Internal Medicine
Meta-Analysis: Reviewing Inhaler Technique for Older People with COPD Can Improve Disease Control
6 Feb, 2019 | 00:46h | UTCReviewing inhaler technique for older people with COPD can improve disease control – NIHR Signal (free)
Original Study: Inhaler Technique Education and Exacerbation Risk in Older Adults with Asthma or Chronic Obstructive Pulmonary Disease: A Meta‐Analysis – Journal of the American Geriatrics Society (free)
2019 ACIP Adult Immunization Schedule
5 Feb, 2019 | 00:39h | UTCRecommended Adult Immunization Schedule, United States, 2019 – Annals of Internal Medicine (free)
Systematic Review: Exercise for Preventing Falls in Older People Living in the Community
5 Feb, 2019 | 00:29h | UTCExercise for preventing falls in older people living in the community – Cochrane Library (free)
News Release: New Cochrane review assesses the benefits and harms of exercise for preventing falls in older people living in the community (free)
Commentaries: Experts assess benefits and harms of exercise for preventing falls in older people – University of Manchester (free) AND Exercise prevents falls in older people – but will any type of exercise do? – Evidently Cochrane (free)
Related: Recommendation Statement: Falls Prevention in Community-Dwelling Older Adults (several guidelines on the subject) AND Meta-analysis: Association of Long-term Exercise Training With Risk of Falls, Fractures, Hospitalizations, and Mortality in Older Adults (link to abstract and commentary) AND Systematic Review: Interventions for Preventing Falls in Older People (free study and commentary) AND Meta-analysis: reducing falls in older adults recently discharged from hospital (link to abstract and commentary)
International Consensus Guidelines for the Optimal Use of the Polymyxins
4 Feb, 2019 | 23:45h | UTCInternational Consensus Guidelines for the Optimal Use of the Polymyxins – Pharmacotherapy (free)
Endorsed by the American College of Clinical Pharmacy (ACCP), European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Infectious Diseases Society of America (IDSA), International Society for Anti‐infective Pharmacology (ISAP), Society of Critical Care Medicine (SCCM), and Society of Infectious Diseases Pharmacists (SIDP).
JAMA Clinical Guidelines Synopsis: Management of Blood Cholesterol
4 Feb, 2019 | 23:53h | UTCGuideline Synopsis: Management of Blood Cholesterol – JAMA (free)
Editorial: A New Personalized, Patient-Centric, and Cost-Conscious Guideline for Contemporary Cholesterol Management (free)
Original Guideline: New AHA/ACC Guideline on the Management of Blood Cholesterol (free guideline and resources)
Coronary Embolus: An Underappreciated Cause of Acute Coronary Syndromes
4 Feb, 2019 | 23:01h | UTCReview: Coronary Embolus: An Underappreciated Cause of Acute Coronary Syndromes – JACC: Cardiovascular Interventions (free for a limited period)
Worldwide Dyslipidemia Guidelines
4 Feb, 2019 | 22:32h | UTCWorldwide Dyslipidemia Guidelines – Current Cardiovascular Risk Reports (free)
Related: JAMA Clinical Guidelines Synopsis: Management of Blood Cholesterol (free guideline and synopsis)
Examination of the Patient with Dizziness or Imbalance
3 Feb, 2019 | 16:51h | UTCExamination of the Patient with Dizziness or Imbalance – Medical Clinics of North America (free)
AGS 2019 Updated Beers Criteria for Potentially Inappropriate Medication Use in Older Adults
3 Feb, 2019 | 16:02h | UTCNews Release: For older people, medications are common; AGS Beers Criteria aims to make them appropriate, too (free)
Commentary: AGS: Beers Criteria for Potentially Inappropriate Med Use in Older Adults Updated – MPR (free)
Related Commentary on Twitter
The #AGSBeersCriteria includes lists of medications that may be inappropriate or unsafe for older adults. See the latest updates for 2019: https://t.co/qGB5Y1cD7S pic.twitter.com/ow0xds2gN7
— American Geriatrics Society (@AmerGeriatrics) February 1, 2019
