Internal Medicine | Page 71 of 487 | Links Medicus Content Curation & Alerts in Medicine

RCT | Efficacy of BCG vaccination in reducing the incidence and severity of COVID-19 in a high-risk population.

19 Oct, 2022 | 14:26h | UTC

Efficacy of Bacillus Calmette–Guérin (BCG) Vaccination in Reducing the Incidence and Severity of COVID-19 in High-Risk Population (BRIC): a Phase III, Multi-centre, Quadruple-Blind Randomised Control Trial – Infectious Diseases and Therapy

Case-control study | Odds of hospitalization for COVID-19 after 3 vs. 2 doses of mRNA vaccine by time since booster dose.

19 Oct, 2022 | 14:27h | UTC

Odds of Hospitalization for COVID-19 After 3 vs 2 Doses of mRNA COVID-19 Vaccine by Time Since Booster Dose – JAMA

News Release: Study indicates COVID-19 boosters among vaccinated individuals significantly reduce hospitalization rates – Providence Health & Services

Systematic Review | Antihistamines to prevent and treat motion sickness.

19 Oct, 2022 | 14:21h | UTC

Antihistamines for motion sickness – Cochrane Library

Summary: Antihistamines to prevent and treat motion sickness – Cochrane Library

Commentary on Twitter

New from Cochrane Evidence: Antihistamines are likely to reduce the risk of developing motion sickness in susceptible adults under normal conditions, e.g. traveling by car or boat, but they may be more likely to cause drowsiness than placebo https://t.co/l3gtX9ad7T… pic.twitter.com/EcQZYmwMrU

— Cochrane ENT (@CochraneENT) October 17, 2022

Pneumonia update for emergency clinicians.

19 Oct, 2022 | 14:19h | UTC

Pneumonia Update for Emergency Clinicians – Current Emergency and Hospital Medicine Reports

RCT | Combination of pitavastatin and ezetimibe vs. monotherapy of pitavastatin in patients with primary hypercholesterolemia.

19 Oct, 2022 | 14:15h | UTC

A Multicenter, Randomized, Double-Blind, Active-Controlled, Factorial Design, Phase III Clinical Trial to Evaluate the Efficacy and Safety of Combination Therapy of Pitavastatin and Ezetimibe Versus Monotherapy of Pitavastatin in Patients With Primary Hypercholesterolemia – Clinical Therapeutics

M-A | Cardiovascular and renal efficacy and safety of sodium-glucose cotransporter-2 inhibitors in patients without diabetes.

19 Oct, 2022 | 14:11h | UTC

Cardiovascular and renal efficacy and safety of sodium-glucose cotransporter-2 inhibitors in patients without diabetes: a systematic review and meta-analysis of randomised placebo-controlled trials – BMJ Open

Retrospective Cohort Study | Trends in the association between diabetes and cardiovascular events, 1994-2019.

18 Oct, 2022 | 12:58h | UTC

Trends in the Association Between Diabetes and Cardiovascular Events, 1994-2019 – JAMA (free for a limited period)

RCT | Two-year effects of Semaglutide in adults with overweight or obesity.

18 Oct, 2022 | 12:53h | UTC

Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial – Nature Medicine

Commentary: STEP 5: Sustained semaglutide treatment maintains weight loss – medwire News

RCT: Effect of continued weekly subcutaneous Semaglutide vs. placebo on weight loss maintenance in adults with overweight or obesity

RCT: High dose once a week Semaglutide (2.4 mg) in adults with overweight or obesity, and type 2 diabetes

RCT: Effect of high-dose subcutaneous Semaglutide vs. placebo in adults with overweight or obesity

RCT: Once-weekly, high-dose semaglutide is effective for improving overweight or obesity among non-diabetic adults

Commentary on Twitter

Results from the STEP 5, testing #semaglutide as an adjuct to behavioral interventions in adults with #overweight or #obesity, demonstrate sustained #weightloss over a period of 104 weeks. @ProfBatterhamMD @seanwharton @DrGeorgiaRigas https://t.co/0mBtzhCYID

— Nature Medicine (@NatureMedicine) October 11, 2022

Perspective | The polypill: from concept and evidence to implementation.

