Internal Medicine
RCT | Cytisinicline shows significant efficacy in smoking cessation over placebo
13 Jul, 2023 | 12:58h | UTCCytisinicline for Smoking Cessation: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
See also: Visual Abstract
Practice Guidance | Six steps to better care for older people in acute hospitals
12 Jul, 2023 | 14:00h | UTCSix steps to better care for older people in acute hospitals – British Geriatrics Society
News Release: New guidance outlines ‘Six steps to better care for older people in hospital’ – British Geriatrics Society
Clinical practice guideline for deprescribing opioid analgesics
12 Jul, 2023 | 13:58h | UTCRelated:
RCT | Opioids not more effective than placebo for acute low back and neck pain
RCT | A deprescribing intervention reduced medication burden among older adults in post-acute care
Deprescribing proton pump inhibitors – Australian Journal of General Practice
Antihypertensive Deprescribing in Older Adults: a Practical Guide – Current Hypertension Reports
Deprescribing in Palliative Cancer Care – Life
Less is More: Deprescribing Medications in Older Adults with Kidney Disease: A Review – Kidney360
Polypharmacy Management in Older Patients – Mayo Clinic Proceedings
Eliminating Medication Overload: A National Action Plan – Lown Institute
Common ED Medication Errors: Polypharmacy – emDocs
Current and future perspectives on the management of polypharmacy – BMC Family Practice
Polypharmacy—an Upward Trend with Unpredictable Effects – Deutsches Ärzteblatt international
Clinical Consequences of Polypharmacy in Elderly – Expert Opinion on Drug Safety
RCT | Self-administered intranasal etripamil superior to placebo for acute supraventricular tachycardia conversion
12 Jul, 2023 | 13:54h | UTC
M-A | The effect of blood pressure lowering medications on the prevention of episodic migraine
12 Jul, 2023 | 13:50h | UTCNews Release: New study shows common blood pressure meds underused for migraine – George Institute for Global Health
Myocarditis: a primer for intensivists
12 Jul, 2023 | 13:42h | UTCMyocarditis: a primer for intensivists – Intensive Care Medicine
Commentary on Twitter
Fulminant myocarditis in #ICU
🫀short/long‑term prognosis
🫀clinical suspicion, initial recognition, differential diagnoses
🫀initial management & temporary #MCS: IABP #ECMO #Impella
🫀endomyocardial biopsy
🫀immunomodulatory therapies
🔓#FOAMcc @yourICM
🖇️https://t.co/JIGm4p0tv5 pic.twitter.com/o4RctuurEL— Intensive Care Medicine (@yourICM) July 11, 2023
Retrospective Analysis | 18% of ICU patients develop sepsis-associated AKI, mostly stage 1, diagnosed by low urine output
12 Jul, 2023 | 13:39h | UTC
Commentary on Twitter
Fulminant myocarditis in #ICU
🫀short/long‑term prognosis
🫀clinical suspicion, initial recognition, differential diagnoses
🫀initial management & temporary #MCS: IABP #ECMO #Impella
🫀endomyocardial biopsy
🫀immunomodulatory therapies
🔓#FOAMcc @yourICM
🖇️https://t.co/JIGm4p0tv5 pic.twitter.com/o4RctuurEL— Intensive Care Medicine (@yourICM) July 11, 2023
Intervention Study | Pharmacist review may reduce antibiotic overuse at discharge
12 Jul, 2023 | 13:37h | UTCCommentary: Pharmacist review identifies improper antibiotic prescriptions – CIDRAP
M-A | Cognitive rehabilitation may improve everyday activities in mild to moderate dementia
12 Jul, 2023 | 13:34h | UTCCognitive rehabilitation for people with mild to moderate dementia – Cochrane Library
USPSTF | Routine depression screening recommended for adults including pregnant and postpartum women
11 Jul, 2023 | 14:09h | UTCEvidence Report: Depression and Suicide Risk Screening: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force – JAMA
Patient Page: Screening for Depression and Suicide Risk in Adults – JAMA
Editorials:
Reframing the Key Questions Regarding Screening for Suicide Risk – JAMA
Suicidality Screening Guidelines Highlight the Need for Intervention Studies – JAMA Network Open
Related:
M-A | P2Y12 inhibitors show superior efficacy over aspirin for secondary prevention in CAD
11 Jul, 2023 | 14:06h | UTCP2Y12 Inhibitor or Aspirin Monotherapy for Secondary Prevention of Coronary Events – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Related:
Monotherapy with a P2Y12 inhibitor or aspirin for secondary prevention in patients with established atherosclerosis: a systematic review and meta-analysis – The Lancet (link to abstract – $ for full-text)
Commentary on Twitter
