Nephrology
Review | Should RAAS blockade therapy be continued in patients with advanced renal disease?
28 Apr, 2023 | 13:00h | UTCShould RAAS blockade therapy be continued in patients with advanced renal disease? – MDedge
Cohort Study | Osmotic demyelination syndrome in patients hospitalized with hyponatremia
25 Apr, 2023 | 14:26h | UTCOsmotic Demyelination Syndrome in Patients Hospitalized with Hyponatremia – NEJM Evidence
Brief Review | Investigation and assessment of adrenal incidentalomas
25 Apr, 2023 | 14:13h | UTCInvestigation and assessment of adrenal incidentalomas – Clinical Medicine Journal
Brief Review | Acute kidney injury
24 Apr, 2023 | 13:24h | UTCAcute kidney injury – Intensive Care Medicine (if the link is paywalled, try this one)
Commentary on Twitter
Acute kidney injury common in #ICU, influencing outcomes: not only focus on prevention, optimize treatment! In this review:
🫘 prevention
🫘 conservative management
🫘 optimal timing of initiation of RR
🫘 longer-term post #AKI follow-up@ForniLuiG
🖇️ https://t.co/SPz70YfJIK pic.twitter.com/qGqo08CP6E— Intensive Care Medicine (@yourICM) April 18, 2023
Study shows that parathyroidectomy in adults with primary hyperparathyroidism probably has no effect on kidney function
21 Apr, 2023 | 12:57h | UTCEstimated Effect of Parathyroidectomy on Long-Term Kidney Function in Adults With Primary Hyperparathyroidism – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentary on Twitter
New: #parathyroidectomy had no effect on long term #KidneyFunction in older adults w/ primary #hyperparathyroidism, but may preserve function in patients under 60. https://t.co/B456rPwGem pic.twitter.com/V8hLmrYiUX
— Annals of Int Med (@AnnalsofIM) April 17, 2023
Cluster RCT | Salt substitute outperforms salt restriction in lowering blood pressure in older patients
18 Apr, 2023 | 13:30h | UTCSalt substitution and salt-supply restriction for lowering blood pressure in elderly care facilities: a cluster-randomized trial – Nature Medicine (if the link is paywalled, try this one)
Commentary: Exploring effectiveness of salt substitutes in elderly care facilities – Medical Xpress
Related:
Salt substitutes vs. regular salt: a quick look.
Effects of salt substitutes on clinical outcomes: a systematic review and meta-analysis – Heart (link to abstract – $ for full-text)
RCT: Reduced-sodium added-potassium salt substitute reduces blood pressure in hypertensive patients
Potassium Enriched Salt Substitution Could Prevent a Large Number of Cardiovascular Deaths
Commentary on Twitter
In a cluster-randomized trial in 48 residential elderly care facilities in China, a low-sodium salt substitute instead of regular salt decreased blood pressure and cardiovascular events, while restricting salt consumption did not show beneficial effects https://t.co/Zp0fWH0aA2
— Nature Medicine (@NatureMedicine) April 13, 2023
Podcast | Resistant hypertension
18 Apr, 2023 | 13:16h | UTC#390 Resistant Hypertension – The Curbsiders
RCT | Heterogeneity in blood pressure response to 4 antihypertensive drugs
17 Apr, 2023 | 13:14h | UTCHeterogeneity in Blood Pressure Response to 4 Antihypertensive Drugs: A Randomized Clinical Trial – JAMA (free for a limited period)
News Release: Personalized blood pressure treatment more effective – Uppsala University
RCT | Methylprednisolone pulse followed by oral prednisone vs. oral prednisone alone in sarcoidosis tubulointerstitial nephritis
17 Apr, 2023 | 12:58h | UTCEfficacy and safety of methylprednisolone pulse followed by oral prednisone vs. oral prednisone alone in sarcoidosis tubulointerstitial nephritis: a randomized, open-label, controlled clinical trial – Nephrology Dialysis Transplantation (free for a limited period)
Review | Why is intradialytic hypotension the commonest complication of outpatient dialysis treatments?
5 Apr, 2023 | 13:28h | UTC
What is acute kidney injury? A visual guide
4 Apr, 2023 | 14:02h | UTCWhat is acute kidney injury? A visual guide – Nature
Review | Prolonged intermittent kidney replacement therapy
3 Apr, 2023 | 13:39h | UTCProlonged Intermittent Kidney Replacement Therapy – Clinical Journal of the American Society of Nephrology (free for a limited period)
Commentary on Twitter
Kidney replacement therapy (KRT) is a vital, supportive treatment for patients with critical illness and severe AKI. This Review discusses the option of prolonged intermittent KRT in the management of patients with kidney failure in the ICU https://t.co/jPHVLRnoqJ@VijayanMD pic.twitter.com/4oWJ6IDR4C
— CJASN (@CJASN) September 30, 2022
RCT | Sparsentan reduces proteinuria in patients with IgA nephropathy
3 Apr, 2023 | 13:35h | UTCSparsentan in patients with IgA nephropathy: a prespecified interim analysis from a randomised, double-blind, active-controlled clinical trial – The Lancet (link to abstract – $ for full-text)
Commentary on Twitter
PROTECT (Interim results): Sparsentan reduces proteinuria in patients with IgA Nephropathy (IgAN)#ISNWCN 🇹🇭 #Nephpearls#VisualAbstract by @dakidneydochttps://t.co/ViW9YncwI6 pic.twitter.com/zEGRSY8N3x
— Edgar V. Lerma 🇵🇭 (@edgarvlermamd) April 1, 2023
Glomerular diseases in pregnancy: pragmatic recommendations for clinical management
3 Apr, 2023 | 13:29h | UTC
Review | Evaluation and management of hypernatremia in adults
30 Mar, 2023 | 14:20h | UTC
Cohort Study | Evaluating 5 creatinine-based formulas for eGFR estimation in older patients
29 Mar, 2023 | 13:12h | UTC
Commentary on Twitter
5 commonly-used creatinine-based equations provided different eGFR estimates in older adults in Sweden. BIS equation outperformed others in predicting 15-year mortality, but its accuracy was reduced in subgroups of low muscle mass and high age. https://t.co/DOJmp4HzZn
— JAMA Network Open (@JAMANetworkOpen) March 23, 2023
Podcast | Pears in primary aldosteronism, mineralocorticoid receptor antagonists, and renovascular hypertension
29 Mar, 2023 | 13:07h | UTC
Study shows increased bleeding complications in ESKD patients undergoing AF ablation
24 Mar, 2023 | 13:09h | UTCSummary: The study analyzed 347 procedures in 307 patients with end-stage kidney disease (ESKD) undergoing atrial fibrillation (AF) catheter ablation in 12 referral centers in Japan.
