Internal Medicine
Review | Covid-19 vaccines — immunity, variants, boosters.
1 Sep, 2022 | 11:57h | UTCCovid-19 Vaccines — Immunity, Variants, Boosters – New England Journal of Medicine
Reports of asymptomatic monkeypox suggest that, at the very least, some infections go unnoticed.
1 Sep, 2022 | 11:54h | UTC
RCT | In patients with rheumatoid arthritis, Tofacitinib is associated with increased risk of infections compared to TNF inhibitors.
1 Sep, 2022 | 11:50h | UTC
Commentary on Twitter
Check out our latest paper on infections in #rheumatoid #arthritis patients from the ORAL Surveillance trial:
▶️ tofacitinib lead to higher infection rates (serious and non-serious) vs TNFi
▶️ increased rates more pronounced in patients aged > 65🔗 https://t.co/3pVrnzzFWD pic.twitter.com/Kf7p6D0jBD
— Annals of the Rheumatic Diseases (@eular_ARD) August 11, 2022
Study Commentary | Zinc for the prevention or treatment of respiratory tract infections: a new systematic review.
1 Sep, 2022 | 11:46h | UTC
Meta-analysis of observational studies | Leisure activities and the risk of dementia.
1 Sep, 2022 | 11:44h | UTCLeisure Activities and the Risk of Dementia: A Systematic Review and Meta-Analysis – Neurology
News Release: Which Leisure Activities Are Linked to Lower Risk of Dementia? – American Academy of Neurology
Study shows dentists should give antibiotics to high-risk patients to help prevent infectious endocarditis.
1 Sep, 2022 | 11:43h | UTCOriginal Study: Antibiotic Prophylaxis Against Infective Endocarditis Before Invasive Dental Procedures – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Commentary: UK dentists should give antibiotics to patients at risk of heart infection – study – The Guardian
RCT | The effect of a liberal approach to glucose control in critically ill patients with type 2 diabetes.
1 Sep, 2022 | 11:37h | UTCThe Effect of a Liberal Approach to Glucose Control in Critically Ill Patients with Type 2 Diabetes: A multicenter, parallel-group, open-label, randomized clinical trial – American Journal of Respiratory and Critical Care Medicine (link to abstract – $ for full-text)
Commentary from the author on Twitter
Excited to share results of the LUCID trial! A liberal approach to blood glucose targets reduced incidence hypoglycemia but did not improve patient-centered outcomes. https://t.co/HO53nzfBQT@MelbourneICU @CRENutrition @BellomoRinaldo @icurah @DogICUma @Eastwoodgm @MACHAustralia
— Alex Poole (@AlexPPoole) May 25, 2022
Systematic Review | The effect of heparin and its preparations on disseminated intravascular coagulation mortality and hospitalization.
1 Sep, 2022 | 11:34h | UTC
M-A | The impact of early versus late initiation of renal replacement therapy in critically ill patients with acute kidney injury on mortality and clinical outcomes.
1 Sep, 2022 | 11:33h | UTCRelated:
Comparison of two delayed strategies for renal replacement therapy initiation for severe acute kidney injury (AKIKI 2): a multicentre, open-label, randomised, controlled trial – The Lancet (link to abstract – $ for full-text)
Guideline | Fecal immunochemical testing in patients with signs or symptoms of suspected colorectal cancer.
31 Aug, 2022 | 11:52h | UTCCommentary: Guidelines update: use of FIT in colorectal cancer referrals – PULSE
Review/Perspective | European hypertension guideline downgrading of beta-blockers is not justified.
31 Aug, 2022 | 11:51h | UTC
RCT | Remote physician visits are noninferior to in-home physician visits for patients receiving acute hospital-level care at home (home hospital).
31 Aug, 2022 | 11:49h | UTCAuthor Interview: Remote vs In-home Physician Visits for Hospital-Level Care at Home – JAMA
Commentary on Twitter
Home hospital care is scaling fast, but the role for remote MD care is unknown. In this #RCT, remote MD care was noninferior to in-home MD care, but in-home MD care was critical to 1 in 5 patients. @hahusersgroup @WHAH_cong #OpenAccess #Research https://t.co/ZoE4oc37jx
— JAMA Network Open (@JAMANetworkOpen) August 30, 2022
Practice guidance for the use of Terlipressin for liver cirrhosis–related complications.
31 Aug, 2022 | 11:46h | UTC
Guideline | Adult- and late-onset male hypogonadism.
31 Aug, 2022 | 11:36h | UTC
Cluster RCT | Effect of different interventions to help primary care clinicians avoid unsafe opioid prescribing in opioid-naive patients with acute noncancer pain.
