Internal Medicine
AHA Scientific Statement: Contemporary diagnosis and management of rheumatic heart disease
20 Oct, 2020 | 01:34h | UTCTop Things to Know: Contemporary Diagnosis and Management of Rheumatic Heart Disease – American Heart Association
KDIGO 2020 Clinical practice guideline for diabetes management in chronic kidney disease
20 Oct, 2020 | 01:33h | UTCExecutive summary: 2020 KDIGO Diabetes Management in CKD Guideline: evidence-based advances in monitoring and treatment – Kidney International
Commentary on Twitter
2020 #KDIGO Diabetes Management in #CKD Guidelinehttps://t.co/G127PgO1fe@deboerih @P_Rossing @goKDIGO pic.twitter.com/3kVNDpAoub
— Kidney International (@Kidney_Int) October 4, 2020
Cohort study: Exposure to modafinil and armodafinil during pregnancy linked to fetal malformations
20 Oct, 2020 | 01:31h | UTCPregnancy and Fetal Outcomes Following Exposure to Modafinil and Armodafinil During Pregnancy – JAMA Internal Medicine (free for a limited period)
Commentaries: Caution in Prescribing Modafinil and Armodafinil to Individuals Who Could Become Pregnant – JAMA Internal Medicine (free for a limited period) AND Narcolepsy Drugs Tied to Increased Risk for Birth Defects – NEJM Journal Watch
Plastic surgery complications: A review for emergency clinicians
20 Oct, 2020 | 01:32h | UTC
[Abstract Only] Systematic review and meta-analysis of native kidney biopsy complications
20 Oct, 2020 | 01:26h | UTCSystematic Review and Meta-Analysis of Native Kidney Biopsy Complications – Clinical Journal of the American Society of Nephrology (link to abstract – $ for full-text)
Commentary on Twitter
A meta-analysis found that although native kidney biopsy is an invasive diagnostic procedure, the rates of bleeding complications are low. Complications are more frequently seen after kidney biopsies of hospitalized patients with AKI. https://t.co/kxK6qxX1fc pic.twitter.com/SgCoI505cc
— CJASN (@CJASN) October 15, 2020
Meta-analysis: Evidence-based prevention of Alzheimer’s disease
20 Oct, 2020 | 01:21h | UTCCommentaries: Biggest risk factors identified to try and prevent Alzheimer’s disease – BMJ AND Systematic review finds ten lifestyle factors that clearly impact the probability of developing Alzheimer’s disease (AD) – Sharp Brains
Commentary on Twitter
Evidence-based #prevention of #Alzheimers disease https://t.co/XOMiEoMlmI via @JNNP_BMJ #dementia @perryd43 @PennilessScribe @u3Y4BDE @SanWren @lfkraus @the_scholar1 @ktanimara @drsharwood @TargetLatino @LilithResists @Joseph_Santoro @liftdupbyangels @mrtom101 @SteveDitchfield pic.twitter.com/T5hqbzmIwi
— Ian Kremer (@LEAD_Coalition) July 24, 2020
[Abstract Only] Meta-analysis: Effect of urate-lowering therapy on cardiovascular and kidney outcomes
20 Oct, 2020 | 01:22h | UTCEffect of Urate-Lowering Therapy on Cardiovascular and Kidney Outcomes: A Systematic Review and Meta-Analysis – Clinical Journal of the American Society of Nephrology (link to abstract – $ for full-text)
Commentary on Twitter
Study found urate-lowering therapy didn't produce benefits on clinical outcomes including major adverse cardiovascular events, all-cause mortality & kidney failure. Insufficient evidence to support urate lowering to improve kidney & cardiovascular outcomes https://t.co/uifm4vikYe pic.twitter.com/3fV60V3Lcx
— CJASN (@CJASN) October 14, 2020
[Preprint] Multi-organ impairment in low-risk individuals with long COVID
18 Oct, 2020 | 23:18h | UTCMulti-organ impairment in low-risk individuals with long COVID – medRxiv
Related study (preprint): Persistent symptoms after Covid-19: qualitative study of 114 long Covid patients and draft quality criteria for services – medRxiv
Commentary on Twitter
"In a young, low-risk population with ongoing symptoms, almost 70% of individuals have impairment in 1 or more organs 4 months after initial symptoms of #SARSCoV2 infection" #LongCovid https://t.co/gPnDtacI1J by @amibanerjee1 and colleagues
via @ahandvanish<-? pic.twitter.com/7mKEsQgq5l— Eric Topol (@EricTopol) October 17, 2020
WHO: Herd immunity, lockdowns and COVID-19
18 Oct, 2020 | 23:19h | UTCCoronavirus disease (COVID-19): Herd immunity, lockdowns and COVID-19 – World Health Organization
Commentary on Twitter
Herd immunity is a concept used for vaccination, in which a population can be protected from a virus if a threshold of vaccination is reached. Vaccinated people are protected from getting the disease & passing it on, breaking any chains of transmission.