Given superior efficacy & similar overall safety, #P2Y12 inhibitor monotherapy might be preferred over #aspirin monotherapy for long-term secondary prevention in pts w/ established #cvCAD. https://t.co/EehIEuWqOt#JACC #P2Y12i #CardioTwitter @FeliceGragnano @vlgmrc @Drroxmehran pic.twitter.com/betLycXGs5
— JACC Journals (@JACCJournals) July 5, 2023
Cohort Study | Long-term use of menopausal hormone therapy linked to heightened dementia risk
11 Jul, 2023 | 14:04h | UTCMenopausal hormone therapy and dementia: nationwide, nested case-control study – The BMJ
Editorial: Menopausal hormone therapy and dementia – The BMJ
News Release: Menopausal hormone therapy linked to increased rate of dementia – BMJ Newsroom
Commentaries: Expert reaction to observational study on HRT and dementia – Science Media Centre
Cohort Study | Fewer than half of new drugs add substantial therapeutic value over existing treatments
11 Jul, 2023 | 14:01h | UTCNews Release: Fewer than half of new drugs add substantial therapeutic value over existing treatments – BMJ Newsroom
Editorial: Patients need better treatments, not just more of the same – The BMJ
AASLD Guidance | Use of TIPS, variceal embolization, and retrograde transvenous obliteration in variceal hemorrhage
11 Jul, 2023 | 13:59h | UTC
Practice Recommendation | Strategies to prevent MRSA transmission and infection in hospitals
10 Jul, 2023 | 14:02h | UTCCommentary: New guidelines recommend antibiotic stewardship for preventing MRSA – CIDRAP
Guideline | Acute liver failure
10 Jul, 2023 | 13:59h | UTCAcute Liver Failure Guidelines – The American Journal of Gastroenterology
Related:
EASL Clinical Practice Guidelines on acute-on-chronic liver failure – Journal of Hepatology
Guidelines for the management of adult acute and acute-on-chronic liver failure in the ICU
Acute-on-chronic liver failure: far to go—a review – Critical Care
RCT | Dual antiplatelet therapy proves noninferior to alteplase in minor ischemic stroke
10 Jul, 2023 | 13:58h | UTCDual Antiplatelet Therapy vs Alteplase for Patients With Minor Nondisabling Acute Ischemic Stroke: The ARAMIS Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
See also: Visual Abstract
RCT | No significant difference in weight loss between intermittent fasting and calorie restriction
10 Jul, 2023 | 13:56h | UTCTime-Restricted Eating Without Calorie Counting for Weight Loss in a Racially Diverse Population: A Randomized Controlled Trial – Annals of Internal Medicine (link to abstract – $ for full-text)
News Release: Intermittent fasting and traditional calorie counting shown to be about equal for weight loss – American College of Physicians
Commentary: Intermittent fasting and calorie counting about equal for weight loss – new study – The Conversation
Related:
Time-Restricted Eating: Integrating The What With The When – Advances in Nutrition
Cohort Study | A diet high in fruits, vegetables, nuts, legumes, fish, and dairy linked with decreased mortality and CVD globally
10 Jul, 2023 | 13:39h | UTCDiet, cardiovascular disease, and mortality in 80 countries – European Heart Journal
News Release: Global diet study challenges advice to limit high-fat dairy foods – European Society of Cardiology
Commentary on Twitter
Fruits, vegetables, nuts, legumes, fish and dairy: the secret to a lower risk of cardiovascular risk and mortality! Read the Prospective Urban Rural Epidemiology study on #EHJ!#diet #cardiovascular #risk #cardiotwitter #EHJ @ESC_Journals @escardio https://t.co/uzDYdhf6DI pic.twitter.com/54ZN3pa6cN
— EHJ Editor-in-Chief (@ehj_ed) July 9, 2023
Review | Evaluation of acute adult disorders of consciousness for the general intensivist
10 Jul, 2023 | 13:37h | UTCState-of-the-Art Evaluation of Acute Adult Disorders of Consciousness for the General Intensivist – Critical Care Medicine (free for a limited period)
Personalized nutrition therapy in critical care: 10 expert recommendations
10 Jul, 2023 | 13:36h | UTCPersonalized nutrition therapy in critical care: 10 expert recommendations – Critical Care
How to avoid harm with feeding critically ill patients: a synthesis of viewpoints of a basic scientist, dietitian and intensivist
10 Jul, 2023 | 13:34h | UTC
Cohort Study | Hypertensive disorders of pregnancy linked to a 66% higher stroke risk in U.S. black women
10 Jul, 2023 | 13:31h | UTCHypertensive Disorders of Pregnancy and Risk of Stroke in U.S. Black Women – NEJM Medicine
M-A | Efficacy of varenicline versus bupropion for smoking cessation
10 Jul, 2023 | 13:23h | UTC
Podcast | Untangling catheter associated UTIs
10 Jul, 2023 | 13:21h | UTC#402 Don’t Get Caught with a CAUTI – The Curbsiders


