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Internal Medicine

Update on the management of diabetes in long-term care facilities.

26 Aug, 2022 | 13:23h | UTC

Update on the management of diabetes in long-term care facilities – BMJ Open Diabetes Research & Care

 


Scoping review of randomized trials with discontinuation of medicines in older adults.

26 Aug, 2022 | 13:16h | UTC

Scoping Review of Randomized Trials With Discontinuation of Medicines in Older Adults – JAMDA

 


Systematic Review | Pulmonary rehabilitation versus usual care for adults with asthma.

26 Aug, 2022 | 13:12h | UTC

Pulmonary rehabilitation versus usual care for adults with asthma – Cochrane Library

Summary: What are the benefits of supervised programmes of exercise and education (known as pulmonary rehabilitation) compared with usual care for adults with asthma? – Cochrane Library

 

Commentary on Twitter

 


A Bayesian reanalysis of the Standard versus Accelerated Initiation of Renal-Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial.

26 Aug, 2022 | 13:08h | UTC

A Bayesian reanalysis of the Standard versus Accelerated Initiation of Renal-Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial – Critical Care

Original Study: Timing of Initiation of Renal-Replacement Therapy in Acute Kidney Injury – New England Journal of Medicine

Related:

Delayed versus early initiation of renal replacement therapy for severe acute kidney injury: a systematic review and individual patient data meta-analysis of randomised clinical trials – The Lancet

RCT: Comparison of two delayed strategies for renal replacement therapy initiation for severe acute kidney injury – waiting too long can be deleterious

Meta-analysis: Early initiation of renal replacement therapy is not associated with survival benefit in critically ill patients with acute kidney injury

 


Randomized Crossover Trial | In patients with diabetic neuropathic pain, amitriptyline supplemented with pregabalin, pregabalin supplemented with amitriptyline, and duloxetine supplemented with pregabalin were similarly effective.

25 Aug, 2022 | 12:14h | UTC

Comparison of amitriptyline supplemented with pregabalin, pregabalin supplemented with amitriptyline, and duloxetine supplemented with pregabalin for the treatment of diabetic peripheral neuropathic pain (OPTION-DM): a multicentre, double-blind, randomised crossover trial – The Lancet

 


RCT | Enoxaparin (40 mg/d) is superior to aspirin (100 mg/d) for the prevention of thromboembolism in patients undergoing hip or knee arthroplasty.

25 Aug, 2022 | 12:12h | UTC

Effect of Aspirin vs Enoxaparin on Symptomatic Venous Thromboembolism in Patients Undergoing Hip or Knee Arthroplasty: The CRISTAL Randomized Trial – JAMA (free for a limited period)

Editorial: Thromboprophylaxis After Hip or Knee Arthroplasty – JAMA

 

Commentary on Twitter

 


Consensus Document | Management of decompensated cirrhosis in the surgical ICU.

25 Aug, 2022 | 12:05h | UTC

Management of Decompensated Cirrhosis in the Surgical ICU: an American Association for the Surgery of Trauma Critical Care Committee Clinical Consensus Document – Trauma Surgery & Acute Care Open

 

Commentary on Twitter

 


Cohort Study | Association between changes in alcohol consumption and cancer risk.

25 Aug, 2022 | 12:03h | UTC

Association Between Changes in Alcohol Consumption and Cancer Risk – JAMA Network Open

Invited Commentary: Reducing Alcohol Use for Cancer Prevention – JAMA Network Open

 


Expert Analysis | Clinical applications of cardiac magnetic resonance imaging in pericardial diseases.

25 Aug, 2022 | 11:59h | UTC

Clinical Applications of Cardiac Magnetic Resonance Imaging in Pericardial Diseases – American College of Cardiology

Related: Case Series: Cardiac magnetic resonance in the assessment of pericardial abnormalities.

 


Observational study suggests Hydroxychloroquine is associated with increased risk of cardiovascular events compared to Methotrexate in patients with heart failure.

25 Aug, 2022 | 11:56h | UTC

Cardiovascular Risks of Hydroxychloroquine vs Methotrexate in Patients With Rheumatoid Arthritis – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Editorial: Hydroxychloroquine: Heart-Throb No More? – Journal of the American College of Cardiology

Commentary: Caution needed with hydroxychloroquine use in older RA patients with heart failure – medwire News

 


Vasospastic angina: a contemporary review of its pathophysiology, diagnosis and management.

