Neurology
Cognitive Impairment and Heart Failure
23 Jul, 2017 | 16:04h | UTCCognitive Impairment and Heart Failure: Systematic Review and Meta-Analysis – Journal of Cardiac Failure (link to abstract – $ for full-text)
Commentary: Cognitive Impairment and HF – American College of Cardiology, Latest in Cardiology (free)
The Evolving Story of Overlapping Surgery
23 Jul, 2017 | 14:09h | UTCViewpoint: The Evolving Story of Overlapping Surgery – JAMA (free) (RT @pash22 see Tweet)
Commentary: 3 steps to restore patient trust in overlapping surgeries – FierceHealthcare (free)
This interesting viewpoint discusses the practice of scheduling overlapping surgeries, in which a qualified practitioner finishes noncritical parts of the first operation while the primary surgeon moves to the next surgery.
Elevated Brain Amyloid and Subsequent Cognitive Decline Among Cognitively Normal Persons
22 Jul, 2017 | 15:32h | UTCAssociation Between Elevated Brain Amyloid and Subsequent Cognitive Decline Among Cognitively Normal Persons – JAMA (link to abstract – $ for full-text)
Commentaries: Elevated Brain Amyloid Linked to Later Cognitive Decline – Medscape (free registration required) AND Amyloid Plaque and Cognitive Decline – Diagnostic Imaging (free) More Data Suggests Brain Amyloid Buildup Leads to Cognitive Decline – MedPage Today (free registration required) AND Elevated amyloid proves a warning sign of cognitive decline to come – Health Imaging (free) AND Study reveals early indication of Alzheimer’s in adults with normal cognition – News Medical (free)
More Millennials Are Having Strokes
22 Jul, 2017 | 14:54h | UTCPrevalence of Cardiovascular Risk Factors and Strokes in Younger Adults – JAMA Neurology (link to abstract – $ for full-text)
Commentaries: More Millennials Are Having Strokes – Scientific American (free) AND Ischemic stroke hospitalizations among younger adults increased 30% or more in recent years – Cardiovascular Business (free) AND Higher incidence of stroke and greater prevalence of stroke risk factors in younger adults over the last decade – 2 Minute Medicine (free) Is Stroke Trending Younger? – MedPage Today (free registration required) AND More Data Suggest Stroke Rates Rising in Younger Adults – Medscape (free registration required)
Short review: Subarachnoid Hemorrhage
21 Jul, 2017 | 18:27h | UTCShort review: Subarachnoid Hemorrhage – NEJM Resident 360 (free)
Cerebellar Dysfunction in Multiple Sclerosis
21 Jul, 2017 | 18:13h | UTCReview: Cerebellar Dysfunction in Multiple Sclerosis – Frontiers in Neurology (free)
Antiplatelet Regimen for Patients With Breakthrough Strokes While on Aspirin
21 Jul, 2017 | 17:51h | UTCAntiplatelet Regimen for Patients With Breakthrough Strokes While on Aspirin: A Systematic Review and Meta-Analysis – Stroke (link to abstract – $ for full-text)
Commentary: Adjusting Antiplatelet Regimen Could Decrease Risk For Stroke Patients on Aspirin Monotherapy – American College of Cardiology, Latest in Cardiology (free)
Meta-analysis of cohort studies: in patients who experienced an ischemic stroke or transient ischemic attack while on aspirin monotherapy, the addition of or a switch to another antiplatelet agent, versus aspirin monotherapy, was associated with a 32 percent reduction in the risk of major adverse cardiovascular events (HR 0.68; 0.54–0.85) and 30 percent reduction in recurrent strokes (HR, 0.70; 0.54–0.92). Additional randomized trials would better clarify the best antiplatet regimen for these patients.
