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Internal Medicine

M-A | Safety and efficacy of interrupting dual antiplatelet therapy one month following percutaneous coronary intervention.

1 Nov, 2022 | 12:14h | UTC

Safety and efficacy of interrupting dual antiplatelet therapy one month following percutaneous coronary intervention: a meta-analysis of randomized controlled trials – BMC Cardiovascular Disorders

 

Commentary on Twitter

Under a http://creativecommons.org/licenses/by/4.0/ license

 


Guideline | Acute behavioral disturbance in emergency departments.

1 Nov, 2022 | 12:10h | UTC

Acute Behavioural Disturbance in Emergency Departments – Royal College of Emergency Medicine

 


M-A | The success rate of cardioversion for AF was similar between anterior-posterior vs. anterior-lateral electrodes position.

1 Nov, 2022 | 12:09h | UTC

Anterior-Posterior versus anterior-lateral electrodes position for electrical cardioversion of atrial fibrillation: A meta-analysis of randomized controlled trials – IJC Heart & Vasculature

 


RCT | Efficacy of RBX2660 for preventing recurrent Clostridioides difficile after antibiotic treatment.

1 Nov, 2022 | 12:07h | UTC

Efficacy and Safety of RBX2660 in PUNCH CD3, a Phase III, Randomized, Double-Blind, Placebo-Controlled Trial with a Bayesian Primary Analysis for the Prevention of Recurrent Clostridioides difficile Infection – Drugs

Commentary: RBX2660 shows promise in breaking the cycle of recurrent C. difficile – MDedge

 


Reviews | Pulmonary embolism response teams.

1 Nov, 2022 | 12:04h | UTC

Pulmonary Embolism Response Teams – emDocs

Related Review: Pulmonary embolism response teams: Purpose, evidence for efficacy, and future research directions – Research and Practice in Thrombosis and Haemostasis

 


Sarcopenia definition, diagnosis and treatment: consensus is growing.

1 Nov, 2022 | 12:01h | UTC

Sarcopenia definition, diagnosis and treatment: consensus is growing – Age and Ageing

Related:

Singapore Clinical Practice Guidelines For Sarcopenia: Screening, Diagnosis, Management and Prevention – The Journal of Frailty & Aging

Physical Frailty: ICFSR International Clinical Practice Guidelines for Identification and Management – The journal of nutrition, health & aging

Best practice guidelines for the management of frailty: a British Geriatrics Society, Age UK and Royal College of General Practitioners report – Age and Ageing

 


Cohort Study | Assessment of Cystatin C level for cardiovascular and mortality risk stratification in adults with mild CKD.

1 Nov, 2022 | 11:56h | UTC

Assessment of Cystatin C Level for Risk Stratification in Adults With Chronic Kidney Disease – JAMA Network Open

Commentary: Cystatin C Is a Better Marker of Cardiovascular Risk in CKD – Renal & Urology News

 

Commentary on Twitter

 


M-A | Association of SGLT2 inhibitors with cardiovascular outcomes and safety events.

1 Nov, 2022 | 11:56h | UTC

Association of sodium-glucose cotransporter 2 inhibitors with cardiovascular outcome and safety events: A meta-analysis of randomized controlled clinical trials – Frontiers in Cardiovascular Medicine

 


Brief Review | Preventing pressure injuries among patients in the intensive care unit.

1 Nov, 2022 | 11:50h | UTC

Preventing pressure injuries among patients in the intensive care unit: insights gained – Intensive Care Medicine

 

Commentary on Twitter

 


ACC Expert consensus for integrating atherosclerotic cardiovascular disease and multimorbidity treatment.

31 Oct, 2022 | 13:59h | UTC

2022 ACC Expert Consensus Decision Pathway for Integrating Atherosclerotic Cardiovascular Disease and Multimorbidity Treatment: A Framework for Pragmatic, Patient-Centered Care: A Report of the American College of Cardiology Solution Set Oversight Committee – Journal of the American College of Cardiology

Commentary: American College of Cardiology shares expert analysis on treating ASCVD patients with multiple chronic conditions – Cardiovascular Business

 

Commentary on Twitter

 


M-A of RCT | Comparison of low carbohydrate vs. low fat diets in Type 2 DM.

