Oncology (all articles) | Page 76 of 122 | Links Medicus Content Curation & Alerts in Medicine

[Abstract Only] Randomized Trial: Triplet-targeted Therapy Improves Survival in BRAF Mutated Advanced Colorectal Cancer

4 Oct, 2019 | 07:24h | UTC

Encorafenib, Binimetinib, and Cetuximab in BRAF V600E–Mutated Colorectal Cancer – New England Journal of Medicine (link to abstract – $ for full-text)

News Release: Triplet-targeted therapy improves survival for patients with advanced colorectal cancer and BRAF mutations – University of Texas MD Anderson Cancer Center (free)

Study: More Than Half of Patients with Cancer Receive Intensive Services at the End of Life at a Substantial Cost to Beneficiaries and the Heath System

4 Oct, 2019 | 07:16h | UTC

Health System and Beneficiary Costs Associated With Intensive End-of-Life Medical Services – JAMA Network Open (free)

BMJ Guideline: Colorectal Cancer Screening with Fecal Immunochemical Testing, Sigmoidoscopy or Colonoscopy

3 Oct, 2019 | 07:45h | UTC

Colorectal cancer screening with faecal immunochemical testing, sigmoidoscopy or colonoscopy: a clinical practice guideline – The BMJ (free)

Editorial: Personalised and risk based cancer screening (free)

Commentaries: Guideline Moves Away from Colorectal Cancer Screening for Some – NEJM Journal Watch (free) AND First Guideline to Say Colon Cancer Screening Is Not for All – Medscape (free registration required)

Related Guidelines: Colorectal Cancer Screening for Average‐risk Adults (guidelines from other organizations)

Related Commentary on Twitter

Routine testing for bowel cancer should not be recommended for everyone aged 50-79 years because, for those at very low risk, the benefit is small and uncertain and there are potential harms, finds new #RapidRecs guideline https://t.co/68xTtEDHxQ

— The BMJ (@bmj_latest) October 3, 2019

[Abstract Only] Cohort Study: Factors Associated with Breast Cancer–related Lymphedema after Neoadjuvant Chemotherapy and Axillary Dissection

2 Oct, 2019 | 01:35h | UTC

Factors Associated with Lymphedema in Women With Node-Positive Breast Cancer Treated With Neoadjuvant Chemotherapy and Axillary Dissection – JAMA Surgery (link to abstract – $ for full-text)

Commentaries: Neoadjuvant Chemotherapy Duration and Obesity May Be Associated With Increased Risk of Lymphedema in Some Women With Breast Cancer – The ASCO Post (free) AND Lymphedema Risk in Breast Ca Linked to NAC Duration – MedPage Today (free registration required)

FDA Issues Drug Safety Alert on Severe Lung Inflammation Due to Treatment with CDK4/6 Inhibitors for Breast Cancer

1 Oct, 2019 | 00:36h | UTC

FDA warns about rare but severe lung inflammation with Ibrance, Kisqali, and Verzenio for breast cancer – U.S. Food & Drug Administration (free)

Commentary: FDA Issues Drug Safety Communication on Lung Inflammation Due to Treatment With CDK4/6 Inhibitors – The ASCO Post (free)

Global Burden of Cancer, 1990 to 2017

30 Sep, 2019 | 00:42h | UTC

Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017: A Systematic Analysis for the Global Burden of Disease Study – JAMA Oncology (free)

Related Commentary on Twitter

To ensure sustainable global development, increased efforts are needed in cancer prevention and in ensuring universal access to cancer care. https://t.co/6HDaU8Ped9

— JAMA Oncology (@JAMAOnc) September 27, 2019

#ESMO19 – Randomized Trial: Improved Overall Survival with a CDK4/6 Inhibitor for Hormone Receptor-positive, ERBB2-negative Advanced Breast Cancer

30 Sep, 2019 | 00:40h | UTC

The Effect of Abemaciclib Plus Fulvestrant on Overall Survival in Hormone Receptor–Positive, ERBB2-Negative Breast Cancer That Progressed on Endocrine Therapy—MONARCH 2: A Randomized Clinical Trial – JAMA Oncology (free)

