Internal Medicine
Cohort Study | Risk factors for heart disease and stroke are largely similar in men and women globally.
14 Sep, 2022 | 13:18h | UTCNews Release: Risk factors for heart disease and stroke are largely similar in men and women globally, finds study – McMaster University
Original Study: Metabolic, behavioural, and psychosocial risk factors and cardiovascular disease in women compared with men in 21 high-income, middle-income, and low-income countries: an analysis of the PURE study – The Lancet (link to abstract – $ for full-text)
Commentary on Twitter
https://twitter.com/TheLancet/status/1569636002762817536
RCT | Extended duration thromboprophylaxis (continued for 56 days postoperatively) is not beneficial after surgical resection of colorectal cancer.
14 Sep, 2022 | 13:22h | UTC
Cohort Study | Prospective associations of daily step counts and intensity with cancer and cardiovascular disease incidence and mortality and all-cause mortality.
14 Sep, 2022 | 13:17h | UTCCommentaries:
Higher Step Counts Equal Better CV Health: UK Biobank – TCTMD
Pace as important as 10,000 steps for health, finds new research – University of Sidney
How Many Steps a Day (and How Fast) to Lengthen Your Life? – HealthDay
M-A of randomized trials | In patients hospitalized with community-acquired pneumonia, corticosteroids reduce the need for mechanical ventilation without significant effects on mortality, treatment failure, or adverse events.
14 Sep, 2022 | 13:16h | UTCEffect of corticosteroids on mortality and clinical cure in community-acquired pneumonia: A systematic review, meta-analysis, and meta-regression of randomized control trials – CHEST Journal (link to abstract – $ for full-text)
Cohort Study | Incidence of antipsychotic use among community dwellers with and without Parkinson’s disease.
14 Sep, 2022 | 13:07h | UTCCommentaries:
Elevated Incidence of Antipsychotic Use Found Prior to Parkinson Disease Diagnosis – AJMC
Antipsychotics Use Climbs in Years Before Parkinson’s Diagnosis: Study – Parkinson’s News Today
RCT | Dexamethasone is not effective for the treatment of dyspnea in patients with cancer and increases the risk of adverse events.
13 Sep, 2022 | 13:22h | UTCEffect of dexamethasone on dyspnoea in patients with cancer (ABCD): a parallel-group, double-blind, randomised, controlled trial – The Lancet Oncology (free for a limited period)
Commentary on Twitter
Our phase III randomized study, published in Lancet Oncology today, showed high-dose steroid didn’t improve SOB and should not be used routinely in pts with lung ca for SOB palliation. My personal link in Lancet Oncology article ⁰https://t.co/Mj0AAzMujB pic.twitter.com/FMG7csHZsn
— Joe Y Chang (@JoeChangMD) September 7, 2022
Dementia: evidence, experience and resources.
13 Sep, 2022 | 13:20h | UTCDementia: evidence, experience and resources – Evidently Cochrane
RCT | A double-dose influenza vaccination during hospitalization for acute coronary syndrome did not improve outcomes compared to standard-dose outpatient vaccination.
13 Sep, 2022 | 13:19h | UTC
Commentary on Twitter
In the VIP-ACS trial, among patients hospitalised with an ACS, double dose influenza vaccination before discharge does not reduce cardiovascular and pulmonary outcomes compared with standard dose vaccination 👉https://t.co/L9e7MXWfWV#EHJ #ESCCongress @ehj_ed @rladeiraslopes pic.twitter.com/95o50krrwm
— European Society of Cardiology Journals (@ESC_Journals) August 31, 2022
Review / Perspective | Which patients with aortic stenosis should be referred to surgery rather than transcatheter aortic valve implantation?
13 Sep, 2022 | 13:18h | UTC
Commentary on Twitter
https://twitter.com/ESC_Journals/status/1526080012729864198
M-A | Blood type linked to the risk of stroke before age 60.
13 Sep, 2022 | 13:17h | UTCContribution of Common Genetic Variants to Risk of Early Onset Ischemic Stroke – Neurology (link to abstract – $ for full-text)
News Releases:
Is your blood type linked to your risk of stroke before age 60? – American Academy of Neurology
Blood Type Linked To Stroke Risk Before 60 – University of Maryland
Cohort Study | Incidence, timing, and causes of late bleeding after TAVR.
13 Sep, 2022 | 13:10h | UTCIncidence, Timing, and Causes of Late Bleeding After TAVR in an Asian Cohort – JACC: Asia
Editorial: Late Bleeding Following TAVR in Japan: An Important Cause of Mortality – JACC: Asia
Commentary: Late Bleeding Not Rare, Ups Mortality After TAVI in All-Asian Cohort: OCEAN-TAVI – TCTMD
Retrospective Cohort Study | Outcomes of partial oral antibiotic treatment for complicated S. aureus bacteremia in people who inject drugs.