Despite a vast majority of patients having subtherapeutic international normalized ratio (INR) values during the peri-procedural period, 35 patients (10%) experienced major complications, with the majority being major bleeding events (19 patients; 5.4%), including 11 cases of cardiac tamponade (3.2%). There were also two peri-procedural deaths (0.6%), both related to bleeding events. A pre-procedural INR value of 2.0 or higher was identified as the only independent predictor of major bleeding.
Current peri-procedural anticoagulation guidelines state that patients undergoing AF ablation should be under therapeutic anticoagulation throughout the peri-procedural period. The findings of this study suggest that these guidelines may not be appropriate for ESKD patients undergoing the procedure, and the role of peri-procedural anticoagulation in this population should be further investigated.
Commentary on Twitter
Peri-procedural anticoagulation in patients with end-stage kidney disease undergoing #afib ablation 👉 despite undertreatment with warfarin, the rate of haemorrhagic complications is high! https://t.co/3W8gEtZYdy#kidney #afib #anticoagulation #ablation #cardiotwitter #europace pic.twitter.com/vI27UeIpRf
— European Society of Cardiology Journals (@ESC_Journals) March 16, 2023
Review | Unapparent systemic effects of regional anticoagulation with citrate in continuous renal replacement therapy
24 Mar, 2023 | 13:04h | UTC
Single-arm study | Inaxaplin reduces proteinuria in patients with APOL1 variants and focal segmental glomerulosclerosis
21 Mar, 2023 | 13:11h | UTCInaxaplin for Proteinuric Kidney Disease in Persons with Two APOL1 Variants – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Inaxaplin Reduces Proteinuria in FSGS With APOL1 Variants – Renal & Urology News
Commentary on Twitter
Original Article: Inaxaplin for Proteinuric Kidney Disease in Persons with Two APOL1 Variants https://t.co/QHcvbYEmiz #nephrology #CKD pic.twitter.com/SLspl6Vagn
— NEJM (@NEJM) March 17, 2023
Perspective | How I prescribe prolonged intermittent renal replacement therapy
14 Mar, 2023 | 13:26h | UTCHow I prescribe prolonged intermittent renal replacement therapy – Critical Care
ISCCM Guidelines on acute kidney injury and renal replacement therapy
13 Mar, 2023 | 14:55h | UTC
Review | Acquired disorders of hypomagnesemia
7 Mar, 2023 | 13:09h | UTCAcquired Disorders of Hypomagnesemia – Mayo Clinic Proceedings
Podcast | Updates in chronic kidney disease
7 Mar, 2023 | 12:51h | UTC#384 Updates in Chronic Kidney Disease with Dr. Joel Topf – The Curbsiders
RCT | Hydrochlorothiazide is not effective for the prevention of kidney-stone recurrence
6 Mar, 2023 | 14:26h | UTCSummary:
This study aimed to assess the effectiveness of hydrochlorothiazide, a thiazide diuretic, in preventing the recurrence of calcium-containing kidney stones. The trial randomly assigned 416 patients with recurrent kidney stones to receive hydrochlorothiazide at a dose of 12.5 mg, 25 mg, or 50 mg once daily, or a placebo once daily, and followed them for a median of 2.9 years.
The results showed that the incidence of kidney stone recurrence did not differ significantly between the hydrochlorothiazide and placebo groups, regardless of the dose. Furthermore, patients who received hydrochlorothiazide were more likely to experience side effects such as hypokalemia, gout, new-onset diabetes mellitus, skin allergy, and a plasma creatinine level exceeding 150% of the baseline level.
Therefore, the effectiveness of hydrochlorothiazide in preventing kidney stone recurrence may be limited, and the common practice of prescribing it for these patients should be reevaluated.
Article: Hydrochlorothiazide and Prevention of Kidney-Stone Recurrence – New England Journal of Medicine (link to abstract – $ for full-text)
Video Summary: Hydrochlorothiazide and Kidney-Stone Recurrence | NEJM
Commentary: Hydrochlorothiazide and Prevention of Kidney Stones – NEJM Resident 360