Internal Medicine
Meta-analysis: Omega-3 Fats Not Beneficial for Diabetes Prevention or Treatment
22 Aug, 2019 | 10:53h | UTCCommentaries: The role of nutrition in disease prevention—how we can find better answers? – The BMJ Opinion (free) AND Omega-3 fats have little or no effect on type 2 diabetes – BMJ (free) AND Lack of omega-3 effect on type 2 diabetes confirmed – Medicine Matters (free) AND Fish oil pills ‘no benefit’ for type 2 diabetes – BBC (free)
Related Randomized Trial: Effects of n−3 Fatty Acid Supplements in Diabetes Mellitus (free study and commentaries)
Clostridioides Difficile: Diagnosis and Treatments
21 Aug, 2019 | 08:40h | UTCClostridioides difficile: diagnosis and treatments – The BMJ (free for a limited period)
Related Guidelines: IDSA Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children (free) AND 2019 update of the WSES guidelines for management of Clostridioides (Clostridium) difficile infection in surgical patients – World Journal of Emergency Surgery (free) AND Consensus on the prevention, diagnosis, and treatment of Clostridium difficile infection – Revista de Gastroenterología de México (free) AND The use of faecal microbiota transplant as treatment for recurrent or refractory Clostridium difficile infection and other potential indications (free) AND Guideline for the Management of Clostridium Difficile Infection in Children and Adolescents With Cancer and Pediatric Hematopoietic Stem-Cell Transplantation Recipients (free) AND Fecal Microbiota Transplantation for Recurrent Clostridium difficile Infection and Other Conditions in Children (free)
USPSTF Statement on BRCA-Related Cancer: Risk Assessment, Genetic Counseling, and Genetic Testing
21 Aug, 2019 | 08:42h | UTCEditorials: Broadening Criteria for BRCA1/2 Evaluation: Placing the USPSTF Recommendation in Context – JAMA (free for a limited period) AND Hereditary Cancer Evaluation in 2019—a Rapidly Evolving Landscape – JAMA Oncology (free for a limited period) AND US Preventive Services Task Force Breast Cancer Recommendation Statement on Risk Assessment, Genetic Counseling, and Genetic Testing for BRCA-Related Cancer – JAMA Surgery (free for a limited period) AND USPSTF Recommendations for BRCA1 and BRCA2Testing in the Context of a Transformative National Cancer Control Plan – JAMA Network Open (free)
Author Interview: USPSTF Recommendation: Assessment, Counseling, and Testing for BRCA-Related Cancer (free audio)
Commentaries: More women should be assessed for BRCA mutations, new recommendations say – CNN (free) AND Expert panel updates advice on BRCA cancer gene screening – Reuters (free)
Study: Billions Could be Saved if Older Generics Were Prescribed
21 Aug, 2019 | 08:32h | UTCCommentary: Prescribing older generics could’ve saved Medicare $17.7B, study finds – Becker’s Hospital Review (free)
Related Study: Potential Savings from Generic Substitution and Therapeutic Interchange of ACE Inhibitors and Angiotensin-II-Receptor Blockers (no abstract – $ for full-text)
AHA Scientific Advisory: Omega-3 Fatty Acids for the Management of Hypertriglyceridemia
20 Aug, 2019 | 08:57h | UTCNews Release: Prescription omega-3 fatty acid medications effectively lower high triglycerides – American Heart Association (free)
Related: Omega-3 Supplements Do Not Reduce the Risk of Cancer or Cardiovascular Disease (randomized trial and systematic reviews on the subject)
Cohort Study: Intensifying Antihypertensive Medication Regimens Among Older Adults at Hospital Discharge Linked to Worse Outcomes
20 Aug, 2019 | 08:35h | UTCClinical Outcomes After Intensifying Antihypertensive Medication Regimens Among Older Adults at Hospital Discharge – JAMA Internal Medicine (free for a limited period)
Commentary: Intensifying Antihypertensives at Discharge Tied to Adverse Events – NEJM Journal Watch (free)
Related Study: Overtreatment of Blood Pressure Common at Hospital Discharge (free)
Guideline: Diagnosis and Management of Sepsis‐induced Coagulopathy and Disseminated Intravascular Coagulation
20 Aug, 2019 | 08:53h | UTCRelated Reviews: Diagnosis of sepsis‐induced disseminated intravascular coagulation and coagulopathy – Acute Medicine & Surgery (free) AND Sepsis-associated disseminated intravascular coagulation and its differential diagnoses – Journal of Intensive Care (free) AND Advance in the Management of Sepsis-Induced Coagulopathy and Disseminated Intravascular Coagulation – Journal of Clinical Medicine (free)
