Internal Medicine | Page 388 of 487 | Links Medicus Content Curation & Alerts in Medicine

“We found low-certainty evidence that either continuation or discontinuation of antiplatelet therapy before non-cardiac surgery may make little or no difference to mortality, bleeding requiring surgical intervention, or ischaemic events”.

Randomized Trial: Subacromial Decompression vs Diagnostic Arthroscopy for Shoulder Impingement

20 Jul, 2018 | 03:28h | UTC

Subacromial decompression versus diagnostic arthroscopy for shoulder impingement: randomised, placebo surgery controlled clinical trial – The BMJ (free)

Commentary: Most common shoulder operation is no more beneficial than placebo surgery – University of Helsinki, via EurekAlert (free)

Related research with similar results: Arthroscopic subacromial decompression for subacromial shoulder pain (free article, editorial and commentaries)

Randomized Trial: Glutamine to Treat Sickle Cell Disease

20 Jul, 2018 | 03:29h | UTC

A Phase 3 Trial of l-Glutamine in Sickle Cell Disease – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: Glutamine to Treat Sickle Cell Disease (free)

Commentaries: Drug may ease pain, lessen hospitalization from sickle cell disease – UPI (free)

Cohort Study: Sulfonylureas as Second Line Drugs in Type 2 Diabetes and the Risk of Adverse Outcomes

20 Jul, 2018 | 03:24h | UTC

Sulfonylureas as second line drugs in type 2 diabetes and the risk of cardiovascular and hypoglycaemic events: population based cohort study – The BMJ (free)

Editorial: Sulfonylureas as second line treatment for type 2 diabetes – The BMJ (free for a limited period)

Commentaries: Diabetes: Switching to Sulfonylureas from Metformin Linked to Increased Side Effects – MedicalResearch.com (free) AND Switching diabetes patients to sulfonylurea linked with complications – Pulse (free) AND Raised risk of MI and mortality when starting sulfonylurea – OnMedica (free)

Clinical Evidence Synopsis: Probiotics to Prevent Clostridium difficile Infection in Patients Receiving Antibiotics

20 Jul, 2018 | 03:23h | UTC

Probiotics to Prevent Clostridium difficile Infection in Patients Receiving Antibiotics – JAMA (free for a limited period)

Original Article: Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children – Cochrane Library (link to abstract – $ for full-text) AND Summary: The use of probiotics to prevent Clostridium difficile diarrhea associated with antibiotic use (free)

Cohort Study: Metformin and Risk of Hypertension

20 Jul, 2018 | 03:20h | UTC

Metformin and Risk of Hypertension in Taiwanese Patients With Type 2 Diabetes Mellitus – Journal of the American Heart Association (free)

“A reduced risk of hypertension is observed in metformin users in a dose‐response pattern”.

Randomized Trial: E-Counseling for Hypertension

20 Jul, 2018 | 03:07h | UTC

Randomized Controlled Trial of E-Counseling for Hypertension: REACH – Circulation: Cardiovascular Quality and Outcomes (free)

Commentaries: Virtual counseling helps lower blood pressure – AHA News (free) AND E-counseling can lower blood pressure, heart disease risk – Medical News Today (free)

Systematic Review: Omega-3 fatty Acids for the Prevention of Cardiovascular Disease

20 Jul, 2018 | 03:18h | UTC

Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease – Cochrane Library (link to abstract – $ for full-text)

Cochrane Summaries: New Cochrane health evidence challenges belief that omega 3 supplements reduce risk of heart disease, stroke or death (free) AND Omega-3 intake for cardiovascular disease (free)

Commentaries: Expert reaction to Cochrane review on omega-3 fatty acids and risk of heart disease, stroke and death – Science Media Centre (free) AND Omega 3 supplements don’t protect against heart disease – new review – The Conversation (free)

Related Meta-Analysis: Omega-3 Fatty Acid Supplements Don’t Reduce Cardiovascular Risk (free article and commentary)

Randomized Trial: Epinephrine in Out-of-Hospital Cardiac Arrest

20 Jul, 2018 | 03:19h | UTC

A Randomized Trial of Epinephrine in Out-of-Hospital Cardiac Arrest – New England Journal of Medicine (free)

