Internal Medicine
Review: Clostridium Difficile Infection
21 Apr, 2019 | 21:16h | UTCRelated Guidelines: IDSA Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children (free) AND 2019 update of the WSES guidelines for management of Clostridioides (Clostridium) difficile infection in surgical patients – World Journal of Emergency Surgery (free) AND The use of faecal microbiota transplant as treatment for recurrent or refractory Clostridium difficile infection and other potential indications (free) AND Guideline for the Management of Clostridium Difficile Infection in Children and Adolescents With Cancer and Pediatric Hematopoietic Stem-Cell Transplantation Recipients (free) AND Fecal Microbiota Transplantation for Recurrent Clostridium difficile Infection and Other Conditions in Children (free)
Review: Treatment of Medication Overuse Headache
21 Apr, 2019 | 21:10h | UTCTreatment of medication overuse headache—A review – Acta Neurologica Scandinavica (free)
Cancer-associated Thrombosis: The When, How and Why
20 Apr, 2019 | 15:19h | UTCCancer-associated thrombosis: the when, how and why – European Respiratory Review (free)
Related: Guideline: Treatment Algorithm in Cancer-Associated Thrombosis (free)
Congratulations to Dr. Caio Julio Fernandes and Colleagues.
Review: Obstructive Sleep Apnea and Comorbidities
20 Apr, 2019 | 13:42h | UTCRelated: Obstructive Sleep Apnea in Cardiovascular Disease: A Review of the Literature and Proposed Multidisciplinary Clinical Management Strategy (free reviews)
Cochrane Review: Nicotine Replacement for Smoking Cessation More Successful in Combination Form
19 Apr, 2019 | 08:42h | UTCDifferent doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation – Cochrane Library (free)
Commentaries: Nicotine replacement: when quitting cigarettes, consider using more nicotine, not less – The Conversation (free) AND Nicotine replacement therapy: new evidence on help to quit smoking – Evidently Cochrane (free) AND Nicotine replacement therapy more successful in combination form – Nuffield Department of Primary Care Health Sciences (free)
Related Commentary on Twitter
Featured Cochrane Review: Different doses, durations and modes of delivery of #nicotine replacement therapy for #smoking cessation from @CochraneTAG – Read comments from lead author https://t.co/WBvMA74iaK and the full review https://t.co/QFLx9Wb9Xc pic.twitter.com/tk2J6WRT3Z
— Cochrane (@cochranecollab) April 18, 2019
Meta-Analysis: Accuracy of Patient Health Questionnaire-9 (PHQ-9) for Screening to Detect Major Depression
19 Apr, 2019 | 08:39h | UTCCommentaries: The accuracy of the Patient Health Questionnaire-9 for detecting major depression – The BMJ Opinion (free) AND Screening tools for depression offer value when combined with an informed shared decision process – The BMJ Opinion (free) AND Using the Patient Health Questionnaire-9 to Screen for Major Depression – NEJM Journal Watch (free)
Small Randomized Trial Suggests Metformin May be Effective for Left Ventricular Hypertrophy in Patients with Coronary Artery Disease Without Diabetes
19 Apr, 2019 | 08:37h | UTCCommentaries: Diabetes drug Metformin may fight heart disease, study says – UPI (free) AND Diabetic drug shown to reduce the risk of heart disease in non-diabetic patients – University of Dundee (free) AND Metformin reduces left ventricular mass in nondiabetic patients with CAD – Cardiovascular Business (free)
Management of Hypertension in Chronic Kidney Disease
19 Apr, 2019 | 08:28h | UTCManagement of Hypertension in Chronic Kidney Disease – Drugs (free)
Another Observational Study Showing Association of Statin Use with Risk of New‐Onset Diabetes Mellitus
19 Apr, 2019 | 08:25h | UTCEditorial: Perils of Observational Data Analyses (free)
Commentary: Statins for primary prevention: do benefits outweigh DM risk? – Univadis (free registration required)
Related: Cohort Study: Statin Use Associated with a 38% Higher Risk of Incident Type 2 Diabetes (free study and commentaries)
Review: Drug-induced Hypersensitivity Syndrome (DiHS)/Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
19 Apr, 2019 | 08:31h | UTC
NCCN Guideline: Management of Immunotherapy-Related Toxicities
18 Apr, 2019 | 08:00h | UTCRelated Guidelines: Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline (free) AND Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group (free)
Related Reviews: New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management – Critical Care (free) AND Severe toxicity from checkpoint protein inhibitors: What intensive care physicians need to know? – Annals of Intensive Care (free) AND Checkpoint Inhibitors: The diagnosis and treatment of side effects – Deutsches Ärzteblatt international (free)
Update in Hospital Medicine: Practical Lessons from Current Literature
17 Apr, 2019 | 06:24h | UTC
Cohort Study: Mid-life Resting Heart Rate Over 75 Beats per Minute Linked to High Risk of Cardiovascular Disease and Mortality
17 Apr, 2019 | 06:15h | UTCCommentary: Mid-life resting heart rate of 75 plus beats/minute linked to doubling in early death risk – BMJ (free)
Management of Transient Ischemic Attack or Nondisabling Stroke Related to Extracranial Internal Carotid Artery Stenosis
17 Apr, 2019 | 05:53h | UTCManagement of transient ischemic attack or nondisabling stroke related to extracranial internal carotid artery stenosis – Canadian Medical Association Journal (free for a limited period)
Randomized Trial: SGLT2 inhibitor Reduces Progression of Kidney Disease in Patients with Type 2 Diabetes and Nephropathy
16 Apr, 2019 | 02:52h | UTCCanagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy – New England Journal of Medicine (free for a limited period)
Commentary: Canagliflozin may offer renal protection in people with type 2 diabetes and CKD – Medicine Matters (free)
“among 1000 patients treated for 2.5 years, 21.2 individuals would need to be treated to prevent the composite primary outcome.” (from Medicine Matters)
Measles Cases are up Nearly 300% From Last Year. This is a Global Crisis
16 Apr, 2019 | 02:54h | UTCMeasles cases are up nearly 300% from last year. This is a global crisis – CNN (free)
WHO Statement: New measles surveillance data for 2019 – World Health Organization (free)
By Henrietta H Fore (executive director of UNICEF) and Tedros Adhanom Ghebreyesus (director general of the World Health Organization).