NICE Guideline: Parkinson’s disease in adults
21 Jul, 2017 | 17:52h | UTCParkinson’s disease in adults – National Institute for Health and Care Excellence (NICE) Guideline (free)
Dementia prevention, intervention, and care
21 Jul, 2017 | 17:40h | UTCReport: Dementia prevention, intervention, and care – The Lancet (free registration required)
Commentaries: Experts: 1 in 3 cases of dementia preventable, nonmedical therapies ideal for dementia – University of Southern California, via EurekAlert (free) AND One Third of Dementia May Be Preventable With Lifestyle Change – Medscape (free registration required) AND Over a Third of Dementia Cases Tied to Modifiable Risk Factors – Physician’s First Watch (free) AND Living healthily, learning more could cut dementia cases by a third – Reuters (free) AND Lifestyle changes could prevent a third of dementia cases, report suggests – The Guardian (free)
New European Society of Medical Oncology (ESMO) Updated Clinical Practice Guidelines
20 Jul, 2017 | 00:07h | UTCHomepage – New European Society of Medical Oncology (ESMO) Updated Clinical Practice Guidelines
New available guidelines are:
– Rectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up (free)
– Chronic myeloid leukaemia: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up (free)
– Multiple myeloma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up (free)
– Cervical cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up (free)
– Management of infusion reactions to systemic anticancer therapy: ESMO Clinical Practice Guidelines (free)
Guidelines for diagnosis, prevention and management of central nervous system involvement in diffuse large B-cell lymphoma
18 Jul, 2017 | 23:13h | UTC
Concise review: Amyotrophic Lateral Sclerosis
18 Jul, 2017 | 22:59h | UTCConcise review: Amyotrophic Lateral Sclerosis – NEJM Resident 360 clinical pearls (free)
Emergency Management of Pediatric Seizures
18 Jul, 2017 | 22:52h | UTCClinical Review: EM Cases: Emergency Management of Pediatric Seizures – emDocs (free)
Inborn Errors of Metabolism and Epilepsy: Current Understanding, Diagnosis, and Treatment Approaches
18 Jul, 2017 | 22:43h | UTCClinical Review: Inborn Errors of Metabolism and Epilepsy: Current Understanding, Diagnosis, and Treatment Approaches – International Journal of Molecular Sciences (free)
Multiple Sclerosis: Immunopathology and Treatment Update
18 Jul, 2017 | 22:41h | UTCClinical Review: Multiple Sclerosis: Immunopathology and Treatment Update – Brain Sciences (free)
Systematic review: Antiepileptic drug monotherapy
17 Jul, 2017 | 01:35h | UTCSystematic review: Antiepileptic drug monotherapy (single drug treatment) for epilepsy – Cochrane Library (free)
Original review: Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data (link to summary – $ for full-text)
Differential diagnosis of neuromyelitis optica spectrum disorders
16 Jul, 2017 | 23:38h | UTCClinical Review: Differential diagnosis of neuromyelitis optica spectrum disorders – Therapeutic Advances in Neurological Disorders (free)
Study: No effect of commercial cognitive training on cognitive function
13 Jul, 2017 | 20:43h | UTCNo Effect of Commercial Cognitive Training on Neural Activity During Decision-Making – The Journal of Neuroscience (link to abstract – $ for full-text)
Commentaries: Brain training has no effect on decision-making or cognitive function – University of Pennsylvania School of Medicine, via NewsWise (free) AND Brain Training: No Effect on Cognitive Performance – Medscape (free registration required) AND Brain-training games don’t really train brains, a new study suggests – The Washington Post (a few articles per month are free)
Blood pressure and in-hospital outcomes in patients presenting with ischaemic stroke
12 Jul, 2017 | 20:13h | UTCBlood pressure and in-hospital outcomes in patients presenting with ischaemic stroke – European Heart Journal (link to abstract – $ for full-text)
Commentary: Blood Pressure and Outcomes After Ischemic Stroke – American College of Cardiology, Latest in Cardiology (free)
Related article: Editorial: Blood Pressure in Acute Stroke Still No Answer for Management – Stroke (free PDF)
Observational analysis of over 300.000 patients suggests a J-shaped, or U-shaped relationships between BP and outcomes (both lower and higher BP levels detrimental). Among patients submitted to thrombolytic therapy, there were fewer complications with lower blood pressure.
