Internal Medicine
Working up high: Hospitalist practice is different at altitude
16 Aug, 2017 | 15:44h | UTCWorking up high: Hospitalist practice is different at altitude – ACP Hospitalist (free)
Related reviews: Acute high-altitude sickness – European Respiratory Review (free) AND Chronic Mountain Sickness: Clinical Aspects, Etiology, Management, and Treatment – High Altitude Medicine & Biology (free)
An order not to hospitalize
16 Aug, 2017 | 15:17h | UTCAn order not to hospitalize – ACP Hospitalist (free)
Original article: Are Hospital/ED Transfers Less Likely Among Nursing Home Residents With Do-Not-Hospitalize Orders? – Journal of Post-Acute and Long-Term Care Medicine (link to abstract – $ for full-text)
Epilepsy ‘Not a Rare Condition’
16 Aug, 2017 | 14:23h | UTCReport: National and State Estimates of the Numbers of Adults and Children with Active Epilepsy — United States, 2015 – CDC MMWR (free)
Commentaries: Epilepsy Isn’t As Rare As Many Might Think – And Cases Are Increasing – Forbes (free) AND Epilepsy ‘Not a Rare Condition’ – MedPage Today (free registration required)
Syphilis in the ED: Presentations, Diagnosis, and Management of the Great Imitator
16 Aug, 2017 | 15:49h | UTCSyphilis in the ED: Presentations, Diagnosis, and Management of the Great Imitator – emDocs (free)
Study: diet soda can really mess with your metabolism
16 Aug, 2017 | 14:15h | UTCStudy: diet soda can really mess with your metabolism – VOX (free)
Original article: Integration of Sweet Taste and Metabolism Determines Carbohydrate Reward – Current Biology (link to abstract – $ for full-text)
See also a related meta-analysis showing little evidence of artificial sweeteners for weight loss in our July 18th issue (see #2)
“New research helps explain why artificial sweeteners are linked to obesity and metabolic disease”.
Standards for Diabetes Self-management Education and Support
16 Aug, 2017 | 13:20h | UTC2017 National Standards for Diabetes Self-management Education and Support – The Diabetes Educator (free)
Commentaries: ADA and AADE Update Standards for Diabetes Self-Management Education and Support – AJMC (free) AND Diabetes groups update standards for self-management – ACP Diabetes (free)
Occupation and Risk of Developing Rheumatoid Arthritis
16 Aug, 2017 | 14:03h | UTCOccupation and Risk of Developing Rheumatoid Arthritis: Results From a Population-Based Case-Control Study – Arthritis Care & Research (link to abstract – $ for full-text)
Commentaries: Certain occupations linked to an increased risk of rheumatoid arthritis – Willey, via EurekAlert (free) AND Occupational Exposures Increase Rheumatoid Arthritis Risk – Medscape (free registration required) AND Some jobs tied to higher risk of rheumatoid arthritis – Reuters (free)
Case-control study suggests bricklayers, concrete workers, electricians and nurses are at increased risk.
SGLT2 agents may reduce cardiovascular risk in diabetics
16 Aug, 2017 | 12:52h | UTCCardiovascular mortality and morbidity in patients with type 2 diabetes following initiation of sodium-glucose co-transporter-2 inhibitors versus other glucose-lowering drugs (CVD-REAL Nordic): a multinational observational analysis – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)
Related article: Lower Risk of Heart Failure and Death in Patients Initiated on SGLT-2 Inhibitors Versus Other Glucose-Lowering Drugs: The CVD-REAL Study – Circulation (free PDF)
Commentary: SGLT2 Agents Cut CV Events in ‘Real-World’ Analysis – MedPage Today (free registration required) AND Cardiovascular disease and mortality appear lower in patients on SGLT2 inhibitors – ACP Diabetes (free)
Another observational study suggests this class of drugs may reduce cardiovascular mortality and morbidity in patients with diabeties.