31 Aug, 2022 | 11:33h | UTC
Commentary on Twitter
This cluster randomized clinical trial found that clinician comparison email feedback had the potential to decrease harm from opioid prescriptions for acute noncancer pain. @RxEricWright @walidgellad #VisualAbstract https://t.co/BizLH13lau pic.twitter.com/EEbdqWRqig
— JAMA Health Forum (@JAMAHealthForum) July 29, 2022
Cohort Study | Association of leisure time physical activity types and risks of all-cause, cardiovascular, and cancer mortality among older adults.
31 Aug, 2022 | 11:29h | UTCNews Release: Many types of leisure time activities may lower risk of death for older adults – NIH News Releases
Commentaries:
Want to lower your risk of early death? 3 activities are most beneficial, study says – CNN
Any Type of Leisure-Time Physical Activity Tied to Lower Mortality Risk – HealthDay
Commentary on Twitter
All types of leisure time physical activities (running, cycling, swimming, aerobic exercise, racket sports, golf, and exercise walking) are associated with lower risks of mortality for people aged 59-82 years. #OAResearch https://t.co/wkunjzOeYo
— JAMA Network Open (@JAMANetworkOpen) August 24, 2022
Cohort Study | Electrocardiographic findings associated with early clinical deterioration in acute pulmonary embolism.
31 Aug, 2022 | 11:30h | UTC
#ESCCongress | Effect of statin therapy on muscle symptoms: an individual participant data meta-analysis of large-scale, randomized, double-blind trials.
30 Aug, 2022 | 12:16h | UTCNews Release: Cardiovascular protection from statins greatly outweighs the risk of muscle symptoms – European Society of Cardiology
Commentary: Only Very Small Risk of Muscle Symptoms With Statins: CTT Collaboration – TCTMD
#ESCCongress – Meta-analysis of randomized trials | Angiotensin receptor blockers and Beta-blockers in Marfan syndrome: an individual patient data meta-analysis of randomized trials.
30 Aug, 2022 | 12:15h | UTCNews Release: Drug combination may delay need for surgery in patients with Marfan syndrome – TCTMD
Commentary: ARBs Halve Rate of Aortic Root Enlargement in Marfan: Meta-analysis – TCTMD
#ESCCongress – M-A | Patients with heart failure benefit from dapagliflozin regardless of ejection fraction.
30 Aug, 2022 | 12:14h | UTCNews Release: Patients with heart failure benefit from dapagliflozin regardless of ejection fraction – European Society of Cardiology
Related:
Consensus Statement | Lipoprotein(a) in atherosclerotic cardiovascular disease and aortic stenosis.
30 Aug, 2022 | 12:10h | UTC
Commentary on Twitter
Lipoprotein(a) in atherosclerotic CV and aortic stenosis – a European Atherosclerosis Society consensus statement https://t.co/Bzzpd3Bx8M
#EHJ #ESCCongress #ESCYoung @escardio @ehj_ed @rladeiraslopes pic.twitter.com/ZcqaPe581K
— European Society of Cardiology Journals (@ESC_Journals) August 29, 2022
#ESCCongress | In critically ill patients with COVID-19, full-dose anticoagulation reduced thrombotic events but increased the risk of bleeding.
30 Aug, 2022 | 12:12h | UTCNews Release: Trial supports full-dose anticoagulation to prevent blood clots in COVID-19 patients – European Society of Cardiology
Related:
Anticoagulants for people hospitalised with COVID‐19 – Cochrane Library
Commentary on Twitter
#OriginalResearch SimPub #ESCCongress: In the #COVID-PACT 2×2 factorial RCT, full-dose prophylactic anticoagulation, but not the addition of clopidogrel, reduced thrombotic complications but w/ increased bleeding among critically-ill patients w/ COVID-19 https://t.co/UNxFCIC5B9 pic.twitter.com/p5LGmpCGeL
— Circulation (@CircAHA) August 29, 2022
Guideline | Management of medication overuse and medication overuse headache.
30 Aug, 2022 | 12:08h | UTC
Salt substitutes vs. regular salt: a quick look.
30 Aug, 2022 | 12:02h | UTCSalt substitutes vs. regular salt: a quick look – Evidently Cochrane
Original Study: Replacing salt with low‐sodium salt substitutes (LSSS) for cardiovascular health in adults, children and pregnant women – Cochrane Library
Related:
Effects of salt substitutes on clinical outcomes: a systematic review and meta-analysis – Heart (link to abstract – $ for full-text)
RCT: Reduced-sodium added-potassium salt substitute reduces blood pressure in hypertensive patients
Potassium Enriched Salt Substitution Could Prevent a Large Number of Cardiovascular Deaths
Commentary on Twitter
https://twitter.com/CochraneLibrary/status/1563130897159028737
Case series of acute cholecystitis associated with the use of Glucagon-Like Peptide-1 Receptor agonists reported to the US Food and Drug Administration.
30 Aug, 2022 | 11:59h | UTCAcute Cholecystitis Associated With the Use of Glucagon-Like Peptide-1 Receptor Agonists Reported to the US Food and Drug Administration – JAMA Internal Medicine (free for a limited period)