Nephrology
KDIGO 2021 Clinical Practice Guideline for the Management of Blood Pressure in Chronic Kidney Disease
24 Feb, 2021 | 02:21h | UTC
Commentary on Twitter (thread – Click for more)
The 2021 KDIGO guideline covers optimal BP targets in patients with CKD, proper BP measurement, lifestyle interventions, antihypertensive medications, and issues specific to management in kidney transplant recipients and children. https://t.co/OXfhCbBQS9
— Kathryn Foti (@fotikat) February 23, 2021
Pro-con Debate: Starting antihypertensive drug treatment with combination therapy
23 Feb, 2021 | 01:26h | UTCCon: Starting Antihypertensive Drug Treatment With Combination Therapy
Pro: Starting Antihypertensive Drug Treatment With Combination Therapy
M-A: Blood pressure effects of sodium reduction
23 Feb, 2021 | 01:28h | UTCCommentaries: The Lower the Sodium, the Better for BP: Updated Meta-analysis – TCTMD AND AHA News: Lower Your Sodium, and Blood Pressure Will Follow – HealthDay
Study: In intensively treated hypertensive patients, a diastolic blood pressure of less than 60 mm Hg was associated with increased risk of cardiovascular events
19 Feb, 2021 | 02:37h | UTCCommentary: Treated Diastolic Blood Pressure: How Low Is Too Low? – NEJM Journal Watch
Commentary on Twitter
Cohort study showed on-treatment diastolic BP <60 was associated with increased risk of adverse outcomes; on-treatment diastolic BP of 70-80 was associated with lowest adverse outcome risk in patients with on-treatment systolic BP <130 mmHg. @MayoClinic https://t.co/0wOfqpMcIH
— JAMA Network Open (@JAMANetworkOpen) February 17, 2021
RCT: Avacopan for the treatment of ANCA-associated vasculitis
18 Feb, 2021 | 02:50h | UTCAvacopan for the Treatment of ANCA-Associated Vasculitis – New England Journal of Medicine (link to abstract – $ for full-text)
Systematic review: Urgent‐start peritoneal dialysis vs. hemodialysis for people with chronic kidney disease
15 Feb, 2021 | 00:46h | UTC
M-A: No link between blood pressure drugs and falls
12 Feb, 2021 | 02:05h | UTCNo link between blood pressure drugs and falls, finds study – University of Oxford
Original study: Association between antihypertensive treatment and adverse events: systematic review and meta-analysis – The BMJ
Commentary on Twitter (thread – click for more)
Can #bloodpressure treatment be harmful? Our new meta-analysis suggests it is NOT linked to #falls or #fractures but may increase the risk of syncope & acute kidney injury https://t.co/H5LlsFVBXJ – see thread @RichardJMcManus @Richard_D_Riley @ebhcmedstats @JulietU_S @drandyclegg pic.twitter.com/UtWjE1BzMW
— James Sheppard (@jamessheppard48) February 10, 2021
Meta-analysis: Chlorthalidone vs. hydrochlorothiazide
11 Feb, 2021 | 02:00h | UTCChlorthalidone versus hydrochlorothiazide: major cardiovascular events, blood pressure, left ventricular mass, and adverse effects – Journal of Hypertension (link to abstract – $ for full-text)
Commentary: Chlorthalidone Compared With HCTZ for MACE Reduction – Renal & Urology News
Combination of vancomycin plus piperacillin and risk of acute kidney injury: a worldwide pharmacovigilance database analysis
11 Feb, 2021 | 01:50h | UTCRelated: Risk of acute kidney injury and Clostridioides difficile infection with piperacillin/tazobactam, cefepime and meropenem with or without vancomycin – Clinical Infectious Diseases AND Vancomycin Plus Piperacillin-Tazobactam and Acute Kidney Injury in Adults: A Systematic Review and Meta-Analysis – Critical Care Medicine (link to abstract – $ for full-text) AND Association of Acute Kidney Injury With Concomitant Vancomycin and Piperacillin/Tazobactam Treatment Among Hospitalized Children – JAMA Pediatrics (link to abstract – $ for full-text) AND Co-administration of vancomycin and piperacillin-tazobactam is associated with increased renal dysfunction in adult and pediatric burn patients – Critical Care
Commentary on Twitter
🚨 New paper from our team @HopitalCochin ⤵️
New data supporting a drug-drug interaction between vancomycin and piperacillin ⚠️ increased risk of acute kidney injury | Great collab with @AdrienContejean
@KerneisSolen
Read more in @BSACandJAC ⤵️https://t.co/eQW5s52fOY@ABsteward— Laurent Chouchana (@LChouchana) February 1, 2021
RCT: No difference in kidney allograft survival in kidney transplant patients allocated to early corticosteroid cessation vs. long-term corticosteroid therapy
5 Feb, 2021 | 01:26h | UTCEarly Corticosteroid Cessation vs Long-term Corticosteroid Therapy in Kidney Transplant Recipients: Long-term Outcomes of a Randomized Clinical Trial – JAMA Surgery (free for a limited period)
