Nephrology
Cohort study: Higher cumulative exposure to Thiazide diuretics linked to an increased risk of skin cancer in people older than 65 years
13 Apr, 2021 | 05:08h | UTCCommentaries: Thiazides May Up Risk for Skin Cancer in Older Adults – HealthDay AND Some blood pressure medication linked to higher risk of skin cancer, study finds – CTV News
Related study: Case-Control Study: Possible Association of Hydrochlorothiazide Use and Risk of Melanoma
Another study shows intravenous radiocontrast use is not associated with reduced kidney function
12 Apr, 2021 | 00:44h | UTCCommentaries: Radiocontrast Exposure Safe for Kidney Function – HCP Live AND Exposure to contrast on CTPA doesn’t cause long-term kidney injury – AuntMinnie
Related: ACR/NKF Consensus Statement: “The Risk of Acute Kidney Injury Developing in Patients with Reduced Kidney Function Following Exposure to Intravenous Iodinated Contrast Media has Been Overstated” (Guideline and commentaries)
Commentary on Twitter (thread – click for more)
Our new paper in @JAMAInternalMed: is IV contrast nephrotoxic? Lots of studies say no, but have ⬆️risk of confounding: people who get contrast ≠ people who don't get it. We used a natural experiment to try to overcome this bias https://t.co/XWEEohAvK0 1/5
— Robert Goulden (@EMrobg) April 5, 2021
Diagnostic Test Interpretation: Evaluation of Hypokalemia
6 Apr, 2021 | 01:07h | UTCEvaluation of Hypokalemia – JAMA (free for a limited period)
RCT: Lumasiran, an RNAi Therapeutic for Primary Hyperoxaluria Type 1
5 Apr, 2021 | 01:01h | UTCLumasiran, an RNAi Therapeutic for Primary Hyperoxaluria Type 1 – New England Journal of Medicine (link to abstract – $ for full-text)
RCT: Comparison of two delayed strategies for renal replacement therapy initiation for severe acute kidney injury – waiting too long can be deleterious
2 Apr, 2021 | 09:17h | UTCComparison of two delayed strategies for renal replacement therapy initiation for severe acute kidney injury (AKIKI 2): a multicentre, open-label, randomised, controlled trial – The Lancet (link to abstract – $ for full-text)
RCT: Reduced-sodium added-potassium salt substitute reduces blood pressure in hypertensive patients
1 Apr, 2021 | 03:32h | UTC
Commentaries on Twitter
Our new trial in India – switching from regular salt to a reduced-sodium added-potassium salt substitute for home cooking helps those with hypertension reduce their blood pressure. Important implications for BP control in LMIC settings #diet #globalhealth https://t.co/DD2knGuifT pic.twitter.com/zL8eVUAsdn
— Jason Wu (@Dr_WuJ) March 30, 2021
Salt substitution (70% sodium chloride/30% potassium chloride blend) is an effective, low-cost intervention for BP controlhttps://t.co/EemPEY9T2k pic.twitter.com/xVITnGLEip
— K Pavithran (@drkpavithran) March 31, 2021
Review: Use of urine electrolytes and urine osmolality in the clinical diagnosis of fluid, electrolytes, and acid-base disorders
25 Mar, 2021 | 08:06h | UTC
Commentary on Twitter
Do people use Urine K/crt ratio? for K disorders? What about FeK? TTKG is out! @askrenal –this flow chart makes sense to me https://t.co/8o8a7VYTMQ pic.twitter.com/UVZiFPo4vK
— Kenar Jhaveri (@kdjhaveri) February 20, 2021
Perspective | Prioritizing peritoneal catheter placement during the COVID-19 pandemic
16 Mar, 2021 | 02:16h | UTC
Commentary on Twitter
Individuals receiving dialysis are at high risk of COVID-19 infection, but promoting peritoneal dialysis is one potential way to substantially lower the risk. This perspective outlines how COVID-19 has changed the importance of timely PD catheter insertion https://t.co/Sy2pUShfNU pic.twitter.com/GueiogpO5b
— CJASN (@CJASN) March 12, 2021
Editorial: How I prescribe continuous renal replacement therapy
16 Mar, 2021 | 01:27h | UTCHow I prescribe continuous renal replacement therapy – Critical Care
Managing Patients with Failing Kidney Allograft: Many Questions Remain
12 Mar, 2021 | 08:06h | UTC
Study: Balanced crystalloids vs. saline in critically ill adults with hyperkalemia or acute kidney injury
9 Mar, 2021 | 02:05h | UTCCan We Use LR for Hyperkalemia? – Journal Feed
RCT: Mixed findings with Terlipressin plus Albumin for the treatment of Type 1 hepatorenal syndrome
4 Mar, 2021 | 08:35h | UTCTerlipressin plus Albumin for the Treatment of Type 1 Hepatorenal Syndrome – New England Journal of Medicine (link to abstract – $ for full-text)
