Internal Medicine
Covid-19: Inhaled Nebulized Interferon Beta-1a shows potential for hospitalized patients in preliminary trial
13 Nov, 2020 | 09:33h | UTC
Preliminary study shows fluvoxamine may reduce clinical deterioration in outpatients with symptomatic COVID-19
13 Nov, 2020 | 09:35h | UTCEditorial: COVID-19 Infection—Preventing Clinical Deterioration
Long Covid: Persistent fatigue following SARS-CoV-2 infection is common and independent of severity of initial infection
13 Nov, 2020 | 09:27h | UTCCommentary: Half of recovered COVID-19 patients report lingering fatigue – CIDRAP
Long Covid: 2 months after being hospitalized for Covid-19, many patients persisted symptomatic and did not resume normal activities
13 Nov, 2020 | 09:28h | UTCSixty-Day Outcomes Among Patients Hospitalized With COVID-19 – Annals of Internal Medicine
Commentary on Twitter
New Mich. hospital data: Of people admitted with COVID, 70% were alive and home 60 days later.
Of those who'd been working, 40% either lost their job or were still too sick to work.
It's not just the deaths; it's the health and economic damage. https://t.co/wMGkJw5KSF pic.twitter.com/8EbHktTxRX
— Atul Gawande (@Atul_Gawande) November 12, 2020
Case report: Persistence and evolution of SARS-CoV-2 in an immunocompromised host
13 Nov, 2020 | 09:24h | UTC
Commentary on Twitter (thread – click for more)
This summer, we partnered with the clinical team of an immunosuppressed patient with recurrent COVID and multiple hospitalizations. His NP swab VL reached 1 billion copies 5 months after initial dx. The team's Q: is this pt being re-infected w/ COVID? 1/ https://t.co/vkVerBUUPg
— Jonathan Li (@DrJLi) November 12, 2020
How risky is air travel in the pandemic? Here’s what the science says
13 Nov, 2020 | 09:22h | UTCHow risky is air travel in the pandemic? Here’s what the science says – Vox
Perspective: Many younger adults need to take Covid-19 more seriously as demographics shift
13 Nov, 2020 | 09:25h | UTCYounger Adults Caught in COVID-19 Crosshairs as Demographics Shift – JAMA
Commentary from the author on Twitter (thread – click for more)
https://twitter.com/jenabbasi/status/1326909913805828100
Older age and frailty are frequently associated with atypical and unspecific COVID-19 presentations, including functional decline, acute mental change, and hypotension
12 Nov, 2020 | 09:22h | UTC
Commentary on Twitter
DIVERGENT: age, #frailty, and presentations of #COVID19
Typical symptoms were uncommon in frail and older
patients; they were more likely to experience functional decline and key features of delirium. #geriatrics @geronsociety @OxfordJournals #gerontolhttps://t.co/jRhwvacsVm pic.twitter.com/9zhHZjsSoy— Marlon Aliberti (@marlon_aliberti) November 5, 2020
Case-control study: COVID-19-associated stroke is associated with worse outcomes and increased mortality
12 Nov, 2020 | 09:24h | UTCCommentary: Risk of death, disability after stroke much higher for COVID-19 patients – Cardiovascular Business
[Abstract Only] Study: An automated predictive model can identify hospitalized adults outside the ICU at risk for clinical deterioration for whom interventions by rapid-response teams could be implemented
13 Nov, 2020 | 09:16h | UTCAutomated Identification of Adults at Risk for In-Hospital Clinical Deterioration – New England Journal of Medicine (link to abstract – $ for full-text)
Review for the public on the different kinds of COVID-19 tests. It covers the differences and similarities between molecular, antigen, and serologic tests.
12 Nov, 2020 | 09:19h | UTC
Wearing cloth or disposable surgical face masks has no effect on vigorous exercise performance in healthy individuals
12 Nov, 2020 | 09:21h | UTCCommentary: Face masks don’t hinder breathing during exercise, study finds – University of Saskatchewan
Why do COVID death rates seem to be falling? Correct use of corticosteroids, hard-won experience, younger patients, and reduced strain on hospitals are all possibilities
12 Nov, 2020 | 09:16h | UTCWhy do COVID death rates seem to be falling? – Nature
[Preprint] Validation of home oxygen saturation as a marker of clinical deterioration in patients with suspected COVID-19: Even small deflections in oxygen saturations of 1-2% below 96% confer an increased mortality risk.