Source: Critical Care Reviews Newsletter
Study: Dual Antiplatelet Therapy Should be Used for 21 Days After Minor Ischemic Stroke or High-risk Transient Ischemic Attack
20 Aug, 2019 | 08:32h | UTCRelated Study: The Benefits of Clopidogrel-aspirin Combination after Minor Stroke/TIA occurs Predominantly Within the First 21 Days (free)
Related Guideline: Dual Antiplatelet Therapy for Acute High-Risk TIA and Minor Ischemic Stroke – The BMJ (free)
Perspective: Early Discharge Hospital at Home
20 Aug, 2019 | 08:14h | UTCEarly discharge hospital at home – NEJM Catalyst (free)
Related: Interventions to Promote Early Discharge and Avoid Inappropriate Hospital (Re)Admission: A Systematic Review – International Journal of Environmental Research and Public Health (free) AND Early discharge hospital at home – Cochrane Library (free) AND Early discharge ‘hospital-at-home’ gives similar outcomes to in-patient care – NIHR Signal (free)
[Abstract Only] Cohort Study: ‘Silent’ Strokes Common After Non-cardiac Surgery, Linked to Cognitive Decline
18 Aug, 2019 | 22:07h | UTCPerioperative covert stroke in patients undergoing non-cardiac surgery (NeuroVISION): a prospective cohort study – The Lancet (link to abstract – $ for full-text)
Commentaries: ‘Silent’ strokes common after surgery, linked to cognitive decline – McMaster University (free) AND ‘Silent’ strokes after elective surgeries in older adults double their risk of later cognitive decline, study finds – The Globe and Mail (free)
Related Commentary on Twitter
NEW: Perioperative covert stroke is associated with increased risk of cognitive decline 1 year after non-cardiac surgery & occurred in 1 in 14 patients aged ≥65 years undergoing non-cardiac surgery: findings from NeuroVISION, a prospective cohort study https://t.co/jWXkl6GllU pic.twitter.com/w3mDziUPSR
— The Lancet (@TheLancet) August 16, 2019
Promising new Tuberculosis Drug Approved, But Will it be Affordable?
18 Aug, 2019 | 22:00h | UTCOriginal News Release: FDA approves new drug for treatment-resistant forms of tuberculosis that affects the lungs – U.S. Food & Drug Administration (free)
See also: New Drug Could Be Game Changer For Drug-Resistant TB. But A Question Looms – NPR (free) AND Treatment for extreme drug-resistant tuberculosis wins US government approval – Nature (free) AND Scientists Discover New Cure for the Deadliest Strain of Tuberculosis – The New York Times (10 articles per month are free) AND U.S. FDA approves TB Alliance’s treatment for drug-resistant tuberculosis – Reuters (free)
Randomized Trial: Bismuth Subsalicylate Reduces Antibiotic Use Among Adult Outpatients With Diarrhea
18 Aug, 2019 | 21:59h | UTC
[Abstract Only] Meta-analysis: Long-term Macrolide Treatment Reduces the Frequency of Exacerbations in Patients with Bronchiectasis
18 Aug, 2019 | 21:19h | UTCLong-term macrolide antibiotics for the treatment of bronchiectasis in adults: an individual participant data meta-analysis – The Lancet Respiratory Medicine (link to abstract – $ for full-text)
Related Commentary on Twitter
A NEW 🔥 systematic review and individual patient data meta-analysis :long-term macrolide treatment significantly reduces the frequency of exacerbations in patients with bronchiectasis, with similar benefits observed in all subgroups based on patient characteristics. #IDTwitter https://t.co/pey2x23BRf
— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) August 10, 2019
Randomized Trial: 2 Weeks of Antibiotic Therapy as Good as 4 Weeks for Septic Arthritis
16 Aug, 2019 | 08:07h | UTCCommentary: Optimal Duration of Antibiotic Use in Septic Arthritis – NEJM Journal Watch (free for a limited period)
Guideline: Diagnosis and Management of Metabolic Acidosis
16 Aug, 2019 | 08:15h | UTC
Meta-Analysis: Association Between Vitamin D Supplementation and Mortality
16 Aug, 2019 | 07:59h | UTCRelated: Meta-Analysis: Vitamin D Not Effective for Cardiovascular Disease Prevention (link to abstract and commentary) AND NICE Guideline: Vitamin D Supplementation (free)
Vitamin D supplementation was not associated with all-cause mortality, cardiovascular mortality, or non-cancer, non-cardiovascular mortality. However, Vitamin D supplementation statistically significantly reduced the risk of cancer death by 16%.