?https://t.co/X9N7zcyfOX pic.twitter.com/V22iA6OqOq
— World Health Organization (WHO) (@WHO) October 16, 2020
New studies show reduced prevalence and severity of SARS-CoV-2 infection in ABO blood group O
18 Oct, 2020 | 23:16h | UTCStudy 1: Reduced prevalence of SARS-CoV-2 infection in ABO blood group O – Blood Advances
Commentaries: People with blood type O may have lower risk of Covid-19 infection and severe illness, two new studies suggest – CNN AND Studies offer new evidence for possible link between blood type and COVID-19 susceptibility – American Society of Hematology
Answering key questions about COVID-19 vaccines
18 Oct, 2020 | 23:10h | UTCAnswering Key Questions About COVID-19 Vaccines – JAMA
Commentary on Twitter
Many individuals are hesitant about receiving #COVID19 vaccines. It is critical that clinicians stay well informed about emerging data so that they can help patients make sound decisions https://t.co/1QDwOKuDqc @JesseGoodmanMD @ImmunizeOrg @pharmacists
— JAMA (@JAMA_current) October 16, 2020
NIHR dynamic review of the evidence around ongoing Covid19 symptoms (often called Long Covid)
18 Oct, 2020 | 23:14h | UTCA dynamic review of the evidence around ongoing Covid19 symptoms (often called Long Covid) – National Institute for Health Research
News Release: Living with COVID: NIHR publishes dynamic themed review into ‘ongoing COVID’
Commentaries: Coronavirus: ‘Long Covid could be four different syndromes’ – BBC AND Long covid could be four different syndromes, review suggests – The BMJ AND ‘Long COVID’ may affect multiple parts of body and mind, doctors say – Reuters
Randomized trial: Effectiveness of pelvic floor muscle training with and without electromyographic biofeedback for urinary incontinence in women
18 Oct, 2020 | 23:06h | UTCCommentary: For Urinary Incontinence, No Need to Add Biofeedback to Pelvic Floor Exercises – NEJM Journal Watch
Commentary on Twitter
This RCT did not find a statistically significant or clinically important difference in severity of urinary incontinence between women randomised to electromyographic biofeedback plus pelvic floor muscle training or to pelvic floor muscle training alonehttps://t.co/z8nxLplT57
— The BMJ (@bmj_latest) October 17, 2020
SCCM International consensus conference on prediction and identification of long-term impairments after critical illness
18 Oct, 2020 | 22:59h | UTCSystematic review: Prediction Models for Physical, Cognitive, and Mental Health Impairments After Critical Illness: A Systematic Review and Critical Appraisal – Critical Care Medicine
Source: Grupo UTI Clínica HCFMUSP
Commentary on Twitter
"Prediction Models for Physical, Cognitive, and Mental Health Impairments After Critical Illness"
Open-access: https://t.co/zGz9Fb0Ku7
Companion to @SCCM's https://t.co/T9Pw40uD48
Led by @HainesKimberley @LizzyHib
Table 4 = awesome?(special thanks @GSCollins @MaartenvSmeden) pic.twitter.com/UyFPKOSHFM— Michael Harhay (@Michael_Harhay) October 15, 2020
Guideline: Management and prevention of anemia (acute bleeding excluded) in adult critical care patients
18 Oct, 2020 | 22:52h | UTC
Commentary on Twitter
Latest guidelines for anemia ?in critically ill patients by @SigLasocki published in @AccpmJ
? what threshold?
? how many RBCs?