Polypharmacy Guideline: Getting it Right for People Prescribed Many Medicines
3 Feb, 2019 | 15:53h | UTCPolypharmacy: Getting our medicines right – Royal Pharmaceutical Society (free)
Shorter Version: Polypharmacy (free)
Commentary: Pharmacists call for regular reviews of medicines – BBC (free)
Related: Reducing Inappropriate Medication Use & Polypharmacy (several articles and commentaries on the subject)
Meta-Analysis: Efficacy and Safety of Statin Therapy in Older People
3 Feb, 2019 | 15:43h | UTCCommentaries: Never too old for statin treatment? – The Lancet (free) AND Efficacy and safety of statin therapy in older people – expert comment – London School of Hygiene & Tropical Medicine (free) AND Expert reaction to meta-analysis looking at statins and cardiovascular events in all ages – Science Media Centre (free) AND Statin therapy reduces cardiovascular disease risk in older people – University of Oxford (free) AND Statins Lower Risk for CV Events in Elders, But Benefits for Primary Prevention Still in Question – NEJM Journal Watch (free)
“However, when stratified by history of vascular disease, a significant benefit among those aged 71 and older was limited to those with prior vascular disease.” (from NEJM Journal Watch)
Guideline: Management of Depression with Specific Comorbid Psychiatric Conditions
3 Feb, 2019 | 13:08h | UTCRelated Guideline: Depression in adults: recognition and management – National Institute for Health and Care Excellence (free)
Review: Benefits of Non‐invasive Ventilation in Acute Hypercapnic Respiratory Failure
3 Feb, 2019 | 11:30h | UTCBenefits of non‐invasive ventilation in acute hypercapnic respiratory failure – Respirology (free)
Related Guidelines: BTS/ICS guideline for the ventilatory management of acute hypercapnic respiratory failure in adults – Thorax (free) AND The Japanese Respiratory Society Noninvasive Positive Pressure Ventilation (NPPV) Guidelines – Respiratory Investigation (free) AND Management of COPD exacerbations: a European Respiratory Society/American Thoracic Society guideline – European Respiratory Journal (free)
Related Reviews: Non‐invasive ventilation for the management of acute hypercapnic respiratory failure due to exacerbation of chronic obstructive pulmonary disease – Cochrane Library (free) AND Noninvasive ventilation in acute respiratory failure: which recipe for success? – European Respiratory Review (free)
AACE/ACE Comprehensive Type 2 Diabetes Management Algorithm 2019
1 Feb, 2019 | 02:50h | UTCAACE/ACE Comprehensive Type 2 Diabetes Management Algorithm 2019 – Endocrine Practice (Free PDF and Slide Presentations)
Related Guidelines: ADA 2019 Standards of Medical Care in Diabetes (free supplement) AND Diabetes Canada 2018 clinical practice guidelines for the prevention and management of diabetes in Canada (free)
Systematic Review: Intermittent Iron Supplementation vs. Daily Supplementation for Preventing or Controlling Anemia
1 Feb, 2019 | 02:43h | UTCIntermittent iron supplementation for reducing anaemia and its associated impairments in adolescent and adult menstruating women – Cochrane Library (free)
Summary: Iron supplements taken one, two or three times a week for preventing anaemia, and its consequences in menstruating women – Cochrane Library (free)
“In comparison with daily supplementation, the provision of iron supplements intermittently is probably as effective in preventing or controlling anemia”
Review: Interstitial Lung Disease and Other Pulmonary Manifestations in Connective Tissue Diseases
1 Feb, 2019 | 02:40h | UTC
Systematic Review: General Health Checks for Reducing Illness and Mortality
1 Feb, 2019 | 02:41h | UTCGeneral health checks in adults for reducing morbidity and mortality from disease – Cochrane Library (free)
Summary: General health checks for reducing illness and mortality – Cochrane Library (free)
“General health checks are unlikely to be beneficial.”