18 Oct, 2022 | 12:55h | UTC

The polypill: from concept and evidence to implementation – The Lancet (free registration required)

News Release: The polypill could avoid millions of premature deaths, heart attacks and strokes every year, say leading cardiology experts – McMaster University

#ESCCongress | In patients within 6 months of a myocardial infarction, a polypill containing aspirin, ramipril, and atorvastatin resulted in a lower risk of major adverse cardiovascular events compared to usual care.

#ESCCongress – M-A: Polypills with and without aspirin substantially reduce cardiovascular disease, myocardial infarction, stroke, revascularization, and cardiovascular death in primary cardiovascular disease prevention.

Opinion: A new important study supports wider use of the polypill

#AHA20 – Randomized trial: A polypill comprising statins, multiple blood pressure lowering drugs, and aspirin prevents cardiovascular events among patients at intermediate cardiovascular risk

Perspective: Are Polypills and Population-based Treatment the Next Big Things?

The Polypill Revisited: Why We Still Need Population-Based Approaches in the Precision Medicine Era

Randomized Trial: Polypill for Cardiovascular Disease Prevention in an Underserved Population

Randomized Trial: Effectiveness of Polypill for Primary and Secondary Prevention of Cardiovascular Diseases

Clinical Impact of the Polypill for Cardiovascular Prevention in Latin America: A Consensus Statement of the Inter-American Society of Cardiology – Global Heart

Perspective: The Polypill and the Long Journey to Major Impact

Research: Low-Dose ‘Triple Pill’ Lowers Blood Pressure More Than Usual Care

Guideline | Diagnosis and management of febrile neutropenia in patients with cancer.

18 Oct, 2022 | 12:52h | UTC

The Dutch Working Party on Antibiotic Policy (SWAB) Recommendations for the Diagnosis and Management of Febrile Neutropenia in Patients with Cancer – Infectious Diseases and Therapy

Outpatient Management of Fever and Neutropenia in Adults Treated for Malignancy: American Society of Clinical Oncology and Infectious Diseases Society of America Clinical Practice Guideline Update – Journal of Clinical Oncology

Management of sepsis in neutropenic cancer patients: 2018 guidelines from the Infectious Diseases Working Party (AGIHO) and Intensive Care Working Party (iCHOP) of the German Society of Hematology and Medical Oncology (DGHO) – Annals of Hematology

SEOM clinical practice guideline: management and prevention of febrile neutropenia in adults with solid tumors (2018) – Clinical and Translational Oncology

Diagnosis and empirical treatment of fever of unknown origin (FUO) in adult neutropenic patients: guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO)

Guideline for the Management of Fever and Neutropenia in Children With Cancer and Hematopoietic Stem-Cell Transplantation Recipients: 2017 Update

Guideline | Sarcopenia: screening, diagnosis, management and prevention.

18 Oct, 2022 | 12:51h | UTC

Singapore Clinical Practice Guidelines For Sarcopenia: Screening, Diagnosis, Management and Prevention – The Journal of Frailty & Aging

Physical Frailty: ICFSR International Clinical Practice Guidelines for Identification and Management – The journal of nutrition, health & aging

Best practice guidelines for the management of frailty: a British Geriatrics Society, Age UK and Royal College of General Practitioners report – Age and Ageing

Systematic Review | Reconstructive surgery for treating pressure ulcers – little evidence to guide recommendations.

18 Oct, 2022 | 12:46h | UTC

Reconstructive surgery for treating pressure ulcers – Cochrane Library

Cohort Study | Association of daily step count and intensity with incident dementia.

18 Oct, 2022 | 12:38h | UTC

Association of Daily Step Count and Intensity With Incident Dementia in 78 430 Adults Living in the UK – JAMA Neurology

Commentaries:

Walking Daily Linked to Lower Dementia Risk, but How Many Steps Does It Take? – Psychiatric News Alert

Higher Step Counts Equal Better CV Health: UK Biobank – TCTMD

Cohort Study | Association of step counts over time with the risk of chronic diseases.