?EPO as a substitute?➡️check the Full ? for the answers !https://t.co/sJIIbunwKB#CriticalCare #ICU #Anemia #MedTwitter #AnesthTwitter https://t.co/AMD5xZnWDr
— Alice Blet, MD, PhD (@BletAlice) October 15, 2020
[Preprint] WHO SOLIDARITY trial results published; Remdesivir, Hydroxychloroquine, Lopinavir, and Interferon do not improve outcomes in Covid-19
16 Oct, 2020 | 09:42h | UTCRepurposed antiviral drugs for COVID-19; interim WHO SOLIDARITY trial results – medRxiv
Commentary: Remdesivir and interferon fall flat in WHO’s megastudy of COVID-19 treatments – Science
Commentaries on Twitter
Results of the @WHO SOLIDARITY trial:
4 drugs tested in 11,266 patients with COVID in 405 hospitals in 30 countries:
– hydroxychloroquine
– lopinavir
– remdesevir
– interferonNo clear benefit of any of them on survival. https://t.co/ohtTAFaSnc pic.twitter.com/2fO9E8zs8h
— Martin Landray (@MartinLandray) October 16, 2020
This is blockbuster from @WHO: 'Remdesivir, Hydroxychloroquine, Lopinavir and Interferon regimens have little or no effect on hospitalized COVID-19, as indicated by mortality, initiation of ventilation and duration of hospital stay. @medrxivpreprint https://t.co/aNGLzLL5uW pic.twitter.com/daOAMVW62u
— Harlan Krumholz (@hmkyale) October 15, 2020
Scientific consensus on the COVID-19 pandemic: we need to act now
16 Oct, 2020 | 09:41h | UTCScientific consensus on the COVID-19 pandemic: we need to act now – The Lancet
Viewpoint: Sensible medicine—balancing intervention and inaction during the COVID-19 pandemic
16 Oct, 2020 | 09:38h | UTCSensible Medicine—Balancing Intervention and Inaction During the COVID-19 Pandemic – JAMA
Author interview: Sensible Medicine—Balancing Intervention and Inaction During the COVID-19 Pandemic
Commentary on Twitter
Has #COVID19 changed how you practice #medicine?
.
More Aggressive? Gentle? Humble? or Nihilistic?
.
Check out @JAMA_current elevating a discussion of Sensible Medicine.https://t.co/IfXVktCMJb @UPMC @UPMCnews @ErinMcCreary @PittCCM @PittTweet— Christopher Seymour (@seymoc) October 15, 2020
NEW Special issue of The Global Burden of Disease Study 2019
16 Oct, 2020 | 09:31h | UTCHomepage: Global Burden of Disease Study 2019 – The Lancet
Editorial: Global health: time for radical change? – The Lancet
Commentary on Twitter
NEW Special issue of #GBDStudy 2019: 286 causes of death, 369 diseases & injuries, 87 risk factors in 204 countries & territories—data reveal how the world’s population was prepared in terms of underlying health for #COVID19 pandemic https://t.co/Af7hOlLFoJ pic.twitter.com/9kSeyB77Fv
— The Lancet (@TheLancet) October 15, 2020
Cochrane living systematic review: Not enough evidence to recommend convalescent plasma for people with COVID‐19
16 Oct, 2020 | 09:34h | UTC
Commentary on Twitter
Just updated: @CochraneCollab living review investigates the use of convalescent plasma to treat people with COVID-19: https://t.co/Or5qmxki8H “We remain very uncertain about the effectiveness & safety of using convalescent plasma for people with #COVID19".
— The Cochrane Library (@CochraneLibrary) October 13, 2020
Life expectancy after bariatric surgery in the Swedish Obese Subjects Study
16 Oct, 2020 | 09:29h | UTCCommentary: Higher average life expectancy after obesity surgery – University of Gothenburg
Commentary on Twitter
This long-term study compared mortality and life expectancy among patients who underwent bariatric surgery or received usual obesity care in the Swedish Obese Subjects study and in persons in the SOS reference study.
— NEJM (@NEJM) October 15, 2020
Systematic review: Management of colonic diverticulitis
16 Oct, 2020 | 09:25h | UTCManagement of Colonic Diverticulitis – Agency for Healthcare Research and Quality
Full report: Management of Colonic Diverticulitis
Evidence summary: Management of Colonic Diverticulitis
Study: Negative D-dimer safely rules out DVT as a stand-alone test
16 Oct, 2020 | 09:26h | UTCNegative D-dimer safely ruled out DVT as a stand-alone test – Blood Advances
Randomized trial: Effect of sustained smoking cessation counseling and free medication vs. shorter-term counseling and medication advice on smoking abstinence
16 Oct, 2020 | 09:23h | UTCCommentary: Long-term, frequent phone counseling helps cancer patients who smoke quit – eCancer
Review: Evaluation and treatment of patients with hypercortisolism
16 Oct, 2020 | 09:24h | UTCEvaluation and Treatment of Patients With Hypercortisolism: A Review – JAMA Surgery