Internal Medicine
Editorial: SARS-CoV-2 Vaccine–Induced Immune Thrombotic Thrombocytopenia – “The very low prevalence of this complication of vaccination, however severe, relative to the benefits of preventing Covid-19 must be emphasized”
18 Apr, 2021 | 21:42h | UTCSARS-CoV-2 Vaccine–Induced Immune Thrombotic Thrombocytopenia – New England Journal of Medicine
COVID vaccines and blood clots: five key questions
18 Apr, 2021 | 21:40h | UTCCOVID vaccines and blood clots: five key questions – Nature
See also (podcast): Coronapod: could COVID vaccines cause blood clots? Here’s what the science says – Nature
Study shows past COVID-19 infection doesn’t fully protect young people against reinfection
18 Apr, 2021 | 21:35h | UTCOriginal study: SARS-CoV-2 seropositivity and subsequent infection risk in healthy young adults: a prospective cohort study – The Lancet Respiratory Medicine
Commentary on Twitter
Risk of covid reinfection in a prospective study of >3,000 Marine recruits
Prior covid: 82% reduced compared w/ no prior covid (+ when reinfections occurred, much less viral loads)
Protection correlated w/ higher spike IgG antibody levels https://t.co/7Jl154lwDX @LancetRespirMed pic.twitter.com/xKVLKm8AA6— Eric Topol (@EricTopol) April 15, 2021
Study: Double masking improves protection from Covid-19 mostly by eliminating any gaps or poor-fitting areas of a mask
18 Apr, 2021 | 21:37h | UTCFitted Filtration Efficiency of Double Masking During the COVID-19 Pandemic – JAMA Internal Medicine
Commentaries: Fit matters most when double masking to protect yourself from COVID-19 – University of North Carolina Health Care AND Check your fit on that double mask if you want it to work against Covid, study says – CNN
Study Commentary | What if the EHR Age-Adjusts D-dimer for You?
18 Apr, 2021 | 21:04h | UTCWhat if the EHR Age-Adjusts D-dimer for You? – Journal Feed
Original study: Multi-center implementation of automated age-adjusted D-dimer results reduces unnecessary PE imaging – The American Journal of Emergency Medicine (link to abstract – $ for full-text)
Case report: Energy drink-induced cardiomyopathy
18 Apr, 2021 | 21:00h | UTCEnergy drink-induced cardiomyopathy – BMJ Case Reports
Commentaries: Student’s heart failure linked to ‘excessive’ energy drinks – BBC AND Heavy energy drink consumption linked to heart failure in a young man – BMJ
Hemodialysis Emergencies: Core Curriculum 2021
16 Apr, 2021 | 06:13h | UTCHemodialysis Emergencies: Core Curriculum 2021 – American Journal of Kidney Diseases
Commentary on Twitter
Hemodialysis Emergencies: Core Curriculum 2021https://t.co/BOQrsABOU3 (FREE)@KeikoGNeph @Mike_J_Choi @MedStarGUH #Hemodialysis pic.twitter.com/KYZRCqm5OA
— AJKD (@AJKDonline) March 26, 2021
RCT: An Enhanced Recovery After Surgery (ERAS) program in laparoscopic distal gastrectomy provided a faster recovery, a shorter postoperative hospitalization length, and lower medical costs without increasing complication and readmission rates
16 Apr, 2021 | 06:16h | UTCRelated: Consensus guidelines for enhanced recovery after gastrectomy – British Journal of Surgery AND Current status of the “enhanced recovery after surgery” program in gastric cancer surgery – Annals of Gastroenterological Surgery
See also: Enhanced Recovery After Surgery (ERAS) Society Guidelines
Study shows antihistamines may impair response to exercise training
16 Apr, 2021 | 06:06h | UTCCommentary: Histamine-suppressing drugs found to reduce benefits of exercise – MedicalXpress
Commentary on Twitter (thread – click for more)
Extremely excited to finally share our newest paper: Histamine H1 and H2 receptors are essential transducers of the integrative exercise training response in humans. Published today in @ScienceAdvances. A thread: (1/12)https://t.co/R4FNiKWyG9 pic.twitter.com/U2HFHOY9eA
— Thibaux Van der Stede (@ThibauxV) April 14, 2021
Advances in Clinical Cardiology 2020: A Summary of Key Clinical Trials
16 Apr, 2021 | 06:14h | UTCAdvances in Clinical Cardiology 2020: A Summary of Key Clinical Trials – Advances in Therapy
[Preprint] Risk of rare blood clotting much higher for COVID-19 than for vaccines
16 Apr, 2021 | 06:37h | UTCNews release: Risk of rare blood clotting higher for COVID-19 than for vaccines – University of Oxford
Original study (preprint): Cerebral venous thrombosis: a retrospective cohort study of 513,284 confirmed COVID-19 cases and a comparison with 489,871 people receiving a COVID-19 mRNA vaccine
Commentaries: Brain clots ‘more likely’ with Covid infection than vaccine – BBC AND Risk for Cerebral Venous Thrombosis Elevated After COVID-19 Diagnosis – NEJM Journal Watch AND Study: COVID much more likely than vaccines to cause blood clots – CIDRAP
Commentary on Twitter
There is an interesting new preprint out that will probably generate a lot of coverage at least in the UK. Essentially it argues that the risk of CVST is much higher from #covid19 than from vaccines.
