Internal Medicine
Meta-analysis of randomized trials bring into question the belief that betablockers cause depression
16 Mar, 2021 | 01:47h | UTCDo β-Blockers Cause Depression? Systematic Review and Meta-Analysis of Psychiatric Adverse Events During β-Blocker Therapy – Hypertension (link to abstract – $ for full-text)
News release: Beta-blockers not likely to cause depression yet may contribute to sleep disturbances – American Heart Association
Commentary: Beta blockers not associated with risk of depression – Charité – Universitätsmedizin Berlin
Central nervous system–active polypharmacy common among older adults with dementia in the US
16 Mar, 2021 | 01:45h | UTCPrevalence of Central Nervous System–Active Polypharmacy Among Older Adults With Dementia in the US – JAMA (free for a limited period)
Commentaries: CNS-Active Polypharmacy Examined in Seniors With Dementia – HealthDay AND A Trio That Could Spell Trouble: Many with Dementia Take Risky Combinations of Medicines – Michigan Medicine – University of Michigan AND Older Adults With Dementia at Risk From Taking Multiple Psychotropics, Study Suggests – Psychiatric News Alert
Commentary on Twitter
In this cross-sectional study of Medicare claims, 14% of older adults with dementia filled prescriptions consistent with CNS-active polypharmacy in 2018 (eg 3+ antidepressants, antipsychotics, BNZ, Z-drugs, or opioids) https://t.co/85BmGgeYil @dtmaust @umichmedicine @PennMedicine
— JAMA (@JAMA_current) March 9, 2021
RCT: No benefit from probiotic therapy in critical illness
16 Mar, 2021 | 01:30h | UTC
Commentary on Twitter
Early & sustained untargeted administration of probiotics to adults admitted to #ICU safe, but not associated with improved outcomes. ROCIT, restoration of gut microflora in critical illness, trial visual abstract full text open access #FOAMcc on @yourICM https://t.co/mP4bkHpqSs pic.twitter.com/bu3EGUyDCm
— Intensive Care Medicine (@yourICM) March 15, 2021
RCT: Little benefit from osteopathic manipulative treatment on activity limitations in patients with nonspecific subacute and chronic low back pain
16 Mar, 2021 | 01:39h | UTCEffect of Osteopathic Manipulative Treatment vs Sham Treatment on Activity Limitations in Patients With Nonspecific Subacute and Chronic Low Back Pain: A Randomized Clinical Trial – JAMA Internal Medicine (free for a limited period)
Visual abstract: Effect of Osteopathic Manipulative Treatment vs Sham Treatment on Activity Limitations in Patients With Nonspecific Subacute and Chronic Low Back Pain
Update on the safety of COVID-19 Vaccine AstraZeneca
16 Mar, 2021 | 02:35h | UTCUpdate on the safety of COVID-19 Vaccine AstraZeneca
Related: Countries should continue AstraZeneca rollout: WHO – MedicalXpress AND Expert reaction to news that Germany has halted vaccinations with the Oxford-AstraZeneca COVID-19 vaccine – Science Media Centre AND AstraZeneca finds no evidence of increased blood clot risk from vaccine – Reuters AND Data suggest no increased risk of blood clots from the AstraZeneca vaccine. Australia shouldn’t pause its rollout – The Conversation
Commentary on Twitter
As of March 8th, Around 17 million people in the EU & UK received the vaccine , there have been 15 events of DVT & 22 events of pulmonary embolism reported among those given the vaccine,This is much lower than would be expected to occur naturally in a general population
Please RT https://t.co/tnn4brxwpp— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) March 14, 2021
B.1.1.7 variant linked to 55% higher mortality compared to other strains of SARS-CoV-2
16 Mar, 2021 | 02:32h | UTCOriginal study: Increased mortality in community-tested cases of SARS-CoV-2 lineage B.1.1.7 – Nature
Related: Death rate 64% higher with B117 COVID variant, study finds (study and commentary)
Commentary on Twitter (thread – Click for more)
https://mobile.twitter.com/_nickdavies/status/1371441682089132032
Antibody response after SARS-CoV-2 infection and implications for immunity: A rapid living review
16 Mar, 2021 | 02:30h | UTC
ACP Practice Points: What is the antibody response and role in conferring natural immunity after SARS-CoV-2 infection?
