Internal Medicine
Vaccine-induced immune thrombotic thrombocytopenia (VITT) – a novel clinico-pathological entity with heterogeneous clinical presentations.
2 Jul, 2021 | 11:39h | UTCCommentary: Blood clots related to AstraZeneca/Oxford vaccine can be mitigated with early detection – MedicalXpress
Delirium in COVID-19: can we make the unknowns knowns?
2 Jul, 2021 | 11:17h | UTCDelirium in COVID-19: can we make the unknowns knowns? – Intensive Care Medicine
Commentary on Twitter
Delirium in #COVID19 critical illness?
➡️high incidence likely due to microvascular disease & inflammatory mechanisms
⬇️standards of care ie strained resources
➡️key predictor of cognitive impairment/dementia post 🏥
➡️long-term post #ICU follow-up pivotal https://t.co/dC339XrfGm pic.twitter.com/nzyPCu16ap— Intensive Care Medicine (@yourICM) June 30, 2021
[Press release] J&J single-shot COVID-19 vaccine generates strong, persistent activity against the rapidly spreading Delta variant and other highly prevalent SARS-CoV-2 viral variants.
2 Jul, 2021 | 11:38h | UTCCommentary: J&J Covid Shot Neutralizes Delta Variant, Company Says – Bloomberg (a few articles per month are free)
Complex Regional Pain Syndrome: A Comprehensive Review
2 Jul, 2021 | 11:13h | UTCComplex Regional Pain Syndrome: A Comprehensive Review – Pain and Therapy
The Management of Restless Legs Syndrome: An Updated Algorithm
2 Jul, 2021 | 11:12h | UTCThe Management of Restless Legs Syndrome: An Updated Algorithm – Mayo Clinic Proceedings
COVID-19 vaccines reduce severity, length, viral load for those who still get infected.
1 Jul, 2021 | 09:57h | UTCOriginal study: Prevention and Attenuation of Covid-19 with the BNT162b2 and mRNA-1273 Vaccines – New England Journal of Medicine
Commentary on Twitter
The @CDCgov trial to rigorously assess mRNA vaccination suppression of covid infections as assessed with frequent NP swabs in nearly 4,000 participants
91% efficacy of blocking transmission of infection (2 doses); 40% reduction of viral load https://t.co/tI6LECbw42 pic.twitter.com/y85Vd9ih5A— Eric Topol (@EricTopol) June 30, 2021
RCT: Novavax vaccine conferred 89.7% protection against symptomatic SARS-CoV-2 infection and 100% protection against hospitalizations or deaths.
1 Jul, 2021 | 09:59h | UTCSafety and Efficacy of NVX-CoV2373 Covid-19 Vaccine – New England Journal of Medicine
Audio interview: Audio Interview: Another New Covid-19 Vaccine – New England Journal of Medicine
Related: Opinion | The mRNA vaccines are extraordinary, but Novavax is even better
Analysis: How long does covid-19 immunity last?
1 Jul, 2021 | 09:56h | UTCHow long does covid-19 immunity last? – The BMJ
The neurological manifestations of post-acute sequelae of SARS-CoV-2 infection.
1 Jul, 2021 | 09:55h | UTC
Perspective | Why no one is sure if Delta is deadlier – “The variants are spreading faster, but they don’t necessarily have incentive to kill more often”.
1 Jul, 2021 | 09:52h | UTCWhy No One Is Sure If Delta Is Deadlier – The Atlantic
AHA Scientific Statement: Managing atrial fibrillation in patients with heart failure and reduced ejection fraction.
1 Jul, 2021 | 09:46h | UTCTop Things to Know: Managing Atrial Fibrillation in Patients With Heart Failure and Reduced Ejection Fraction
Commentary on Twitter
Pleased to share AHA Scientific statement on ‘Managing AF in pts with HFrEF’ just published @CirculationEP. https://t.co/WRx3QnrxHF Many thanks to the writing group and reviewers for making this excellent guidance document possible @AHAScience @American_Heart @CircAHA #Epeeps pic.twitter.com/PoqqlyA0iA
— Rakesh Gopinath (@drrakeshg1) June 23, 2021
Long COVID or post-acute sequelae of COVID-19 (PASC): An overview of biological factors that may contribute to persistent symptoms.
30 Jun, 2021 | 10:24h | UTC
Case Series: Myocarditis following immunization with mRNA COVID-19 vaccines.