Related Commentary on Twitter
Vitamin D supplementation alone was not associated with all cause mortality in adults compared with placebo or no treatment. However, it was associated with a reduced risk of cancer mortality by 16%, finds #BMJResearch https://t.co/jc4Tdxl6Bb
— The BMJ (@bmj_latest) August 12, 2019
Essential Tremor: Diagnosis and Management
16 Aug, 2019 | 07:55h | UTCEssential tremor: diagnosis and management – The BMJ (free for a limited period)
CDC Updates Recommendations for Human Papillomavirus Vaccination for Adults
16 Aug, 2019 | 07:53h | UTCCommentaries: CDC Recommends HPV Catch-Up Vaccine in Those 26 and Younger – NEJM Journal Watch (free) AND Confused About Who Should Get the HPV Vaccine, and When? The CDC Has New Recommendations – Time (free)
[Abstract Only] Study: Diabetes Being Overtreated in Many Vulnerable Clinically Complex Adults
16 Aug, 2019 | 07:50h | UTCSevere Hypoglycemia Attributable to Intensive Glucose-Lowering Therapy Among US Adults With Diabetes – Mayo Clinic Proceedings (link to abstract – $ for full-text)
Commentary: Too Much of a Good Thing Can Be Dangerous, Finds Researchers Investigating Hypoglycemia – Mayo Clinic (free)
Related Studies: Overtreatment and Deintensification of Diabetic Therapy among Medicare Beneficiaries – Journal of General Internal Medicine (free) AND Rates of Deintensification of Blood Pressure and Glycemic Medication Treatment Based on Levels of Control and Life Expectancy in Older Patients With Diabetes Mellitus – JAMA Internal Medicine (free)
Study: Optimal Combination of Compression Rate and Depth During CPR for Functionally Favorable Survival
15 Aug, 2019 | 08:22h | UTCOptimal Combination of Compression Rate and Depth During Cardiopulmonary Resuscitation for Functionally Favorable Survival – JAMA Cardiology (free for a limited period)
Commentaries: Push Hard, Push Fast, Do Not Stop—Optimal Chest Compression Rate and Depth – JAMA Cardiology (free for a limited period) AND Study Details Optimal CPR Speed, Depth – NEJM Journal Watch (free)
Related: Performing CPR? Humming the Macarena Could Help (free)
Consensus Statement for Enhanced Recovery: Perioperative Opioid Minimization in Opioid-Naïve Patients
15 Aug, 2019 | 08:37h | UTCRelated Position Statements on Perioperative Opioid Therapy: American Society for Enhanced Recovery and Perioperative Quality Initiative Joint Consensus Statement on Perioperative Management of Patients on Preoperative Opioid Therapy (free) AND American Society for Enhanced Recovery and Perioperative Quality Initiative-4 Joint Consensus Statement on Persistent Postoperative Opioid Use: Definition, Incidence, Risk Factors, and Health Care System Initiatives (free)
See also: American Society of Enhanced Recovery (ASER) and Perioperative Quality Initiative (POQI) joint consensus statements (free) AND Enhanced Recovery After Surgery (ERAS) Society Guidelines (free articles)
[Abstract Only] Randomized Trial: Ibuprofen Administered at Doses of 400, 600, and 800 mg Had Similar Analgesic Efficacy in Acute Pain.
15 Aug, 2019 | 06:58h | UTCComparison of Oral Ibuprofen at Three Single-Dose Regimens for Treating Acute Pain in the Emergency Department: A Randomized Controlled Trial – Annals of Emergency Medicine (link to abstract – $ for full-text)
Commentary: Don’t Use More Than 400 mg of Ibuprofen for Pain Control – NEJM Journal Watch (free for a limited period)
Related Commentary on Twitter
Hot off the Press: Comparison of Oral Ibuprofen at Three Single-Dose Regimens for Treating Acute Pain in the Emergency Department: A Randomized Controlled Trial https://t.co/Wq6PCgRaUw @painfreeED pic.twitter.com/7PLtD3IJ7I
— AnnalsofEM (@AnnalsofEM) August 13, 2019
Study: Midlife to Late-Life Blood Pressure Patterns and Incident Dementia
14 Aug, 2019 | 10:33h | UTCAssociation of Midlife to Late-Life Blood Pressure Patterns With Incident Dementia – JAMA (free for a limited period)
Related Research: Association of Intensive vs Standard Blood Pressure Control With Cerebral White Matter Lesions – JAMA (free for a limited period)
Editorial: Blood Pressure, Brain Volume and White Matter Hyperintensities, and Dementia Risk (free for a limited period)
Video Summary: Hypertension and Dementia (free)
Commentary: Expert reaction to two studies looking at blood pressure and dementia – Science Media Centre (free)
[Abstract Only] Cohort Study: Individuals with 1 or 2 Small Adenomas at Baseline Screening Colonoscopy Have a Similar Risk of Advanced Neoplasia over 10 years as Individuals with no Baseline Adenomas
14 Aug, 2019 | 08:34h | UTCBaseline Colonoscopy Findings Associated with 10-Year Outcomes in a Screening Cohort Undergoing Colonoscopy Surveillance – Gastroenterology (link to abstract – $ for full-text)
Related Study: Colonoscopy Adenoma Findings and Long-term Colorectal Cancer Incidence (free study, commentaries and guidelines on the subject)
Source: NEJM Journal Watch ($)
USPSTF Draft Recommendation Statement: Screen for Illicit Drug Use in Adults Age 18 Years or Older
14 Aug, 2019 | 08:24h | UTCCommentaries: For the first time, U.S. panel recommends screening adults for illicit drug use – STAT (free) AND Screen All Adult Patients for Drug Abuse, National Panel Urges – The New York Times (10 articles per month are free) AND