Internal Medicine
[Abstract Only] Randomized Trial: SGLT2 Inhibitor Reduces Adverse Renal Events in Patients with Type 2 Diabetes and Nephropathy
14 Jun, 2019 | 06:49h | UTCCanagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Canagliflozin and Renal Events in Diabetes With Established Nephropathy Clinical Evaluation – CREDENCE – American College of Cardiology (free)
Updated Geriatric Cardiology Guidelines of the Brazilian Society of Cardiology
14 Jun, 2019 | 06:53h | UTC
Consensus: Diagnosis, Treatment and Follow Up of Acute Pulmonary Embolism
14 Jun, 2019 | 07:03h | UTCRelated Guidelines: BTS Guideline: Outpatient Management of Pulmonary Embolism (free) AND ACEP Clinical Policy: Evaluation and Management of Suspected Acute Venous Thromboembolism (free) AND Evaluation of Patients With Suspected Acute Pulmonary Embolism: Best Practice Advice From the Clinical Guidelines Committee of the American College of Physicians (free) AND 2014 ESC Guidelines on the diagnosis and management of acute pulmonary embolism: The Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology (ESC) (free)
Higher Doses of Antidepressants “Not Optimal”, According to New Review
14 Jun, 2019 | 02:32h | UTCHigher doses of antidepressants “not optimal”, according to new review – The Mental Elf (free)
Original Article: Meta-analysis: Optimal Dose of Antidepressants in Major Depression (free study and commentaries)
[Abstract Only] Risks of 23 Specific Malformations Associated with Prenatal Exposure to 10 Antiepileptic Drugs
14 Jun, 2019 | 02:33h | UTCRisks of 23 specific malformations associated with prenatal exposure to 10 antiepileptic drugs – Neurology (link to abstract – $ for full-text)
Commentaries: Epilepsy drugs linked to higher risk of birth defects, study says – CNN (free) AND Study Confirms Teratogenicity of Valproic Acid, Topiramate – MPR (free)
Related: Guideline: Valproate Use in Women and Girls Of Childbearing Years (free) AND Research: Topiramate Use Early in Pregnancy and the Risk of Oral Clefts (free)
Influenza Virus-related Critical Illness: Prevention, Diagnosis, Treatment
14 Jun, 2019 | 02:30h | UTCInfluenza virus-related critical illness: prevention, diagnosis, treatment – Critical Care (free)
Cohort Study: Gabapentinoids linked to Increased Risk of Suicidal Behavior
14 Jun, 2019 | 02:26h | UTCEditorial: Gabapentinoids linked to new risks, including suicidal behavior (free)
Commentaries: Epilepsy drugs linked to increased risk of suicidal behavior, particularly in young people – The BMJ (free) AND Expert reaction to study on gabapentinoids and risk of suicidal behavior – Science Media Centre (free)
[Abstract Only] Prevalence of Infective Endocarditis in Patients with Positive Blood Cultures According to the Organism
13 Jun, 2019 | 10:29h | UTCInfective Endocarditis in Patients With Positive Blood Cultures – American College of Cardiology (free)
Original Article: Prevalence of infective endocarditis in patients with positive blood cultures: a Danish nationwide study – European Heart Journal (link to abstract – $ for full-text)
Systematic Review of Perioperative Cardiac Risk Prediction Indices
13 Jun, 2019 | 10:30h | UTC
Ann Robinson’s journal review—12 June 2019
13 Jun, 2019 | 07:34h | UTCAnn Robinson’s journal review, 12 June 2019 – The BMJ Opinion (free)
Meta-Analysis: CT Angiography in Patients with Stable Chest Pain
13 Jun, 2019 | 07:29h | UTC
Related Commentary on Twitter
Massive meta-analysis in @bmj_latest shows PPV of CCTA is as low as 51% in low risk pts sent for testing:https://t.co/ydHdqzFWSA
One could have easily predicted this as @khurramn1 and I laid out for stress testing.