30 Jun, 2021 | 10:22h | UTCSee also: Patients With Acute Myocarditis Following mRNA COVID-19 Vaccination – JAMA Cardiology
Editorials: Myocarditis Occurring After Immunization With mRNA-Based COVID-19 Vaccines AND Temporal Associations Between Immunization With the COVID-19 mRNA Vaccines and Myocarditis: The Vaccine Safety Surveillance System Is Working
Commentary: More Evidence Links Myocarditis to mRNA COVID-19 Vaccines – TCTMD
Commentary on Twitter
2 new reports of myocarditis after mRNA vaccination documenting its rare occurrence
23 males serving in the military among 2.8 million doses givenhttps://t.co/yPbYxkuSHi
4 cases in North Carolina, including a 70-year-old womanhttps://t.co/Iwj2Hx6O2U@JAMACardio pic.twitter.com/fv2JoOFAyt— Eric Topol (@EricTopol) June 29, 2021
Systematic Review: Cilostazol for intermittent claudication – “Cilostazol has been shown to improve walking distance in people with intermittent claudication. However, participants taking cilostazol had higher odds of experiencing headache”.
1 Jul, 2021 | 09:42h | UTCCilostazol for intermittent claudication – Cochrane Library
Summary: Cilostazol for peripheral arterial disease – Cochrane Library
Covid: Masks upgrade cuts infection risk, research finds.
30 Jun, 2021 | 10:16h | UTCCovid: Masks upgrade cuts infection risk, research finds – BBC
Pulmonary embolism in patients with COVID-19: incidence, risk factors, clinical characteristics, and outcome.
30 Jun, 2021 | 10:13h | UTC
RCT: Among patients with diarrhea-predominant irritable bowel syndrome, a low FODMAP diet achieved earlier symptomatic improvements in stool frequency and excessive wind.
30 Jun, 2021 | 10:09h | UTC
Should I get my second AstraZeneca dose? Yes, it almost doubles your protection against Delta.
30 Jun, 2021 | 10:11h | UTCRelated: Effectiveness of COVID-19 vaccines against the B.1.617.2 variant – medRxiv
M-A: SGLT2 inhibitors decrease cardiovascular death and heart failure hospitalizations in patients with heart failure.
30 Jun, 2021 | 10:08h | UTC
IHME COVID-19 model has been updated for over 200 world locations.
29 Jun, 2021 | 10:13h | UTCCOVID-19 Projections – Institute for Health Metrics and Evaluation
Video: Insights from IHME’s latest COVID-19 model update
Commentary on Twitter
📣 NEW ✨ Our COVID-19 model has been updated for over 200 world locations 🌎 🌍 🌏 📊 (https://t.co/5biAggRz1T)
📺 Full video: https://t.co/wLGeAiiYhy
📄 PDFs with explanations of country-specific projections: https://t.co/9KQxWwhQqx pic.twitter.com/8sSEzyXEf8— Institute for Health Metrics and Evaluation (IHME) (@IHME_UW) June 27, 2021
SARS-CoV-2 mRNA vaccines induce persistent human germinal center responses, suggesting immunity will be long-lasting.
29 Jun, 2021 | 10:03h | UTCSARS-CoV-2 mRNA vaccines induce persistent human germinal centre responses – Nature
Commentaries: Immune response to FDA-approved vaccines is strong and potentially long-lasting – News Medical
Commentary on Twitter (thread – click for more)
Just published @nature
A bonus factor after covid vaccination: germinal center factories for durable, antigen-specific, B cells and plasmoblasts induced by mRNA vaccination, as determined by lymph node aspirates from vaccinees https://t.co/5eR0gDSWHq
@TheBcellArtist @WUSTLmed pic.twitter.com/C5xPSrh5Gw— Eric Topol (@EricTopol) June 28, 2021
Case report: Thrombosis with Thrombocytopenia After the Messenger RNA–1273 Vaccine.
29 Jun, 2021 | 10:07h | UTCThrombosis With Thrombocytopenia After the Messenger RNA–1273 Vaccine – Annals of Internal Medicine
[Preprint] 3rd AstraZeneca shot gives strong immunity.
29 Jun, 2021 | 10:01h | UTCStudy: 3rd AstraZeneca shot gives strong immunity – Reuters
Original Study (preprint): Tolerability and Immunogenicity After a Late Second Dose or a Third Dose of ChAdOx1 nCoV-19 (AZD1222) – SSRN/The Lancet
Ivermectin for the treatment of COVID-19: A systematic review and meta-analysis of randomized controlled trials – “IVM did not reduce all-cause mortality, length of stay or viral clearance in RCTs in COVID-19 patients with mostly mild disease”.
29 Jun, 2021 | 10:00h | UTC
Podcast | Evaluation and management of hypercalcemia.
29 Jun, 2021 | 09:51h | UTC#281 Hypercalcemia: Calci-fun! with Dr. Carl Pallais – The Curbsiders