Antidepressant Switching vs Augmentation in Resistent Depression?
12 Jul, 2017 | 15:24h | UTCEffect of Antidepressant Switching vs Augmentation on Remission Among Patients With Major Depressive Disorder Unresponsive to Antidepressant Treatment: The VAST-D Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
Commentaries: Study Compares Switching Meds vs an Additional Med for Patients Unresponsive to an Antidepressant – The Jama Network (free) AND For Treatment-Resistant Depression, Add an Antipsychotic or Switch Antidepressants? – Physician’s First Watch (free)
Augmentation with aripiprazole led to a modestly increased likelihood of remission, but with more adverse effects. “Given the small effect size and adverse effects associated with aripiprazole, further analysis including cost-effectiveness is needed to understand the net utility of this approach”.
Positive airway pressure doesn’t reduce cardiovascular events and death in adults with sleep apnea
12 Jul, 2017 | 15:01h | UTCAssociation of Positive Airway Pressure With Cardiovascular Events and Death in Adults With Sleep Apnea: A Systematic Review and Meta-analysis – JAMA (link to abstract – $ for full-text)
Commentaries: More Doubt Cast on CPAP for Reducing CVD Risk in Sleep Apnea Patients – MedPage Today (free registration required) AND Positive airway pressure doesn’t reduce heart risk with sleep apnea – Reuters (free)
“PAP for obstructive sleep apnea improves quality of life but not CV events or BP with up to 5 years of follow up” (RT @AnilMakam see Tweet)
Effect of Depth and Duration of Cooling on Death or Disability at Age 18 Months Among Neonates With Hypoxic-Ischemic Encephalopathy
11 Jul, 2017 | 21:35h | UTCEffect of Depth and Duration of Cooling on Death or Disability at Age 18 Months Among Neonates With Hypoxic-Ischemic Encephalopathy: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
Interview with the author: Effect of Depth and Duration of Cooling on Death or Disability at Age 18 Months Among Neonates With Hypoxic-Ischemic Encephalopathy – MedicalResearch.com (free)
Source: EvidenceAlerts (free resource to find articles of interest)
Deutetrabenazine for treatment of involuntary movements in patients with tardive dyskinesia
11 Jul, 2017 | 16:44h | UTCDeutetrabenazine for treatment of involuntary movements in patients with tardive dyskinesia (AIM-TD): a double-blind, randomised, placebo-controlled, phase 3 trial – The Lancet Psychiatry (link to abstract – $ for full-text)
Commentaries: Drug Eases Tardive Dyskinesia Linked to Antipsychotic Use – Medscape (free registration required) AND Second Tardive Dyskinesia Drug Works – MedPage Today (free registration required)
Gabapentin for chronic neuropathic pain in adults
9 Jul, 2017 | 00:26h | UTCCochrane Review: Gabapentin for chronic neuropathic pain in adults – Cochrane Library (link to abstract – $ for full-text)
Commentary: Analgesic Effects of Gabapentin Assessed in Chronic Neuropathic Pain – MPR (free)
“Gabapentin at doses of 1800 mg to 3600 mg daily (1200 mg to 3600 mg gabapentin encarbil) can provide good levels of pain relief to some people with postherpetic neuralgia and peripheral diabetic neuropathy”.
Association of Playing High School Football With Cognition and Mental Health Later in Life
8 Jul, 2017 | 20:22h | UTCEditorial: Reassuring News About Football and Cognitive Decline? Not So Fast
Commentaries: What Are Outcomes Later in Life for High School Football Players? – The JAMA Network (free) AND High School Football: No Link to Later Cognitive Decline – Medscape (free registration required)