Oncology (all articles)
RCT | 10-year results show low-dose tamoxifen reduces noninvasive breast cancer recurrence
17 Apr, 2023 | 12:50h | UTCRandomized Placebo Controlled Trial of Low-Dose Tamoxifen to Prevent Recurrence in Breast Noninvasive Neoplasia: A 10-Year Follow-Up of TAM-01 Study – Journal of Clinical Oncology (link to abstract – $ for full-text)
ASCO Policy Statement on biosimilar and interchangeable products in oncology
12 Apr, 2023 | 13:18h | UTCASCO Policy Statement on Biosimilar and Interchangeable Products in Oncology – JCO Oncology Practice
RCT | Effects of focal vs. extended irreversible electroporation ablation of localized prostate cancer
12 Apr, 2023 | 13:05h | UTCEffect of Focal vs Extended Irreversible Electroporation for the Ablation of Localized Low- or Intermediate-Risk Prostate Cancer on Early Oncological Control: A Randomized Clinical Trial – JAMA Surgery (link to abstract – $ for full-text)
Commentary on Twitter
Irreversible electroporation (IRE) can provide promising oncological control as a focal therapy for patients with localized low-intermediate risk prostate cancer patients. https://t.co/lmYnYpSRmY
— JAMA Surgery (@JAMASurgery) February 1, 2023
Review | Diagnostic, structured classification and therapeutic approach in cystic pancreatic lesions
12 Apr, 2023 | 12:58h | UTCRelated:
Cystic pancreatic lesions: MR imaging findings and management.
Recommendations for the management of incidental pancreatic findings in adults.
Pancreatic cystic neoplasms: a review of current recommendations for surveillance and management
Management of Pancreatic Cystic Lesions
Consensus Recommendations: Diagnosis and Surveillance of Incidental Pancreatic Cystic Lesions
Review: Pancreatic Cystic Lesions
Guidelines on pancreatic cystic neoplasms
RCT | Low-dose olanzapine enhances appetite & weight gain in chemotherapy patients
11 Apr, 2023 | 14:41h | UTCRandomized Double-Blind Placebo-Controlled Study of Olanzapine for Chemotherapy-Related Anorexia in Patients With Locally Advanced or Metastatic Gastric, Hepatopancreaticobiliary, and Lung Cancer – Journal of Clinical Oncology (link to abstract – $ for full-text)
Commentaries:
Low-dose olanzapine improves appetite in chemotherapy patients – MDedge
Commentary on Twitter
This trial is as good as it gets ⭐️⭐️⭐️⭐️⭐️
✅Patient centered supportive care trial
✅Inexpensive medication
✅Conducted in a LMIC
✅Clinically relevant endpoint
✅ Randomized/double-blinded study
✅Potential to immediately change practicehttps://t.co/3nRrFJaS20Kudos!
— Manni Mohyuddin (@ManniMD1) March 29, 2023
RCT | Exploring the potential of peritumoral lidocaine infiltration to improve outcomes in early breast cancer
11 Apr, 2023 | 14:37h | UTCEffect of Peritumoral Infiltration of Local Anesthetic Before Surgery on Survival in Early Breast Cancer – Journal of Clinical Oncology (link to abstract – $ for full-text)
Screening colonoscopy in seniors: common in patients with limited life expectancy and associated with higher complication risks
11 Apr, 2023 | 14:30h | UTCFrequency of Use and Outcomes of Colonoscopy in Individuals Older Than 75 Years – JAMA Internal Medicine (link to abstract – $ for full-text)
Related: Study reveals overuse of surveillance colonoscopy in older adults with limited life expectancy
Commentary:
In older adults >75 years of age, most screening colonoscopies were in patients in patients with limited life expectancy (defined as <10 years) and associated with increased risk of adverse events. https://t.co/XOsy2UKNRx @Jessica_Halabi @MRothbergMD @burkegastrodoc
— JAMA Internal Medicine (@JAMAInternalMed) April 4, 2023
SR | Risk factors for cholangitis after pancreatoduodenectomy
11 Apr, 2023 | 14:21h | UTC
Late mortality in childhood cancer survivors: causes & modifiable risk factors
11 Apr, 2023 | 14:16h | UTCSpecific causes of excess late mortality and association with modifiable risk factors among survivors of childhood cancer: a report from the Childhood Cancer Survivor Study cohort – The Lancet (link to abstract – $ for full-text)
News Release: Healthy lifestyle associated with reduced mortality risk in childhood cancer survivors – St. Jude Children’s Research Hospital
Single-arm study | Effects of CAR-T therapy in children with relapsed or refractory high-risk neuroblastoma
11 Apr, 2023 | 14:09h | UTCGD2-CART01 for Relapsed or Refractory High-Risk Neuroblastoma – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: CAR-T Therapy Helps Kids Battling Deadly Nervous System Tumors – HealthDay
Commentary on Twitter
https://twitter.com/NEJM/status/1643730240689295360
Study identifies top 3 anticancer drugs with highest atrial fibrillation rates
11 Apr, 2023 | 13:55h | UTCCommentary: More AF Surveillance Needed in Chemotherapy Trials, Meta-analysis Hints – TCTMD
Cohort Study | Long-term mortality in individuals diagnosed with cancer during pregnancy or postpartum