31 Oct, 2022 | 13:55h | UTC

Comparison of the Effectiveness of Low Carbohydrate Versus Low Fat Diets, in Type 2 Diabetes: Systematic Review and Meta-Analysis of Randomized Controlled Trials – Nutrients

 


RCT | Effects of a low-carbohydrate dietary intervention on hemoglobin A1c.

31 Oct, 2022 | 13:54h | UTC

Effects of a Low-Carbohydrate Dietary Intervention on Hemoglobin A1c: A Randomized Clinical Trial – JAMA Network Open

See also: Visual Abstract

News Release: At risk for diabetes? Cut the carbs, says new study – Tulane University

Commentaries:

Expert reaction to study looking at effects of a low-carbohydrate dietary intervention and improved glycaemia – Science Media Centre

Low-Carb Diet Promising for Lowering Blood Sugar in Prediabetes – TCTMD

 


Dose-reduced direct oral anticoagulants: practical considerations.

31 Oct, 2022 | 13:52h | UTC

Peripheral Matters | Dose-Reduced Direct Oral Anticoagulants: Practical Considerations – American College of Cardiology

 


Cohort Study | Risk factors of pancreatic cancer in patients with Type 2 DM.

31 Oct, 2022 | 13:47h | UTC

Risk Factors of Pancreatic Cancer in Patients With Type 2 Diabetes Mellitus: The Hong Kong Diabetes Study – Journal of the Endocrine Society

 


M-A of RCT | Combination of ulinastatin and somatostatin evaluated in acute pancreatitis.

31 Oct, 2022 | 13:44h | UTC

The combination of ulinastatin and somatostatin reduces complication rates in acute pancreatitis: a systematic review and meta-analysis of randomized controlled trials – Scientific Reports

 


WHO Report | Fungal priority pathogens list to guide research, development and public health action.

28 Oct, 2022 | 13:31h | UTC

WHO fungal priority pathogens list to guide research, development and public health action – World Health Organization

News Release: WHO releases first-ever list of health-threatening fungi – World Health Organization

 

Commentary on Twitter (thread – click for more)

 


RCT | Haloperidol for the treatment of delirium in ICU patients did not significantly improve outcomes.

28 Oct, 2022 | 13:29h | UTC

Haloperidol for the Treatment of Delirium in ICU Patients – New England Journal of Medicine (link to abstract – $ for full-text)

 

Commentary on Twitter

 


CDC study shows healthcare workers have a low risk of infection after exposure to patients with monkeypox.

28 Oct, 2022 | 13:21h | UTC

Health Care Personnel Exposures to Subsequently Laboratory-Confirmed Monkeypox Patients — Colorado, 2022 – Morbidity and Mortality Weekly Report

Commentaries:

Clinicians at Low Risk of Acquiring Monkeypox From Patients – JAMA

Low risk of monkeypox spread noted in health workers – CIDRAP

Risk of Monkeypox Transmission Low in Health Care Settings – HealthDay

 


RCT | Selective decontamination of the GI tract did not significantly reduce mortality in ICU patients on mechanical ventilation.

27 Oct, 2022 | 12:40h | UTC

Effect of Selective Decontamination of the Digestive Tract on Hospital Mortality in Critically Ill Patients Receiving Mechanical Ventilation: A Randomized Clinical Trial – JAMA (free for a limited period)

See also: Visual Abstract

Related study: Association Between Selective Decontamination of the Digestive Tract and In-Hospital Mortality in Intensive Care Unit Patients Receiving Mechanical Ventilation: A Systematic Review and Meta-analysis – JAMA (free for a limited period)

 


M-A | Selective decontamination of the GI tract may reduce in-hospital mortality in ICU patients receiving mechanical ventilation.