Commentary: Two Studies Show CDK4/6 Inhibitors Improve Overall Survival in Advanced Breast Cancer [ESMO 2019 Press Release] (free)

#ESMO19 – Just presented at the European Society of Medical Oncology Congress 2019 in Barcelona

#ESMO19 – [Not Published Yet] Randomized Trial: Many Men with Prostate Cancer May Avoid Postoperative Radiotherapy, Study Suggests

30 Sep, 2019 | 00:39h | UTC

Men with Prostate Cancer can be Spared Radiotherapy after Surgery [ESMO 2019 Press Release] (free)

#ESMO19 – Just presented at the European Society of Medical Oncology Congress 2019 in Barcelona

#ESMO19 – [Abstract Only] Randomized Trial: Improved Overall Survival at 5 Years with Combined Immunotherapy for Advanced Melanoma

30 Sep, 2019 | 00:37h | UTC

Five-Year Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Skin cancer: Half of people surviving advanced melanoma – BBC (free) AND Combination immunotherapy drugs herald new hope for melanoma patients with long term survival rates – The Royal Marsden NHS Foundation Trust (free)

#ESMO19 – Just presented at the European Society of Medical Oncology Congress 2019 in Barcelona

Related Commentary on Twitter

With a 5-year min follow-up, the combination of nivolumab plus ipilimumab associated with 5-year survival of 52% in patients with metastatic #melanoma, compared with 44% for nivolumab alone and 26% for ipilimumab alone. See the CheckMate 067 trial. #ESMO19 https://t.co/f50KNzH5tp

— NEJM (@NEJM) September 28, 2019

#ESMO19 – [Abstract Only] Randomized Trial: Improved Overall Survival with Combined Immunotherapy for Advanced Non–Small-Cell Lung Cancer

30 Sep, 2019 | 00:35h | UTC

Nivolumab plus Ipilimumab in Advanced Non–Small-Cell Lung Cancer – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Two immunotherapy drug combination offers chemotherapy-free option for advanced NSCLC – European Society for Medical Oncology (free) AND Nivolumab/Low-dose Ipilimumab: A Potential Chemotherapy-Sparing Option in Advanced NSCLC – Pharmacy Times (free)

#ESMO19 – Just presented at the European Society of Medical Oncology Congress 2019 in Barcelona

Related Commentary on Twitter

Chemo-naïve patients with adv #NSCLC with PD-L1 expression assigned to nivolumab + ipilimumab, nivolumab alone, or chemo. Patients receiving nivolumab + ipilimumab had better clin outcomes. See the CheckMate 227 trial. #ESMO19 https://t.co/jU9S62qZLa

— NEJM (@NEJM) September 28, 2019

Cohort Study: Improved Survival After Mohs Micrographic Surgery for Early-Stage Invasive Melanoma

30 Sep, 2019 | 00:12h | UTC

Comparison of Survival After Mohs Micrographic Surgery vs Wide Margin Excision for Early-Stage Invasive Melanoma – JAMA Dermatology (free for a limited period)

Editorial: Improving Survival for Patients With Early-Stage Melanoma (free for a limited period)

Commentaries: Mohs micrographic surgery may up survival in stage I melanoma – MedicalXpress (free) AND Mohs Tied to Better OS in Early Invasive Melanoma – MedPage Today (free registration required)

Study: BCG Vaccination in Childhood Associated with Reduced Risk of Lung Cancer

27 Sep, 2019 | 08:24h | UTC

Association of BCG Vaccination in Childhood With Subsequent Cancer Diagnoses: A 60-Year Follow-up of a Clinical Trial – JAMA Network Open (free)

Commentaries: BCG Vaccination and Cancer Risk: What’s the Link? – MPR (free) AND BCG Vax: A Shot Against Lung Cancer in Native Populations? – MedPage Today (free registration required)

Meta-analysis: Therapies for Preventing Cardiotoxicity in Patients Undergoing Chemotherapy

