Internal Medicine
ACR/NKF Consensus Statement: “The Risk of Acute Kidney Injury Developing in Patients with Reduced Kidney Function Following Exposure to Intravenous Iodinated Contrast Media has Been Overstated”
22 Jan, 2020 | 09:44h | UTCCommentary: Risk of kidney injury in contrast CT imaging overstated, experts say – UPI (free)
Related: Another Study Questions the Association of Contrast Use and Acute Kidney Injury (studies on the subject)
Position Paper: Diagnosis and Risk Stratification of Chest Pain Patients in the Emergency Department
22 Jan, 2020 | 09:43h | UTCDiagnosis and risk stratification of chest pain patients in the emergency department: focus on acute coronary syndromes. A position paper of the Acute Cardiovascular Care Association – European Heart Journal: Acute Cardiovascular Care (free for a limited period)
WHO Q & A – E-cigarettes: How Risky Are They?
22 Jan, 2020 | 09:39h | UTCE-cigarettes: how risky are they? – World Health Organization (free)
Related Commentary on Twitter (Thread – Click for More)
E-cigarettes are harmful to health and are not safe.
They are particularly risky when used by adolescents. Nicotine is highly addictive & young people’s brains develop up to their mid-twenties. Exposure to nicotine can have long-lasting, damaging effects.https://t.co/S8ZHoux45e pic.twitter.com/mkx0d5GCpW— World Health Organization (WHO) (@WHO) January 21, 2020
[Abstract Only] Meta-Analysis: Treatment of Uncomplicated Acute Diverticulitis Without Antibiotics May be Safe
22 Jan, 2020 | 09:31h | UTCTreatment of Uncomplicated Acute Diverticulitis Without Antibiotics: A Systematic Review and Meta-analysis – Diseases of the Colon & Rectum (link to abstract – $ for full-text)
Related: Randomized Trial: Antibiotic Avoidance Associated with Similar Long-term Outcomes in Uncomplicated Diverticulitis (randomized trials on the subject)
Randomized Trial: Hydroxyethyl Starch vs. Saline for Volume Replacement Therapy in High-Risk Patients Undergoing Major Abdominal Surgery
22 Jan, 2020 | 09:36h | UTCEffect of Hydroxyethyl Starch vs Saline for Volume Replacement Therapy on Death or Postoperative Complications Among High-Risk Patients Undergoing Major Abdominal Surgery: The FLASH Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Hydroxyethyl Starch for Fluid Replacement Therapy in High-Risk Surgical Patients: Context and Caution (free for a limited period)
Related Cochrane Review: Colloids vs Crystalloids for Fluid Resuscitation in Critically Ill People (free)
Related Commentary on Twitter
FLASH trial published today in @JAMA_current, comparing saline versus HES in high risk surgical patients.https://t.co/5xet1jOtEA
Our accompanying editorial, which hopefully helps to contextualizing the results can be found at:https://t.co/Ebl9ieG5Sp— Fernando Zampieri (@f_g_zampieri) January 21, 2020
Managing Clinical Uncertainty: A Teachable Moment
22 Jan, 2020 | 09:33h | UTCManaging Clinical Uncertainty: A Teachable Moment – JAMA Internal Medicine (free for a limited period)
[Abstract Only] Systematic Review: No Benefit from Flexible Titration Above Minimum Licensed Dose in Prescribing Antidepressants for Major Depression
22 Jan, 2020 | 09:27h | UTCNo benefit from flexible titration above minimum licensed dose in prescribing antidepressants for major depression: systematic review – Acta Psychiatrica Scandinavica (link to abstract – $ for full-text)
Related Meta-analysis: Optimal Dose of Antidepressants in Major Depression – The Lancet Psychiatry (free study and commentaries)
[Abstract Only] Randomized Trial: Effectiveness of Mirtazapine as Add-on to Paroxetine vs. Paroxetine or Mirtazapine Monotherapy in Patients with Depression with Early Non-response to Paroxetine
22 Jan, 2020 | 09:08h | UTCEffectiveness of mirtazapine as add-on to paroxetine v. paroxetine or mirtazapine monotherapy in patients with major depressive disorder with early non-response to paroxetine: a two-phase, multicentre, randomized, double-blind clinical trial – Psychological Medicine (link to abstract – $ for full-text)
Palliative Sedation: A Safety Net for the Relief of Refractory and Intolerable Symptoms at the End of Life
22 Jan, 2020 | 09:06h | UTC
Pain and Delirium: Mechanisms, Assessment, and Management
22 Jan, 2020 | 09:04h | UTCPain and delirium: mechanisms, assessment, and management – European Geriatric Management (free)
Podcast: Lipids Update and Cardiovascular Risk Reduction
21 Jan, 2020 | 03:10h | UTCSee also: Episode List
Document to Defeat Malpractice Suits: 10 Tips for Hospitalists
21 Jan, 2020 | 03:08h | UTC
Screening for Colon Cancer in Older Adults: Risks, Benefits, and When to Stop
21 Jan, 2020 | 03:02h | UTC
Editorial – Back to Basics: 10 Facts Every Person Should Know About Back Pain
21 Jan, 2020 | 03:04h | UTCCommentary: Myths may worsen low back pain and promote ineffective treatments – Reuters (free)
Study – Troponin Testing and Coronary Syndrome in Geriatric Patients with Nonspecific Complaints: Are We Overtesting?