25 Aug, 2022 | 11:53h | UTC

Vasospastic Angina: A Contemporary Review of its Pathophysiology, Diagnosis and Management – Heart International

 

Commentary on Twitter

 


Review | Prevention of first decompensation in advanced chronic liver disease.

25 Aug, 2022 | 11:52h | UTC

Prevention of First Decompensation in Advanced Chronic Liver Disease – Clinics in Liver Disease

 

Commentary on Twitter

 


Review | Subphenotypes in acute kidney injury.

25 Aug, 2022 | 11:50h | UTC

Subphenotypes in acute kidney injury: a narrative review – Critical Care

 


USPSTF Recommendation Statement | Statin use for the primary prevention of cardiovascular disease in adults.

24 Aug, 2022 | 14:21h | UTC

Statin Use for the Primary Prevention of Cardiovascular Disease in Adults: US Preventive Services Task Force Recommendation Statement – JAMA

Editorials:

Statins for Primary Cardiovascular Disease Prevention: Time to Curb Our Enthusiasm – JAMA Internal Medicine

Statins and Primary Atherosclerotic Cardiovascular Disease Prevention—What We Know, Where We Need to Go, and Why Are We Not There Already? – JAMA Network Open

Evidence Report: Statin Use for the Primary Prevention of Cardiovascular Disease in Adults: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force – JAMA

Author Interview: USPSTF Recommendation: Statin Use for the Primary Prevention of Cardiovascular Disease in Adults – JAMA

Patient Page: Statins for the Prevention of Cardiovascular Disease – JAMA

Commentary: Latest statins guidance keeps more conservative approach to preventing first stroke or heart attack – CNN

 


Retrospective Cohort Study | Clinical and genetic risk factors for acute incident venous thromboembolism in ambulatory patients with COVID-19.

24 Aug, 2022 | 14:17h | UTC

Clinical and Genetic Risk Factors for Acute Incident Venous Thromboembolism in Ambulatory Patients With COVID-19 – JAMA Internal Medicine

 

Commentary on Twitter

 


Monkeypox: a clinical update for pediatricians.

24 Aug, 2022 | 14:19h | UTC

Monkeypox: A clinical update for paediatricians – Journal of Pediatrics and Child Health

Related:

Cohort Study | Clinical presentation and virological assessment of confirmed human monkeypox virus cases in Spain.

CDC Report | Epidemiologic and clinical characteristics of Monkeypox cases in the US.

Update on the Monkeypox Outbreak – JAMA

Antivirals with Activity Against Monkeypox: A Clinically Oriented Review – Clinical Infectious Diseases

Clinical features and novel presentations of human monkeypox in a central London centre during the 2022 outbreak: descriptive case series – The BMJ

WHO Declares Global Public Health Emergency Over Monkeypox Virus Outbreak – Health Policy Watch

Monkeypox Virus Infection in Humans across 16 Countries — April–June 2022 – New England Journal of Medicine

Monkeypox: A Contemporary Review for Healthcare Professionals – Open Forum Infectious Diseases

 


Long-term results of a RCT | Vasopressin and methylprednisolone did not improve outcomes in patients with in-hospital cardiac arrest.

24 Aug, 2022 | 14:15h | UTC

Effect of vasopressin and methylprednisolone vs. placebo on long-term outcomes in patients with in-hospital cardiac arrest a randomized clinical trial – Resuscitation

Original Study: RCT: Vasopressin + Methylprednisolone increase the likelihood of return of spontaneous circulation compared to placebo in patients with in-hospital cardiac arrest.

 


Retrospective Cohort Study | Association of COVID-19 vs. Influenza with risk of arterial and venous thrombotic events among hospitalized patients.

24 Aug, 2022 | 14:16h | UTC

Association of COVID-19 vs Influenza With Risk of Arterial and Venous Thrombotic Events Among Hospitalized Patients – JAMA

Commentary: Higher risk of vein blood clots in COVID vs flu patients – CIDRAP

News Release: People with Severe COVID-19 Face Increased Risk of Life-Threatening Blood Clots – Penn Medicine News

 

Commentary on Twitter

 


Position Statement | Chronic kidney disease as cardiovascular risk factor in routine clinical practice.

