Internal Medicine | Page 396 of 487 | Links Medicus Content Curation & Alerts in Medicine

“In adults with septic shock treated with low dose corticosteroids, short- and longer-term mortality are unaﬀected, adverse events increase, but duration of shock, mechanical ventilation and ICU stay are reduced”.

Guideline: Use of Atraumatic Needles in All Patients Undergoing Lumbar Puncture

23 May, 2018 | 12:32h | UTC

Rapid Recommendations: Atraumatic (pencil-point) versus conventional needles for lumbar puncture: a clinical practice guideline – The BMJ (free)

“We issue a strong recommendation for use of atraumatic needles in all patients (adults and children) undergoing lumbar puncture because they decrease complications and are no less likely to work than conventional needles”

Meta-Analysis: Aldosterone Antagonists for ST-Segment Elevation Myocardial Infarction Without Heart Failure

23 May, 2018 | 12:28h | UTC

Aldosterone Antagonist Therapy and Mortality in Patients With ST-Segment Elevation Myocardial Infarction Without Heart Failure: A Systematic Review and Meta-analysis – JAMA Internal Medicine (free for a limited period)

Invited Commentary: Mineralocorticoid Receptor Antagonists in ST-Segment Elevation Myocardial Infarction – JAMA Internal Medicine (free for a limited period)

Aldosterone antagonists are beneficial for patients with STEMI and reduced ejection fraction. This meta-analysis suggests that patients with STEMI and LVEF greater than 40% or without heart failure also have improved outcomes with aldosterone antagonists.

Randomized Trial: Five-Year Outcomes with PCI Guided by FFR

23 May, 2018 | 12:27h | UTC

Five-Year Outcomes with PCI Guided by Fractional Flow Reserve – New England Journal of Medicine (free)

Commentary: FFR in PCI for Stable CAD: Lasting Benefit Shown by FAME 2, SCAAR Data – TCTMD (free)

Retrospective Cohort: More Patients Choosing Active Surveillance for Low-Risk Prostate Cancer

23 May, 2018 | 12:17h | UTC

Use of Conservative Management for Low-Risk Prostate Cancer in the Veterans Affairs Integrated Health Care System From 2005-2015 – JAMA (free for a limited period)

Commentaries: VA health care successfully reduces ‘rush to treatment’ rates for low-risk prostate cancer – eCancer News (free) AND Watching but not treating cancer can be hard. Sometimes it’s the right approach – The Washington Post (a few articles per month are free)

Cohort Study: Amyloid-β (1-40) Predicts Mortality in Acute Coronary Syndrome

23 May, 2018 | 12:13h | UTC

Amyloid-β (1-40) and Mortality in Patients With Non–ST-Segment Elevation Acute Coronary Syndrome: A Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentary: Amyloid Biomarker Predictive of Mortality in Non-STEMI Heart Attack – MedicalResearch.com (free) AND Amyloid-Beta (1–40) Strong Predictor of Mortality in Acute Coronary Syndrome – NEJM Physician’s First Watch (free)

Randomized Controlled Trial: Canakinumab for the Treatment of Autoinflammatory Recurrent Fever Syndromes

23 May, 2018 | 12:13h | UTC

Canakinumab for the Treatment of Autoinflammatory Recurrent Fever Syndromes – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Autoinflammatory Syndromes Show Dramatic Response to Canakinumab – RheumNow (free)

Guideline Summary: CVD and Risk Management Standards in Diabetes

21 May, 2018 | 13:20h | UTC

Summary with Key Points: CVD and Risk Management Standards in Diabetes – American College of Cardiology (free)

Original Synopsis: Cardiovascular Disease and Risk Management: Review of the American Diabetes Association Standards of Medical Care in Diabetes 2018 – Annals of Internal Medicine (free)

Randomized Trial: Comparison of Intubation Techniques in Patients with Difficult Airways

21 May, 2018 | 13:18h | UTC

Effect of Use of a Bougie vs Endotracheal Tube and Stylet on First-Attempt Intubation Success Among Patients With Difficult Airways Undergoing Emergency Intubation: A Randomized Clinical Trial – JAMA (free for a limited period)

Commentaries: JC: Don’t blame it on the Bougie – St Emlyn’s (free) AND EM Nerd-The Peculiar Case of the Parallel Pathways – EmNerd (free) AND The humble bougie markedly boosts first-pass intubation success – Univadis (free registration required)

Meta-Analysis: Dose Increase vs. Unchanged Continuation of Antidepressants After Initial Treatment Failure

21 May, 2018 | 13:11h | UTC

Dose Increase Versus Unchanged Continuation of Antidepressants After Initial Antidepressant Treatment Failure in Patients With Major Depressive Disorder: A Systematic Review and Meta-Analysis of Randomized, Double-Blind Trials – The Journal of Clinical Psychiatry (link to abstract – $ for full-text)

Commentary: Depression: boosting SSRIs doesn’t work – Univadis (free registration required)

“Meta-analysis: there is evidence from RCTs against increasing the dose of SSRIs (with the possible exception of citalopram) in adult patients with major depression and antidepressant treatment failure” (via @psychopharmacol see Tweet)