The Alzheimer’s Disease Clinical Spectrum: Diagnosis and Management
1 Feb, 2019 | 02:38h | UTC
Randomized Trial: Oral versus Intravenous Antibiotics for Bone and Joint Infection
30 Jan, 2019 | 23:56h | UTCOral versus Intravenous Antibiotics for Bone and Joint Infection – New England Journal of Medicine (link to abstract – $ for full-text)
Related Trial: Partial Oral vs. Intravenous Antibiotic Treatment of Endocarditis (link to abstract and commentaries)
Commentary: Oral antibiotics may work for some ortho, heart infections – CIDRAP (free)
Related Commentary on Twitter
In this trial, 1054 participants with complex orthopedic infections were assigned to receive either oral or intravenous antibiotics for the first 6 weeks of treatment. At 1 year, oral therapy was noninferior to intravenous therapy.
— NEJM (@NEJM) January 30, 2019
10 Myths About Frusemide
30 Jan, 2019 | 23:31h | UTC10 myths about frusemide – Intensive Care Medicine (free)
Note: if the above link is paywalled, try this one
Randomized Trial: E-Cigarettes vs. Nicotine-Replacement Therapy
30 Jan, 2019 | 23:35h | UTCA Randomized Trial of E-Cigarettes versus Nicotine-Replacement Therapy – New England Journal of Medicine (link to abstract – $ for full-text)
Editorial: The Dangerous Flavors of E-Cigarettes (free)
Commentaries: E-cigarettes more effective than nicotine replacement therapies, finds major trial – Queen Mary University of London (free) AND UK study shows e-cigarettes help adult smokers quit, but US experts urge caution – CNN (free) AND E-Cigarettes Are Effective at Helping Smokers Quit, a Study Says – The New York times (10 articles per month are free) AND E-cigarettes ‘much better for quitting smoking’ – BBC (free) AND Study Found Vaping Beat Traditional Smoking-Cessation Options – NPR (free)
Related Commentary on Twitter
Trial finds e-cigarettes more effective than nicotine-replacement therapy with respect to the 1-year abstinence rate (18% vs. 10%). Throat or mouth irritation was more common with e-cigarettes, and nausea was more common with nicotine-replacement. https://t.co/cyEnDP630v pic.twitter.com/1je5vN87ru
— NEJM (@NEJM) January 30, 2019
Perspective: Are Probiotics Money Down the Toilet? Or Worse?
30 Jan, 2019 | 23:34h | UTCAre Probiotics Money Down the Toilet? Or Worse? – JAMA (free for a limited period)
Related: Randomized Trials: Probiotics Ineffective Against Gastroenteritis (link to abstract and commentaries) AND Perspective: The Problem with Probiotics (free commentaries) AND Probiotics: Does the Evidence Match the Hype? (link to abstract and commentaries) AND Systematic Review: Harms Reporting in Trials with Probiotics (link to abstract and commentaries)
Perspective: Debates in Sepsis
30 Jan, 2019 | 23:20h | UTCDebates in sepsis – ACP Hospitalist (free)
Related: Point and Counterpoint: Should the Surviving Sepsis Campaign Guidelines Be Retired? (free commentaries) AND The 2018 Surviving Sepsis Campaign’s Treatment Bundle: When Guidelines Outpace the Evidence Supporting Their Use (free commentaries)
ESC Position Statement: Depression and Coronary Heart Disease
30 Jan, 2019 | 23:30h | UTC
Observational Study: β-Blocker Therapy Reduces the Risk for COPD Hospitalization
30 Jan, 2019 | 01:22h | UTCCommentary: Beta-Blocker Use Linked to Lower Risk for COPD Hospitalization – NEJM Journal Watch (free)
Related review and meta-analysis: Beta-blockers in patients with chronic obstructive disease and coexistent cardiac illnesses – COPD Research and Practice (free) AND Beta-blocker use and COPD mortality: a systematic review and meta-analysis – BMC Pulmonary Medicine (free)
Related observational studies: β-Blockers in COPD: A Cohort Study From the TONADO Research Program – CHEST (free) AND Effect of β blockers in treatment of chronic obstructive pulmonary disease: a retrospective cohort study – The BMJ (free)