Editorial: Testing Epinephrine for Out-of-Hospital Cardiac Arrest (free)

Commentary: Using adrenaline in cardiac arrests results in less than 1 percent more people leaving hospital alive – University of Warwick, via EurekAlert (free)

See also: Infographic detailing result findings (free)

“A clinical trial of the use of adrenaline in cardiac arrests has found that its use results in less than 1% more people leaving hospital alive – but almost doubles the risk of severe brain damage for survivors of cardiac arrest” (from University of Warwick).

ESMO Guideline: Management of Constipation in Advanced Cancer

20 Jul, 2018 | 03:06h | UTC

Diagnosis, assessment and management of constipation in advanced cancer: ESMO Clinical Practice Guidelines – Annals of Oncology (free)

Review: Noninvasive Ventilation in Acute Respiratory Failure

20 Jul, 2018 | 02:47h | UTC

Noninvasive ventilation in acute respiratory failure: which recipe for success? – European Respiratory Review (free)

Source: Critical Care Reviews Newsletter

Study: Overprescription of Antibiotics in Urgent Care Clinics

20 Jul, 2018 | 02:43h | UTC

Comparison of Antibiotic Prescribing in Retail Clinics, Urgent Care Centers, Emergency Departments, and Traditional Ambulatory Care Settings in the United States – JAMA Internal Medicine (free for a limited period)

Commentaries: Overprescription in Urgent Care Clinics—The Fast and the Spurious – JAMA Internal Medicine (free for a limited period) AND Urgent care centers often prescribe unnecessary antibiotics – Reuters (free) AND Study spotlights inappropriate prescribing in urgent care – CIDRAP (free)

Richard Lehman’s Journal Review – 16 July 2018

20 Jul, 2018 | 02:28h | UTC

Richard Lehman’s journal review, 16 July 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

Position Statement: Reducing Inappropriate Medication Use & Polypharmacy

20 Jul, 2018 | 02:21h | UTC

International Group for Reducing Inappropriate Medication Use & Polypharmacy (IGRIMUP): Position Statement and 10 Recommendations for Action – Drugs & Aging (free)

Meta-Analysis: Effects of Aspirin for CV Disease Prevention According to Bodyweight and Dose

20 Jul, 2018 | 02:20h | UTC

Effects of aspirin on risks of vascular events and cancer according to bodyweight and dose: analysis of individual patient data from randomised trials – The Lancet (free)

Commentaries: Weight-adjusted aspirin for cardiovascular prevention – The Lancet (free) AND One dose of aspirin doesn’t fit all – University of Oxford (free)

Practice Changing Article. “Low doses of aspirin (75–100 mg) were only effective in preventing vascular events in patients weighing less than 70 kg, and had no benefit in the 80% of men and nearly 50% of all women weighing 70 kg or more. By contrast, higher doses of aspirin were only effective in patients weighing 70 kg or more.”

Cohort Study: Inferior Vena Cava Filters and Mortality in Patients with Contraindication to Anticoagulation

20 Jul, 2018 | 02:17h | UTC

Association of Inferior Vena Cava Filter Placement for Venous Thromboembolic Disease and a Contraindication to Anticoagulation With 30-Day Mortality – JAMA Network Open (free)

Commentaries: Inferior Vena Cava Filters and Mortality: Is It the Underlying Process, the Patient, or the Device? (free)

“Could IVC filters be causing harm? They began being used before @US_FDA started approving devices. This article raises possibility of increased mortality. Maybe where we need trials to determine safety and effectiveness”. (via @hmkyale see Tweet)

Guideline: Management of Non ST-segment Elevation Acute Coronary Syndrome

20 Jul, 2018 | 02:14h | UTC

2018 Guidelines of the Taiwan Society of Cardiology, Taiwan Society of Emergency Medicine and Taiwan Society of Cardiovascular Interventions for the management of non ST-segment elevation acute coronary syndrome – Journal of the Formosan Medical Association (free)

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