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Internal Medicine

Review | Revisiting resistant hypertension

1 Aug, 2023 | 14:16h | UTC

Revisiting resistant hypertension: a comprehensive review – Internal Medicine Journal

Related: Resistant hypertension: A stepwise approach – Cleveland Clinic Journal of Medicine

Podcast: #390 Resistant Hypertension – The Curbsiders

 


Review | Vegetarian and vegan diets: benefits and drawbacks

1 Aug, 2023 | 14:11h | UTC

Vegetarian and vegan diets: benefits and drawbacks – European Heart Journal (free for a limited period)

 

Commentary on Twitter

 


BTS Guideline for pleural disease

31 Jul, 2023 | 14:44h | UTC

British Thoracic Society Guideline for pleural disease – Thorax

 


Opinion Video | Critical analysis of the data behind Covid-19 booster shots

31 Jul, 2023 | 14:40h | UTC

“FLAWED Booster data was used by FDA for Mass Vax Campaign & We PROVE it in our new PAPER” – YouTube Video by Dr Vinay Prassad

Original Publication: Correspondence | Potential “healthy vaccinee bias” in a study of BNT162b2 vaccine against Covid-19

 


Observational Study | More data suggesting Rosuvastatin 10mg/Ezetimibe 10mg combo may be an alternative to Rosuvastatin 20mg

31 Jul, 2023 | 14:38h | UTC

Combination Lipid-Lowering Therapy in Patients Undergoing Percutaneous Coronary Intervention – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries:

Statins post PCI: Moderate intensity plus ezetimibe may be preferable – Cardiology News

Combination Lipid-Lowering Therapy After PCI – American College of Cardiology

Related: Open-label RCT | Moderate-intensity statin plus ezetimibe is noninferior to high-intensity statin monotherapy in patients with atherosclerotic cardiovascular disease.

 

Commentary on Twitter

 


M-A | Various exercise training modes reduce resting blood pressure, isometric exercise most effective

31 Jul, 2023 | 14:35h | UTC

Exercise training and resting blood pressure: a large-scale pairwise and network meta-analysis of randomised controlled trials – British Journal of Sports Medicine

News Release: Static isometric exercise, such as wall sits, best for lowering blood pressure – BMJ Newsroom

Commentary: Wall squats and planks best at lowering blood pressure – BBC

 


Review | Perioperative iron deficiency anemia

31 Jul, 2023 | 14:02h | UTC

Perioperative iron deficiency anaemia – BJA Education

 


RCT | Combined endovenous ablation and compression speeds up venous leg ulcers healing

31 Jul, 2023 | 13:49h | UTC

Endovenous ablation for venous leg ulcers – Cochrane Library

Summary: What are the benefits and risks of endovenous ablation (using heat or medication to permanently close veins) for treating venous leg ulcers – Cochrane Library

 


WHO updates guidelines on fats and carbohydrates

28 Jul, 2023 | 14:25h | UTC

News Release: WHO updates guidelines on fats and carbohydrates – World Health Organization

Guidelines:

Saturated fatty acid and trans-fatty acid intake for adults and children: WHO guideline – World Health Organization

Total fat intake for the prevention of unhealthy weight gain in adults and children: WHO guideline – World Health Organization

Carbohydrate intake for adults and children: WHO guideline – World Health Organization

 

Commentary on Twitter (thread – click for more)

 


Study | Only 11% of sports supplements listing botanical ingredients accurately declare contents, 12% contain FDA-prohibited stimulants

28 Jul, 2023 | 14:21h | UTC

Presence and Quantity of Botanical Ingredients With Purported Performance-Enhancing Properties in Sports Supplements – JAMA Network Open

Commentaries:

Ensuring the Safety and Value of Supplements – JAMA Network Open

Sports Supplements Can Be Contaminated with Botanical Stimulants and Anabolic Agents – NEJM Journal Watch

 


Position Paper | Prioritizing deprescribing in fall prevention strategies

28 Jul, 2023 | 14:12h | UTC

European position paper on polypharmacy and fall-risk-increasing drugs recommendations in the World Guidelines for Falls Prevention and Management: implications and implementation – European Geriatric Medicine

Original Guideline: World guidelines for falls prevention and management for older adults: a global initiative – Age and Ageing

 


Cohort Study | Exploring the potential impact of artificial sweeteners on type 2 diabetes risk

28 Jul, 2023 | 14:07h | UTC

Artificial Sweeteners and Risk of Type 2 Diabetes in the Prospective NutriNet-Santé Cohort – Diabetes Care

 


RCT | Liraglutide aids weight management in patients with suboptimal weight loss post metabolic surgery

28 Jul, 2023 | 14:05h | UTC

Safety and Efficacy of Liraglutide, 3.0 mg, Once Daily vs Placebo in Patients With Poor Weight Loss Following Metabolic Surgery: The BARI-OPTIMISE Randomized Clinical Trial – JAMA Surgery

See also: Visual Abstract

 


RCT – 2ry Analysis | Elevated intracranial bleeding risk with low-dose aspirin in older adults

27 Jul, 2023 | 13:09h | UTC

Low-Dose Aspirin and the Risk of Stroke and Intracerebral Bleeding in Healthy Older People: Secondary Analysis of a Randomized Clinical Trial – JAMA Network Open

See also: Visual Abstract

News Release: Low dose aspirin won’t help some older adults trying to avoid a stroke: study – Monash University

Commentary: Daily aspirin doesn’t prevent strokes in older, healthy people after all – The Conversation

Original Study: Randomized Trial: Effect of Aspirin on All-Cause Mortality in the Healthy Elderly

Related Guideline: USPSTF Recommendation Statement: Aspirin Use to Prevent Cardiovascular Disease.

