Nephrology
M-A | The impact of early versus late initiation of renal replacement therapy in critically ill patients with acute kidney injury on mortality and clinical outcomes.
1 Sep, 2022 | 11:33h | UTCRelated:
Comparison of two delayed strategies for renal replacement therapy initiation for severe acute kidney injury (AKIKI 2): a multicentre, open-label, randomised, controlled trial – The Lancet (link to abstract – $ for full-text)
Review/Perspective | European hypertension guideline downgrading of beta-blockers is not justified.
31 Aug, 2022 | 11:51h | UTC
Guideline | Management of kidney transplant patients with HLA antibodies.
31 Aug, 2022 | 11:47h | UTC
Salt substitutes vs. regular salt: a quick look.
30 Aug, 2022 | 12:02h | UTCSalt substitutes vs. regular salt: a quick look – Evidently Cochrane
Original Study: Replacing salt with low‐sodium salt substitutes (LSSS) for cardiovascular health in adults, children and pregnant women – Cochrane Library
Related:
Effects of salt substitutes on clinical outcomes: a systematic review and meta-analysis – Heart (link to abstract – $ for full-text)
RCT: Reduced-sodium added-potassium salt substitute reduces blood pressure in hypertensive patients
Potassium Enriched Salt Substitution Could Prevent a Large Number of Cardiovascular Deaths
Commentary on Twitter
A quick look at the evidence from @CochranePH on using low-sodium #salt substitutes instead of regular salt. Can salt substitutes reduce #BloodPressure and prevent heart attacks, and are there any risks? A new @CochraneUK blog: https://t.co/iy7CVA8H34 pic.twitter.com/9MRIsEI71Z
— The Cochrane Library (@CochraneLibrary) August 26, 2022
Cohort Study | Comparing kidney health outcomes in children, adolescents, and adults with focal segmental glomerulosclerosis.
30 Aug, 2022 | 11:53h | UTC
Commentary on Twitter
This study of patients with focal segmental glomerulosclerosis (FSGS) suggests that kidney survival is similar across children, adolescents and adults.#OAResearch @umichmedicine https://t.co/Hm69eMpRe6
— JAMA Network Open (@JAMANetworkOpen) August 25, 2022
[News release – not published yet] #ESCCongres – RCT | Evening dosing of blood pressure medication not better than morning dosing.
29 Aug, 2022 | 12:30h | UTCRelated Consensus Statement: Bedtime dosing of antihypertensive medications: systematic review and consensus statement: International Society of Hypertension position paper endorsed by World Hypertension League and European Society of Hypertension – Journal of Hypertension
Related study (conflicting results): Bedtime Hypertension Treatment Improves Cardiovascular Risk Reduction in Randomized Trial
Bedtime dosing of antihypertensive medications: systematic review and consensus statement. – “use of bedtime drug dosing of antihypertensive drugs should not be routinely recommended”.
29 Aug, 2022 | 12:28h | UTC
RCT | Acetazolamide resulted in faster decongestion in patients with acute decompensated heart failure with volume overload.
29 Aug, 2022 | 12:25h | UTCAcetazolamide in Acute Decompensated Heart Failure with Volume Overload – New England Journal of Medicine (link to abstract – $ for full-text)
News Release: Acetazolamide improves decongestion in patients with acute decompensated heart failure – European Society of Cardiology
Commentary: Acetazolamide in Decompensated Heart Failure With Volume Overload – ADVOR – American College of Cardiology
Commentary on Twitter
ADVOR: In a placebo-controlled trial, patients with acute decompensated heart failure and volume overload who had been randomly assigned to receive IV acetazolamide plus a loop diuretic had a higher incidence of decongestion. #ESCCongress https://t.co/YeoffDhXwc pic.twitter.com/YV3gM3gxij
— NEJM (@NEJM) August 27, 2022
RCT | Efficacy of potassium supplementation on the risk of peritonitis in hypokalemic patients receiving peritoneal dialysis.
26 Aug, 2022 | 13:25h | UTCEfficacy of Potassium Supplementation in Hypokalemic Patients Receiving Peritoneal Dialysis: A Randomized Controlled Trial – American Journal of Kidney Diseases (link to abstract – $ for full-text)
Commentary on Twitter
Efficacy of Potassium Supplementation in Hypokalemic Patients Receiving Peritoneal Dialysis: A Randomized Controlled Trialhttps://t.co/DlEUJJUPr4@PD_Perls @DWJohnsonNeph #VisualAbstract pic.twitter.com/9D0VifCPMb
— AJKD (@AJKDonline) May 23, 2022
A Bayesian reanalysis of the Standard versus Accelerated Initiation of Renal-Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial.
26 Aug, 2022 | 13:08h | UTCOriginal Study: Timing of Initiation of Renal-Replacement Therapy in Acute Kidney Injury – New England Journal of Medicine
Related:
Brief Review | New drugs for acute kidney injury.
