Internal Medicine
[Abstract Only] Randomized Trial: Polypill for Cardiovascular Disease Prevention in an Underserved Population
19 Sep, 2019 | 08:19h | UTCPolypill for Cardiovascular Disease Prevention in an Underserved Population – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Polypill Drops BP, LDL Cholesterol in a Disadvantaged US Population – TCTMD (free) AND One daily combo pill helps lower heart disease risk in study of underserved patients – American Heart Association (free) AND Fixed Dose Combination Polypill Can Reduce Barriers to Cardiovascular Care – MedicalResearch.com (free) AND One pill with four drugs may lower heart risks in poor population – Reuters (free) AND All-in-One Pill Reduces Blood Pressure, Cholesterol Levels in U.S. Study – Vanderbilt University Medical Center (free)
Related Randomized Trial: Effectiveness of Polypill for Primary and Secondary Prevention of Cardiovascular Diseases (link to abstract and commentaries)
See also: Clinical Impact of the Polypill for Cardiovascular Prevention in Latin America: A Consensus Statement of the Inter-American Society of Cardiology – Global Heart (free) AND Perspective: The Polypill and the Long Journey to Major Impact (opinion and reviews on the subject) AND Research: Low-Dose ‘Triple Pill’ Lowers Blood Pressure More Than Usual Care (free commentaries)
Alex Nowbar’s journal review—18 September 2019
19 Sep, 2019 | 08:11h | UTCAlex Nowbar’s journal review, 18 September 2019 – The BMJ Opinion (free)
Alex Nowbar reviews the latest research from the top medical journals.
[Abstract Only] Study: Blood Culture Results Before and After Antimicrobial Administration in Patients with Severe Manifestations of Sepsis
18 Sep, 2019 | 10:12h | UTCBlood Culture Results Before and After Antimicrobial Administration in Patients with Severe Manifestations of Sepsis: A Diagnostic Study – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Initiating empirical therapy for sepsis reduces blood culture sensitivity – MedicalXpress (free) AND Study changes guidelines for sepsis management – University of Arizona College of Medicine (free)
[Abstract Only] Study: Benefits and Harms of Aspirin for Primary Prevention of Cardiovascular Disease
18 Sep, 2019 | 08:36h | UTCPersonalized Prediction of Cardiovascular Benefits and Bleeding Harms From Aspirin for Primary Prevention: A Benefit–Harm Analysis – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Aspirin may benefit some people without cardiovascular disease, new analysis finds – ACP Internist (free) AND Some Adults Without Heart Disease May Benefit From Aspirin – MedicalResearch.com (free) AND Expert reaction to study looking at benefits and harms of aspirin in people without cardiovascular disease – Science Media Centre (free)
AAOS Systematic Literature Review: Summary on the Management of Surgical Site Infections
18 Sep, 2019 | 02:51h | UTCOriginal Guideline: Management of Surgical Site Infections – American Academy of Orthopedic Surgeons (free) / Full Guideline (free PDF)
Source: Medscape
Review: Improving the Quality of Life of People with Advanced Respiratory Disease and Severe Breathlessness
18 Sep, 2019 | 02:29h | UTCRelated Guideline: Danish respiratory society position paper: palliative care in patients with chronic progressive non-malignant lung diseases – European Clinical Respiratory Journal (free)
New NICE Guidelines: Management of Pneumonia in Adults
17 Sep, 2019 | 08:31h | UTCDiagnosis and Management Pneumonia in Adults – National Institute for Health and Care Excellence (free)
Related NICE Guidelines: Pneumonia (community-acquired): antimicrobial prescribing (free) AND Pneumonia (hospital-acquired): antimicrobial prescribing (free)
See also: NICE Antimicrobial prescribing guidelines (resource covering many common conditions) AND NICE Summary of antimicrobial prescribing guidance – managing common infections (free PDF)
Viewpoint: “It’s All in Your Head”—Medicine’s Silent Epidemic
17 Sep, 2019 | 08:01h | UTC“It’s All in Your Head”—Medicine’s Silent Epidemic – JAMA Neurology (free for a limited period)
Cohort Study: Donepezil Associated with Increased Risk of Rhabdomyolysis
17 Sep, 2019 | 08:07h | UTCCommentaries: Commonly used drug for Alzheimer’s disease doubles risk of hospitalization – Canadian Medical Association Journal (free) Study: Common Alzheimer’s disease drug doubles hospitalization risk – UPI (free) AND Rhabdomyolysis risk with donepezil double that of other AD meds – OnMedica (free)
Scientific Statement: Review of Current Evidence and Clinical Recommendations on the Effects of Low-carbohydrate and Very-low-carbohydrate (Including Ketogenic) Diets for the Management of Body Weight and Other Cardiometabolic Risk Factors
17 Sep, 2019 | 07:25h | UTC
Review: Understanding Tumor Lysis Syndrome
17 Sep, 2019 | 07:40h | UTCUnderstanding tumor lysis syndrome – Intensive Care Medicine (free for a limited period)
Cohort Study: Lower Carbohydrate Diets and All-cause and Cause-specific Mortality