10 Apr, 2023 | 13:48h | UTCLong-term Mortality in Individuals Diagnosed With Cancer During Pregnancy or Postpartum – JAMA Oncology (free for a limited period)
Commentary on Twitter
https://twitter.com/JAMAOnc/status/1644369444276428800
Phase 2 RCT | Addition of metastasis-directed therapy to intermittent hormone therapy for oligometastatic prostate cancer
10 Apr, 2023 | 13:41h | UTCAddition of Metastasis-Directed Therapy to Intermittent Hormone Therapy for Oligometastatic Prostate Cancer: The EXTEND Phase 2 Randomized Clinical Trial – JAMA Oncology (free for a limited period)
Commentary on Twitter
Randomized trial of intermittent hormone therapy +/- radiation to oligometastatic sites of #prostatecancer shows significantly improved PFS & assoc time off hormone therapy & w/normal testosterone from combination. https://t.co/ZnmkQuqHZm #RadOnc #PCSM #GUCSM
— JAMA Oncology (@JAMAOnc) April 6, 2023
Cohort Study | Impact of complications after resection of pancreatic cancer on disease recurrence and survival
10 Apr, 2023 | 13:34h | UTC
Commentary on Twitter
Major complications after🦀surgery are known to impair DF- and OS ➡️📜of all 🇳🇱 pat undergoing panc surgery 2014–2017 (n=1071) confirms via causal mediation 📈that this is mediated due to omission of adjuvant CTX!https://t.co/8kjr9MpRt4#some4surgery #some4hpb @BJSAcademy pic.twitter.com/EZd7Yvi4z2
— BJS Open (@BjsOpen) April 1, 2023
ESMO Guideline | Updated treatment recommendations for prostate cancer
6 Apr, 2023 | 13:18h | UTC
Guideline | Muscle-invasive and metastatic bladder cancer
6 Apr, 2023 | 13:19h | UTCMuscle-invasive and Metastatic Bladder Cancer – European Association of Urology (see PDF)
SR | Insufficient evidence on skin-sparing mastectomy efficacy and safety for breast cancer
6 Apr, 2023 | 13:04h | UTCSkin‐sparing mastectomy for the treatment of breast cancer – Cochrane Database of Systematic Reviews
RCT | Enzalutamide versus standard antiandrogen therapy in hormone-sensitive prostate cancer with metastasis
5 Apr, 2023 | 13:30h | UTCTestosterone suppression plus enzalutamide versus testosterone suppression plus standard antiandrogen therapy for metastatic hormone-sensitive prostate cancer (ENZAMET): an international, open-label, randomised, phase 3 trial – The Lancet Oncology (link to abstract – $ for full-text)
News Release: ENZAMET shows promise as prostate cancer treatment – University of Adelaide
Review | Comprehensive care of women with genetic predisposition to breast and ovarian cancer
5 Apr, 2023 | 13:32h | UTC
Updated ADAURA trial results | Adjuvant Osimertinib improves disease-free survival in resected EGFR-mutated NSCLC
5 Apr, 2023 | 13:21h | UTCNews Release: Trial Shows Significant Disease-free Survival for Patients Diagnosed With Non-small Cell Lung Cancer – Yale School of Medicine
Cohort study | Younger stroke survivors show elevated cancer risk for up to 8 years
4 Apr, 2023 | 13:46h | UTCSummary: In this cohort study, 390,398 patients aged 15 years or older in the Netherlands, without a history of cancer and with a first-ever ischemic stroke or intracerebral hemorrhage (ICH), were analyzed between January 1, 1998, and January 1, 2019. The primary outcome was the cumulative incidence of first-ever cancer after the index stroke, stratified by stroke subtype, age, and sex, compared with age-, sex-, and calendar year-matched peers from the general population.
The findings revealed that, in the first year after a stroke, patients aged 15 to 49 years had a 3- to 5-fold increased risk of cancer compared to individuals without a stroke. In contrast, the risk was only slightly elevated for patients aged 50 years or older. The cancer risk remained elevated for up to 8 years after an ischemic stroke and 6 years after an ICH in the younger age group, with the highest risks observed for lung cancer, gastrointestinal cancer, and hematologic cancer.
The findings may be confounded by shared risk factors, such as smoking. Alternatively, the increased cancer risk may have a causal mechanism between cancer and stroke, possibly related to the hypercoagulable state induced by cancer. However, the study design does not allow for conclusions about causal mechanisms, and the researchers called for further studies investigating the usefulness of cancer screening after a stroke.
S1-guideline cutaneous and subcutaneous leiomyosarcoma
4 Apr, 2023 | 13:37h | UTCS1-guideline cutaneous and subcutaneous leiomyosarcoma – Journal of the German Dermatology Society
Brief Review | What every gastroenterologist should know about gastrointestinal neuroendocrine tumors
4 Apr, 2023 | 13:29h | UTC
Cohort Study | Celiac axis stenosis is an underestimated risk factor for increased morbidity after pancreatoduodenectomy
4 Apr, 2023 | 13:20h | UTC
Cohort Study | Assessing active surveillance outcomes in non-intraabdominal desmoid-type fibromatosis patients
4 Apr, 2023 | 13:21h | UTC