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Internal Medicine

M-A | Efficacy and safety of Roxadustat in patients with chronic kidney disease.

29 Nov, 2022 | 14:00h | UTC

Efficacy and Safety of Roxadustat in Patients with Chronic Kidney Disease: An Updated Meta-Analysis of Randomized Controlled Trials including 6,518 Patients – BioMed Research International

Related:

Roxadustat Versus Epoetin Alfa for Treating Anemia in Patients with Chronic Kidney Disease on Dialysis: Results from the Randomized Phase 3 ROCKIES Study – Journal of the American Society of Nephrology

Roxadustat for Anemia in Patients with Kidney Disease Not Receiving Dialysis – New England Journal of Medicine

Roxadustat Treatment for Anemia in Patients Undergoing Long-Term Dialysis- New England Journal of Medicine

 

RCT | Rezafungin vs. caspofungin for treatment of candidaemia and invasive candidiasis.

29 Nov, 2022 | 13:54h | UTC

Rezafungin versus caspofungin for treatment of candidaemia and invasive candidiasis (ReSTORE): a multicentre, double-blind, double-dummy, randomised phase 3 trial – The Lancet (link to abstract – $ for full-text)

 

Review | Infectious complications of abortion.

29 Nov, 2022 | 13:56h | UTC

Infectious Complications of Abortion – Open Forum Infectious Diseases

 

Brief Review | Tailoring treatments to older people in intensive care. A way forward.

29 Nov, 2022 | 13:51h | UTC

Tailoring treatments to older people in intensive care. A way forward – Intensive Care Medicine

 

Commentary on Twitter

 

Brief Review | When the kidneys hurt, the other organs suffer.

29 Nov, 2022 | 13:50h | UTC

When the kidneys hurt, the other organs suffer – Intensive Care Medicine (if the link is paywalled, try this one)

 

Commentary on Twitter

 

2023 GOLD Report | Global strategy for prevention, diagnosis and management of COPD.

27 Nov, 2022 | 22:32h | UTC

2023 GOLD REPORT: global strategy for prevention, diagnosis and management of COPD: 2023 Report – Global Initiative for Chronic Obstructive Lung Disease

 

Seminar | Monkeypox.

27 Nov, 2022 | 22:29h | UTC

Monkeypox – The Lancet

Commentaries:

Study shows there is substantial monkeypox transmission before symptoms appear.

Global monkeypox case hospitalisation rates: A rapid systematic review and meta-analysis – eClinicalMedicine 

Human monkeypox virus infection in women and non-binary individuals during the 2022 outbreaks: a global case series – The Lancet 

Monkeypox — A Sobering Sentinel for Pandemic Preparedness and Sexual Health System Capacity – New England Journal of Medicine 

CDC study shows healthcare workers have a low risk of infection after exposure to patients with monkeypox. 

Monkeypox – New England Journal of Medicine 

Diagnosis and Management of Monkeypox: A Review for the Emergency Clinician – Annals of Emergency Medicine 

Monkeypox: disease epidemiology, host immunity and clinical interventions. 

Monkeypox: A clinical update for paediatricians – Journal of Pediatrics and Child Health 

Cohort Study | Clinical presentation and virological assessment of confirmed human monkeypox virus cases in Spain. 

CDC Report | Epidemiologic and clinical characteristics of Monkeypox cases in the US. 

Update on the Monkeypox Outbreak – JAMA 

Antivirals with Activity Against Monkeypox: A Clinically Oriented Review – Clinical Infectious Diseases 

Clinical features and novel presentations of human monkeypox in a central London centre during the 2022 outbreak: descriptive case series – The BMJ 

WHO Declares Global Public Health Emergency Over Monkeypox Virus Outbreak – Health Policy Watch 

Monkeypox Virus Infection in Humans across 16 Countries — April–June 2022 – New England Journal of Medicine 

Monkeypox: A Contemporary Review for Healthcare Professionals – Open Forum Infectious Diseases 

 

Commentary on Twitter

 

SR | E-cigarettes are more effective than traditional nicotine-replacement methods in helping people quit smoking.

