer (free)

Editorials: Medications to Reduce Breast Cancer Risk: Promise and Limitations (free for a limited period) AND Breast Cancer Chemoprevention—Can We Make a Case for Precision Medicine? (free for a limited period)

Evidence Report and Systematic Review: Medication Use for the Risk Reduction of Primary Breast Cancer in Women – US Preventive Services Task Force (free)

Author Interview: USPSTF Recommendation: Medication Use to Reduce Risk of Breast Cancer (free audio)

Commentaries: Medication can lower some women’s risk of breast cancer – Reuters (free) AND USPSTF: Aromatase Inhibitors Recommended to Help Prevent Breast Cancer – NEJM Journal Watch (free)

#ESCCongress – Study: Cancer Now Leading Cause of Death in High-income Countries

4 Sep, 2019 | 09:32h | UTC

Variations in common diseases, hospital admissions, and deaths in middle-aged adults in 21 countries from five continents (PURE): a prospective cohort study – The Lancet (free for a limited period – registration required)

Commentaries: Cancer now leading cause of death in high-income countries — while heart disease burden persists in low-income and middle-income countries – The Lancet (free) AND Cardiovascular Disease Leading Cause of Death World-Wide, but Cancer Rising Cause in Rich Countries: Study – McMaster University (free) AND Cancer ‘biggest middle-age killer in rich nations’ – BBC (free) AND Cancer overtakes heart disease as biggest rich-world killer – Reuters (free) AND Cancer now tops heart disease as the No. 1 cause of death in these countries – CNN (free)

Related Commentary on Twitter

Presenting now #ESCCongress—#CVD remains leading cause of mortality globally, accounting for 40% of deaths, but in HIC, #cancer is now responsible for twice as many deaths: findings from #PUREStudy

Free to read with reg until Sept 10 #LancetCardiology https://t.co/iXSfIio77D pic.twitter.com/eHEJ0kWWfa

— The Lancet (@TheLancet) September 3, 2019