Neurology
Randomized trial: Prednisone is an effective short-term preventive therapy in patients with episodic cluster headache
25 Nov, 2020 | 09:01h | UTCSafety and efficacy of prednisone versus placebo in short-term prevention of episodic cluster headache: a multicentre, double-blind, randomised controlled trial – The Lancet Neurology (link to abstract – $ for full-text)
Commentary from the author on Twitter
Finally published online! After countless years and a lot of work our study on prednisone for the treatment of episodic cluster headache. Thanks to all the many people that were involved in this study, Very proud!!! #PredCH #Clusterheadachehttps://t.co/d88TUWTY5i
— Mark Obermann (@ProfObermann) November 25, 2020
Opinion – Football and dementia: heading must be banned until the age of 18
24 Nov, 2020 | 09:24h | UTCFootball and dementia: heading must be banned until the age of 18 – The Conversation
Randomized, placebo-controlled, crossover trial: Amantadine, modafinil, and methylphenidate are no better than placebo for fatigue in multiple sclerosis
24 Nov, 2020 | 09:02h | UTCSafety and efficacy of amantadine, modafinil, and methylphenidate for fatigue in multiple sclerosis: a randomised, placebo-controlled, crossover, double-blind trial – The Lancet Neurology (link to abstract – $ for full-text)
Older adults with COVID-19 commonly present to the ED with delirium
20 Nov, 2020 | 08:46h | UTCDelirium in Older Patients With COVID-19 Presenting to the Emergency Department – JAMA Network Open
Commentaries: Delirium could signal Covid-19 infection in older adults, study finds – STAT AND Delirium fairly common in older COVID-19 patients – CIDRAP AND Delirium is first symptom for many elderly COVID-19 patients – UPI
Commentary on Twitter
In older ED patients w/ COVID-19 only 56% had a fever, 51% SOB & 50% cough. 28% had delirium & one third of delirious pts lacked typical symptoms. In the ED delirium may the only symptom of #COVID19. @sharon_inouye @ACEPNow @GeriatricEDNews @AGEM_SAEM @JAMANetworkOpen pic.twitter.com/MxjSTx3Ffi
— Maura Kennedy (@MauraKennedyMD) November 19, 2020
Systematic review: Management of primary headaches in pregnancy
18 Nov, 2020 | 09:00h | UTCManagement of Primary Headaches in Pregnancy – Agency for Healthcare Research and Quality
Full report: Management of Primary Headaches in Pregnancy
Evidence Summary: Management of Primary Headaches in Pregnancy
Sleep problems in dementia: Despite many drugs being widely prescribed, systematic review finds lack of evidence and no randomized controlled trials to guide decisions about drug treatment
17 Nov, 2020 | 09:29h | UTCPharmacotherapies for sleep disturbances in dementia – Cochrane Library
Case-control study: COVID-19-associated stroke is associated with worse outcomes and increased mortality
12 Nov, 2020 | 09:24h | UTCCommentary: Risk of death, disability after stroke much higher for COVID-19 patients – Cardiovascular Business
Meta-analysis: Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging can reduce cases of severe disability but increases symptomatic intracranial hemorrhage and deaths
11 Nov, 2020 | 09:06h | UTCIntravenous alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data – The Lancet (free registration required)
Commentary on Twitter
Latebreaking at #ESOWSO2020—Intravenous alteplase for #stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data https://t.co/KDX2lHisbj pic.twitter.com/cnoiRhIReF
— The Lancet (@TheLancet) November 8, 2020
Another study shows improved outcomes with dual antiplatelet therapy in the first weeks after an acute ischemic stroke or transient ischemic attack
9 Nov, 2020 | 01:16h | UTCRelated Guideline: Dual antiplatelet therapy with aspirin and clopidogrel for acute high risk transient ischaemic attack and minor ischaemic stroke – The BMJ
International consensus guidance for management of myasthenia gravis: The 2020 version includes updated recommendations for thymectomy, for early immunosuppression in ocular MG, and for the management of MG associated with immune checkpoint inhibitor treatment
6 Nov, 2020 | 09:46h | UTCInternational consensus guidance for management of myasthenia gravis: 2020 update – Neurology
[Abstract Only] More than a third of older adults are prescribed potentially inappropriate drugs, study finds
6 Nov, 2020 | 09:42h | UTCOriginal study: Potentially Inappropriate Medications Are Associated with Increased Healthcare Utilization and Costs – Journal of the American Geriatrics Society (link to abstract – $ for full-text)
[Abstract Only] New clinical prediction rule for distinguishing bacterial from aseptic meningitis in children
6 Nov, 2020 | 09:32h | UTCClinical Prediction Rule for Distinguishing Bacterial From Aseptic Meningitis – Pediatrics (link to abstract – $ for full-text)
Commentary: How to Tell Bacterial vs Viral Meningitis – Journal Feed
Commentary on Twitter
