Internal Medicine
Interpreting a Covid-19 Test Result
13 May, 2020 | 02:18h | UTCPractice Pointer: Interpreting a covid-19 test result – The BMJ
Related: Interpreting Diagnostic Tests for SARS-CoV-2 – JAMA
Editorial: Waste in Covid-19 Research
13 May, 2020 | 02:17h | UTCWaste in covid-19 research – The BMJ
Related Landmark Paper from the Author: Avoidable waste in the production and reporting of research evidence – The Lancet (free registration required)
Related Commentary on Twitter
"A deluge of poor quality research is sabotaging an effective evidence based response" say @PaulGlasziou, Sharon Sanders and @Tammy_Hoffmann https://t.co/jvx8FQxQCo
— The BMJ (@bmj_latest) May 12, 2020
New Clinical Risk Score to Predict the Occurrence of Critical Illness in Hospitalized Patients With COVID-19
13 May, 2020 | 02:14h | UTCSee also: Calculation Tool For Predicting Critical-ill COVID-19 At Admission
Related Preprint Study (just published): Development and validation of the COVID-19 severity index (CSI): a prognostic tool for early respiratory decompensation – medRxiv AND Calculation Tool: https://covidseverityindex.org/
Study Commentary – Virus Wars: Return of Lopinavir/Ritonavir (Along with Ribavirin and Interferon)
13 May, 2020 | 02:12h | UTCVirus Wars: Return of Lopinavir/Ritonavir (along with ribavirin and interferon) – PulmCrit
Original Article: Triple Therapy Antiviral Combination Seems Promising for COVID-19 in Open-label, Randomized, Phase 2 Trial (study and commentaries)
Gastrointestinal, Hepatobiliary, and Pancreatic Manifestations of COVID-19
13 May, 2020 | 02:05h | UTC
Hydroxychloroquine in Patients with COVID-19: A Systematic Review and Meta-analysis
13 May, 2020 | 01:53h | UTC“While initial studies with hydroxychloroquine showed some ray of hope, recent studies that have emerged found either no benefit or a possible harm in COVID-19.”
Remdesivir in COVID-19: A Critical Review of Pharmacology, Pre-clinical and Clinical Studies
13 May, 2020 | 01:50h | UTC“While the first double-blind, randomized-controlled trial (DBRCT) found no significant benefit with remdesivir compared to placebo, preliminary reports from another DBRCT showed a significant faster recovery, without any difference in mortality.”
The Dangers of Using Tumor Markers to Evaluate Nonspecific Symptoms
13 May, 2020 | 01:45h | UTCThe Dangers of Using Tumor Markers to Evaluate Nonspecific Symptoms: A Teachable Moment – JAMA Internal Medicine (free for a limited period)
The FDA has Authorized the use of Remdesivir: But There’s no Good Evidence it Reduces Mortality in Covid-19
13 May, 2020 | 01:49h | UTC
Observational Study: Hydroxychloroquine, Azithromycin, or Both Not Associated with Lower In-hospital Mortality
12 May, 2020 | 03:39h | UTC
Abdominal Imaging Findings in COVID-19: Preliminary Observations
12 May, 2020 | 03:28h | UTCAbdominal Imaging Findings in COVID-19: Preliminary Observations – Radiology
News Release: Imaging reveals bowel abnormalities in patients with COVID-19 – Radiological Society of North America
Richard Lehman’s Covid-19 Reviews—11 May 2020
12 May, 2020 | 03:22h | UTCRichard Lehman’s Covid-19 Reviews, 11 May 2020 – The BMJ Opinion
In this weekly round-up, Richard Lehman looks at a personal selection of articles of relevance to clinicians dealing with covid-19
Coagulation Abnormalities and Thrombosis in Patients with COVID-19
12 May, 2020 | 03:16h | UTCCoagulation abnormalities and thrombosis in patients with COVID-19 – The Lancet
Related Commentary on Twitter
Good to see these welcome recommendations today for diagnosis of clotting and its prevention in patients with severe #COVID19 @TheLancetHaem https://t.co/RrtXSIu2Ne by @MarcelLevi @JerroldLevy and colleagues pic.twitter.com/dU17RIj1f2
— Eric Topol (@EricTopol) May 11, 2020
2020 ACR Guideline for the Management of Gout
12 May, 2020 | 03:14h | UTCNews Release: ACR releases gout management guideline
Perspective: Which COVID-19 Antivirals Actually Work?
12 May, 2020 | 03:18h | UTCPerspective: Which COVID-19 Antivirals Actually Work? – Forbes
Related: Hong Kong Doctors See Progress In Treatment Of COVID-19 – Forbes
Triple Therapy Antiviral Combination Seems Promising for COVID-19 in Open-label, Randomized, Phase 2 Trial
11 May, 2020 | 00:42h | UTCCommentaries: Interferon beta-1b for COVID-19 – The Lancet AND New triple antiviral drug combination shows early promise for treating COVID-19 in phase 2 randomized trial – The Lancet AND A Drug Cocktail Hastens Recovery in Some Coronavirus Patients – The New York Times AND Triple drug therapy helps coronavirus patients recover more quickly, study finds – CNN AND Triple antiviral drug shows early promise in COVID-19 trial – Reuters AND Expert reaction to a study about a phase 2 trial of a triple antiviral drug combination treatment for COVID-19 – Science Media Centre
Perspective: When Should Clinicians Act on Non–Statistically Significant Results From Clinical Trials?
11 May, 2020 | 00:23h | UTCWhen Should Clinicians Act on Non–Statistically Significant Results From Clinical Trials? – JAMA (via @AndersPerner)
Author Interview: When Should Physicians Act on Non–Statistically Significant Results From Clinical Trials?
“The burden of proof required to do “more” should probably be higher than to do “less,” particularly if doing “more” is likely to increase overall health care costs.”
The Emerging Long-term Complications of Covid-19, Explained
11 May, 2020 | 00:27h | UTCThe emerging long-term complications of Covid-19, explained – Vox
Related: Coronavirus: Sickest patients face long recovery – BBC AND Surviving Covid-19 May Not Feel Like Recovery for Some – New England Journal of Medicine
Canadian Guideline: Acetylsalicylic Acid for Prevention of Vascular Events
11 May, 2020 | 00:05h | UTC
Study: Combustible vs. Electronic Cigarettes Alterations in Vascular Function
11 May, 2020 | 00:10h | UTCCommentary: Like Tobacco, Long-term E-Cigarettes Harm Vascular Function – TCTMD AND Vascular Damage Similar With E-cigarettes, Traditional Cigarettes – American College of Cardiology
Large Observational Study Finds Hydroxychloroquine Provides no Benefit in Hospitalized Patients with Covid-19
8 May, 2020 | 10:41h | UTCEditorial: The Urgency of Care during the Covid-19 Pandemic — Learning as We Go
Treatment of Community-Acquired Pneumonia During the COVID-19 Pandemic
8 May, 2020 | 10:35h | UTC
RCEM Position Statement COVID-19: Resetting Emergency Department Care
8 May, 2020 | 10:32h | UTC
COVID-19 in Older People: A Rapid Clinical Review
8 May, 2020 | 10:22h | UTCCOVID-19 in Older People: A Rapid Clinical Review – Age and Ageing
Guideline Synopsis: Initial Management of Acute Pancreatitis
8 May, 2020 | 10:12h | UTCInitial Management of Acute Pancreatitis – JAMA
Original Guideline: American Gastroenterological Association Institute Guideline on Initial Management of Acute Pancreatitis