17 Sep, 2019 | 07:19h | UTCCommentary: Lower Carbohydrate Diets, All-Cause and Cause-Specific Mortality – American College of Cardiology (free)
Cohort Study: Associations of Subjective Memory Complaints and Simple Memory Task Scores with Future Dementia in the Primary Care Setting
17 Sep, 2019 | 01:05h | UTCCommentary: Memory complaints, simple scores predict dementia in primary care – Univadis (free registration required)
Review: Association Between Antipsychotic Medication Use and Diabetes
17 Sep, 2019 | 01:01h | UTCAssociation Between Antipsychotic Medication Use and Diabetes – Current Diabetes Reports (free)
ACC Consensus Decision Pathway for Heart Failure Hospitalizations
16 Sep, 2019 | 02:24h | UTCKey Points to Remember: ACC Consensus Decision Pathway for Heart Failure Hospitalizations – American College of Cardiology (free)
[Abstract Only] Study: High Prevalence of Obstructive Sleep Apnea in Patients with Resistant Hypertension
16 Sep, 2019 | 02:18h | UTCPrevalence, Characteristics and Association of Obstructive Sleep Apnea with Blood Pressure Control in Patients with Resistant Hypertension – Annals of the American Thoracic Society (link to abstract – $ for full-text)
Commentaries: Most patients with resistant hypertension have sleep apnoea – OnMedica (free) AND More Severe OSA Leads to Higher Blood Pressure in Patients with Resistant Hypertension – American Thoracic Society (free) AND Obstructive Sleep Apnea Common in Patients with Resistant Hypertension – MedicalResearch.com (free)
ACE inhibitors and ARBs: Managing Potassium and Renal Function
16 Sep, 2019 | 02:14h | UTCEditorial: ACE inhibitor and ARB therapy: Practical recommendations (free)
Meta-Analysis: Parenteral Methotrexate Better Than Oral MTX for Achieving Reduction in Disease Activity in Patients with Rheumatoid Arthritis
15 Sep, 2019 | 23:59h | UTCCommentary: Rheumatoid arthritis: parenteral MTX tops pills for efficacy – Univadis (free registration required)
Evaluation and Management of Angioedema in the Emergency Department
15 Sep, 2019 | 23:43h | UTCSource: Medscape
Updates in Pathophysiology, Definition and Classification of Hepatorenal Syndrome
15 Sep, 2019 | 23:34h | UTCNews in pathophysiology, definition and classification of hepatorenal syndrome: A step beyond the International Club of Ascites (ICA) consensus document – Journal of Hepatology (free for a limited period)
Related Article: Diagnosis and management of acute kidney injury in patients with cirrhosis: revised consensus recommendations of the International Club of Ascites – Gut (free PDF)
Related Guidelines: Cirrhosis in Over 16s: Assessment and Management – National Institute for Health and Care Excellence (free) AND 2018 KASL clinical practice guidelines for liver cirrhosis: Ascites and related complications – Clinical and Molecular Hepatology (free) AND 2018 Recommendations of the Brazilian Society of Hepatology for the management of acute kidney injury in patients with cirrhosis (free PDF) AND Evidence-based clinical practice guidelines for liver cirrhosis 2015 – Journal of Gastroenterology (free) AND Chinese guidelines on the management of ascites and its related complications in cirrhosis – Hepatology International (free)
NICE Guideline: Tuberculosis
13 Sep, 2019 | 08:27h | UTCTuberculosis – National Institute for Health and Care Excellence (free)
Related: WHO Guidelines on Tuberculosis Infection Prevention and Control (free guidelines)
The Lancet Commission: Management of Multidrug-resistant and Incurable Tuberculosis
13 Sep, 2019 | 08:22h | UTCThe Lancet Respiratory Medicine Commission: 2019 update: epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant and incurable tuberculosis – The Lancet (free registration required)
Related Articles: Management of drug-resistant tuberculosis – The Lancet (free registration required) AND Challenges and controversies in childhood tuberculosis – The Lancet (free)
Editorial: Tuberculosis needs accelerated and continued attention (free)
Related: WHO Consolidated Guidelines on Drug-resistant Tuberculosis Treatment (free) AND Randomized Trial: 9-month Treatment for Multi-drug Resistant TB is as Effective as 24-month Treatment (free)
Meta-analysis: Combined Lifestyle Factors and Risk of Incident Type 2 Diabetes and Prognosis Among Individuals with Type 2 Diabetes
13 Sep, 2019 | 08:16h | UTCCommentary: Diabetes Risk Plummets by 75% When Multiple Risk Factors Tackled – Medscape (free registration required)
Chest Radiograph Signs Suggestive of Pericardial Disease
13 Sep, 2019 | 08:14h | UTCChest Radiograph Signs Suggestive of Pericardial Disease – American College of Cardiology (free)
Pneumococcal Disease: A Systematic Review of Health Utilities, Resource Use, Costs, and Economic Evaluations of Interventions
13 Sep, 2019 | 08:11h | UTCRelated: Pneumococcal infection in adults: burden of disease – Clinical Microbiology and Infection (free) AND The remaining challenges of pneumococcal disease in adults – European Respiratory Review (free)