RCT: Albumin provides no benefit to hospitalized patients with decompensated cirrhosis
4 Mar, 2021 | 08:37h | UTCA Randomized Trial of Albumin Infusions in Hospitalized Patients with Cirrhosis – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Albumin provides no benefit to hospitalized patients with advanced liver disease – University College London
Management of congenital nephrotic syndrome: consensus recommendations of the ERKNet-ESPN Working Group
4 Mar, 2021 | 08:13h | UTC
Systematic review: Aldosterone antagonists for people with chronic kidney disease requiring dialysis
3 Mar, 2021 | 08:27h | UTCAldosterone antagonists for people with chronic kidney disease requiring dialysis – Cochrane Library
Systematic review: Walking for hypertension
2 Mar, 2021 | 01:14h | UTCWalking for hypertension – Cochrane Library
Summary: The effect of walking on blood pressure control – Cochrane Library
M-A: Adjuvant corticosteroids are effective in lowering the risk of kidney scarring in children with acute pyelonephritis
28 Feb, 2021 | 20:38h | UTCAdjuvant corticosteroids for prevention of kidney scarring in children with acute pyelonephritis: a systematic review and meta-analysis – Archives of Disease in Childhood (link to abstract – $ for full-text)
ICU-based renal replacement therapy
25 Feb, 2021 | 08:23h | UTCICU-Based Renal Replacement Therapy – Critical Care Medicine
Commentary on Twitter
Renal Replacement in #ICU
?history/development
?(fast) evolution of tech & machines
?pivotal role of nursing
?mode: CRRT vs IHD
?CRRT & blood purification
?peds & neonates #PedsICU
?complications
?anticoagulation@CritCareMed #FOAMcc #FOANed #CCC50 https://t.co/NxC88pbIB6 pic.twitter.com/OGVkwkrjLi— M Velia Antonini (@FOAMecmo) February 4, 2021
KDIGO 2021 Clinical Practice Guideline for the Management of Blood Pressure in Chronic Kidney Disease
24 Feb, 2021 | 02:21h | UTC
Commentary on Twitter (thread – Click for more)
The 2021 KDIGO guideline covers optimal BP targets in patients with CKD, proper BP measurement, lifestyle interventions, antihypertensive medications, and issues specific to management in kidney transplant recipients and children. https://t.co/OXfhCbBQS9
— Kathryn Foti (@fotikat) February 23, 2021
Pro-con Debate: Starting antihypertensive drug treatment with combination therapy
23 Feb, 2021 | 01:26h | UTCCon: Starting Antihypertensive Drug Treatment With Combination Therapy
Pro: Starting Antihypertensive Drug Treatment With Combination Therapy
M-A: Blood pressure effects of sodium reduction
23 Feb, 2021 | 01:28h | UTCCommentaries: The Lower the Sodium, the Better for BP: Updated Meta-analysis – TCTMD AND AHA News: Lower Your Sodium, and Blood Pressure Will Follow – HealthDay
Study: In intensively treated hypertensive patients, a diastolic blood pressure of less than 60 mm Hg was associated with increased risk of cardiovascular events
19 Feb, 2021 | 02:37h | UTCCommentary: Treated Diastolic Blood Pressure: How Low Is Too Low? – NEJM Journal Watch
Commentary on Twitter
Cohort study showed on-treatment diastolic BP <60 was associated with increased risk of adverse outcomes; on-treatment diastolic BP of 70-80 was associated with lowest adverse outcome risk in patients with on-treatment systolic BP <130 mmHg. @MayoClinic https://t.co/0wOfqpMcIH
— JAMA Network Open (@JAMANetworkOpen) February 17, 2021
RCT: Avacopan for the treatment of ANCA-associated vasculitis
18 Feb, 2021 | 02:50h | UTCAvacopan for the Treatment of ANCA-Associated Vasculitis – New England Journal of Medicine (link to abstract – $ for full-text)
Systematic review: Urgent‐start peritoneal dialysis vs. hemodialysis for people with chronic kidney disease
15 Feb, 2021 | 00:46h | UTC
M-A: No link between blood pressure drugs and falls
12 Feb, 2021 | 02:05h | UTCNo link between blood pressure drugs and falls, finds study – University of Oxford
Original study: Association between antihypertensive treatment and adverse events: systematic review and meta-analysis – The BMJ
Commentary on Twitter (thread – click for more)
Can #bloodpressure treatment be harmful? Our new meta-analysis suggests it is NOT linked to #falls or #fractures but may increase the risk of syncope & acute kidney injury https://t.co/H5LlsFVBXJ – see thread @RichardJMcManus @Richard_D_Riley @ebhcmedstats @JulietU_S @drandyclegg pic.twitter.com/UtWjE1BzMW
— James Sheppard (@jamessheppard48) February 10, 2021