Neurology
Systematic Review: Lorazepam Confirmed as First-line Treatment for Prolonged Seizures in Children
20 Apr, 2018 | 00:55h | UTCOriginal article: Drug management for acute tonic-clonic convulsions including convulsive status epilepticus in children – Cochrane Library (free)
Opinion: The Case Against Thrombolytic Therapy in Stroke
18 Apr, 2018 | 01:01h | UTCThe Case Against Thrombolytic Therapy in Stroke – By John Mandrola, in Medscape (free registration required)
Related: For Many Strokes, There’s an Effective Treatment. Why Aren’t Some Doctors Offering It? – The New York Times (10 articles per month are free)
Review: Emergency Management of Intracerebral Hemorrhage
15 Apr, 2018 | 23:36h | UTCEM Cases: Emergency Management of Intracerebral Hemorrhage – The Golden Hour – emDocs (free)
Guideline: Primary Care of Adults with Intellectual and Developmental Disabilities
14 Apr, 2018 | 19:44h | UTCRelated guideline: Care and support of people growing older with learning disabilities – National Institute for Health and Care Excellence (free)
Systematic Review: Non-invasive Brain Stimulation Techniques for Chronic Pain
14 Apr, 2018 | 19:42h | UTCNon-invasive brain stimulation techniques for chronic pain – Cochrane Library (free)
“There is a lack of high-quality evidence to support or refute the effectiveness of non-invasive brain stimulation techniques for chronic pain”
Cross-sectional analysis: sedentary behavior linked to reduced medial temporal lobe thickness
14 Apr, 2018 | 18:05h | UTCCommentaries: Sitting Is Bad for Your Brain – Not Just Your Metabolism or Heart – University of California – Los Angeles, via NewsWise (free) AND Could Too Much Sitting Possibly Make Your Brain Thinner? – Forbes (free)
Research: respiratory infections as triggers for acute myocardial infarction and stroke
13 Apr, 2018 | 01:35h | UTCCommentaries: Flu and pneumonia infections increase risk of having a heart attack and stroke – European Respiratory Foundation, via Eurekalert (free) AND Do Pneumococcal and Respiratory Virus Infections Trigger Cardiovascular Morbidity? – NEJM Journal Watch (free for a limited period)
See also: related study published recently showing a similar six-fold increase in myocardial infarctions in the week following a flu diagnosis (link to abstract and commentaries).
Cohort study: risk of unnatural mortality in people with epilepsy
13 Apr, 2018 | 01:32h | UTCRisk of Unnatural Mortality in People With Epilepsy – JAMA Neurology (free for a limited period)
Editorial: Deaths in Epilepsy: What We Are Missing (free for a limited period)
Commentaries: Patients with epilepsy have greater risk of unnatural death – OnMedica (free) AND Epilepsy Diagnosis Tied to Suicide, Accident Risk – MedPage Today (free registration required)
Research: β-Amyloid accumulation in the human brain after one night of sleep deprivation
12 Apr, 2018 | 02:50h | UTCCommentaries: Don’t lose sleep over reports that one bad night can spark dementia – NHS Choices (free) AND One night of sleep deprivation leads to increase in Alzheimer’s protein – New Atlas (free) AND Expert reaction to study investigating sleep deprivation and amyloid build up – Science Media Centre (free)
Research framework: toward a biological definition of Alzheimer’s disease
12 Apr, 2018 | 02:55h | UTCCommentaries: Scientists Push Plan To Change How Researchers Define Alzheimer’s – NPR (free) AND Researchers Propose New Alzheimer’s Definition Based on Biomarkers – MedPage Today (free registration required) AND New biological research framework for Alzheimer’s seeks to spur discovery – NIH / National Institute on Aging, via EurekAlert (fee)
Cohort study: long-term risk of dementia among people with traumatic brain injury
12 Apr, 2018 | 02:52h | UTCLong-term risk of dementia among people with traumatic brain injury in Denmark: a population-based observational cohort study – The Lancet Psychiatry (link to abstract – $ for full-text)
Commentaries: Study confirms link between traumatic brain injury and dementia – UW Medicine, via EurekAlert (free) AND Traumatic brain injury increases risk of dementia – OnMedica (free) AND Brain injury may increase dementia risk – NHS Choices (free)
Related articles: Traumatic brain injury and the risk of dementia diagnosis: A nationwide cohort study – PLOS One (free) AND Clinicopathological Evaluation of Chronic Traumatic Encephalopathy in Players of American Football – JAMA (free)
Perspective: change your mind-set, reduce your chronic pain