27 Nov, 2022 | 22:26h | UTC

Electronic cigarettes for smoking cessation – Cochrane Library

News Release: E-cigarettes are more effective than nicotine-replacement therapy in helping smokers quit – University of Oxford

Commentaries: 

Latest Cochrane Review finds high certainty evidence that nicotine e-cigarettes are more effective than traditional nicotine-replacement therapy (NRT) in helping people quit smoking – Cochrane Library

Expert reaction to Cochrane review on electronic cigarettes for smoking cessation – Science Media Centre

 

Commentary on Twitter

 

Improving antimicrobial stewardship with penicillin allergy testing: a review of current practices and unmet needs.

27 Nov, 2022 | 22:25h | UTC

Improving antimicrobial stewardship with penicillin allergy testing: a review of current practices and unmet needs – JAC-Antimicrobial Resistance

Related:

Management of Patients with Suspected or Confirmed Antibiotic Allergy. Executive Summary of Guidance from the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC), the Spanish Society of Allergy and Clinical Immunology (SEAIC), the Spanish Society of Hospital Pharmacy (SEFH) and the Spanish Society of Intensive Medicine and Coronary Care Units (SEMICYUC) – Journal of Investigational Allergology and Clinical Immunology (PDF)

The prevalence of penicillin allergy labeling ranged from 0.9% to 10.2% across practices in a large pediatric cohort, raising questions regarding the validity of those labels and the unnecessary use of second-line antibiotics that may follow.

The prevalence of penicillin allergy labeling ranged from 0.9% to 10.2% across practices in a large pediatric cohort, raising questions regarding the validity of those labels and the unnecessary use of second-line antibiotics that may follow.

M-A: Most patients with allergy to Penicillin can be given Cefazolin

Systematic review: Safety and efficacy of de-labelling penicillin allergy in adults using direct oral challenge

Penicillin allergy labels increase second-line broad-spectrum antibiotic prescribing for pediatric respiratory tract infections

Podcast: A Clinical Pharmacologist’s Perspective on Penicillin Allergy

Study: Development and Validation of a Penicillin Allergy Clinical Decision Rule

Management of a surgical patient with a label of penicillin allergy: narrative review and consensus recommendations – British Journal of Anaesthesia

NICE: Double Check Patients with ‘Penicillin Allergy’ to Avoid Increased MRSA Risk

Cohort Study: Risk of Meticillin Resistant Staphylococcus Aureus and Clostridium Difficile in Patients with a Documented Penicillin Allergy

 

Consensus Paper | Prevention of alcohol withdrawal syndrome in the surgical ICU.

27 Nov, 2022 | 22:22h | UTC

Prevention of alcohol withdrawal syndrome in the surgical ICU: an American Association for the Surgery of Trauma Critical Care Committee Clinical Consensus Document – Trauma Surgery & Acute Care Open

 

M-A | Effectiveness of home-based exercise delivered by digital health in older adults.

27 Nov, 2022 | 22:20h | UTC

Effectiveness of home-based exercise delivered by digital health in older adults: a systematic review and meta-analysis – Age and Ageing

 

Commentary on Twitter

 

Review | Abdominophrenic dyssynergia.

27 Nov, 2022 | 22:15h | UTC

Abdominophrenic Dyssynergia: A Narrative Review – The American Journal of Gastroenterology

 

Commentary from the author on Twitter

 

ED-initiated buprenorphine: basics, barriers, and beyond the ED.

27 Nov, 2022 | 22:16h | UTC

ED-Initiated Buprenorphine: Basics, Barriers, and Beyond the ED – emDocs

 

Review | Public health measures and prevention of alcohol-associated liver disease.

27 Nov, 2022 | 22:14h | UTC

Public Health Measures and Prevention of Alcohol-Associated Liver Disease – Journal of Clinical and Experimental Hepatology

 

Commentary from one of the authors on Twitter

 

SR | Interventions for the long‐term prevention of hereditary angioedema attacks.

27 Nov, 2022 | 22:12h | UTC

Interventions for the long‐term prevention of hereditary angioedema attacks – Cochrane Library

Summary: Drug treatments for the prevention of attacks of hereditary angioedema – Cochrane Library

 

Commentary on Twitter

 

SR | Yoga for chronic non‐specific low back pain.

