Nephrology
Meta-analysis: Chlorthalidone vs. hydrochlorothiazide
11 Feb, 2021 | 02:00h | UTCChlorthalidone versus hydrochlorothiazide: major cardiovascular events, blood pressure, left ventricular mass, and adverse effects – Journal of Hypertension (link to abstract – $ for full-text)
Commentary: Chlorthalidone Compared With HCTZ for MACE Reduction – Renal & Urology News
Combination of vancomycin plus piperacillin and risk of acute kidney injury: a worldwide pharmacovigilance database analysis
11 Feb, 2021 | 01:50h | UTCRelated: Risk of acute kidney injury and Clostridioides difficile infection with piperacillin/tazobactam, cefepime and meropenem with or without vancomycin – Clinical Infectious Diseases AND Vancomycin Plus Piperacillin-Tazobactam and Acute Kidney Injury in Adults: A Systematic Review and Meta-Analysis – Critical Care Medicine (link to abstract – $ for full-text) AND Association of Acute Kidney Injury With Concomitant Vancomycin and Piperacillin/Tazobactam Treatment Among Hospitalized Children – JAMA Pediatrics (link to abstract – $ for full-text) AND Co-administration of vancomycin and piperacillin-tazobactam is associated with increased renal dysfunction in adult and pediatric burn patients – Critical Care
Commentary on Twitter
? New paper from our team @HopitalCochin ⤵️
New data supporting a drug-drug interaction between vancomycin and piperacillin ⚠️ increased risk of acute kidney injury | Great collab with @AdrienContejean@KerneisSolen
Read more in @BSACandJAC ⤵️https://t.co/eQW5s52fOY@ABsteward— Laurent Chouchana (@LChouchana) February 1, 2021
RCT: No difference in kidney allograft survival in kidney transplant patients allocated to early corticosteroid cessation vs. long-term corticosteroid therapy
5 Feb, 2021 | 01:26h | UTCEarly Corticosteroid Cessation vs Long-term Corticosteroid Therapy in Kidney Transplant Recipients: Long-term Outcomes of a Randomized Clinical Trial – JAMA Surgery (free for a limited period)
Commentary: Long-Term Corticosteroids Not Necessary After Kidney Transplant – Physician’s Weekly AND Is it OK to Cut Back on Prednisone After Kidney Transplant? – MedPage Today (free registration required)
Commentary on Twitter
16 years of follow up there was no difference in allograft or patient survival between kidney transplant patients treated with tacrolimus and MMF maintenance immunosuppression who were randomized to continue or withdraw #corticosteroids https://t.co/dQijSfgZJE #nosteroids pic.twitter.com/DbG6RFKFdp
— JAMA Surgery (@JAMASurgery) February 3, 2021
SR/MA: Colistin nephrotoxicity
5 Feb, 2021 | 01:21h | UTC
Dialysis patients have 4-fold greater risk of dying from COVID-19
5 Feb, 2021 | 01:39h | UTCNews Release: Dialysis patients have 4-fold greater risk of dying from COVID-19 – Canadian Medical Association Journal
Original Study: COVID-19 in patients undergoing long-term dialysis in Ontario – Canadian Medical Association Journal
Consensus recommendations: Diagnosis and management of Bartter syndrome
3 Feb, 2021 | 01:04h | UTC
Podcast: Hypertension Update
2 Feb, 2021 | 01:07h | UTC#254 Hypertension Update with Dr. Wanpen Vongpatanasin – The Curbsiders Internal Medicine Podcast
Review: Ambulatory blood pressure monitoring to diagnose and manage hypertension
25 Jan, 2021 | 01:24h | UTCAmbulatory Blood Pressure Monitoring to Diagnose and Manage Hypertension – Hypertension
Meta-analysis: Early initiation of renal replacement therapy is not associated with survival benefit in critically ill patients with acute kidney injury
20 Jan, 2021 | 01:25h | UTC
Randomized trial: Preoperative exercise improves vascular caliber and maturation of arteriovenous fistula
19 Jan, 2021 | 01:33h | UTC
Perspective: Addressing polypharmacy in outpatient dialysis units
19 Jan, 2021 | 01:27h | UTCRelated: Targeted Deprescribing in an Outpatient Hemodialysis Unit: A Quality Improvement Study to Decrease Polypharmacy – American Journal of Kidney Diseases (link to abstract – $ for full-text)
Meta-analysis of randomized trials: SGLT-2 inhibitors and GLP-1 receptor agonists reduce cardiovascular and renal outcomes in type 2 diabetes
15 Jan, 2021 | 08:41h | UTCCalculator based on the results: interactive decision support tool for outcomes
Cohort study: Piperacillin/tazobactam linked to increased risk of acute kidney injury when compared to cefepime or meropenem
15 Jan, 2021 | 08:24h | UTC
Commentary on Twitter
NEW ?? #CID @IDSAInfo
Risk of AKI & CDI with piperacillin/tazobactam, cefepime and meropenem with or without vancomycin #IDTwitter @danlivorsi
TZP ⬆️ AKI risk, which was exacerbated by concurrent vancomycin.