FDA Safety Alert: Liquid-filled Intragastric Balloon Systems
16 Aug, 2017 | 13:46h | UTCFDA Safety Alert: Liquid-filled Intragastric Balloon Systems: Letter to Healthcare Providers – Potential Risks (free)
Commentaries: Five People Die After Using Weight Loss Balloons for Obesity – Time (free) AND FDA Warns of Gastric Balloon Deaths – MedPage Today (free registration required) AND Five Deaths Tied to Intragastric Balloons, FDA Says – Medscape (free registration required)
Foot care for people with diabetes: prevention of complications and treatment
15 Aug, 2017 | 21:24h | UTCRelated guideline: Diabetic foot problems: prevention and management – National Institute for Health and Care Excellence (free)
Special issue: 60 years of metformin use
16 Aug, 2017 | 13:11h | UTCSpecial issue: 60 years of metformin use – Diabetologia (Source: ACP Diabetes Monthly)
– Editorial: 60 years of metformin use: a glance at the past and a look to the future (free)
– Metformin: historical overview (free)
– The mechanisms of action of metformin (free)
– Metformin: clinical use in type 2 diabetes (free)
– A new perspective on metformin therapy in type 1 diabetes (free)
– Metformin use in pregnancy: promises and uncertainties (free)
– Metformin and ageing: improving ageing outcomes beyond glycaemic control (free)
– Repurposing metformin for the prevention of cancer and cancer recurrence (free)
– The pharmacogenetics of metformin (free)
– Metformin therapy for the reproductive and metabolic consequences of polycystic ovary syndrome (free)
– The effects of metformin on gut microbiota and the immune system as research frontiers (free)
The Effects of Cannabis Among Adults With Chronic Pain
15 Aug, 2017 | 22:25h | UTCRelated article: Benefits and Harms of Plant-Based Cannabis for Posttraumatic Stress Disorder: A Systematic Review – Annals of Internal Medicine (free)
Commentaries: Evidence on cannabis for chronic pain and PTSD – American College of Physician’s, via EurekAlert (free) AND Evidence Lacking on Benefits of Cannabis for Treating Chronic Pain, PTSD – Physician’s First Watch (free) AND Limited evidence available to determine effectiveness and safety of cannabis to treat chronic pain – 2 Minute Medicine (free) AND Little evidence that marijuana helps chronic pain, PTSD, studies find – CNN (free text and video)
Relationship of Alcohol Consumption to All-Cause, Cardiovascular, and Cancer-Related Mortality
15 Aug, 2017 | 22:44h | UTCRelationship of Alcohol Consumption to All-Cause, Cardiovascular, and Cancer-Related Mortality in U.S. Adults – Journal of The American College of Cardiology (link to abstract and infographic – $ for full-text)
Commentaries: Consuming Alcohol in Moderation Can Lower Mortality Risks – American College of Cardiology, Latest in Cardiology (free) AND Alcohol Consumption and All-Cause, CV, and Cancer-Related Mortality – American College of Cardiology, Latest in Cardiology (free) AND Can drinking a little bit help you live longer? – Reuters (free)
Risk traumatic brain injuries associated with antidepressant use among patients with Alzheimer’s disease
15 Aug, 2017 | 20:40h | UTCCommentary: Antidepressant use increases risk of head injuries among persons with Alzheimer’s disease – University of Eastern Finland, via EurekAlert (free)
The 10-Year Prognostic Value of Zero and Minimal CAC
15 Aug, 2017 | 20:54h | UTCThe 10-Year Prognostic Value of Zero and Minimal CAC – Journal of The American College of Cardiology (no abstract – $ for full text)
Commentary: Calcium in Arteries Influences Heart Attack Risk – UT Southwestern Medical Center, via NewsWise (free) AND Study: Calcium in arteries influences heart attack risk – UPI (free)
“Half of the participants had no calcium deposits in their arteries or a zero coronary artery calcium, or CAC, score, and had less than a 3 percent chance of a cardiovascular event over a 10-year period despite having other risk factors for heart disease and stroke such as type 2 diabetes, high blood pressure and high bad cholesterol levels” (from UPI)