25 Aug, 2022 | 11:58h | UTCNew drugs for acute kidney injury – Intensive Care Medicine
Review | Subphenotypes in acute kidney injury.
25 Aug, 2022 | 11:50h | UTCSubphenotypes in acute kidney injury: a narrative review – Critical Care
Position Statement | Chronic kidney disease as cardiovascular risk factor in routine clinical practice.
24 Aug, 2022 | 14:14h | UTC
Guideline | Management of adults with diabetes on dialysis.
23 Aug, 2022 | 13:16h | UTCManagement of adults with diabetes on dialysis – Joint British Diabetes Societies for Inpatient Care (PDF)
News Release: Latest JBDS dialysis guideline published – Diabetes Times
Observational analysis shows chronic kidney disease is associated with increased risk of intracerebral hemorrhage.
23 Aug, 2022 | 13:12h | UTCAssociation of Chronic Kidney Disease With Risk of Intracerebral Hemorrhage – JAMA Neurology (link to abstract – $ for full-text)
Review | Drug regimens of novel antibiotics in critically ill patients with varying renal functions.
23 Aug, 2022 | 12:49h | UTC
AHA Scientific Statement | Cardiovascular effects of home dialysis therapies.
22 Aug, 2022 | 12:24h | UTCTop Things to Know: CV Effects of Home Dialysis Therapies – American Heart Association
Commentaries:
AHA Urges More Home-Based Dialysis in Advanced Kidney Failure – TCTMD
Commentary on Twitter (thread – click for more)
1/
Our @AHAScience Scientific Statement on the cardiovascular impact of home dialysis therapies is now out in @CircAHAhttps://t.co/h7PBHe5zZjHere are the key points in a very brief ?
— Bourne Auguste (@bourneauguste) August 15, 2022
Review | Hemoperfusion in the intensive care unit.
22 Aug, 2022 | 11:56h | UTCHemoperfusion in the intensive care unit – Intensive Care Medicine
Cohort Study | Aldosterone linked to increased risk of chronic kidney disease progression and end-stage kidney disease.
19 Aug, 2022 | 16:09h | UTCOriginal Study: Aldosterone in chronic kidney disease and renal outcomes – European Heart Journal
Editorial: Aldosterone excess and cardiorenal risk: more common than appreciated – European Heart Journal
Commentary on Twitter
Aldosterone in chronic kidney disease and renal outcomes https://t.co/G8FA4H5QX4 #EHJ #ESCYoung @ehj_ed @rladeiraslopes @escardio pic.twitter.com/D48MeAeSR1
— European Society of Cardiology Journals (@ESC_Journals) August 9, 2022
M-A | Performance of confirmatory tests for diagnosing primary aldosteronism.
18 Aug, 2022 | 12:54h | UTC
Commentary on Twitter
Less than 1% of patients suffering from PA are treated. Current strategies for diagnosing PA don't work well. Simplify testing for better diagnosis and treatment #hypertension #PrimaryAldosteronism @dr_alexleung @JanicePasieka @IAESurgeonshttps://t.co/AKkyUfSLoG pic.twitter.com/HcLQTdB2ao
— Hypertension (@HyperAHA) August 16, 2022
Network M-A | Efficacy and safety of 12 immunosuppressive agents for idiopathic membranous nephropathy in adults.
16 Aug, 2022 | 13:10h | UTCRelated:
Guideline for use of GLP-1 receptor agonists and SGLT2 inhibitors for cardiorenal risk reduction in adults.
15 Aug, 2022 | 12:29h | UTCSee related systematic review: The Effectiveness of Sodium-Glucose Cotransporter 2 Inhibitors and Glucagon-like Peptide-1 Receptor Agonists on Cardiorenal Outcomes: Systematic Review and Meta-analysis – Canadian Journal of Cardiology
Commentary on Twitter (thread – click for more)
https://mobile.twitter.com/CJCJournals/status/1557751107006472193
Harmonization of American and European hypertension guidelines: comparisons, reflections, and recommendations.
12 Aug, 2022 | 15:19h | UTCHarmonization of the American College of Cardiology/American Heart Association and European Society of Cardiology/European Society of Hypertension Blood Pressure/Hypertension Guidelines: Comparisons, Reflections, and Recommendations – European Heart Journal (also available at Circulation)
M-A | Effect of goal-directed fluid therapy on renal function in critically ill patients.
12 Aug, 2022 | 14:19h | UTC
RCT | Removal of small, asymptomatic kidney stones and incidence of relapse.
11 Aug, 2022 | 12:23h | UTCRemoval of Small, Asymptomatic Kidney Stones and Incidence of Relapse – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
Removal of small, asymptomatic kidney stones during surgery to remove ureteral or contralateral stones resulted in less relapse than nonremoval and in similar numbers of subsequent emergency department visits. https://t.co/MRgFUnF1C0 pic.twitter.com/19ahPuHyNS
— NEJM (@NEJM) August 10, 2022