FEP&MER ⬆️CDI risk relative to TZP. https://t.co/0pIurl7A7w pic.twitter.com/ZjjvN2rkWP— Antibiotic Steward? Bassam Ghanem (@ABsteward) December 31, 2020
Study: Despite recommendations, less than 2 percent of patients with treatment-resistant hypertension were tested for primary aldosteronism in a large U.S. cohort
14 Jan, 2021 | 01:55h | UTCTesting for Primary Aldosteronism and Mineralocorticoid Receptor Antagonist Use Among U.S. Veterans: A Retrospective Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Primary Aldosteronism Testing Rare in Treatment-Resistant HTN – HealthDay AND Primary Aldosteronism Testing Rare for Patients with Resistant Hypertension – NEJM Journal Watch
Commentary from the author on Twitter (thread – click for more)
Our new study is out in @AnnalsofIM w/@BhallaResearch @thebyrdlab @johnleppert! ?https://t.co/UCrAD4ed0w
We asked: Are patients w/treatment resistant HTN being appropriately tested for primary aldosteronism (PA) & managed w/mineralocorticoid receptor antagonists (MRAs)? 1/ pic.twitter.com/jO4cqA37sD
— Jordy Cohen, MD, MSCE (@jordy_bc) December 28, 2020
ACR Consensus Statement: Use of intravenous gadolinium-based contrast media in patients with kidney disease
14 Jan, 2021 | 01:52h | UTC
Commentary on Twitter
The potential harms of delaying or withholding group II GBCM for an MRI likely outweigh the risks of NSF in patients with acute kidney injury or moderate-to-severe loss of kidney function. This study in @radiology_rsna explains why. https://t.co/yZV38mpuLN #AbdRad pic.twitter.com/i46pK2FyB7
— RSNA (@RSNA) December 11, 2020
A randomized trial of albumin infusion to prevent intradialytic hypotension in hospitalized hypoalbuminemic patients
14 Jan, 2021 | 01:42h | UTC
Podcast: Nephrotic Syndrome vs. Glomerulonephritis
13 Jan, 2021 | 01:44h | UTC
The Top Nephrology Stories of 2020
12 Jan, 2021 | 01:33h | UTCThe Top Nephrology Stories of 2020 – NephJC
Systematic Review: “For the general population of persons with elevated blood pressure, the benefits of trying to achieve a lower blood pressure target rather than a standard target (140/90 mm Hg or less) do not outweigh the harms associated with that intervention.”
12 Jan, 2021 | 01:30h | UTCBlood pressure targets in adults with hypertension – Cochrane Library
Summary: The use of lower blood pressure targets for people with hypertension – Cochrane Library
Related systematic review: Blood pressure targets in people with cardiovascular disease – Cochrane Library
Commentary on Twitter
The use of lower #bloodpressure targets for people with #hypertension https://t.co/W1bF8W7CDD Updated @CochraneHTN systematic review includes 11 randomised controlled trials involving 38,688 adult participants.
— Cochrane (@cochranecollab) December 30, 2020
Study suggests that 7 days of home blood pressure monitoring is likely better than 24h ambulatory monitoring or 3 office measurements
10 Jan, 2021 | 20:17h | UTCEditorial: Which Blood Pressure Measurement Best Predicts Cardiovascular Outcomes?
Commentary: Is Home BP Monitoring the Best Approach For Diagnosing HTN? – American College of Cardiology
Randomized trial: In kidney transplantation, oxygenated cold perfusion preservation is safe and reduces post-transplant complications compared to standard cold perfusion preservation in kidney transplantation
16 Dec, 2020 | 10:06h | UTCOxygenated versus standard cold perfusion preservation in kidney transplantation (COMPARE): a randomised, double-blind, paired, phase 3 trial – The Lancet (link to abstract – $ for full-text)
Commentary: Oxygenated hypothermic perfusion reduces post-kidney transplant complications – 2 Minute Medicine
Observational study suggests we should individualize blood pressure targets among critically ill patients with different ranges of pre-illness baseline mean perfusion pressure
16 Dec, 2020 | 10:01h | UTCCommentary: Personalized Pressors – REACT Study Group – Journal Feed
Randomized trial: In acutely ill children, the risk of electrolyte disorders is markedly increased with plasmalike isotonic fluid therapy compared with moderately hypotonic fluid therapy containing 20 mmol/L of potassium
15 Dec, 2020 | 01:25h | UTCRisk of Electrolyte Disorders in Acutely Ill Children Receiving Commercially Available Plasmalike Isotonic Fluids: A Randomized Clinical Trial – JAMA Pediatrics (link to abstract – $ for full-text)
Commentary: Isotonic Fluids Without Potassium Could Be Harmful for Some Acutely Ill Kids – Medscape (free registration required)
Commentary on Twitter
A randomized pragmatic clinical trial shows a high risk of #hypokalemia and a small risk of #hypernatremia in acutely ill children receiving plasma-like fluid therapy https://t.co/FOoJeaSSes @TerhiTapiainen
— JAMA Pediatrics (@JAMAPediatrics) October 27, 2020
Systematic review: Among patients with advanced chronic kidney disease and uremic pruritus, gabapentinoids are the most studied treatments and show the greatest reduction in itch scores
13 Dec, 2020 | 23:16h | UTCInterventions for itch in people with advanced chronic kidney disease – Cochrane Library
Commentary: What is the best treatment for itch in people with chronic kidney disease? – Cochrane Library
Supplement: Lupus in the 21st Century
13 Dec, 2020 | 23:13h | UTCHomepage: Lupus in the 21st Century
Editorial: Lupus in the 21st century
- Classifying and diagnosing systemic lupus erythematosus in the 21st century
- New biomarkers in SLE: from bench to bedside
- Treatment targets in SLE: remission and low disease activity state
- Long-term outcomes in systemic lupus erythematosus: trends over time and major contributors
- Lupus nephritis: clinical presentations and outcomes in the 21st century
- The management of neuropsychiatric lupus in the 21st century: still so many unmet needs?
- The patient’s perspective: are quality of life and disease burden a possible treatment target in systemic lupus erythematosus?
- Treating systemic lupus erythematosus in the 21st century: new drugs and new perspectives on old drugs