21 Jan, 2020 | 02:58h | UTCCommentaries: Study questions routine troponin testing for ACS in geriatric patients with NSCs – Society for Academic Emergency Medicine (free) AND This Old Heart of Mine and Troponin Testing – The Skeptics Guide to EM (free)
Cohort Study: Premature Menopause Linked to Increased Risk of Development of Chronic Conditions and Multimorbidity
21 Jan, 2020 | 01:30h | UTCCommentary: Premature menopause increases the risk of multiple health problems in your 60s – European Society of Human Reproduction and Embryology (free)
Meta-Analysis of Randomized Trials: Effects of Metformin on Blood Lipid Profiles in Nondiabetic Adults
21 Jan, 2020 | 01:09h | UTC
The PEPTIC Randomized Clinical Trial: Similar Outcomes with Stress Ulcer Prophylaxis with Proton Pump Inhibitors vs. Histamine-2 Receptor Blockers Among ICU Patients Receiving Invasive Mechanical Ventilation
19 Jan, 2020 | 21:42h | UTCEditorial: Proton Pump Inhibitors vs Histamine-2 Receptor Blockers for Stress Ulcer Prophylaxis in Critically Ill Patients: Issues of Interpretability in Pragmatic Trials (free for a limited period)
Conference Presentation: Effect of Stress Ulcer Prophylaxis With PPIs vs H2RBs on Mortality in Ventilated ICU Patients (free)
Commentaries: JC: The PEPTIC study PPI vs H2RBs on the ICU – St Emlyn’s (free) AND Risks And Benefits Of Proton Pump Inhibitors To Prevent Gi Bleeds In Intensive Care Patients – MedicalResearch.com (free)
[Abstract Only] Cohort Study: Risk of Hypertension Into Adulthood in Persons Born Prematurely
19 Jan, 2020 | 20:46h | UTCRisk of hypertension into adulthood in persons born prematurely: a national cohort study – European Heart Journal (link to abstract – $ for full-text)
Source: EvidenceAlerts
Cohort Study: Incidental Lymphopenia and Mortality
19 Jan, 2020 | 20:45h | UTCCommentaries: Lymphopenia may hint a higher risk of future illness, death – News Medical (free) AND Incidental Low Lymphocyte Count Linked to Increased Mortality – MedicalResearch.com (free)
Perspective: Invalidity of an Oft-Cited Estimate of the Relative Harms of Electronic Cigarettes
17 Jan, 2020 | 09:38h | UTCCommentary: Frequently cited claim that e-cigarettes are ‘95% safer’ is misleading and outdated – Virginia Commonwealth University (free)
Editorial: How I Search for a Sepsis Source
17 Jan, 2020 | 02:01h | UTCHow I search for a sepsis source – Critical Care (free)
Review: Current Evidence on Oral Antibiotics for Infective Endocarditis
17 Jan, 2020 | 01:58h | UTCRelated: Randomized Trial: Partial Oral vs. Intravenous Antibiotic Treatment of Endocarditis (free study and commentaries)
Cohort Study: Interventions and Operations 5 Years After Bariatric Surgery
16 Jan, 2020 | 08:51h | UTCAuthor Interview: Interventions and Operations 5 Years After Bariatric Surgery (free)
Commentaries: Bariatric Surgery Is Safe and It Works – JAMA Surgery (free for a limited period) AND Procedures And Hospitalizations Common After Bariatric Procedures – MedicalResearch.com (free) AND More Interventions Follow Gastric Bypass than Gastric Sleeve, Large Study Shows – Health Sciences at the University of Pittsburgh (free)
Related Study: Cohort Study: Risk of Operative and Nonoperative Interventions After Roux-en-Y Gastric Bypass vs. Vertical Sleeve Gastrectomy (free)
Randomized Trial: Twice-daily vs. Alternate-day Oral Iron Therapy in the Treatment of Iron-deficiency Anemia
16 Jan, 2020 | 03:23h | UTC