Related Randomized Trials:

Randomized Trial: Aspirin for Primary Prevention of Cardiovascular Disease

Randomized Trial: Effects of Aspirin for Primary Prevention in Persons with Diabetes

Related Meta-Analysis:

Meta-Analysis: Association of Aspirin Use for Primary Prevention with Cardiovascular Events and Bleeding Events

Meta-Analysis: Efficacy and Safety of Aspirin for Primary Prevention of Cardiovascular Events

Aspirin for primary prevention of cardiovascular disease: a meta-analysis with a particular focus on subgroups – BMC Medicine

Related Opinions:

Aspirin for Primary Prevention: Is This the End of the Road?

Evidence evolving on aspirin as prevention – ACP Internist

#347 USPSTF Update: Aspirin for Primary Prevention of CVD – The Curbsiders

 


AGA clinical practice update on evaluation and management of belching, abdominal bloating, and distention

27 Jul, 2023 | 13:04h | UTC

AGA Clinical Practice Update on Evaluation and Management of Belching, Abdominal Bloating, and Distention: Expert Review – Gastroenterology

 


Cohort Study | 9.9% of patients acquire C. difficile carriage in healthcare facilities, most do not develop clinical infection

27 Jul, 2023 | 13:01h | UTC

Natural History of Clostridioides difficile Colonization and Infection Following New Acquisition of Carriage in Healthcare Settings: A Prospective Cohort Study – Clinical Infectious Diseases

 


Podcast | Obesity medicine, GLP1 agonists, weight loss management tools and tips

27 Jul, 2023 | 12:55h | UTC

#405 Obesity Medicine, GLP1 agonists, Weight Loss Management Tools and Tips – The Curbsiders

 


Podcast | Celiac disease pearls

27 Jul, 2023 | 12:53h | UTC

#89: Celiac Disease – The Great Mimicker – The Cribsiders

 


RCT | Pitavastatin effective in the primary prevention of cardiovascular disease in HIV-infected individuals

26 Jul, 2023 | 13:35h | UTC

Pitavastatin to Prevent Cardiovascular Disease in HIV Infection – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries:

Pitavastatin lowers risk of cardiovascular events in people living with HIV – Aidsmap

Statins reduce cardiovascular risk in people living with HIV, new global study finds – STAT

Pitavastatin Cuts MACE in HIV-Infected Patients: REPRIEVE – TCTMD

 

Commentary on Twitter

 


ISCHEMIA Trial 2ry Analysis | Patients with CCD and daily/weekly angina seem to benefit most from complete revascularization

26 Jul, 2023 | 13:33h | UTC

Complete Revascularization and Angina-Related Health Status in the ISCHEMIA Trial – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries:

Complete Revascularization and Angina-Related Health Status – American College of Cardiology

More Angina Relief With Complete Revascularization in Stable CAD: ISCHEMIA – TCTMD

Related/Original Articles:

Follow-up of the ISCHEMIA trial | Similar survival after invasive vs. conservative management of stable coronary disease.

ISCHEMIA Trial: Health-Status Outcomes with Initial Invasive vs. Conservative Care in Stable Coronary Disease

ISCHEMIA Trial: Initial Invasive vs. Conservative Strategy for Stable Coronary Disease

ISCHEMIA Trial: Health Status after Invasive or Conservative Care in Coronary and Advanced Kidney Disease

ISCHEMIA Trial: Management of Coronary Disease in Patients with Advanced Kidney Disease

 


Perspective | What does it mean to discover a coronary blockage?

26 Jul, 2023 | 13:31h | UTC

Chapter 1: What Does it Mean to Discover a Coronary Blockage? – By Dr John Mandrola

Chapter 2: On the meaning of a coronary blockage – By Dr John Mandrola

 


Perspective | Reconsidering the language of serious illness

26 Jul, 2023 | 13:29h | UTC

Reconsidering the Language of Serious Illness – JAMA (free for a limited period)

 

Commentary on Twitter

 


Mitigating neurological, cognitive, and psychiatric sequelae of COVID-19-related critical illness

26 Jul, 2023 | 13:28h | UTC

Mitigating neurological, cognitive, and psychiatric sequelae of COVID-19-related critical illness – The Lancet Respiratory Medicine

 


Systematic Review | Monocyte distribution width as a diagnostic marker for infection

26 Jul, 2023 | 13:26h | UTC

Monocyte Distribution Width as a Diagnostic Marker for Infection – CHEST

Related: Comparison of the Diagnostic Accuracies of Monocyte Distribution Width, Procalcitonin, and C-Reactive Protein for Sepsis: A Systematic Review and Meta-Analysis – Critical Care Medicine

 

Commentary on Twitter

 


Cohort Study | More data suggests SGLT-2 inhibitors could reduce gout flares

26 Jul, 2023 | 13:24h | UTC

Comparative Effectiveness of Sodium–Glucose Cotransporter-2 Inhibitors for Recurrent Gout Flares and Gout-Primary Emergency Department Visits and Hospitalizations: A General Population Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries:

SGLT-2 inhibitors reduced gout flares in patients with diabetes, gout – ACP Internist

SGLT2i Use Linked to Reduced Risk for Flare in Adults With Gout, T2D – HealthDay

SGLT2 inhibitors linked with fewer gout flares in diabetes – MDedge

 


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