12 Apr, 2018 | 00:33h | UTCChange Your Mind-Set, Reduce Your Chronic Pain – Scientific American (free)
Randomized trial: aminophylline for treatment of postdural puncture headache
12 Apr, 2018 | 00:31h | UTCAminophylline for treatment of postdural puncture headache: A randomized clinical trial – Neurology (link to abstract – $ for full-text)
Source: ACP Journal Wise ($)
Longitudinal study: lasting cognitive gains from meditation
11 Apr, 2018 | 02:01h | UTCCommentary: Seven-year follow-up shows lasting cognitive gains from meditation – University of California, via ScienceDaily (free)
Consensus statement: endovascular therapy of acute ischemic stroke
11 Apr, 2018 | 02:03h | UTCRelated guideline: 2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association / American Stroke Association (free PDF)
Meta-analysis: migraine and the risk of cardiovascular and cerebrovascular events
6 Apr, 2018 | 01:41h | UTCCommentary: Migraines tied to higher risk for stroke, MI in large meta-analysis – Univadis (free registration required)
Observational study: time to endovascular treatment and outcome in acute ischemic stroke
6 Apr, 2018 | 01:30h | UTCTime to Endovascular Treatment and Outcome in Acute Ischemic Stroke: MR CLEAN Registry Results – Circulation (link to abstract – $ for full-text)
Commentary: Time to endovascular therapy predicted functional outcome after stroke in registry study – ACP Hospitalist (free)
“Every hour of delay from stroke onset to the start of endovascular therapy resulted in a 5.3% decreased probability of functional independence” (from ACP Hospitalist)
Narrative review: diagnosis and management of acute ischemic stroke
3 Apr, 2018 | 17:54h | UTCReview: Diagnosis and Management of Acute Ischemic Stroke – Mayo Clinic Proceedings (free)
Related guideline: 2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association / American Stroke Association (free PDF) AND Summary for ED-relevant care: 2018 AHA/ASA Ischemic Stroke Updates – emDocs (free)
Cohort study: increased cardiovascular risk with extremes of temperature
3 Apr, 2018 | 17:48h | UTCRelated study: Big Swings in Daily Temperatures Linked to Spikes in MI Rates – TCTMD (free)
“Cold and hot weather associated with risk of cardiovascular disease hospitalization” (via @kamleshkhunti see Tweet)
Illustrative teaching case: oral contraceptives and ischemic stroke risk
3 Apr, 2018 | 17:33h | UTCOral Contraceptives and Ischemic Stroke Risk – Stroke (free for a limited period)
Key points: Oral Contraceptives and Ischemic Stroke Risk – American College of Cardiology (free)
Cohort study: most affected health domains after ischemic stroke
3 Apr, 2018 | 17:31h | UTCThe most affected health domains after ischemic stroke – Neurology (link to abstract – $ for full-text)
Commentaries: Stroke affects more than just the physical – American Academy of Neurology, via EurekAlert (free) AND Physical, Executive Function Most Affected After Ischemic Stroke – Physician’s Weekly (free) AND Nonphysical Problems Common After Stroke – Medscape (free registration required) AND Mild Stroke Alters Far More Than the Physical – MedPage Today (free)
“Mild disability still comes with social, cognitive impact, study suggests” (from MedPage Today)
Meta-analysis: effects of telestroke on thrombolysis times and outcomes
3 Apr, 2018 | 15:25h | UTCEffects of Telestroke on Thrombolysis Times and Outcomes: A Meta-analysis – Prehospital Emergency Care (link to abstract – $ for full-text)
Source: EvidenceAlerts
Life After Stroke: a round up of Cochrane evidence
30 Mar, 2018 | 04:16h | UTCLife After Stroke: a round up of Cochrane evidence – Evidently Cochrane (free)
Meta-Analysis: Patent foramen ovale closure vs. medical therapy for cryptogenic stroke
30 Mar, 2018 | 04:27h | UTC“5-study EHJ meta analysis confirms value of PFO closure after cryptogenic stroke. “Number Needed to Close”: 178 pts to prevent one stroke over 1 year. Size matters (no effect for small shunts, “NNC” 96 for large shunts)” (via @Steph_Achenbach see Tweet)
Can Learning Stress-Reducing Techniques Help Reduce Seizures?
30 Mar, 2018 | 04:07h | UTCBehavioral interventions as a treatment for epilepsy: A multicenter randomized controlled trial – Neurology (link to abstract – $ for full-text)
Commentaries: Can Learning Stress-Reducing Techniques Help Reduce Seizures? – American Academy of Neurology, via NewsWise (free) AND Stress Reduction Techniques Cut Seizure Rate in Severe Epilepsy – Medscape (free registration required) AND Stress-Reducing Techniques Lead to Fewer Seizures – MedPage Today (free registration required)