Neurology
RCT | Efficacy of prednisolone for Bell Palsy in children.
5 Sep, 2022 | 14:39h | UTCEfficacy of Prednisolone for Bell Palsy in Children: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial – Neurology (link to abstract – $ for full-text)
Commentary on Twitter
In children with Bell's palsy the vast majority recover without treatment. The study, although underpowered, does not provide evidence that early treatment with prednisolone improves complete recovery.https://t.co/QUVA14vZDG
— Santi Mintegi (@MintegiSanti) August 29, 2022
A pilot study showed GnRH replacement could improve cognition in Down syndrome.
5 Sep, 2022 | 14:34h | UTCGnRH replacement rescues cognition in Down syndrome – Science (link to abstract – $ for full-text)
News Release: A therapy found to improve cognitive function in patients with Down syndrome – INSERM
Commentary: A Hormone May Boost Cognition in Down Syndrome – Scientific American
Meta-analysis of observational studies | Leisure activities and the risk of dementia.
1 Sep, 2022 | 11:44h | UTCLeisure Activities and the Risk of Dementia: A Systematic Review and Meta-Analysis – Neurology
News Release: Which Leisure Activities Are Linked to Lower Risk of Dementia? – American Academy of Neurology
Systematic Review | Duplex ultrasound for diagnosing symptomatic carotid stenosis in the extracranial segments.
1 Sep, 2022 | 11:36h | UTC
Meta-analysis of cohort studies | Vegetarian and vegan diets and the risk of cardiovascular disease, ischemic heart disease and stroke.
31 Aug, 2022 | 11:42h | UTC
RCT | Efficacy and safety of Vamorolone vs. Placebo and Prednisone among boys with Duchenne Muscular Dystrophy.
31 Aug, 2022 | 11:40h | UTC
Guideline | Management of medication overuse and medication overuse headache.
30 Aug, 2022 | 12:08h | UTC
M-A | Midodrine for the prevention of vasovagal syncope.
30 Aug, 2022 | 11:56h | UTCRelated: RCT: Midodrine can reduce the recurrence of vasovagal syncope.
#ESCCongress – RCT | In comatose survivors of out-of-hospital cardiac arrest, targeting a mean arterial blood pressure of 77 mmHg vs. 63 mmHg did not result in different outcomes.
29 Aug, 2022 | 12:13h | UTCBlood-Pressure Targets in Comatose Survivors of Cardiac Arrest – New England Journal of Medicine (link to abstract – $ for full-text)
News Release: Trial finds no benefit of raising blood pressure target in post cardiac arrest patients – European Society of Cardiology
Commentary: Blood Pressure Targets Show No Benefit in Comatose Survivors of Cardiac Arrest – HCPLive
Commentary on Twitter
BOX BP: This randomized trial found no difference in the rate of death or severe disability/coma when patients following out-of-hospital cardiac arrest were managed with higher or lower blood pressure targets. #ESCCongress https://t.co/5qOMtiPSck pic.twitter.com/QOl5KetTvn
— NEJM (@NEJM) August 27, 2022
#ESCCongress – RCT | In comatose survivors of out-of-hospital cardiac arrest, a restrictive vs. a liberal oxygenation strategy resulted in similar incidences of death, severe disability, and coma.
29 Aug, 2022 | 12:12h | UTCOxygen Targets in Comatose Survivors of Cardiac Arrest – New England Journal of Medicine (link to abstract – $ for full-text)
News Release: Restrictive oxygenation in post cardiac arrest patients is not harmful – European Society of Cardiology
Commentary on Twitter
BOX Oxygen: This RCT found no difference in the rate of death or severe disability/coma when mechanically ventilated patients following out-of-hospital cardiac arrest were managed with higher or lower oxygenation targets. #ESCCongress https://t.co/qqtd4SyVrl pic.twitter.com/q73gqSuAn4
— NEJM (@NEJM) August 27, 2022
Meta-analysis of randomized trials | Use of dexmedetomidine in patients with sepsis.
29 Aug, 2022 | 12:08h | UTC
Randomized Crossover Trial | In patients with diabetic neuropathic pain, amitriptyline supplemented with pregabalin, pregabalin supplemented with amitriptyline, and duloxetine supplemented with pregabalin were similarly effective.
25 Aug, 2022 | 12:14h | UTC
RCTs | Ublituximab vs. Teriflunomide in relapsing multiple sclerosis.
25 Aug, 2022 | 12:04h | UTCUblituximab versus Teriflunomide in Relapsing Multiple Sclerosis – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
In two parallel randomized trials in patients with MS, ublituximab resulted in lower relapse rates and fewer brain lesions on MRI than teriflunomide over a period of 96 weeks but did not affect disability. https://t.co/fpdtYhTNER pic.twitter.com/EPJEetSVdS
— NEJM (@NEJM) August 24, 2022
Study Commentary | Is the evidence strong for spinal cord stimulation for diabetic neuropathy? Not all experts agree.
