Internal Medicine
Study: Local Anesthetic With or Without Corticosteroid for Lumbar Spinal Stenosis
26 Aug, 2017 | 16:22h | UTCSource: ACP Journal Wise ($)
“Epidural injections of corticosteroid plus lidocaine offered no benefits from 6 weeks to 12 months beyond that of injections of lidocaine alone”
Systematic Review: Low molecular weight heparin for prevention of venous thromboembolism in patients with lower-limb immobilization
26 Aug, 2017 | 19:37h | UTCLow molecular weight heparin for prevention of venous thromboembolism in patients with lower-limb immobilization – Cochrane Library (link to abstract – $ for full-text)
“Moderate-quality evidence showed that the use of LMWH in outpatients reduced DVT when immobilization of the lower limb was required, when compared with no prophylaxis or placebo”.
Systematic Review: Medical Treatment of Nocturia in Men with Lower Urinary Tract Symptoms
26 Aug, 2017 | 16:52h | UTCSource: ACP Journal Wise ($)
Study: Gastrointestinal Safety of Direct Oral Anticoagulants
26 Aug, 2017 | 16:46h | UTCCommentary: Which NOACS are riskiest for gastrointestinal bleeding? – Pharmacy News (free)
Source: ACP Journal Club ($)
Observational study suggests Apixaban may be associated with a more favorable gastrointestinal safety profile. Further randomized trials are needed to confirm these findings.
Review: Light-chain cardiac amyloidosis
26 Aug, 2017 | 16:08h | UTCLight-chain cardiac amyloidosis: strategies to promote early diagnosis and cardiac response – Heart (free)
Systematic review: Interventions to Prevent Age-Related Cognitive Decline, Mild Cognitive Impairment, and Clinical Alzheimer’s-Type Dementia
26 Aug, 2017 | 16:07h | UTC
Systematic Review: Preventing Complications and Treating Symptoms of Diabetic Peripheral Neuropathy
26 Aug, 2017 | 16:05h | UTCSystematic Review: Preventing Complications and Treating Symptoms of Diabetic Peripheral Neuropathy – Agency for Healthcare Research and Quality (US) (free)
Review: Changing Definitions of Sepsis
26 Aug, 2017 | 16:01h | UTCChanging Definitions of Sepsis – Turkish Journal of Anesthesiology and Reanimation (free)
Review: Lymphedema: From diagnosis to treatment
26 Aug, 2017 | 15:59h | UTCLymphedema: From diagnosis to treatment – Turkish Journal of Surgery (free)
Review: Drug-induced liver injury
26 Aug, 2017 | 15:48h | UTCReview: Drug-induced liver injury: recent advances in diagnosis and risk assessment – Gut (free)
Guideline: treatment of hypertension in people with diabetes
24 Aug, 2017 | 23:17h | UTCDiabetes and Hypertension: A Position Statement by the American Diabetes Association (free) (RT @Abraham_RMI and @ADA_Journals see Tweet)
Commentary: ADA Offers Position Statement on Diabetes and Hypertension – AJMC (free)
“the guideline continues the advice that most patients with diabetes should be treated to a blood pressure goal of <140/90 mm Hg; a goal of <130/80 can be considered for patients who have other cardiovascular risk factors” (from AJMC)
Guideline: use of imaging in the clinical management of peripheral joint osteoarthritis
24 Aug, 2017 | 23:09h | UTC
The Case for a Breakfast Feast
24 Aug, 2017 | 23:13h | UTCThe Case for a Breakfast Feast – The New York Times (free)
Related article: Meal Frequency and Timing Are Associated with Changes in Body Mass Index in Adventist Health Study 2 – The Journal of Nutrition (link to abstract – $ for full-text)
Systematic Review and Meta-analysis: Screening for Occult Cancer in Patients With Unprovoked Venous Thromboembolism
24 Aug, 2017 | 20:41h | UTCScreening for Occult Cancer in Patients With Unprovoked Venous Thromboembolism: A Systematic Review and Meta-analysis of Individual Patient Data – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Outcomes of limited cancer screening after unprovoked VTE similar to extensive screening – ACP Hospitalist (free) AND Cancer Screening Not Recommended in Patients With VTEs – Medscape (free registration required) AND Extensive cancer screening may not improve outcomes for patients with unprovoked venous thromboembolism – 2 Minute Medicine (free) AND Screening for Occult Cancer in Patients With Unprovoked Venous Thromboembolism – ASCO Post (free)
Randomized Clinical Trial: Oral Steroid Does Not Reduce Symptoms in Lower Respiratory Tract Infection
24 Aug, 2017 | 20:43h | UTCEffect of Oral Prednisolone on Symptom Duration and Severity in Nonasthmatic Adults With Acute Lower Respiratory Tract Infection: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
Commentaries: Oral Steroid Does Not Reduce Lower Respiratory Tract Infection Symptoms in Nonasthmatic Adults – JAMA Network (free) AND No Benefit for Oral Steroids in Lower Respiratory Tract Infection – Medscape (free registration required) AND Don’t use steroids for chest infections, GPs advised – Pulse (free)
In patients with acute respiratory infection, without evidence of pneumonia or asthma, the addition of corticosteroids did not reduce symptom duration or severity.