Commentary: Long-Term Corticosteroids Not Necessary After Kidney Transplant – Physician’s Weekly AND Is it OK to Cut Back on Prednisone After Kidney Transplant? – MedPage Today (free registration required)
Commentary on Twitter
16 years of follow up there was no difference in allograft or patient survival between kidney transplant patients treated with tacrolimus and MMF maintenance immunosuppression who were randomized to continue or withdraw #corticosteroids https://t.co/dQijSfgZJE #nosteroids pic.twitter.com/DbG6RFKFdp
— JAMA Surgery (@JAMASurgery) February 3, 2021
SR/MA: Colistin nephrotoxicity
5 Feb, 2021 | 01:21h | UTC
Dialysis patients have 4-fold greater risk of dying from COVID-19
5 Feb, 2021 | 01:39h | UTCNews Release: Dialysis patients have 4-fold greater risk of dying from COVID-19 – Canadian Medical Association Journal
Original Study: COVID-19 in patients undergoing long-term dialysis in Ontario – Canadian Medical Association Journal
Consensus recommendations: Diagnosis and management of Bartter syndrome
3 Feb, 2021 | 01:04h | UTC
Podcast: Hypertension Update
2 Feb, 2021 | 01:07h | UTC#254 Hypertension Update with Dr. Wanpen Vongpatanasin – The Curbsiders Internal Medicine Podcast
Review: Ambulatory blood pressure monitoring to diagnose and manage hypertension
25 Jan, 2021 | 01:24h | UTCAmbulatory Blood Pressure Monitoring to Diagnose and Manage Hypertension – Hypertension
Meta-analysis: Early initiation of renal replacement therapy is not associated with survival benefit in critically ill patients with acute kidney injury
20 Jan, 2021 | 01:25h | UTC
Randomized trial: Preoperative exercise improves vascular caliber and maturation of arteriovenous fistula
19 Jan, 2021 | 01:33h | UTC
Perspective: Addressing polypharmacy in outpatient dialysis units
19 Jan, 2021 | 01:27h | UTCRelated: Targeted Deprescribing in an Outpatient Hemodialysis Unit: A Quality Improvement Study to Decrease Polypharmacy – American Journal of Kidney Diseases (link to abstract – $ for full-text)
Meta-analysis of randomized trials: SGLT-2 inhibitors and GLP-1 receptor agonists reduce cardiovascular and renal outcomes in type 2 diabetes
15 Jan, 2021 | 08:41h | UTCCalculator based on the results: interactive decision support tool for outcomes
Cohort study: Piperacillin/tazobactam linked to increased risk of acute kidney injury when compared to cefepime or meropenem
15 Jan, 2021 | 08:24h | UTC
Commentary on Twitter
NEW 🔥🔥 #CID @IDSAInfo
Risk of AKI & CDI with piperacillin/tazobactam, cefepime and meropenem with or without vancomycin #IDTwitter @danlivorsi
TZP ⬆️ AKI risk, which was exacerbated by concurrent vancomycin.
FEP&MER ⬆️CDI risk relative to TZP. https://t.co/0pIurl7A7w pic.twitter.com/ZjjvN2rkWP— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) December 31, 2020
Study: Despite recommendations, less than 2 percent of patients with treatment-resistant hypertension were tested for primary aldosteronism in a large U.S. cohort
14 Jan, 2021 | 01:55h | UTCTesting for Primary Aldosteronism and Mineralocorticoid Receptor Antagonist Use Among U.S. Veterans: A Retrospective Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Primary Aldosteronism Testing Rare in Treatment-Resistant HTN – HealthDay AND Primary Aldosteronism Testing Rare for Patients with Resistant Hypertension – NEJM Journal Watch
Commentary from the author on Twitter (thread – click for more)
Our new study is out in @AnnalsofIM w/@BhallaResearch @thebyrdlab @johnleppert! 👇https://t.co/UCrAD4ed0w
We asked: Are patients w/treatment resistant HTN being appropriately tested for primary aldosteronism (PA) & managed w/mineralocorticoid receptor antagonists (MRAs)? 1/ pic.twitter.com/jO4cqA37sD
— Jordy Cohen, MD, MSCE (@jordy_bc) December 28, 2020
ACR Consensus Statement: Use of intravenous gadolinium-based contrast media in patients with kidney disease
14 Jan, 2021 | 01:52h | UTC
Commentary on Twitter
The potential harms of delaying or withholding group II GBCM for an MRI likely outweigh the risks of NSF in patients with acute kidney injury or moderate-to-severe loss of kidney function. This study in @radiology_rsna explains why. https://t.co/yZV38mpuLN #AbdRad pic.twitter.com/i46pK2FyB7
— RSNA (@RSNA) December 11, 2020
A randomized trial of albumin infusion to prevent intradialytic hypotension in hospitalized hypoalbuminemic patients
14 Jan, 2021 | 01:42h | UTC
Podcast: Nephrotic Syndrome vs. Glomerulonephritis
13 Jan, 2021 | 01:44h | UTC
The Top Nephrology Stories of 2020
12 Jan, 2021 | 01:33h | UTCThe Top Nephrology Stories of 2020 – NephJC