26 Sep, 2019 | 08:35h | UTC

Efficacy of Neurohormonal Therapies in Preventing Cardiotoxicity in Patients With Cancer Undergoing Chemotherapy – JACC CardioOncology (free)

Related Commentary on Twitter

Efficacy of Neurohormonal Therapies to Prevent Cardiotoxicity in Pts w/ Cancer

Featured in Inaugural Issue @JACCJournals
#JACCCardioOnc w/@Hirji1987 @ambarish4786

Meta-analysis (n=17): ~4% attenuation of LVEF decline, unmet need for large powered RCTshttps://t.co/TCC4NnxQli pic.twitter.com/G1yLF4b83T

— Muthu Vaduganathan (@mvaduganathan) September 24, 2019

ATS Research Statement: Knowledge Gaps and Research Priorities in Immune Checkpoint Inhibitor–related Pneumonitis

19 Sep, 2019 | 07:59h | UTC

Knowledge Gaps and Research Priorities in Immune Checkpoint Inhibitor–related Pneumonitis. An Official American Thoracic Society Research Statement – American Journal of Respiratory and Critical Care Medicine (free)

Related: Immune Checkpoint Inhibitor Toxicities (guidelines and reviews on the subject)

ASCO Guideline: Management of Osteoporosis in Survivors of Adult Cancers with Nonmetastatic Disease

22 Sep, 2019 | 23:02h | UTC

Management of Osteoporosis in Survivors of Adult Cancers With Nonmetastatic Disease: ASCO Clinical Practice Guideline – Journal of Clinical Oncology (free)

[Abstract Only] Study: Smartphone App for Triage of Skin Lesions Has a High Sensitivity in Detecting Skin Cancers

22 Sep, 2019 | 22:48h | UTC

Accuracy of a smartphone application for triage of skin lesions based on machine learning algorithms – Journal of the European Academy of Dermatology and Venereology (link to abstract – $ for full-text)

Commentaries: Smart Phone App Uses Machine Learning to Triage Skin Cancers – MedicalResearch.com (free) AND SkinVision algorithm detects 95% of skin cancer, study finds – News Medical (free)

Cohort Study: Lateral Nodal Features on Restaging MRI Associated with Lateral Local Recurrence in Low Rectal Cancer

22 Sep, 2019 | 22:46h | UTC

Lateral Nodal Features on Restaging Magnetic Resonance Imaging Associated With Lateral Local Recurrence in Low Rectal Cancer After Neoadjuvant Chemoradiotherapy or Radiotherapy – JAMA Surgery (free for a limited period)

Commentaries: Lateral Lymph Nodes as the Achilles Heel of Low Rectal Cancer Surgery After Neoadjuvant Chemoradiation Therapy: Are We Close to Solving the Riddle? – JAMA Surgery (free) AND Features on Restaging MRI Associated With Local Recurrence After Neoadjuvant Treatment in Low Rectal Cancer – The ASCO Post (free) AND MRI Helps Decisions on Lateral Nodal Disease in Rectal Cancer – Medscape (free registration required)

Cohort Study: Early Palliative Care Linked to Increased Survival and Reduced Risk of Death in an Acute Care Setting Among Patients with Advanced Lung Cancer

20 Sep, 2019 | 08:21h | UTC

Association of Early Palliative Care Use With Survival and Place of Death Among Patients With Advanced Lung Cancer Receiving Care in the Veterans Health Administration – JAMA Oncology (free for a limited period)

Editorial: Prolonged Survival With Palliative Care—It Is Possible, but Is It Necessary? (free)

Commentaries: Early Palliative Care Associated with Increased Survival in Lung Cancer Patients – MedicalResearch.com (free) AND Early palliative care for advanced lung cancer increases survival – Veterans Affairs Research Communications (free)

Related Systematic Review: Early palliative care for adults with advanced cancer – Cochrane Library (free summary and original article)

Study: Half of Trials Supporting New Cancer Drug Approvals in Europe Were Judged to be at High Risk of Bias