The MSE (Meningitis Score for Emergencies): a tool that distinguishes aseptic from bacterial meningitis in children aged 1 month to 14 years. An impressive collaborative work of @TSEUP . #AlDiaSEUP @MintegiSanti @JavierBenitoF https://t.co/r6QHjUka88
— riseup-sperg (@riseup_sperg) August 25, 2020
Review: Electrodiagnostic studies can help establish if a patient is likely to have a muscle disease, a disorder of neuromuscular junction transmission, axon loss, or demyelinating disease
5 Nov, 2020 | 08:56h | UTCUsing and interpreting electrodiagnostic tests – Cleveland Clinic Journal of Medicine
The neurological sequelae of pandemics and epidemics. A review of large and important epidemics of human history in which neurological manifestations are evident
5 Nov, 2020 | 08:51h | UTCThe neurological sequelae of pandemics and epidemics – Journal of Neurology
[Preprint] Cognitive deficits in people who have recovered from COVID-19 relative to controls: An N=84,285 online study
28 Oct, 2020 | 09:14h | UTCCommentaries: Recovered COVID-19 patients exhibit cognitive deficits – News Medical AND Expert reaction to preprint suggesting patients who recovered from COVID-19 could suffer serious cognitive decline – Science Media Centre
Cohort study: Exposure to modafinil and armodafinil during pregnancy linked to fetal malformations
20 Oct, 2020 | 01:31h | UTCPregnancy and Fetal Outcomes Following Exposure to Modafinil and Armodafinil During Pregnancy – JAMA Internal Medicine (free for a limited period)
Commentaries: Caution in Prescribing Modafinil and Armodafinil to Individuals Who Could Become Pregnant – JAMA Internal Medicine (free for a limited period) AND Narcolepsy Drugs Tied to Increased Risk for Birth Defects – NEJM Journal Watch
Vertical transmission of Zika virus and its outcomes: a Bayesian synthesis of prospective studies
20 Oct, 2020 | 01:30h | UTCCommentary: Desideratum: a developmentalist view of Zika virus infection – The Lancet Infectious Diseases
Meta-analysis: Evidence-based prevention of Alzheimer’s disease
20 Oct, 2020 | 01:21h | UTCCommentaries: Biggest risk factors identified to try and prevent Alzheimer’s disease – BMJ AND Systematic review finds ten lifestyle factors that clearly impact the probability of developing Alzheimer’s disease (AD) – Sharp Brains
Commentary on Twitter
Evidence-based #prevention of #Alzheimers disease https://t.co/XOMiEoMlmI via @JNNP_BMJ #dementia @perryd43 @PennilessScribe @u3Y4BDE @SanWren @lfkraus @the_scholar1 @ktanimara @drsharwood @TargetLatino @LilithResists @Joseph_Santoro @liftdupbyangels @mrtom101 @SteveDitchfield pic.twitter.com/T5hqbzmIwi
— Ian Kremer (@LEAD_Coalition) July 24, 2020
Non-respiratory presentations of COVID-19, a clinical review
14 Oct, 2020 | 09:33h | UTC
Case report: Sudden irreversible hearing loss post COVID-19
14 Oct, 2020 | 09:24h | UTCSudden irreversible hearing loss post COVID-19 – BMJ Case Reports
Commentaries: Coronavirus: Patient has sudden permanent hearing loss – BBC AND First reported UK case of sudden permanent hearing loss linked to COVID-19 – BMJ
Commentary on Twitter
Sudden hearing loss after #COVID19.
Report of 1st UK case and review of the other 4 published reports (must be *extremely rare*)https://t.co/wCkrgHcwKH pic.twitter.com/onQxxYiImb— Eric Topol (@EricTopol) October 13, 2020
Study: Neurologic manifestations occur in most hospitalized Covid‐19 patients
9 Oct, 2020 | 09:11h | UTCCommentaries: COVID-19 neurological symptoms emerge in most hospitalized patients, study says AND Many hospitalized COVID-19 patients exhibit neurological symptoms, study finds – News Medical AND More than 80% of people hospitalized for COVID-19 suffer neurological symptoms, from confusion to altered brain function – Business Insider
Cerebral venous thrombosis: A practical guide
8 Oct, 2020 | 08:54h | UTCCerebral venous thrombosis: a practical guide – Practical Neurology
Long-term health consequences of COVID-19
6 Oct, 2020 | 00:58h | UTCLong-term Health Consequences of COVID-19 – JAMA
Commentary on Twitter
Persistent post-COVID symptoms could be the from direct tissue invasion by the virus, profound inflammation & cytokine storm, related immune system damage, hypercoagulable state, or some combination https://t.co/G8tI9U3TaL @CarlosdelRio7 lfcollins_md @PreetiNMalani
— JAMA (@JAMA_current) October 5, 2020
Systematic review: Carotid endarterectomy for symptomatic carotid stenosis
6 Oct, 2020 | 00:10h | UTCCarotid endarterectomy for symptomatic carotid stenosis – Cochrane Library
Drug-related orthostatic hypotension: Beyond anti-hypertensive medications
2 Oct, 2020 | 09:13h | UTCDrug-Related Orthostatic Hypotension: Beyond Anti-Hypertensive Medications – Drugs & Aging
Commentary on Twitter
Drug-Related Orthostatic Hypotension: Beyond Anti-Hypertensive Medications. An open access review … https://t.co/YB0KiEiAtF pic.twitter.com/YzfsmQmtbZ
— Rohan Elliott (@elliott_rohan) September 30, 2020