Bottom line: don't send low risk patients for testing. pic.twitter.com/kcOabpZrjF
— Venk Murthy MD PhD (@venkmurthy) June 12, 2019
Cohort Studies: Increasing Red Meat Consumption Linked to Increased Mortality
13 Jun, 2019 | 07:26h | UTCCommentaries: Increasing red meat consumption linked with higher risk of premature death – Harvard T.H. Chan School of Public Health (free) AND The Swap: Less Processed Meat, More Plant-Based Foods May Boost Longevity – NPR (free)
USPSTF Statement: Screening for HIV Infection
12 Jun, 2019 | 08:28h | UTCScreening for HIV Infection: US Preventive Services Task Force Recommendation Statement (free)
Editorials: HIV Screening and Preexposure Prophylaxis Guidelines: Following the Evidence (free) AND New USPSTF Guidelines for HIV Screening and Preexposure Prophylaxis (PrEP): Straight A’s (free)
Evidence Reports and Systematic Reviews: Screening for HIV Infection in Asymptomatic, Nonpregnant Adolescents and Adults (free) AND Screening for HIV Infection in Pregnant Women (free)
Author Interviews: Screening for HIV infection and Use of Preexposure Prophylaxis for Prevention of HIV Infection: US Preventive Services Task Force Recommendation Statements (free audio) AND HIV Screening and Preexposure Prophylaxis Guidelines (free audio)
USPSTF Statement: Preexposure Prophylaxis for the Prevention of HIV Infection
12 Jun, 2019 | 08:25h | UTCEditorials: HIV Screening and Preexposure Prophylaxis Guidelines: Following the Evidence (free) AND New USPSTF Guidelines for HIV Screening and Preexposure Prophylaxis (PrEP): Straight A’s (free)
Evidence Report and Systematic Review: Preexposure Prophylaxis for the Prevention of HIV Infection (free)
Author Interviews: Screening for HIV infection and Use of Preexposure Prophylaxis for Prevention of HIV Infection: US Preventive Services Task Force Recommendation Statements (free audio) AND HIV Screening and Preexposure Prophylaxis Guidelines (free audio)
Commentaries: Expert Panel Recommends Wider Use Of Daily Pill To Prevent HIV Infections – NPR (free) AND HIV prevention pill recommended for healthy people at risk – Reuters (free)
Related: British Guidelines on the Use of HIV Pre–exposure Prophylaxis (PrEP) (several guidelines on the subject)
Meta-Research: A Comprehensive Review of Randomized Trials Leading to “Medical Reversals” in Three Medical Journals
12 Jun, 2019 | 08:23h | UTCCommentaries: Almost 400 medical practices found ineffective in analysis of 3,000 studies – eLIFE (free) AND Hundreds of current medical practices may be ineffective – Medical News Today (free)
Related Commentary on Twitter
A review of more than 3,000 randomized clinical trials in NEJM, Lancet and JAMA reveals 396 medical reversals (results later shown to be wrong, usually in systematic reviews). 22 studies in pulmonary diseases and 45 in critical care medicine were affected. https://t.co/uAW9r3SMJs
— CryptoMD (@ClaudiaCDobler) June 11, 2019
[Abstract Only] Aspirin for Primary Prevention of CV Events
12 Jun, 2019 | 05:28h | UTCAspirin for Primary Prevention of CV Events – American College of Cardiology (free)
Original Article: Aspirin for Primary Prevention of Cardiovascular Events – Journal of the American College of Cardiology (free)
Related: Aspirin for Primary Prevention: Is This the End of the Road? (selection of resources on the subject)
[Abstract Only] Meta-analysis: Cardiovascular Events and Mortality in White Coat Hypertension
11 Jun, 2019 | 03:33h | UTCCardiovascular Events and Mortality in White Coat Hypertension: A Systematic Review and Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: People with Untreated “White Coat Hypertension” Twice as Likely to Die from Heart Disease – Penn Medicine (free) AND Untreated white-coat hypertension associated with increased cardiovascular and mortality risk – ACP Internist (free) AND Patients whose blood pressure only spikes at the doctor’s office are twice as likely to die of a heart attack or other cardiac event – STAT (free)
Top 10 Medical Myths, Busted
11 Jun, 2019 | 03:31h | UTCTop 10 medical myths, busted – ACP Internist (free)
“Ten medical myths persist despite all the evidence.”
Risk of Hospitalization for Serious Adverse Gastrointestinal Events Associated with Sodium Polystyrene Sulfonate
11 Jun, 2019 | 02:36h | UTCRisk of Hospitalization for Serious Adverse Gastrointestinal Events Associated With Sodium Polystyrene Sulfonate Use in Patients of Advanced Age – JAMA Internal Medicine (free for a limited period)
Editorial: Sodium Polystyrene Sulfonate for Hyperkalemia (free)
Commentary: Sodium Polystyrene Sulfonate Tied to Increased Risk for Serious GI Events in Seniors – NEJM Journal Watch (free)
Randomized Trial: Self-management Support Intervention Improve Outcomes in Older Adults with Asthma
11 Jun, 2019 | 02:43h | UTCEffect of a Self-management Support Intervention on Asthma Outcomes in Older Adults: The SAMBA Study Randomized Clinical Trial – JAMA Internal Medicine (free for a limited period)
Commentary: Study reports asthma control in older patients and shows lower ED visits – The Mount Sinai Hospital (free)
Consensus Recommendations: Acute-on-chronic Liver Failure
9 Jun, 2019 | 22:08h | UTCRelated: Management of acute-on-chronic liver failure: an algorithmic approach – Hepatology International (free) AND cute-on-chronic liver failure: an update – Gut (free)
EULAR Recommendations for the Management of Gout
9 Jun, 2019 | 22:11h | UTC
[Abstract Only] Vitamin D Fails to Prevent Type 2 Diabetes in Patients with Pre-diabetes
9 Jun, 2019 | 21:55h | UTCVitamin D Supplementation and Prevention of Type 2 Diabetes – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: NIH-funded trial finds vitamin D does not prevent type 2 diabetes in people at high risk – NIH News Releases (free) AND Vitamin D fails to prevent type 2 diabetes in large study – Reuters (free) AND Vitamin D Supplements Do Not Significantly Reduce Risk of Developing Type 2 Diabetes, According to Research Presented Today at the ADA’s Scientific Sessions – American Diabetes Association (free)
Meta-analysis: Optimal Dose of Antidepressants in Major Depression
9 Jun, 2019 | 22:07h | UTCCommentaries: Which antidepressant doses are optimal? – The Lancet Psychiatry (free) AND Expert reaction to systematic review and dose-response meta-analysis of antidepressants – Science Media Centre (free)
Meta-analysis: Aspirin has Potential Benefits for Primary Prevention of Cardiovascular Outcomes in Diabetes
9 Jun, 2019 | 21:45h | UTCCommentary: Aspirin offers benefit for primary CVD prevention in DM – Univadis (free registration required)
Related Randomized Trial: Effects of Aspirin for Primary Prevention in Persons with Diabetes (free study and commentaries)