20 Sep, 2019 | 07:46h | UTC

Design characteristics, risk of bias, and reporting of randomised controlled trials supporting approvals of cancer drugs by European Medicines Agency, 2014-16: cross sectional analysis – The BMJ (free)

Editorial: Flawed evidence underpins approval of new cancer drugs (free)

Commentaries: Gauging the validity of cancer drug trials: a call for collaboration – The BMJ Opinion (free) AND Questions raised over quality of trials supporting new cancer drugs approvals – OnMedica (free) AND Evidence underpinning approval of new cancer drugs raises questions – The BMJ (free)

“Around half of trials that supported new cancer drug approvals in Europe between 2014 and 2016 were judged to be at high risk of bias, which indicates that treatment effects might have been exaggerated, concludes a new study.” (from The BMJ news release)

Expert Panel Recommendations: Renal Cell Cancer Treatment, Focus on Surgery

18 Sep, 2019 | 01:47h | UTC

Renal cell cancer treatment: an expert panel recommendation from the Latin American cooperative group-genitourinary and the Latin American renal cancer group: focus on surgery – Therapeutic Advances in Urology (free)

Observational Study Suggests Breast Cancer Screening May be Beneficial for High-Risk Men

18 Sep, 2019 | 01:16h | UTC

Breast Cancer Screening in High-Risk Men: A 12-Year Longitudinal Observational Study of Male Breast Imaging Utilization and Outcomes – Radiology (free)

Commentaries: Screening mammography could benefit men at high risk of breast cancer – Radiological Society of North America (free) AND Mammographic Screening for Breast Cancer of Potential Benefit in High-Risk Men – NEJM Journal Watch (free)

Review: Understanding Tumor Lysis Syndrome

17 Sep, 2019 | 07:40h | UTC

Understanding tumor lysis syndrome – Intensive Care Medicine (free for a limited period)

Small Randomized Trial Suggests a Benefit from Metformin as Adjunctive Therapy in Patients with Epidermal Growth Factor Receptor–Mutated Lung Adenocarcinoma

16 Sep, 2019 | 00:46h | UTC

Effect of Metformin Plus Tyrosine Kinase Inhibitors Compared With Tyrosine Kinase Inhibitors Alone in Patients With Epidermal Growth Factor Receptor–Mutated Lung Adenocarcinoma: A Phase 2 Randomized Clinical Trial – JAMA Oncology (free for a limited period)

Commentary: Metformin Repurposed: Boosts Survival in TKI-Treated Lung Cancer – MedPage Today (free registration required)

Observational Study Suggests Antibiotics Can Greatly Impair the Response to Immune Checkpoint Inhibitors in Patients with Cancer

16 Sep, 2019 | 00:48h | UTC

Association of Prior Antibiotic Treatment With Survival and Response to Immune Checkpoint Inhibitor Therapy in Patients With Cancer – JAMA Oncology (free for a limited period)

Author Interview: Association of Prior Antibiotic Treatment With Survival and Response to Immune Checkpoint Inhibitor Therapy in Patients With Cancer (free audio)

Commentaries: Antibiotics reduce survival rates in cancer patients taking immunotherapy – Imperial College London (free) AND Antibiotics prior to immunotherapy lower survival rate for cancer patients, study says – UPI (free)

Related Commentary on Twitter

The potential of antecedent antibiotics (pATB)to counter #cancer immunotherapy benefits. A small prospective non-randomized @JAMAOnc report w/ an alarming survival curvehttps://t.co/swS6Z4fnC0
by @DJPinato @tnewsomdavis @diego0001 @profbower
@DPHPC @ImperialSandC @ChelwestFT pic.twitter.com/AeSAmVTjNT

— Eric Topol (@EricTopol) September 13, 2019

European Guidelines on Endoscopic Management of Polyposis Syndromes

15 Sep, 2019 | 23:58h | UTC

Endoscopic management of polyposis syndromes: European Society of Gastrointestinal Endoscopy (ESGE) Guideline – Endoscopy (free)

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