25 Aug, 2022 | 11:52h | UTCOriginal Study: RCT: Effect of High-frequency (10-kHz) Spinal Cord Stimulation in Patients With Painful Diabetic Neuropathy
Systematic Review | Anticholinergic burden for prediction of cognitive decline or neuropsychiatric symptoms in older adults with mild cognitive impairment or dementia.
24 Aug, 2022 | 14:10h | UTCRelated:
Commonly-prescribed drugs and dementia: should we be worried? – Evidently Cochrane
How well do you know your anticholinergic (antimuscarinic) drugs? – Therapeutics Initiative
Anticholinergic drugs and risk of dementia: case-control study – The BMJ
RCT | Efficacy of Ubrogepant in the acute treatment of migraine with mild pain versus moderate or severe pain.
24 Aug, 2022 | 13:52h | UTC
Much anticipated Alzheimer Disease prevention trial finds no clinical benefit from drug targeting amyloid; highlights need to consider other approaches.
23 Aug, 2022 | 13:29h | UTCMuch Anticipated Alzheimer Disease Prevention Trial Finds No Clinical Benefit From Drug Targeting Amyloid; Highlights Need to Consider Other Approaches – JAMA (free for a limited period)
Commentary on Twitter
The hypothesis that amyloid deposits in the brain cause Alzheimer disease has gotten many hits over the years, as one antiamyloid treatment after another failed to show a clinical benefit. Time to move on? @RitaRubin writes about the debate. https://t.co/913A0WWcR7
— JAMA (@JAMA_current) August 17, 2022
A cohort study of patients with mild traumatic brain injury found that 56% of patients had incomplete recovery after 6 months.
23 Aug, 2022 | 13:27h | UTCCommentary: Incomplete Recovery Common 6 Months After Mild TBI – Medscape (free registration required)
Commentary on Twitter (thread – click for more)
1/🧵Mild Traumatic Brain Injury (TBI) isn’t “Mild” 🧠
Our daughter fell off a high diving board headfirst to cement years ago. Though she had 2 cracks through her foramen magnum, her GCS was 15 & CT had no bleeding.
“She’s OK,” they said.
Wrong answer 😔#TrackTBI Data… pic.twitter.com/1FZuRnt4so— WesElyMD (@WesElyMD) August 22, 2022
Guideline | Application of anti-seizure medications in the perioperative period of supratentorial craniocerebral surgery.
23 Aug, 2022 | 13:13h | UTC
Observational analysis shows chronic kidney disease is associated with increased risk of intracerebral hemorrhage.
23 Aug, 2022 | 13:12h | UTCAssociation of Chronic Kidney Disease With Risk of Intracerebral Hemorrhage – JAMA Neurology (link to abstract – $ for full-text)
Review | Manipulating temperature: devices for targeted temperature management in brain injury.
22 Aug, 2022 | 11:55h | UTCManipulating temperature: devices for targeted temperature management (TTM) in brain injury – Intensive Care Medicine (if the link is paywalled, try this one)
Neurological and psychiatric risk trajectories after SARS-CoV-2 infection: an analysis of 2-year retrospective cohort studies including 1 284 437 patients.
18 Aug, 2022 | 12:49h | UTC
Commentary on Twitter
NEW—People with #COVID19 continue to face increased risks of some neurological and psychiatric conditions up to 2 years after infection, according to a study published in @TheLancetPsych: https://t.co/9fD5zMU3hE pic.twitter.com/8YhTKJ9v72
— The Lancet (@TheLancet) August 17, 2022
Launch of first WHO position paper on optimizing brain health across life.
17 Aug, 2022 | 14:41h | UTCNews Release: Launch of first WHO position paper on optimizing brain health across life – World Health Organization
WHO position paper: Optimizing brain health across the life course – World Health Organization
Commentary on Twitter (thread – click for more)
Optimizing #BrainHealth 🧠
▶️reduces the burden of neurological disorders
▶️improves mental + physical health
▶️creates positive social & economic impactscontributing to greater well-being, advancing society. 👉https://t.co/kVPgcFxBPG
— World Health Organization (WHO) (@WHO) August 9, 2022
RCT | Effect of remote ischemic conditioning vs. usual care on neurologic function in patients with acute moderate ischemic stroke.
17 Aug, 2022 | 14:32h | UTCEffect of Remote Ischemic Conditioning vs Usual Care on Neurologic Function in Patients With Acute Moderate Ischemic Stroke: The RICAMIS Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Remote Ischemic Conditioning: Feasible and Potentially Beneficial for Ischemic Stroke – JAMA (free for a limited period)
Video Summary: Effect of Remote Ischemic Conditioning vs Usual Care on Neurologic Function in Patients With Acute Moderate Ischemic Stroke – JAMA
Study suggests long covid symptoms affect 1 in 8 patients.
16 Aug, 2022 | 13:52h | UTCNews Release: Most reliable estimates to date suggest one in eight COVID-19 patients develop long COVID symptoms – Lancet
Commentaries:
Long COVID symptoms affect 1 in 8 adults, some for 2 years – CIDRAP
Covid-19: One in eight adults develops long covid symptoms, study suggests – The BMJ