16 Mar, 2021 | 02:29h | UTC
Assessing risk for healthcare workers during the covid-19 pandemic
16 Mar, 2021 | 02:25h | UTCAssessing risk for healthcare workers during the covid-19 pandemic – The BMJ
Commentary on Twitter
NEW #BMJEducation article discusses how employers can assess risks for healthcare workers during the #COVID19 pandemic. @Azeem_Majeed @kamleshkhunti @RaoMala @CNagpaul Amanda Griffiths https://t.co/YbpZhrLsmz pic.twitter.com/e3TU56EQqH
— The BMJ (@bmj_latest) March 15, 2021
More than half of COVID-19 patients report depressive symptoms months later, study finds
16 Mar, 2021 | 02:11h | UTCOriginal study: Association of Acute Symptoms of COVID-19 and Symptoms of Depression in Adults – JAMA Network Open
Commentary on Twitter
Survey study finds 52% of individuals with prior #COVID19 met criteria for moderate or greater symptoms of depression; more likely in younger, male, and those with more severe #COVID19 @royperlis @HarvardMed @Ognyanova @RutgersU @NorthwesternU @dellavolpe https://t.co/4krNvFb29T
— JAMA Network Open (@JAMANetworkOpen) March 13, 2021
M-A: Effects of influenza vaccine on mortality and cardiovascular outcomes in patients with cardiovascular disease
14 Mar, 2021 | 20:25h | UTC
Perspective | New lung cancer screening guideline comes with many caveats
14 Mar, 2021 | 20:23h | UTCNew lung cancer screening guideline comes with many caveats – Lown Institute
Original Guideline: USPSTF Statement: begin screening for lung cancer at age 50 years instead of 55 years for patients at risk (article and commentaries)
Clinical trial shows alcohol use disorder recovery can start without sobriety
14 Mar, 2021 | 20:17h | UTC
Commentary on Twitter (thread – click for more)
1/A new trial found a harm reduction treatment effective in reducing drinking in persons experiencing homelessness – from @TheLancetPsych — I was happy to write the editorial—. Press summary here: https://t.co/WoLVWqinm6
— Stefan Kertesz, MD, MSc (@StefanKertesz) March 12, 2021
New COVID-19 risk calculator can predict severe disease or death among hospitalized patients with COVID-19
14 Mar, 2021 | 20:54h | UTCSee calculator: Severe COVID-19 Adaptive Risk Predictor (SCARP)
WHO adds Janssen vaccine to list of safe and effective emergency tools against COVID-19
14 Mar, 2021 | 20:57h | UTC
Commentary on Twitter (thread – click for more)
https://twitter.com/hildabast/status/1370537307392987141
[Preprint] RCT: Full-dose/therapeutic anticoagulation provides no benefit in critically ill patients with Covid-19
14 Mar, 2021 | 20:59h | UTCTherapeutic Anticoagulation in Critically Ill Patients with Covid-19-Preliminary Report – medRxiv
Related (results on moderately ill patients): [Not published yet] Full-dose Heparin best for moderate COVID-19 regardless of D-dimer — Data released from ACTIV-4a, ATTACC, and REMAP-CAP trials
Covid vaccinations: No reason to stop using AstraZeneca jab, says WHO
14 Mar, 2021 | 20:46h | UTCCovid vaccinations: No reason to stop using AstraZeneca jab, says WHO
See also: Benefits Of AstraZeneca Vaccine Outweigh Risks, Say EMA and WHO Officials – Urging Jabs To Continue While Safety Data Around Blood Clots Is Reviewed – Health Policy Watch AND COVID-19 Vaccine AstraZeneca: PRAC investigating cases of thromboembolic events – vaccine’s benefits currently still outweigh risks – Update – European Medicines Agency AND Canada says AstraZeneca vaccine is safe after Norway and Denmark suspend use – Reuters
Study: Healthcare settings did not increase the risk for Covid-19 infection among health care workers in the US. Exposure outside the workplace was the strongest risk factor for SARSCoV2 seropositivity
14 Mar, 2021 | 20:41h | UTCCommentaries: Healthcare settings do not increase risk for Covid-19 infection spread – University of Maryland School of Medicine AND Did Healthcare Workers Catch Covid In Or Outside The Hospital? – MedicalResearch.com AND Community Covid-19 Risk Higher Than Workplace Risk for Health Care Personnel – Physician’s Weekly
Commentary on Twitter
Cross-sectional study finds #COVID19 exposure outside the workplace was the strongest risk factor for #SARSCoV2 seropositivity. No workplace factors were associated with seropositivity. @EmoryMedicine @UMMC @HopkinsMedicine @CDCgov https://t.co/DbdSxTEb8n
— JAMA Network Open (@JAMANetworkOpen) March 10, 2021
Study shows increased risk of all-cause mortality in STEMI patients without standard modifiable risk factors
12 Mar, 2021 | 08:13h | UTC
Commentary on Twitter
#Swedish study published in @TheLancet shows patients with myocardial infarction without standard risk factors suffer worse outcomes. Use of guideline-indicated treatments attenuated the risk, underscoring a therapeutic need for this lower-risk group.https://t.co/U49IXNtACK
— The Lancet Reg Health-Europe (@LancetRH_Europe) March 10, 2021
Consensus Statement: Preoperative management of endocrine, hormonal, and urologic medications
11 Mar, 2021 | 08:04h | UTC
[Press release – not published yet] Novavax reports 96% efficacy against original strain of COVID-19, 86% efficacy against B.1.1.7 variant, and 55% efficacy against B1.351 variant
12 Mar, 2021 | 08:33h | UTCPress release: Novavax Confirms High Levels of Efficacy Against Original and Variant COVID-19 Strains in United Kingdom and South Africa Trials
Commentaries: Novavax Reports Its COVID-19 Vaccine is 96% Efficacious, Based on Phase 3 Trial Results – TIME AND Novavax Says Vaccine Is 96% Effective At Preventing Original Covid-19 Virus – Forbes
Commentary on Twitter
https://twitter.com/m_scribe/status/1370126020121083913
ERS Guideline: Management of hospitalized adults with COVID-19
12 Mar, 2021 | 08:36h | UTC
NCCN Best Practices Guidance: Management of COVID-19 Infection in Patients with Cancer
12 Mar, 2021 | 08:31h | UTC
COVID-19 and liver disease: mechanistic and clinical perspectives
12 Mar, 2021 | 08:29h | UTC
Covid-19: European countries suspend use of Oxford-AstraZeneca vaccine after reports of blood clots
12 Mar, 2021 | 08:32h | UTCSee also: More European nations pause AstraZeneca vaccine use as blood clot reports investigated – CNN AND Denmark, Norway and Iceland suspend AstraZeneca COVID shots after blood clot reports – Reuters
Commentary on Twitter
Denmark has temporarily suspended use of the Oxford-AstraZeneca covid-19 vaccine as a precautionary move after reports of blood clots. But the EMA and the UK’s regulatory body say there is no indication that vaccination is linked to thromboembolic events https://t.co/sW8GRqcnLg
— The BMJ (@bmj_latest) March 11, 2021