24 Aug, 2022 | 14:14h | UTC

Chronic kidney disease as cardiovascular risk factor in routine clinical practice: a position statement by the Council of the European Renal Association – European Journal of Preventive Cardiology (PDF)

 


Systematic Review | Anticholinergic burden for prediction of cognitive decline or neuropsychiatric symptoms in older adults with mild cognitive impairment or dementia.

24 Aug, 2022 | 14:10h | UTC

Anticholinergic burden for prediction of cognitive decline or neuropsychiatric symptoms in older adults with mild cognitive impairment or dementia – Cochrane Library

Summary: The impact of cumulative medications with anticholinergic effects on future adverse clinical outcomes in people with dementia – Cochrane Library

Related:

Quantifying Anticholinergic Burden and Sedative Load in Older Adults with Polypharmacy: A Systematic Review of Risk Scales and Models – Drugs & Aging

Commonly-prescribed drugs and dementia: should we be worried? – Evidently Cochrane

Anticholinergic burden (prognostic factor) for prediction of dementia or cognitive decline in older adults with no known cognitive syndrome – Cochrane Library

Anticholinergic drugs and dementia: time for transparency in the face of uncertainty – Cochrane Library

Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study – JAMA Internal Medicine

How well do you know your anticholinergic (antimuscarinic) drugs? – Therapeutics Initiative

Anticholinergic drugs and risk of dementia: case-control study – The BMJ

 


Podcast | USPSTF Update: aspirin for primary prevention of cardiovascular disease.

24 Aug, 2022 | 14:05h | UTC

#347 USPSTF Update: Aspirin for Primary Prevention of CVD – The Curbsiders

Related Guideline: USPSTF Recommendation Statement: Aspirin Use to Prevent Cardiovascular Disease.

Related Randomized Trials:

Randomized Trial: Aspirin for Primary Prevention of Cardiovascular Disease

Randomized Trial: Effects of Aspirin for Primary Prevention in Persons with Diabetes

Randomized Trial: Effect of Aspirin on All-Cause Mortality in the Healthy Elderly

Related Meta-Analysis:

Meta-Analysis: Association of Aspirin Use for Primary Prevention with Cardiovascular Events and Bleeding Events

Meta-Analysis: Efficacy and Safety of Aspirin for Primary Prevention of Cardiovascular Events

Aspirin for primary prevention of cardiovascular disease: a meta-analysis with a particular focus on subgroups – BMC Medicine

Related Opinions:

Aspirin for Primary Prevention: Is This the End of the Road?

Evidence evolving on aspirin as prevention – ACP Internist

 


Podcast | Myositis and myopathy.

24 Aug, 2022 | 14:04h | UTC

#348 Myositis and Myopathy, LIVE! – The Curbsiders

 


M-A | Incidence and mortality of non-AIDS-defining cancers among people living with HIV.

23 Aug, 2022 | 13:26h | UTC

Incidence and mortality of non-AIDS-defining cancers among people living with HIV: A systematic review and meta-analysis – eClinicalMedicine

Related: Study: Cancer Patients with HIV Infection Have Worse Outcomes

 


Guideline | Management of adults with diabetes on dialysis.

23 Aug, 2022 | 13:16h | UTC

Management of adults with diabetes on dialysis – Joint British Diabetes Societies for Inpatient Care (PDF)

News Release: Latest JBDS dialysis guideline published – Diabetes Times

 


Evidence-based clinical practice guidelines for chronic pancreatitis.

23 Aug, 2022 | 13:15h | UTC

Evidence-based clinical practice guidelines for chronic pancreatitis 2021 – Journal of Gastroenterology

Related:

ACG Clinical Guideline: Chronic Pancreatitis – American Journal of Gastroenterology

Pancreatitis – National Institute for Health and Care Excellence

United European Gastroenterology evidence-based guidelines for the diagnosis and therapy of chronic pancreatitis

Guidelines for the understanding and management of pain in chronic pancreatitis – Pancreatology

 


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