Cohort Study | Prospective associations of daily step counts and intensity with cancer and cardiovascular disease incidence and mortality and all-cause mortality.

Daily steps and all-cause mortality: a meta-analysis of 15 international cohorts.

M-A | Impact of metformin on the clinical and metabolic parameters of women with polycystic ovary syndrome.

18 Oct, 2022 | 12:37h | UTC

Impact of metformin on the clinical and metabolic parameters of women with polycystic ovary syndrome: a systematic review and meta-analysis of randomised controlled trials – Therapeutic Advances in Endocrinology and Metabolism

Post-trial follow-up | Longer-term all-cause and cardiovascular mortality with intensive blood pressure control.

17 Oct, 2022 | 12:41h | UTC

Longer-Term All-Cause and Cardiovascular Mortality With Intensive Blood Pressure Control: A Secondary Analysis of a Randomized Clinical Trial – JAMA Cardiology (free for a limited period)

Author Interview: Longer-Term All-Cause and Cardiovascular Mortality With Intensive Blood Pressure Control – JAMA

Commentaries:

Benefits of Intensive Blood Pressure Control May Not Persist After Trial Intervention – HCP Live

Study Highlights Importance of Long-term Management of Hypertension – Wake Forest University School of Medicine

SPRINT Trial final report: targeting a systolic BP of less than 120 mm Hg in patients at increased CV risk is associated with improved CV and mortality outcomes but increases the risk of serious adverse events.

Study: Real-world blood pressure measurements vs. measurements taken in the SPRINT trial

Studies: Intensive versus Standard Blood-Pressure Control

Commentary on Twitter

In a secondary analysis of SPRINT, the mortality benefits of intensive BP control attenuated after the trial, while outpatient systolic BP increased by an average of 7 mm Hg for participants in the intensive treatment group. https://t.co/INSo2zYzhp #Research

— JAMA Cardiology (@JAMACardio) October 12, 2022

[Not published yet] Aspirin noninferior to LMW Heparin for prevention of death or pulmonary embolism after fracture surgery.

17 Oct, 2022 | 12:36h | UTC

Aspirin as effective as standard blood thinner to prevent life-threatening blood clots and death after fracture surgery – University of Maryland School of Medicine

Position Statement | Use of biomarkers for the management of heart failure and acute coronary syndrome.

17 Oct, 2022 | 12:34h | UTC

Saudi Heart Association Position Statement on the Use of Biomarkers for the Management of Heart Failure and Acute Coronary Syndrome – Journal of the Saudi Heart Association

Cohort Study | Visit-to-visit SBP variability linked to increased risk of atrial fibrillation in middle-aged and older populations.

17 Oct, 2022 | 12:30h | UTC

Visit-to-visit SBP variability and risk of atrial fibrillation in middle-aged and older populations – Journal of Hypertension

Special Issue | Antibiotic resistance in the ICU.

17 Oct, 2022 | 12:28h | UTC

Homepage: Antibiotic Resistance

Editorial: Antibiotic Resistance

Antibiotic Stewardship in Critical and Emergency Care

Pharmacokinetic/Pharmacodynamic Principles to Combat Antimicrobial Resistance

Multidrug-Resistant Gram-Negative Bacteria in the ICU

Rapid Diagnostics and Antimicrobial Resistance in the ICU

Diagnostic Stewardship in Five Common Infectious Syndromes

Does Antimicrobial Resistance Affect Clinical Outcomes in the ICU?

Reducing Antibiotic Resistance in the ICU

Fungal infections | Pathogenesis, antifungals and alternate treatment approaches.

17 Oct, 2022 | 12:24h | UTC

Fungal infections: Pathogenesis, antifungals and alternate treatment approaches – Current Research in Microbial Sciences

Commentary on Twitter

Fungal infections:

Pathogenesis, antifungals and alternate treatment approacheshttps://t.co/JMcmzsL3GA #OpenAccess pic.twitter.com/5xAi5IGRGf

— MicrobesInfect (@MicrobesInfect) April 27, 2022

Under a Creative Commons license