13 Sep, 2022 | 13:09h | UTCOutcomes of Partial Oral Antibiotic Treatment for Complicated S. aureus Bacteremia in People Who Inject Drugs – Clinical Infectious Diseases (free PDF for a limited period)
Commentaries on Twitter
Interesting cohort study from @WashUID led by @LauraMarks5: IV–>PO antibiotics for PWID with Staph bacteremia associated with comparable outcomes to "standard of care" all IV, esp after 10 days of IV. Don't d/c all abx at time of discharge! @CIDJournal https://t.co/0rOfYSTnkH pic.twitter.com/yqCjifWAEK
— Paul Sax (@PaulSaxMD) September 6, 2022
🆕⚡⚡#CID @LauraMarks5
PWID w comp SA bacteremia who received oral antibiotics after an incomplete IV antibiotic(~10d) were significantly less likely to experience microbiologic failure or death than pts discharged without oral antibiotics #IDTwitter https://t.co/5zXeNfx2YL pic.twitter.com/hVhFD4iJik— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) September 2, 2022
Review | Acute pancreatitis: diagnosis and treatment.
13 Sep, 2022 | 13:04h | UTCAcute Pancreatitis: Diagnosis and Treatment – Drugs
Commentaries:
Evidence-Based Disposition of Acute Pancreatitis – emDocs
Pancreatitis – National Institute for Health and Care Excellence
Levoketoconazole in the treatment of patients with endogenous Cushing’s syndrome: a double-blind, placebo-controlled, randomized withdrawal study.
13 Sep, 2022 | 13:02h | UTCRelated study: Efficacy and safety of levoketoconazole in the treatment of endogenous Cushing’s syndrome (SONICS): a phase 3, multicentre, open-label, single-arm trial – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)
Practical Recommendations | How to deal with sleep problems during heat waves.
11 Sep, 2022 | 23:00h | UTCCommentary: How to sleep in a heat wave, according to experts – CNN
Two large clinical trials showed Vitamin D supplements do not reduce the risk of Covid-19.
11 Sep, 2022 | 22:56h | UTCEditorial: Can vitamin D protect against covid-19? – The BMJ
News Release: No link between vitamin D supplements and reduced risk of covid-19 – BMJ Newsroom
Cohort study showed a possible link between artificial sweeteners and heart disease.
11 Sep, 2022 | 22:55h | UTCNews Release: Possible link between artificial sweeteners and heart disease – BMJ Newsroom
Original Study: Artificial sweeteners and risk of cardiovascular diseases: results from the prospective NutriNet-Santé cohort – The BMJ
Monkeypox: disease epidemiology, host immunity and clinical interventions.
11 Sep, 2022 | 22:54h | UTC
Commentary on Twitter
Monkeypox: disease epidemiology, host immunity and clinical interventions https://t.co/dmu06NZoPt pic.twitter.com/vZqbxp7Wzn
— Nature Rev Immunol (@NatRevImmunol) September 8, 2022
Guideline | Perioperative care of patients undergoing major complex spinal instrumentation surgery.
11 Sep, 2022 | 22:49h | UTC
Nonadherence was revealed through measurements of serum concentrations of antihypertensive drugs in one-third of patients with resistant hypertension previously evaluated as adherent.
11 Sep, 2022 | 22:35h | UTC
M-A | Combination therapy with rifaximin and lactulose in hepatic encephalopathy.
11 Sep, 2022 | 22:33h | UTCCommentary: Rifaximin Plus Lactulose Linked to Greater Effectiveness, Decreased Mortality in HE – AJMC
Early versus delayed non–vitamin k antagonist oral anticoagulant therapy after acute ischemic stroke in atrial fibrillation: a registry-based randomized controlled noninferiority study.
8 Sep, 2022 | 14:46h | UTCEarly Versus Delayed Non–Vitamin K Antagonist Oral Anticoagulant Therapy After Acute Ischemic Stroke in Atrial Fibrillation (TIMING): A Registry-Based Randomized Controlled Noninferiority Study – Circulation (free for a limited period)
Commentary on Twitter
Congrats to my good friend/colleague @BoNorrving for the TIMING study! Starting NOAC after stroke d/t AF <4 d is safe (no ICH) and = or better than 5-10 d. Registry-based, pragmatic, investigator led, PROBE design. High value = science first approach.
https://t.co/35qiZ5Ivoa— Dr. Lee Schwamm (@Braindoc_MGH) September 7, 2022
Guideline Summary | Management of patients with suspected or confirmed antibiotic allergy.
8 Sep, 2022 | 14:42h | UTCRelated:
M-A: Most patients with allergy to Penicillin can be given Cefazolin
Podcast: A Clinical Pharmacologist’s Perspective on Penicillin Allergy
Study: Development and Validation of a Penicillin Allergy Clinical Decision Rule
NICE: Double Check Patients with ‘Penicillin Allergy’ to Avoid Increased MRSA Risk
International consensus statement on obstructive sleep apnea.
8 Sep, 2022 | 14:41h | UTCInternational consensus statement on obstructive sleep apnea – Allergy & Rhinology (PDF)
Systematic Review | Chest physiotherapy for pneumonia in adults.
8 Sep, 2022 | 14:36h | UTCChest physiotherapy for pneumonia in adults – Cochrane Library
Summary: Chest physiotherapy for pneumonia in adults – Cochrane Library