NT-proBNP not helpful for heart failure drug titration
24 Aug, 2017 | 20:34h | UTCEffect of Natriuretic Peptide–Guided Therapy on Hospitalization or Cardiovascular Mortality in High-Risk Patients With Heart Failure and Reduced Ejection Fraction: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
Commentaries: Natriuretic Peptide-Guided Therapy No Better Than Usual Care in Heart Failure Patients – Physician’s First Watch (free) AND NT-proBNP Tx Disappoints for HF Drug Titration – MedPage Today (free registration required)
Study: Longer sleep is associated with lower BMI and favorable metabolic profiles
24 Aug, 2017 | 20:38h | UTCCommentaries: Short sleep linked to body mass, waist size – Reuters (free) AND Insufficient sleep may be adding to your waistline – University of Leeds, via Science Daily (free)
Guideline: EULAR recommendations for the treatment of systemic sclerosis
24 Aug, 2017 | 20:36h | UTC
Review: Incidence, prevalence, and management of MRSA bacteremia
22 Aug, 2017 | 20:04h | UTC
Guidelines: diagnosis and management of noncystic fibrosis bronchiectasis
22 Aug, 2017 | 20:27h | UTC
Guideline: Prevention of acute kidney injury and protection of renal function in the intensive care unit
22 Aug, 2017 | 19:48h | UTCExpert opinion of the Working Group on Prevention, AKI section, European Society of Intensive Care Medicine
Study: Weight Loss Associated with Less Progression of Changes in Knee Articular Cartilage
22 Aug, 2017 | 19:58h | UTCCommentaries: Weight Loss Can Slow Down Knee Joint Degeneration – RSNA Press Release (free) AND Osteoarthritis: Knee joint degeneration slowed with weight loss, study confirms – Medical News Today (free)
Review: Cost-Effectiveness of Cardiotoxicity Monitoring
22 Aug, 2017 | 19:01h | UTCRelated Guidelines and Reviews: Prevention and Monitoring of Cardiac Dysfunction in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline (free) AND 2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines (free) AND Canadian Cardiovascular Society Guidelines for Evaluation and Management of Cardiovascular Complications of Cancer Therapy (free) AND Cardiotoxicity of anticancer treatments: Epidemiology, detection, and management – CA: A Cancer Journal for Clinicians (free) AND Radiation Associated Cardiac Disease – American College of Cardiology, Latest in Cardiology (free) AND Cardiac Toxicity Of Cancer Chemotherapy – US Cardiology Review (free)
Study: Particulate Matter Exposure and Stress Hormone Levels
22 Aug, 2017 | 18:36h | UTCCommentaries: Air pollution ups stress hormones, alters metabolismo – Reuters (free) AND AND Novel Study Shows How Air Pollution Increases CVD Risk – MedPage Today (free registration required) AND Air pollution linked to cardiovascular disease; air purifiers may lessen impact – American Heart Association, via Science Daily (free)
Related: The cost of a polluted environment: 1.7 million child deaths a year, says WHO – World Health Organization (free) AND Estimates and 25-year trends of the global burden of disease attributable to ambient air pollution: an analysis of data from the Global Burden of Diseases Study 2015 – The Lancet (free) AND Death in the Air: Air Pollution Costs Money and Lives – World Bank (free infographic and report)
Study: Dexamethasone vs Placebo on Acute Sore Throat in Adults
22 Aug, 2017 | 15:00h | UTCMultimedia: Author Interview (free) AND JAMA Report Video (free)
Commentaries: Study Examines Effectiveness of Steroid Medication for Sore Throat – The JAMA Network (free) AND Corticosteroids for sore throat: a mixed bag of results – Clinical Advisor (free)
Source: ACP Journal Club ($)
Dexamethasone increased complete symptom resolution at 48 hours (35.4% vs 27.1%), but not at 24 hours. Trade-offs between the benefits and risks of dexamethasone in this situation are uncertain.