Neurology
RCT | Safety and efficacy of rituximab vs. dimethyl fumarate in patients with relapsing-remitting multiple sclerosis or clinically isolated syndrome.
18 Jul, 2022 | 10:53h | UTCSafety and efficacy of rituximab versus dimethyl fumarate in patients with relapsing-remitting multiple sclerosis or clinically isolated syndrome in Sweden: a rater-blinded, phase 3, randomised controlled trial – The Lancet Neurology (link to abstract – $ for full-text)
News Release: Fewer relapses in MS with off-label drug – Karolinska Institutet
Systematic Review | Antithrombotic therapy to prevent cognitive decline in people with small vessel disease on neuroimaging but without dementia.
15 Jul, 2022 | 12:47h | UTC
Commentary on Twitter
BREAKING: Our new Cochrane review: no evidence of clinically relevant cognitive benefit of antithrombotic therapy on top of usual Rx for cerebral small vessel disease but without dementia (but may ⬆️ bleed risk) @DrTerryQuinn @StrokeImperial @CochraneDCIG https://t.co/WaaydHdBqq pic.twitter.com/qpL9TooQNa
— Joseph Kwan, MD 🇬🇧 (@drjkwan) July 13, 2022
Systematic Review | Vagus nerve stimulation for focal seizures
15 Jul, 2022 | 12:45h | UTCVagus nerve stimulation for focal seizures – Cochrane Library
Summary: Vagus nerve stimulation for focal seizures – Cochrane Library
Brain volume abnormalities and clinical outcomes following pediatric traumatic brain injury.
15 Jul, 2022 | 12:41h | UTCBrain volume abnormalities and clinical outcomes following paediatric traumatic brain injury – Brain
News Release: Head injuries in children linked to reduced brain size and learning difficulties – Imperial College London
Commentary: Experts use MRI to pinpoint link between pediatric TBI and cognitive impairment – Health Imaging
Commentary on Twitter
Bourke et al. identify paediatric brain injury patients with low brain volume for their age and associated cognitive difficulties by generating age norms from over 1,200 healthy paediatric controls. https://t.co/N06ELchNPd pic.twitter.com/ouDU1kTYPT
— Brain (@Brain1878) July 8, 2022
RCT | Endovascular thrombectomy NOT noninferior to standard bridging thrombolytic with endovascular thrombectomy within 4.5 h of stroke onset.
13 Jul, 2022 | 11:57h | UTCEndovascular thrombectomy versus standard bridging thrombolytic with endovascular thrombectomy within 4·5 h of stroke onset: an open-label, blinded-endpoint, randomised non-inferiority trial – The Lancet (link to abstract – $ for full-text)
Related Study: Thrombectomy alone versus intravenous alteplase plus thrombectomy in patients with stroke: an open-label, blinded-outcome, randomised non-inferiority trial – The Lancet (link to abstract – $ for full-text)
Commentary on Twitter
Two new RCTs show we shouldn't skip bridging intravenous thrombolysis in eligible thrombectomy patients: DIRECT-SAFE (n=293) & SWIFT DIRECT (n=408) @TheLancet @SNISinfo@cvsection https://t.co/Tks14TlaVFhttps://t.co/WaTPn34diy pic.twitter.com/Gcddws8oDf
— Babak Jahromi MD PhD FRCSC (@babaksjahromi) July 9, 2022
RCT | Thrombectomy alone NOT noninferior to intravenous alteplase plus thrombectomy in patients with stroke.
13 Jul, 2022 | 11:55h | UTCThrombectomy alone versus intravenous alteplase plus thrombectomy in patients with stroke: an open-label, blinded-outcome, randomised non-inferiority trial – The Lancet (link to abstract – $ for full-text)
Related Study: Endovascular thrombectomy versus standard bridging thrombolytic with endovascular thrombectomy within 4·5 h of stroke onset: an open-label, blinded-endpoint, randomised non-inferiority trial – The Lancet (link to abstract – $ for full-text)
Commentary on Twitter
Two new RCTs show we shouldn't skip bridging intravenous thrombolysis in eligible thrombectomy patients: DIRECT-SAFE (n=293) & SWIFT DIRECT (n=408) @TheLancet @SNISinfo@cvsection https://t.co/Tks14TlaVFhttps://t.co/WaTPn34diy pic.twitter.com/Gcddws8oDf
— Babak Jahromi MD PhD FRCSC (@babaksjahromi) July 9, 2022
Podcast | Multiple sclerosis pearls for the primary care physician.