27 Nov, 2022 | 22:08h | UTC

Yoga for chronic non‐specific low back pain – Cochrane Library

Summary: Yoga for chronic non-specific low back pain – Cochrane Library

Commentaries: 

Yoga may have health benefits for people with chronic non-specific lower back pain – Cochrane Library

Is yoga good for back pain? Here’s the evidence – Evidently Cochrane

 

Evidence Analysis | Recognizing and managing frailty in older adults.

27 Nov, 2022 | 22:09h | UTC

Recognising and managing frailty in older adults – Cochrane Library

 

Review | Deprescribing proton pump inhibitors.

27 Nov, 2022 | 22:06h | UTC

Deprescribing proton pump inhibitors – Australian Journal of General Practice

 

M-A | Cardioprotective effects of influenza vaccination in patients with high risk of cardiovascular disease.

25 Nov, 2022 | 12:47h | UTC

Cardioprotective effects of influenza vaccination among patients with established cardiovascular disease or at high cardiovascular risk: a systematic review and meta-analysis – European Journal of Preventive Cardiology (free for a limited period)

Related:

RCT | Influenza vaccine to reduce adverse vascular events in patients with heart failure.

RCT | A double-dose influenza vaccination during hospitalization for acute coronary syndrome did not improve outcomes compared to standard-dose outpatient vaccination.

 

2ry analysis of a RCT | Decongestion with acetazolamide in acute heart failure across the spectrum of left ventricular EF.

25 Nov, 2022 | 12:45h | UTC

Decongestion with Acetazolamide in Acute Decompensated Heart Failure across the Spectrum of Left Ventricular Ejection Fraction: a Pre-specified Analysis from the ADVOR trial – Circulation

Original Study: RCT | Acetazolamide resulted in faster decongestion in patients with acute decompensated heart failure with volume overload.

 

Commentary on Twitter

 

Study shows there is substantial monkeypox transmission before symptoms appear.

25 Nov, 2022 | 12:43h | UTC

Transmission dynamics of monkeypox in the United Kingdom: contact tracing study – The BMJ

Editorial: The dynamics of monkeypox transmission – The BMJ

News Release: Evidence for “substantial” monkeypox transmission before symptoms – BMJ Newsroom

Commentaries:

Expert reaction to study looking at monkeypox transmission before symptoms appear – Science Media Centre

Study finds evidence of ‘considerable’ presymptomatic spread of monkeypox – The Guardian

 

RCT | Vitamin D fails to prevent statin-associated muscle symptoms among new statin users.

25 Nov, 2022 | 12:40h | UTC

Statin-Associated Muscle Symptoms Among New Statin Users Randomly Assigned to Vitamin D or Placebo – JAMA Cardiology (free for a limited period)

Commentary: Vitamin D fails to reduce statin-associated muscle pain – Northwestern University

 

Commentary on Twitter

 

Case–control study | GLP-1 receptor agonists linked to increased risk of thyroid cancer.

25 Nov, 2022 | 12:42h | UTC

GLP-1 Receptor Agonists and the Risk of Thyroid Cancer – Diabetes Care (link to abstract – $ for full-text)

Commentary: GLP-1 receptor agonists associated with thyroid cancer – ACP Internist

 

Cohort Study | Development of interstitial lung disease among patients with atrial fibrillation receiving oral anticoagulants.

25 Nov, 2022 | 12:23h | UTC

Development of Interstitial Lung Disease Among Patients With Atrial Fibrillation Receiving Oral Anticoagulants in Taiwan – JAMA Network Open

Commentaries:

Interstitial Lung Disease With Non–Vitamin K Oral Anticoagulants—A Clinical Concern? – JAMA Network Open

Slight Risk of Interstitial Lung Disease Seen With Certain DOACs – TCTMD

 

Review | Obesity as a risk factor for cardiac arrhythmias.

25 Nov, 2022 | 12:21h | UTC

Obesity as a risk factor for cardiac arrhythmias – BMJ Medicine

 

Commentary on Twitter

 

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