27 Oct, 2022 | 12:39h | UTC

Association Between Selective Decontamination of the Digestive Tract and In-Hospital Mortality in Intensive Care Unit Patients Receiving Mechanical Ventilation: A Systematic Review and Meta-analysis – JAMA (free for a limited period)

Related Study: Effect of Selective Decontamination of the Digestive Tract on Hospital Mortality in Critically Ill Patients Receiving Mechanical Ventilation: A Randomized Clinical Trial – JAMA (free for a limited period)

 


RCT | A lower oxygen saturation target did not improve outcomes after out-of-hospital cardiac arrest.

27 Oct, 2022 | 12:38h | UTC

Effect of Lower vs Higher Oxygen Saturation Targets on Survival to Hospital Discharge Among Patients Resuscitated After Out-of-Hospital Cardiac Arrest: The EXACT Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Early Oxygen Supplementation After Resuscitation From Cardiac Arrest – JAMA (free for a limited period)

Related:

RCT | In critically ill patients receiving MV, there was no difference in outcomes between different O2 saturation targets.

Effect of Low-Normal vs High-Normal Oxygenation Targets on Organ Dysfunction in Critically Ill Patients: A Randomized Clinical Trial – JAMA

Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure – New England Journal of Medicine

Oxygen targets – Intensive Care Medicine (if the link is paywalled, try this one)

Thoracic Society of Australia and New Zealand Position Statement on Acute Oxygen Use in Adults: ‘Swimming between the flags’ – Respirology

Long-term mortality and health-related quality of life of lower versus higher oxygenation targets in ICU patients with severe hypoxaemia – Intensive Care Medicine

Oxygen Targets During Mechanical Ventilation in the ICU: A Systematic Review and Meta-Analysis – Critical Care Explorations

Higher versus lower oxygenation strategies in the general intensive care unit population: A systematic review, meta-analysis and meta-regression of randomized controlled trials – Journal of Critical Care

 


Review | Monkeypox.

27 Oct, 2022 | 12:36h | UTC

Monkeypox – New England Journal of Medicine

Related:

Diagnosis and Management of Monkeypox: A Review for the Emergency Clinician – Annals of Emergency Medicine

Monkeypox: disease epidemiology, host immunity and clinical interventions.

Monkeypox: A clinical update for paediatricians – Journal of Pediatrics and Child Health

Cohort Study | Clinical presentation and virological assessment of confirmed human monkeypox virus cases in Spain.

CDC Report | Epidemiologic and clinical characteristics of Monkeypox cases in the US.

Update on the Monkeypox Outbreak – JAMA

Antivirals with Activity Against Monkeypox: A Clinically Oriented Review – Clinical Infectious Diseases

Clinical features and novel presentations of human monkeypox in a central London centre during the 2022 outbreak: descriptive case series – The BMJ

WHO Declares Global Public Health Emergency Over Monkeypox Virus Outbreak – Health Policy Watch

Monkeypox Virus Infection in Humans across 16 Countries — April–June 2022 – New England Journal of Medicine

Monkeypox: A Contemporary Review for Healthcare Professionals – Open Forum Infectious Diseases

 

Commentary on Twitter

 


Review | Iron deficiency and cardiovascular disease.

27 Oct, 2022 | 12:31h | UTC

Iron deficiency and cardiovascular disease – European Heart Journal

 

Commentary on Twitter

Under a https://creativecommons.org/licenses/by-nc/4.0/ license

 


Cohort Study | Cannabis, cocaine, methamphetamine, and opiates linked to increased risk of incident atrial fibrillation.

27 Oct, 2022 | 12:29h | UTC

Cannabis, cocaine, methamphetamine, and opiates increase the risk of incident atrial fibrillation – European Heart Journal

Editorial: Drug abuse and risk of atrial fibrillation: a neglected association – European Heart Journal

Commentaries:

Illicit drugs associated with increased likelihood of developing atrial fibrillation – European Society of Cardiology/News Medical

Marijuana, Meth, Cocaine Use Can Help Trigger Dangerous A-Fib – HealthDay

 

Commentary on Twitter

 


Case-control study | Alcohol intake as a risk factor for acute stroke.

27 Oct, 2022 | 12:26h | UTC

Alcohol Intake as a Risk Factor for Acute Stroke: The INTERSTROKE Study – Neurology (PDF)

 

Commentary on Twitter

 


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