12 Nov, 2020 | 09:18h | UTC
Commentary on Twitter
*BREAKING* First paper examining home oxygen saturation in COVID confirmed cases as a trigger for initial hospital assessment. We need to rapidly implement a hybrid community-hospital COVID Oximetry@home #COVIDvirtualward @richardhorton1 @bmj_latest https://t.co/0SjrUT0Tjw pic.twitter.com/0TgPPRUBqv
— Matt Inada-Kim (@mattinadakim) November 8, 2020
Randomized trial: vitamin D, omega-3 fatty acids, or a strength-training exercise program do not improve clinical outcomes in older adults
11 Nov, 2020 | 09:11h | UTCEffect of Vitamin D Supplementation, Omega-3 Fatty Acid Supplementation, or a Strength-Training Exercise Program on Clinical Outcomes in Older Adults: The DO-HEALTH Randomized Clinical Trial – JAMA (free for a limited period)
Derivation and validation of the HA2T2 (Hypoxia, Age, Troponin) COVID‐19 mortality risk score
11 Nov, 2020 | 09:18h | UTC
Commentary on Twitter
Predicting in-hospital mortality among patients with #COVID19 using the simple HA2T2 (hypoxia, age and troponin) score. https://t.co/FTDceIijZl @KevinManocha @bradpeltzer @MonikaSafford @ParagGoyalMD @JAHA_AHA @WeillCornell @nyphospital pic.twitter.com/vGTNSg8wyO
— Jim Cheung (@DrJCheungEP) November 10, 2020
[Not Published Yet] Randomized trial: Long-acting injectable drug every 8 weeks is highly effective in preventing HIV acquisition in women
11 Nov, 2020 | 09:17h | UTCCommentary: NIH study finds long-acting injectable drug prevents HIV acquisition in cisgender women – NIH News Releases
[Abstract Only] Randomized trial: Intravenous haloperidol more effective than ondansetron for cannabis hyperemesis syndrome
11 Nov, 2020 | 09:08h | UTC
Commentary on Twitter
Excited to have been involved in this practice-changing RCT comparing Haloperidol (superior) to Ondansetron for Cannabis Hyperemesis Syndrome from @Qemerg @therealdraa_ron @savforrester Marco Sivilotti and others! Check it out!https://t.co/ylms5JIO9v
— Andrew K Hall (@AKHallMD) November 5, 2020
KDIGO Guideline Synopsis: Diabetes management in chronic kidney disease. Use of ACE inhibitors or ARBs, glycemic monitoring and targets, and choice of antihyperglycemic drugs are covered
11 Nov, 2020 | 09:09h | UTCOriginal guideline: Kidney Disease: Improving Global Outcomes (KDIGO) 2020 Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease
Podcast on chronic cough. Don’t be afraid to try empiric therapies! PPIs for GERD, antihistamines and intranasal steroids for post-nasal drip, and inhaled corticosteroids for post-viral cough are generally low-risk and will treat many cases.
11 Nov, 2020 | 09:04h | UTC#241 Chronic Cough – The Curbsiders Internal Medicine Podcast
News Release [Not Published Yet]: Vaccine candidate 90% effective against Covid-19 according to manufacturer
10 Nov, 2020 | 09:41h | UTCNews Release: Pfizer and Biontech announce vaccine candidate against Covid-19 achieved success in first interim analysis from phase 3 study
Commentaries: What Pfizer’s landmark COVID vaccine results mean for the pandemic – Nature AND Covid-19: Vaccine candidate may be more than 90% effective, interim results indicate – The BMJ AND Covid vaccine: First ‘milestone’ vaccine offers 90% protection – BBC AND Hopes rise for end of pandemic as Pfizer says vaccine is 90% effective – The Guardian AND Four reasons for encouragement based on Pfizer’s Covid-19 vaccine results – STAT AND Expert reaction to Pfizer and BioNTech reporting interim results from phase 3 COVID-19 vaccine trial – Science Media Centre
Meta-analysis: Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging can reduce cases of severe disability but increases symptomatic intracranial hemorrhage and deaths
11 Nov, 2020 | 09:06h | UTCIntravenous alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data – The Lancet (free registration required)
Commentary on Twitter
Latebreaking at #ESOWSO2020—Intravenous alteplase for #stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data https://t.co/KDX2lHisbj pic.twitter.com/cnoiRhIReF
— The Lancet (@TheLancet) November 8, 2020
Another study shows hydroxychloroquine does not benefit adults hospitalized with COVID-19
10 Nov, 2020 | 09:39h | UTCEditorial: Misguided Use of Hydroxychloroquine for COVID-19: The Infusion of Politics Into Science
Commentary: Hydroxychloroquine does not benefit adults hospitalized with COVID-19 – NIH News Releases
Patients with Covid-19 and myocardial injury have increased in-hospital mortality, particularly if echocardiographic abnormalities are present
10 Nov, 2020 | 09:37h | UTC
Case reports: Multidrug-resistant Candida auris infections in critically ill Covid-19 patients
10 Nov, 2020 | 09:33h | UTCCommentaries: Candida auris Infection in COVID-19 Patients – NEJM Journal Watch AND Drug-resistant superbug thriving in hospitals hit hard by COVID-19 – National Geographic