13 Jul, 2022 | 11:33h | UTC#344 Multiple Sclerosis with Dr. Annette Okai – The Curbsiders
What cardiologists should know about sleep.
13 Jul, 2022 | 11:32h | UTCWhat cardiologists should know about sleep – European Heart Journal (free for a limited period)
RCT | Adjunctive transdermal cannabidiol no better than placebo for drug-resistant focal epilepsy.
12 Jul, 2022 | 12:54h | UTC
Commentary on Twitter
In this randomized clinical trial, transdermal cannabidiol was well-tolerated and safe, but did not decrease seizure frequency at week 12 of the double-blind period among the placebo, 195-mg cannabidiol, and 390-mg cannabidiol treatments. https://t.co/lR3kEzPE5T
— JAMA Network Open (@JAMANetworkOpen) July 8, 2022
Cochrane review on endovascular thrombectomy and intra-arterial interventions for acute ischemic stroke.
12 Jul, 2022 | 12:29h | UTCCochrane Review on Endovascular Thrombectomy and Intra-Arterial Interventions for Acute Ischemic Stroke – Stroke (free for a limited period)
Brain stimulation may reduce negative symptoms of schizophrenia, meta-analysis suggests.
12 Jul, 2022 | 11:56h | UTCOriginal Study: Assessment of Noninvasive Brain Stimulation Interventions for Negative Symptoms of Schizophrenia: A Systematic Review and Network Meta-analysis – JAMA Psychiatry (link to abstract – $ for full-text)
Author Interview: Assessment of Noninvasive Brain Stimulation Interventions for Negative Symptoms of Schizophrenia
RCT | Acupuncture for patients with chronic tension-type headache.
11 Jul, 2022 | 12:12h | UTCAcupuncture for Patients With Chronic Tension-Type Headache: A Randomized Controlled Trial – Neurology (link to abstract – $ for full-text)
News Release: Can acupuncture reduce headaches? – American Academy of Neurology
Commentary:
New Evidence on the Efficacy of Acupuncture for Chronic Tension-type Headache – NeurologyToday
An ancient practice may offer relief from chronic tension headaches – CNN
Related: Acupuncture for the prevention of tension‐type headache – Cochrane Library
Brief Review | Monitoring cerebral oxygenation in acute brain-injured patients.
11 Jul, 2022 | 11:51h | UTCMonitoring cerebral oxygenation in acute brain-injured patients – Intensive Care Medicine (if the link is paywalled, try this one)
Commentary on Twitter
Monitoring cerebral oxygenation to understand brain dysfunction after #ABI & individualize management
🧠 pathophysiology of cerebral oxygenation
⚙️ technology of cerebral oxygen measurement
📖 evidence/clinical applications#FOAMcc @yourICM @chiara_robba
📎https://t.co/QpXQjznu8z pic.twitter.com/TrR62tWIyC— Intensive Care Medicine (@yourICM) July 9, 2022
RCT | Sacral neuromodulation for neurogenic lower urinary tract dysfunction.
8 Jul, 2022 | 11:47h | UTCSacral Neuromodulation for Neurogenic Lower Urinary Tract Dysfunction – NEJM Evidence
Commentary on Twitter
Pts with neurogenic lower urinary tract dysfunction had sacral neuromodulators implanted and optimized. They were then randomized to have the device either remain ON or switched OFF for 2 months. The success rate was 76% in the ON group vs 42% in the OFF. https://t.co/dhteW70jXp pic.twitter.com/1c0w8HOMJm
— NEJM Evidence (@NEJMEvidence) July 7, 2022
RCT | Effect of electroacupuncture on insomnia in patients with depression.