Longer sleep is associated with lower BMI and favorable metabolic profiles
15 Aug, 2017 | 19:45h | UTCCommentaries: Short sleep linked to body mass, waist size – Reuters (free) AND Insufficient sleep may be adding to your waistline – University of Leeds, via Science Daily (free)
Sepsis in the burn patient
15 Aug, 2017 | 19:29h | UTCReview: Sepsis in the burn patient: a different problem than sepsis in the general population – Burns & Trauma (free)
Blood pressure targets for hypertension in older adults
15 Aug, 2017 | 19:55h | UTCBlood pressure targets for hypertension in older adults – Cochrane Library (free)
Full review: Blood pressure targets for hypertension in older adults – Cochrane Library (link to abstract – $ for full-text)
Related guideline: Pharmacologic Treatment of Hypertension in Adults Aged 60 Years or Older to Higher Versus Lower Blood Pressure Targets: A Clinical Practice Guideline From ACP and AAFP (free)
“At the present time there is insufficient evidence to know whether a higher BP target (less than150 to 160/95 to 105 mmHg) or a lower BP target (less than 140/90 mmHg) is better for older adults with high BP”
Ibuprofen versus placebo effect on acute kidney injury in ultramarathons
15 Aug, 2017 | 16:09h | UTCIbuprofen versus placebo effect on acute kidney injury in ultramarathons: a randomised controlled trial – Emergency Medicine Journal (link to abstract – $ for full-text)
Commentaries: Ibuprofen linked to slight risk of kidney damage in ultramarathoners – Reuters (free) AND Study reveals harmful effects on kidney of Ibuprofen – Stanford Daily (free)
Chronic Pancreatitis: Current Status and Challenges for Prevention and Treatment
15 Aug, 2017 | 15:41h | UTCReview: Chronic Pancreatitis: Current Status and Challenges for Prevention and Treatment – Digestive Diseases and Sciences (free)
Related guidelines: United European Gastroenterology evidence-based guidelines for the diagnosis and therapy of chronic pancreatitis (free) AND Guidelines for the understanding and management of pain in chronic pancreatitis – Pancreatology (free)
The effect of high-flow nasal cannula in reducing the mortality and the rate of endotracheal intubation
15 Aug, 2017 | 16:26h | UTCThe effect of high-flow nasal cannula in reducing the mortality and the rate of endotracheal intubation when used before mechanical ventilation compared with conventional oxygen therapy and noninvasive positive pressure ventilation. A systematic review and meta-analysis – American Journal of Emergency Medicine (link to abstract – $ for full-text)
Related systematic review: High-flow nasal cannula oxygen therapy is superior to conventional oxygen therapy but not to noninvasive mechanical ventilation on intubation rate: a systematic review and meta-analysis – Critical Care (free)
Source: Hospital Medicine Virtual Journal Club
“When used before mechanical ventilation, high-flow nasal cannula can improve the prognosis of patients compared both with the conventional oxygen therapy and noninvasive positive pressure ventilation”
Pathogenesis and management of hypoglycemia
15 Aug, 2017 | 15:41h | UTCReview: Pathogenesis and management of hypoglycemia – European Journal of Endocrinology (free)
Management of urinary tract infections in patients with neurogenic bladder
15 Aug, 2017 | 15:38h | UTCReview: Management of urinary tract infections in patients with neurogenic bladder: challenges and solutions – Research and Reports in Urology (free)
Car crashes in older adult drivers using Zolpidem
15 Aug, 2017 | 01:13h | UTC“Car crashes in older adult drivers: Zolpidem (aOR 2.27) > zolpidem + zopiclone combo (aOR 2.20)” (RT @psychopharmacol see Tweet)
Richard Lehman’s journal review, 14 August 2017
15 Aug, 2017 | 01:01h | UTC8 – Richard Lehman’s journal review, 14 August 2017 – The BMJ Blogs (free)
Richard Lehman reviews the latest research in the top medical journals