Randomized Trial: Statins Safe and Effective for Patients with Rheumatoid Arthritis
16 Apr, 2019 | 02:50h | UTCCommentaries: Statins safe for rheumatoid arthritis patients – University of Dundee (free) AND Statins safe for preventing cardiovascular events in rheumatoid arthritis patients, study suggests – Wiley (free)
Alex Nowbar’s Research Reviews – 15 April 2019
16 Apr, 2019 | 02:31h | UTCAlex Nowbar’s research reviews, 15 April 2019 – The BMJ Opinion (free)
Review: Acute Renal Failure of Nosocomial Origin
16 Apr, 2019 | 02:07h | UTCAcute Renal Failure of Nosocomial Origin – Deutsches Ärzteblatt international (free)
Meta-Analysis: Direct Oral Anticoagulants in Patients with Venous Thromboembolism and Thrombophilia
15 Apr, 2019 | 02:06h | UTC
EASL Guideline: Drug-induced Liver Injury
15 Apr, 2019 | 00:48h | UTCEASL Clinical Practice Guidelines: Drug-induced liver injury – Journal of Hepatology (free)
Related Review: Drug-induced liver injury: recent advances in diagnosis and risk assessment – Gut (free)
Related Commentary on Twitter
The @EASLedu guidelines on drug-induced liver injury are now available.
Including a special section on liver manifestations in cancer #Immunotherapy https://t.co/ptqeIRoFvO #liverdisease #DILI @EASLnews pic.twitter.com/SLrMGYsFQn— Journal of Hepatology (@JHepatology) April 6, 2019
Top Studies Relevant to Primary Care from 2018
15 Apr, 2019 | 00:43h | UTCTop studies relevant to primary care from 2018 – Canadian Family Physician (free)
Review: Prevention of Complications From use of Conventional Immunosuppressants
15 Apr, 2019 | 00:35h | UTC
Compendium on the Pathophysiology and Treatment of Hypertension
12 Apr, 2019 | 01:49h | UTCCompendium on the Pathophysiology and Treatment of Hypertension – Circulation Research (free articles)
– Homepage
– Editorial: Introduction to a Compendium on the Pathophysiology and Treatment of Hypertension
– Adherence in Hypertension: A Review of Prevalence, Risk Factors, Impact, and Management
– Two-Drug Combinations as First-Step Antihypertensive Treatment
– Preeclampsia: Pathophysiology, Challenges, and Perspectives
– Treatment of Resistant and Refractory Hypertension
– Hypertension Management in Older and Frail Older Patients
– Neurovascular and Cognitive Dysfunction in Hypertension: Epidemiology, Pathobiology, and Treatment
– Metabolic Surgery for Hypertension in Patients With Obesity
– Blood Pressure Measurement and Treatment Decisions: Masked and White-Coat Hypertension
Sibling Controlled Cohort Study: Stress Related Disorders and Risk of Cardiovascular Disease
12 Apr, 2019 | 01:42h | UTCEditorial: Stress, psychiatric disorders, and cardiovascular disease (free)
Commentaries: Stress-related disorders linked to heightened risk of cardiovascular disease – The BMJ (free) AND Stress from Traumatic Events Linked to Increased Risk of Heart Disease – MedicalResearch.com (free) AND Expert reaction to study looking at stress related disorders and risk of cardiovascular disease – Science Media Centre (free)
Related Commentary on Twitter
Stress related disorders–conditions triggered by a significant life event or trauma–may be linked to a heightened risk of cardiovascular disease (CVD), finds a large Swedish study published in @bmj_latest today https://t.co/01pyFcInu8 Linked editorial: https://t.co/vt7EWu4g9v pic.twitter.com/F9C77VJ9M2
— BMJ Group (@bmj_company) April 11, 2019