8 Jul, 2022 | 11:45h | UTCInvited Commentary: Effects of Electroacupuncture for Depression-Related Insomnia – JAMA Network Open
Commentary on Twitter
This randomized clinical trial found that an 8-weeek electroacupuncture with standard care improved sleep quality for patients with insomnia and depression, compared with sham acupuncture and/or standard care. https://t.co/nacnxEI4Ik
— JAMA Network Open (@JAMANetworkOpen) July 7, 2022
Guideline on the treatment of Parkinson’s Disease – Invasive therapies.
7 Jul, 2022 | 12:48h | UTC
M-A | Cognitive and neuropsychiatric effects of noradrenergic treatment in Alzheimer’s disease.
7 Jul, 2022 | 12:34h | UTCCommentaries:
Perspective | The future of intensive care: delirium should no longer be an issue.
7 Jul, 2022 | 12:28h | UTCThe future of intensive care: delirium should no longer be an issue – Critical Care
Commentary on Twitter
The future of intensive care: delirium should
no longer be an issue
Excellent review by @KatarzynaKotfis @markvdboogaard @WesElyMD https://t.co/KEb6MngpRg pic.twitter.com/yfkgKEZQCS— Peter Nydahl (@NydahlPeter) July 6, 2022
Under a http://creativecommons.org/licenses/by/4.0/ license
Podcast | Headache update: making migraines less painful.
7 Jul, 2022 | 12:24h | UTC#341: Headache Update: Making Migraines Less Painful with Dr. Kevin Weber – The Curbsiders
Cohort Study | Half of non-hospitalized patients with minor head injury experience incomplete recovery after 3 months.
6 Jul, 2022 | 11:25h | UTCAssociation between hypotension during 24 h ambulatory blood pressure monitoring and reflex syncope.
5 Jul, 2022 | 12:18h | UTC
Commentary on Twitter
Association between hypotension during 24 h ambulatory blood pressure monitoring and reflex syncope: the SynABPM 1 study.https://t.co/tMlGHQ4Csm#hypotension #bloodpressure #cardiotwitter @ESC_Journals @escardio pic.twitter.com/JpX6kxwj1R
— EHJ Editor-in-Chief (@ehj_ed) July 2, 2022
Under a https://creativecommons.org/licenses/by-nc/4.0/ license
Review | Bridging knowledge gaps in the diagnosis and management of neuropsychiatric sequelae of COVID-19.
5 Jul, 2022 | 12:07h | UTC
Commentary on Twitter
Neuropsychiatric post-acute sequelae of #COVID19 appear common but heterogeneous. Studies such as the NIH RECOVER initiative are needed to clarify neuropsychiatric PASC epidemiology, pathophysiology, mechanisms of injury and targets for intervention. https://t.co/AjwoLrZXc7
— JAMA Psychiatry (@JAMAPsych) July 1, 2022
Review | Electroencephalographic burst-suppression, perioperative neuroprotection, postoperative cognitive function, and mortality.
5 Jul, 2022 | 11:52h | UTCElectroencephalographic Burst-Suppression, Perioperative Neuroprotection, Postoperative Cognitive Function, and Mortality: A Focused Narrative Review of the Literature – Anesthesia & Analgesia (free for a limited period)
Commentary on Twitter
Check out this review article "Electroencephalographic Burst-Suppression, Perioperative Neuroprotection, Postoperative Cognitive Function, and Mortality: A Focused Narrative Review of the Literature" from Drs. Ma and Bebawyhttps://t.co/QpT1Hd2eHQ pic.twitter.com/JE0ugHGrXh
— Anesthesia&Analgesia (@IARS_Journals) July 1, 2022
NICE Guideline | Management of multiple sclerosis in adults.
4 Jul, 2022 | 13:00h | UTCMultiple sclerosis in adults: management – National Institute for Health and Care Excellence
Using the intranasal route to administer drugs to treat neurological and psychiatric illnesses: rationale, successes, and future needs.
4 Jul, 2022 | 12:26h | UTCUsing the Intranasal Route to Administer Drugs to Treat Neurological and Psychiatric Illnesses: Rationale, Successes, and Future Needs – CNS Drugs (if the link is paywalled, try this one)