Quick thread on this:https://t.co/0MdDU2z9bp— Kai Kupferschmidt (@kakape) April 15, 2021
Evolving changes in mortality of 13,301 critically ill adult patients with COVID-19 over 8 months
16 Apr, 2021 | 06:35h | UTC
Commentary on Twitter
Our paper on covid-19 pandemic trends in the first 8 months in the pandemic at @yourICM. Patients are getting younger, less frail, and mortality decreased over time. Very poor outcomes for elder frail patients. https://t.co/DHJvr22zFl
— Fernando Zampieri (@f_g_zampieri) April 14, 2021
M-A: Treatment with hydroxychloroquine is associated with increased mortality in COVID-19 patients
16 Apr, 2021 | 06:30h | UTC
Commentaries on Twitter
The use of hydroxychloroquine in COVID19 will be remembered as one of the worst examples of medicine going against its core principle:
First Do No Harm. https://t.co/PGq4D5pJ1H— Maurizio Cecconi (@DrMCecconi) April 15, 2021
What collaboration can achieve
Just out in @NatureComms our meta-analysis of 14 unpublished & 14 published RCTs on Hydroxychloroquine/ Choloroquine
Thanks so much to the great team – and special thanks for rapidly sharing the data of unpublished trials!https://t.co/Dg1DmAx1Kq
— Lars G. Hemkens (@LGHemkens) April 15, 2021
Perspective | Ivermectin is the new Hydroxychorloquine
16 Apr, 2021 | 06:28h | UTCIvermectin is the new Hydroxychorloquine – Science-Based Medicine
Video | Coronavirus variants: What you need to know
16 Apr, 2021 | 06:32h | UTCCoronavirus variants: What you need to know – Nature Video
Editorial: Covid-19 has redefined airborne transmission
16 Apr, 2021 | 06:26h | UTCCovid-19 has redefined airborne transmission – The BMJ
Commentaries: Future attempts to reduce Covid-19 spread should focus on tackling airborne transmission – News Medical AND Open the windows to curb COVID spread: experts – MedicalXpress
Related: CDC Updated Guidance: “It is possible for people to be infected through contact with contaminated surfaces or objects, but the risk is generally considered to be low” (CDC Guidance and more) AND Deep Cleaning Isn’t a Victimless Crime – The Atlantic
Were pregnant women more affected by COVID-19 in the second wave of the pandemic?
16 Apr, 2021 | 06:24h | UTCWere pregnant women more affected by COVID-19 in the second wave of the pandemic? – The Lancet
Vaccines alone will not stop Covid spreading – here’s why (visual guide to the “Swiss cheese model”)
15 Apr, 2021 | 06:53h | UTCVaccines alone will not stop Covid spreading – here’s why – BBC
Genomics and epidemiology of the P.1 SARS-CoV-2 lineage in Manaus, Brazil – “we estimate that P.1 may be 1.7–2.4-fold more transmissible”
15 Apr, 2021 | 07:09h | UTCGenomics and epidemiology of the P.1 SARS-CoV-2 lineage in Manaus, Brazil – Science
Commentary: The P.1 coronavirus variant is twice as transmissible as earlier strains – ScienceNews
Pandemic Boosts an Old Idea—Bringing Acute Care to the Patient
15 Apr, 2021 | 06:51h | UTCPandemic Boosts an Old Idea—Bringing Acute Care to the Patient – JAMA
Related studies: Cohort Study: Selected patients with Covid-19 can be safely discharged on home oxygen, with low mortality and readmission rates AND Association of a Bundled Hospital-at-Home and 30-Day Postacute Transitional Care Program With Clinical Outcomes and Patient Experiences – JAMA Internal Medicine
Ulcerative colitis: an update
15 Apr, 2021 | 06:16h | UTCUlcerative colitis: an update – Clinical Medicine Journal
Review: Endocrine complications of immunotherapies
15 Apr, 2021 | 06:13h | UTCEndocrine complications of immunotherapies: a review – Clinical Medicine Journal
USPSTF Statement: Insufficient evidence to recommend Vitamin D deficiency screening
14 Apr, 2021 | 01:47h | UTCVitamin D Deficiency in Adults: Screening – U.S. Preventive Services Task Force
Evidence Report: Screening for Vitamin D Deficiency in Adults: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force
Editorial: The USPSTF 2021 Recommendations on Screening for Asymptomatic Vitamin D Deficiency in Adults: The Challenge for Clinicians Continues – JAMA AND Why USPSTF Still Finds Insufficient Evidence to Support Screening for Vitamin D Deficiency – JAMA Network Open
JAMA Patient Page: Screening for Vitamin D Deficiency in Adults
Study shows practitioners overestimate the probability of disease before and after testing
14 Apr, 2021 | 01:44h | UTCAccuracy of Practitioner Estimates of Probability of Diagnosis Before and After Testing – JAMA Internal Medicine (free for a limited period)
Commentary: Physicians, Probabilities, and Populations—Estimating the Likelihood of Disease for Common Clinical Scenarios – JAMA Internal Medicine (free for a limited period)
Commentary on Twitter
How good are doctors at diagnosis?
This is the most relevant paper I have written. Not perfect but addresses a huge issue I think could change medicine if acknowledged
…it has changed how I think about diagnosishttps://t.co/4ZtoD3F4rF @JAMAInternalMed @drjohnm
1/n— Dan Morgan (@dr_dmorgan) April 12, 2021
M-A: Effectiveness of treatments for acute and subacute mechanical non-specific low back pain
14 Apr, 2021 | 01:39h | UTC
Commentary on Twitter
Just published in BJSM 🔥🔥🔥
Effectiveness of treatments for acute and subacute mechanical non-specific low back pain: a systematic review with network meta-analysis
👀👀👇👇🔎https://t.co/bx06RPLTbT pic.twitter.com/RzHkwN2nTp
— Physio Meets Science (@PhysioMeScience) April 13, 2021